Suppression of extracellular signals and cell proliferation by the black tea polyphenol, theaflavin-3,3'-digallate.

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Carcinogenesis

• Publication date

  1999-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/CARCIN/20.4.733PMID 10223207
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Inhibition of cyclin‐dependent kinases 2 and 4 activities as well as induction of cdk inhibitors p21 and p27 during growth arrest of human breast carcinoma cells by (−)‐epigallocatechin‐3‐gallate

  1999cited by this paper
• Quantitation of chemopreventive synergism between (-)-epigallocatechin-3-gallate and curcumin in normal, premalignant and malignant human oral epithelial cells.

  1998cited by this paper
• Protective role of black tea against oxidative damage of human red blood cells.

  1998cited by this paper
• Inhibitory effect of black tea on the growth of established skin tumors in mice: effects on tumor size, apoptosis, mitosis and bromodeoxyuridine incorporation into DNA.

  1997cited by this paper
• Inhibition of tumor promoter-induced activator protein 1 activation and cell transformation by tea polyphenols, (-)-epigallocatechin gallate, and theaflavins.

  1997cited by this paper
• Suppression of extracellular signals and cell proliferation through EGF receptor binding by (−)‐epigallocatechin gallate in human A431 epidermoid carcinoma cells

  1997cited by this paper
• Mitosis-specific Negative Regulation of Epidermal Growth Factor Receptor, Triggered by a Decrease in Ligand Binding and Dimerization, Can Be Overcome by Overexpression of Receptor*

  1997cited by this paper
• (-)-Epigallocatechin-3-gallate blocks the induction of nitric oxide synthase by down-regulating lipopolysaccharide-induced activity of transcription factor nuclear factor-kappaB.

  1997cited by this paper
• (−)-Epigallocatechin-3-gallate Blocks the Induction of Nitric Oxide Synthase by Down-Regulating Lipopolysaccharide-Induced Activity of Transcription Factor Nuclear Factor-κB

  1997cited by this paper
• Green tea constituent epigallocatechin-3-gallate and induction of apoptosis and cell cycle arrest in human carcinoma cells.

  1997cited by this paper
• Composition of polyphenols in fresh tea leaves and associations of their oxygen-radical-absorbing capacity with antiproliferative actions in fibroblast cells

  1996cited by this paper
• Tea in chemoprevention of cancer.

  1996cited by this paper
• ANTIOXIDANT PROPERTIES OF POLYPHENOLS EXTRACTED FROM GREEN AND BLACK TEAS

  1995cited by this paper
• Inhibition of Tumor Promotion through Blocking Signal Transduction

  1995cited by this paper
• Polyphenols as cancer chemopreventive agents

  1995cited by this paper
• Inhibitory effects of tea extracts and (-)-epigallocatechin gallate on DNA synthesis and proliferation of hepatoma and erythroleukemia cells.

  1993cited by this paper
• Tea and cancer.

  1993cited by this paper
• Synthetic oligonucleotides as therapeutic agents.

  1991cited by this paper
• Clinical significance of the expression of epidermal growth factor and its receptor in esophageal cancer

  1991cited by this paper
• Signal transduction by receptors with tyrosine kinase activity.

  1990cited by this paper

• Theaflavin-3,3′-digallate protects against myocardial ischemia/reperfusion injury and hypoxia/reoxygenation injury by activating the PI3K/Akt/mTOR pathway

  2025cites this paper
• The Inhibiting Effect of GB-2, (+)-Catechin, Theaflavin, and Theaflavin 3-Gallate on Interaction between ACE2 and SARS-CoV-2 EG.5.1 and HV.1 Variants

  2024cites this paper
• A systematic review of tea pigments: Prevention of major diseases, protection of organs, and potential mechanisms and applications

  2023cites this paper
• Theaflavin-3,3′-Digallate from Black Tea Inhibits Neointima Formation Through Suppression of the PDGFRβ Pathway in Vascular Smooth Muscle Cells

  2022cites this paper
• Anti-Cancer Properties of Theaflavins

  2021influential citation
• Phytochemicals as Potential Chemopreventive and Chemotherapeutic Agents for Emerging Human Papillomavirus–Driven Head and Neck Cancer: Current Evidence and Future Prospects

  2021cites this paper
• Anticancer Effects and Molecular Target of Theaflavins from Black Tea Fermentation in Vitro and in Vivo.

  2021cites this paper
• Potential Bioactive Components and Health Promotional Benefits of Tea (Camellia sinensis).

  2020cites this paper
• The enzyme‐oriented regulation of theaflavin‐3, 3 ′ ‐digallate synthesis and the accurate determination of its yield

  2020cites this paper
• Theaflavin TF3 relieves hepatocyte lipid deposition through activating AMPK signaling pathway by targeting plasma kallikrein.

  2020cites this paper
• Molecular evidences of health benefits of drinking black tea

  2019cites this paper
• Genetic and Epigenetic Targets of Natural Dietary Compounds as Anticancer Agents

  2019cites this paper
• Dose-dependent green tea effect on decrease of inflammation in human oral gingival epithelial keratinocytes: in vitro study

  2019cites this paper
• Optimization and Validation of Reversed Phase High Performance Chromatography Method for Rapid Estimation of Theaflavin

  2018cites this paper
• The effect of melatonin treatment on doxorubicin-induced skeletal muscle atrophy within a cancer model

  2018cites this paper
• Development of a Time-Resolved Fluorescence Resonance Energy Transfer Ultrahigh-Throughput Screening Assay for Targeting the NSD3 and MYC Interaction

  2018cites this paper
• Effectivity of Black Tea Polyphenol in Adipogenesis Related IGF-1 and Its Receptor Pathway Through In Silico Based Study

  2018cites this paper
• Theaflavins from black tea affect growth, development, and motility in Dictyostelium discoideum.

  2017cites this paper
• Theaflavin-3,3'-digallate represses osteoclastogenesis and prevents wear debris-induced osteolysis via suppression of ERK pathway.

  2017cites this paper
• Cycloartenyl Ferulate downregulates lipopolysaccharide stimulated iNOS mRNA via NF-kB suppression in RAW 264.7 macrophages

  2017cites this paper
• Novel polysaccharide-polypeptides nanocomplexes: assembly, characterization, and applications in delivery of black tea polyphenols

  2017cites this paper
• Secondary metabolism in evergreen species with high tolerance to osmotic stress: what is the role for these species as biofactories?

  2017cites this paper
• Health Benefits of Tea: Beneficial Effects of Tea on Human Health

  2017cites this paper
• Research progress on theaflavins: efficacy, formation, and preparation

  2017cites this paper
• Black tea: Phytochemicals, cancer chemoprevention, and clinical studies

  2017cites this paper
• The Impact of Physical Activity and Antioxidants on Tumor-Skeletal Muscle Crosstalk during Cancer : Deciphering Signaling Pathways Involved in Tumor Growth and Muscle Wasting

  2016cites this paper
• Pyrogallol, an absorbable microbial gallotannins-metabolite and mango polyphenols (Mangifera Indica L.) suppress breast cancer ductal carcinoma in situ proliferation in vitro.

  2016cites this paper
• The Janus-Faced Role of Antioxidants in Cancer Cachexia: New Insights on the Established Concepts

  2016cites this paper
• Identification of Small Molecules that Disrupt Signaling between ABL and Its Positive Regulator RIN1

  2015cites this paper
• Theaflavin-3, 3′-digallate decreases human ovarian carcinoma OVCAR-3 cell-induced angiogenesis via Akt and Notch-1 pathways, not via MAPK pathways

  2015cites this paper
• Theaflavin-3,3′-digallate, a black tea polyphenol, stimulates lipolysis associated with the induction of mitochondrial uncoupling proteins and AMPK–FoxO3A–MnSOD pathway in 3T3-L1 adipocytes

  2015cites this paper
• Title Identification of small molecules that disrupt signaling between ABL and its positive regulator RIN 1 Permalink

  2015cites this paper
• Theaflavin-3, 3′-digallate, a black tea polyphenol, attenuates adipocyte-activated inflammatory response of macrophage associated with the switch of M1/M2-like phenotype

  2014cites this paper
• Camellia sinensis ) terhadap Ekspresi IGF-1 , ERK 1 / 2 dan PPAR pada Jalur MAPK ( Mitogen Activated Protein Kinase )

  2014cites this paper
• Black Tea Magic: Overview of Global Research on Human Health and Therapeutic Potentialities

  2014cites this paper
• Chemopreventive properties of South African herbal teas, rooibos (Aspalathus linearis) and honeybush (Cyclopia spp) : mechanisms against skin carcinogenesis

  2013cites this paper
• Black tea in chemo-prevention of cancer and other human diseases

  2013influential citation
• Novel Therapeutic Approaches to Multiple Sclerosis: Neuroprotective Drugs for Relapsing-Remitting Multiple Sclerosis

  2013cites this paper
• Red Orange: Experimental Models and Epidemiological Evidence of Its Benefits on Human Health

  2013cites this paper
• Mitogenesis of Vascular Smooth Muscle Cell Stimulated by Platelet-Derived Growth Factor-bb Is Inhibited by Blocking of Intracellular Signaling by Epigallocatechin-3-O-Gallate

  2013cites this paper
• Active extracts of black tea (Camellia Sinensis) induce apoptosis of PC-3 prostate cancer cells via mitochondrial dysfunction.

  2013cites this paper
• POTENSI EKSTRAK KULIT BUAH RAMBUTAN (Nephelium lappaceum L.) TERHADAP AKUMULASI LIPID PADA HEPAR TIKUS OBESITAS

  2013cites this paper
• Cancer Chemoprevention by Black Tea Polyphenols

  2013cites this paper
• Histamine: an undercover agent in multiple rare diseases?

  2012cites this paper
• Pengaruh Sari Seduh Teh Hitam (Camellia sinensis) terhadap Ekspresi IGF-1, ERK1/2 dan PPAR pada Jalur MAPK (Mitogen Activated Protein Kinase) Jaringan Lemak Viseral Tikus Wistar dengan Diet Tinggi Lemak

  2012cites this paper
• Dietary Effects of Post-fermented Green Tea by Monascus pilosus on the Body Weight, Serum Lipid Profiles and the Activities of Hepatic Antioxidative Enzymes in Mouse Fed a High Fat Diet

  2012cites this paper
• Investigation of the apoptotic way induced by digallic acid in human lymphoblastoid TK6 cells

  2012cites this paper
• A RAPID HPLC-DAD METHOD FOR ANALYSIS OF THEAFLAVINS USING C12 AS STATIONARY PHASE*

  2012cites this paper
• Vaginal Gel Formulation Based on Theaflavin Derivatives As a Microbicide to Prevent HIV Sexual Transmission

  2012cites this paper
• Effect of tea polyphenols on the adhesion of highly metastatic human lung carcinoma cell lines to endothelial cells in vitro.

  2012cites this paper
• Maternal consumption of coffee and tea during pregnancy and risk of childhood ALL: results from an Australian case–control study

  2011cites this paper
• Comparative Antimutagenic and Anticancer Activity of Three Fractions of Black Tea Polyphenols Thearubigins

  2011cites this paper
• Molecular binding of black tea theaflavins to biological membranes: relationship to bioactivities.

  2011cites this paper
• Black tea theaflavins inhibit formation of toxic amyloid-β and α-synuclein fibrils.

  2011cites this paper
• Cocoa tea (Camellia ptilophylla Chang), a natural decaffeinated species of tea – Recommendations on the proper way of preparation for consumption

  2011cites this paper
• Maternal consumption of coffee and tea during pregnancy and risk of childhood brain tumors: results from an Australian case–control study

  2011cites this paper
• Epigallocatechin-3-gallate effectively attenuates skeletal muscle atrophy caused by cancer cachexia.

  2011cites this paper
• Effect of solvent fractions of kombucha tea on viability and invasiveness of cancer cells—Characterization of dimethyl 2-(2-hydroxy-2-methoxypropylidine) malonate and vitexin

  2011cites this paper
• Characterization of anti-proteolytic and anti- proliferative activities of pentagalloylglucose; its potential application as a therapeutic agent in vascular diseases

  2010cites this paper
• Tea catechins as inhibitors of receptor tyrosine kinases: mechanistic insights and human relevance.

  2010cites this paper
• Indian Herbal Medicine for Cancer Therapy and Prevention: Bench to Bedside

  2010cites this paper
• Natural polyphenols that display anticancer properties through inhibition of kinase activity.

  2010cites this paper
• A Thought on the Biological Activities of Black Tea

  2009cites this paper
• Changes in the Composition of Catechins, Theaflavins and Alkaloids in Leaves from Korean Yabukida Tea Plant During Processing to Fermented Black Tea

  2009cites this paper
• Natural Polyphenols that Display Anticancer Activity through Inhibition of Kinase Activity

  2009influential citation
• Sennoside B inhibits PDGF receptor signaling and cell proliferation induced by PDGF-BB in human osteosarcoma cells.

  2009cites this paper
• Chá: aspectos relacionados à qualidade e perspectivas

  2009cites this paper
• Current Understanding of Dietary Polyphenols and their Role in Health and Disease

  2009cites this paper
• Green and black tea are equally potent stimuli of NO production and vasodilation: new insights into tea ingredients involved

  2009cites this paper
• Tea Consumption and Risk of Breast Cancer

  2009cites this paper
• Theaflavin-3-gallate and theaflavin-3'-gallate, polyphenols in black tea with prooxidant properties.

  2008cites this paper
• The use of in vitro assays to screen for endocrine modulation

  2008cites this paper
• Combination of HSCCC and Sephadex LH-20 methods An approach to isolation and purification of the main individual theaflavins from black tea.

  2008cites this paper
• Epigallocatechin-3-gallate inhibits interleukin-1beta-induced MUC5AC gene expression and MUC5AC secretion in normal human nasal epithelial cells.

  2008cites this paper
• Flavonoids as RTK inhibitors and potential anticancer agents

  2008cites this paper
• Modulation of Cell Signal Transduction by Tea and Ginger

  2008cites this paper
• Cancer chemoprevention and chemotherapy: dietary polyphenols and signalling pathways.

  2008cites this paper
• Inhibition of Nm23H2 gene product (NDPK-B) by angiostatin, polyphenols and nucleoside analogs.

  2008cites this paper
• Molecular mechanism of black tea polyphenols induced apoptosis in human skin cancer cells: involvement of Bax translocation and mitochondria mediated death cascade.

  2007cites this paper
• Molecular targets of tea polyphenols in the cardiovascular system.

  2007cites this paper
• Theanaphthoquinone inhibits fatty acid synthase expression in EGF-stimulated human breast cancer cells via the regulation of EGFR/ErbB-2 signaling.

  2007influential citation
• The inhibitory effect of (-)-epigallocatechin gallate on activation of the epidermal growth factor receptor is associated with altered lipid order in HT29 colon cancer cells.

  2007cites this paper
• Breast cancer prevention by green tea catechins and black tea theaflavins in the C3(1) SV40 T,t antigen transgenic mouse model is accompanied by increased apoptosis and a decrease in oxidative DNA adducts.

  2007cites this paper
• Suppression of free-radicals and protection against H2O2-induced oxidative damage in HPF-1 cell by oxidized phenolic compounds present in black tea

  2007cites this paper
• Purinergic regulation of angiogenesis by human breast carcinoma-secreted nucleoside diphosphate kinase

  2007cites this paper
• Monitoring the binding processes of black tea thearubigin to the bovine serum albumin surface using quartz crystal microbalance with dissipation monitoring.

  2007cites this paper
• Molecular and cellular targets

  2006cites this paper
• Intracellular signaling network as a prime chemopreventive target of (-)-epigallocatechin gallate.

  2006cites this paper
• New insights on the anticancer properties of dietary polyphenols

  2006cites this paper
• Possible mechanisms of the cancer-preventive activities of green tea.

  2006cites this paper
• Chemoprevention of breast cancer: current status and future prospects.

  2006cites this paper
• Theaflavin‐3, 3′‐digallate induces epidermal growth factor receptor downregulation

  2006cites this paper
• Green tea, the "Asian paradox," and cardiovascular disease.

  2006cites this paper
• Chemoprevention of breast cancer 2250 occurrence of breast cancer is correlated with estrogens , chemicals produced by the ovaries

  2006cites this paper
• Chemoprevention of Pancreatic Cancer: A Review of the Molecular Pathways Involved, and Evidence for the Potential for Chemoprevention

  2006cites this paper
• Polyphenolic fractions from wine by-products as potential antitumoral and/or protective agents against UV damage.

  2006cites this paper
• Flavonoids as Nutraceuticals

  2006cites this paper
• Redox Properties of Tea Polyphenols and Related Biological Activities

  2005cites this paper
• Comparative studies on the hypolipidemic and growth suppressive effects of oolong, black, pu-erh, and green tea leaves in rats.

  2005cites this paper
• Inhibition in Human Esophageal Cancer KYSE 150 Cells Growth Factor Receptor and Direct Effects on Growth Dependent Inactivation of Epidermal − Auto-oxidation )-Epigallocatechin-3-Gallate : − Mechanism of Action of ( Updated

  2005cites this paper