Size matters: of the small HSP27 and its large oligomers

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Cell Death and Differentiation

• Publication date

  2002-04-25

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1038/sj.cdd.4401005PMID 11973606
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Heat shock proteins: endogenous modulators of apoptotic cell death.

  2001cited by this paper
• Differential regulation of HSP27 oligomerization in tumor cells grown in vitro and in vivo

  2000cited by this paper
• Inhibition of Daxx-Mediated Apoptosis by Heat Shock Protein 27

  2000cited by this paper
• Hsp27 negatively regulates cell death by interacting with cytochrome c

  2000cited by this paper
• An N-terminal 33-amino-acid-deletion variant of hsp25 retains oligomerization and functional properties.

  2000cited by this paper
• Regulation of Hsp27 Oligomerization, Chaperone Function, and Protective Activity against Oxidative Stress/Tumor Necrosis Factor α by Phosphorylation*

  1999cited by this paper
• HSP27 inhibits cytochrome c‐dependent activation of procaspase‐9

  1999cited by this paper
• Binding of non‐native protein to Hsp25 during heat shock creates a reservoir of folding intermediates for reactivation

  1997cited by this paper
• Heat shock protein 27 stimulates recovery of RNA and protein synthesis following a heat shock

  1997cited by this paper
• Human hsp27, Drosophila hsp27 and human alphaB‐crystallin expression‐mediated increase in glutathione is essential for the protective activity of these proteins against TNFalpha‐induced cell death.

  1996cited by this paper
• Modulation of cellular thermoresistance and actin filament stability accompanies phosphorylation-induced changes in the oligomeric structure of heat shock protein 27

  1995cited by this paper

• Role of T-2 toxin in the modulation of oxidative homeostasis and immune function in three-dimensional hepatic cell cultures of chicken origin.

  2026cites this paper
• Advances in the structures, mechanisms and targeting of molecular chaperones

  2025cites this paper
• Mechanical activation and expression of HSP27 in epithelial ovarian cancer

  2024cites this paper
• Development of nimesulide analogs as a dual inhibitor targeting tubulin and HSP27 for treatment of female cancers

  2022cites this paper
• HSP27 role in cardioprotection by modulating chemotherapeutic doxorubicin-induced cell death

  2021cites this paper
• Heat Shock Proteins and exosomes in cancer theranostics.

  2021cites this paper
• Flavonoids: Potential Candidates for the Treatment of Neurodegenerative Disorders

  2021cites this paper
• Nephroprotective Effect of Cilastatin against Gentamicin-Induced Renal Injury In Vitro and In Vivo without Altering Its Bactericidal Efficiency

  2020cites this paper
• Loss of NF-E2 expression contributes to the induction of profibrotic signaling in diabetic kidneys.

  2020cites this paper
• Indispensable Role of Protein Turnover in Autophagy, Apoptosis and Ubiquitination Pathways

  2020cites this paper
• Functional Diversity of Non-Histone Chromosomal Protein HmgB1

  2020cites this paper
• Analysis of HspB1 (Hsp27) Oligomerization and Phosphorylation Patterns and Its Interaction with Specific Client Polypeptides.

  2018cites this paper
• Adapting to stress — chaperome networks in cancer

  2018cites this paper
• Heat shock protein 27 acts as a predictor of prognosis in chronic heart failure patients.

  2017cites this paper
• Evaluating the Effect of Phosphorylation on the Structure and Dynamics of Hsp27 Dimers by Means of Ion Mobility Mass Spectrometry.

  2017cites this paper
• Quaternary dynamics underlie the chaperone function of Hsp27 and αB-crystallin in maintaining proteostasis

  2017cites this paper
• Gene analysis for studying the process of weight regain after weight loss

  2017cites this paper
• The Conjugated Double Bond of Coniferyl Aldehyde Is Essential for Heat Shock Factor 1 Mediated Cytotoprotection.

  2017cites this paper
• Heat Shock Proteins in Multiple Sclerosis.

  2017cites this paper
• Noxa/HSP27 Complex Delays Degradation of Ubiquitylated IkBα in Airway Epithelial Cells to Reduce Pulmonary Inflammation

  2017cites this paper
• Targeting Hsp27/eIF4E interaction with phenazine compound: a promising alternative for castration-resistant prostate cancer treatment

  2017cites this paper
• Mammalian HspB1 (Hsp27) is a molecular sensor linked to the physiology and environment of the cell

  2017cites this paper
• Weight loss-induced stress in subcutaneous adipose tissue is related to weight regain

  2016cites this paper
• Niemann-Pick Type C Disease: Protective Mechanisms from Neurodegeneration and Targets for Therapeutic Intervention.

  2016influential citation
• Heat Shock Protein Beta-1 Modifies Anterior to Posterior Purkinje Cell Vulnerability in a Mouse Model of Niemann-Pick Type C Disease

  2016cites this paper
• Small Heat Shock Proteins and Fibrosis

  2015cites this paper
• Proteomic Analysis Reveals PGAM1 Altering cis-9, trans-11 Conjugated Linoleic Acid Synthesis in Bovine Mammary Gland

  2015cites this paper
• Kynuramines induce overexpression of heat shock proteins in pancreatic cancer cells via 5-hydroxytryptamine and MT1/MT2 receptors.

  2015cites this paper
• Immense Cellular Implications Associated to Small Stress Proteins Expression: Impacts on Human Pathologies

  2015cites this paper
• Palytoxin induces dissociation of HSP 27 oligomers through a p38 protein kinase pathway.

  2015cites this paper
• Cilastina protege del fracaso renal agudo inducido por gentamicina sin comprometer su eficacia bactericida

  2014cites this paper
• Transduced protein transduction domain linked HSP27 protected LECs against UVB radiation-induced damage.

  2014cites this paper
• Heat shock protein 27 phosphorylation state is associated with cancer progression

  2014cites this paper
• HspB1, HspB5 and HspB4 in Human Cancers: Potent Oncogenic Role of Some of Their Client Proteins

  2014cites this paper
• Circulating heat shock protein 27 as a biomarker for the differentiation of patients with lung cancer and healthy controls--a clinical comparison of different enzyme linked immunosorbent assays.

  2014cites this paper
• Bioassay guided identification of small chaperone proteins α-crystallin and Hsp27 inhibitors from Copaiba oil

  2014cites this paper
• The effect of heat shock protein 27 on extravillous trophoblast differentiation and on eukaryotic translation initiation factor 4E expression.

  2014cites this paper
• Heat shock proteins in fibrosis and wound healing: good or evil?

  2014cites this paper
• The role of heat shock proteins in Amyotrophic Lateral Sclerosis: The therapeutic potential of Arimoclomol.

  2014cites this paper
• Photobiomodulation in animal models of ageing and Alzheimer's disease

  2013influential citation
• Expression of heat shock proteins in medulloblastoma.

  2013cites this paper
• Synthesis and anticancer mechanism investigation of dual Hsp27 and tubulin inhibitors.

  2013cites this paper
• Rôle de la petite protéine de choc thermique alphaB crystallin dans la fibrogénèse pulmonaire et son implication dans la voie de signalisation du transforming growth factor - béta1

  2013cites this paper
• Proteomic analysis of a dynamic Salmonella-host interactome

  2013cites this paper
• Targeting heat shock proteins in prostate cancer.

  2013cites this paper
• Small heat shock proteins HSP27 (HspB1), αB-crystallin (HspB5) and HSP22 (HspB8) as regulators of cell death.

  2012cites this paper
• Cilastatin protects against cisplatin-induced nephrotoxicity without compromising its anticancer efficiency in rats.

  2012cites this paper
• Heat shock proteins in hematopoietic malignancies.

  2012cites this paper
• Roles of the N‐ and C‐terminal sequences in Hsp27 self‐association and chaperone activity

  2012cites this paper
• Alteration of protein folding and degradation in motor neuron diseases: Implications and protective functions of small heat shock proteins.

  2012cites this paper
• HspB1 dynamic phospho-oligomeric structure dependent interactome as cancer therapeutic target.

  2012cites this paper
• Immunocompetent cells and cytokine expression in the rat periodontal ligament at the initial stage of orthodontic tooth movement.

  2011cites this paper
• The heat shock proteins as targets for radiosensitization and chemosensitization in cancer

  2011influential citation
• Structure-functions of HspB1 (Hsp27).

  2011cites this paper
• Heat shock proteins in oncology: diagnostic biomarkers or therapeutic targets?

  2011cites this paper
• High-mobility group box 1 is essential for mitochondrial quality control.

  2011influential citation
• OGX-427 inhibits tumor progression and enhances gemcitabine chemotherapy in pancreatic cancer

  2011cites this paper
• Interactome and Pathway Analysis of EBNA Transformed Human B-Cell.

  2011cites this paper
• Increased levels of serum heat shock protein 27 as a possible marker for incipient obstructive pulmonary disease in a risk cohort

  2011cites this paper
• Hsp-27 induction requires POU4F2/Brn-3b TF in doxorubicin-treated breast cancer cells, whereas phosphorylation alters its cellular localisation following drug treatment

  2011cites this paper
• The Use of Proteomics in the Study of Molecular Responses and Toxicity Pathways in Biological Systems

  2011cites this paper
• Apigenin-induced apoptosis of leukemia cells is mediated by a bimodal and differentially regulated residue-specific phosphorylation of heat-shock protein–27

  2010cites this paper
• Dynamic processes that reflect anti-apoptotic strategies set up by HspB1 (Hsp27).

  2010cites this paper
• The role of heat shock protein (HSP) in atherosclerosis: Pathophysiology and clinical opportunities.

  2010cites this paper
• Hsp70 and Hsp27: Emerging Targets in Cancer Therapy

  2010cites this paper
• Expression and functions of heat shock proteins in the normal and pathological mammalian eye.

  2010cites this paper
• Examination of association with candidate genes for diabetic nephropathy in a Mexican American population.

  2010cites this paper
• Cellular Stress Responses: Cell Survival and Cell Death

  2010cites this paper
• Hsp27 Protects Adenocarcinoma Cells from UV-Induced Apoptosis by Akt and p21-Dependent Pathways of Survival

  2010cites this paper
• TRAIL-induced caspase/p38 activation is responsible for the increased catalytic and invasive activities of Akt.

  2010cites this paper
• Characterization of the interaction between the adaptor protein Nck and the protein kinase PKR

  2010cites this paper
• La protéine de stress Hsp27 / HspB1, une cible de choix en thérapie anti-cancéreuse

  2010cites this paper
• Rôle des protéines de choc thermique HSP90 et HSP70 dans la différenciation macrophagique

  2010cites this paper
• Molecular Cancer esearch Damage and Cellular Stress Responses 27 Protects Adenocarcinoma Cells from UV-Induced ptosis by Akt and p 21-Dependent Pathways R

  2010cites this paper
• Small Interfering RNA-Mediated Silencing of Heat Shock Protein 27 (HSP27) Increases Chemosensitivity to Paclitaxel by Increasing Production of Reactive Oxygen Species in Human Ovarian Cancer Cells (HO8910)

  2009cites this paper
• Protective Effect of Post-Ischaemic Viral Delivery of Heat Shock Proteins in vivo

  2009cites this paper
• The 27-kDa Heat Shock Protein Confers Cytoprotective Effects through a β2-Adrenergic Receptor Agonist-Initiated Complex with β-Arrestin

  2009cites this paper
• Genetic Association Tests for Binary Traits with an Application

  2009cites this paper
• Long-term Exposure to Low Lithium Concentrations Stimulates Proliferation, Modifies Stress Protein Expression Pattern and Enhances Resistance to Oxidative Stress in SH-SY5Y Cells

  2009cites this paper
• Heat shock protein 27 overexpression mitigates cytokine-induced islet apoptosis and streptozotocin-induced diabetes.

  2009influential citation
• Induction of heat shock proteins for protection against oxidative stress.

  2009cites this paper
• The cytotoxic pathway triggered by palytoxin involves a change in the cellular pool of stress response proteins.

  2009cites this paper
• Heat shock protein 27 in neuronal survival and neurite outgrowth.

  2009cites this paper
• Disaggregating chaperones: an unfolding story.

  2009cites this paper
• The heat shock protein 27 (Hsp27) operates predominantly by blocking the mitochondrial-independent/extrinsic pathway of cellular apoptosis

  2009cites this paper
• Proteomic analysis reveals multiple patterns of response in cells exposed to a toxin mixture.

  2009cites this paper
• Heat shock proteins: essential proteins for apoptosis regulation

  2008influential citation
• The Role of heat shock protein 27 in extravillous trophoblast differentiation

  2008cites this paper
• HSP27 and cell death in spinocerebellar ataxia type 3

  2008cites this paper
• Heat Shock Proteins as Therapeutic Targets in Amyotrophic Lateral Sclerosis

  2008cites this paper
• Effect of heat shock factor inhibitor, KNK437, on stress-induced hsp30 gene expression in Xenopus laevis A6 cells

  2008cites this paper
• Heat shock enhances NGF-induced neurite elongation which is not mediated by Hsp25 in PC12 cells.

  2008cites this paper
• Melatonin stimulates HSP27 phosphorylation in human pancreatic carcinoma cells (PANC-1).

  2007cites this paper
• Hsp70 and Hsp27 as pharmacological targets in apoptosis modulation for cancer therapy

  2007cites this paper
• Heat Shock Protein-27 (Hsp-27) in Breast Cancers: Regulation of Expression and Function

  2007cites this paper
• Réponses cellulaires vis-à vis de l’exposition au cadmium chez les animaux

  2007influential citation
• Anti-cancer therapeutic approaches based on intracellular and extracellular heat shock proteins.

  2007cites this paper
• Anti-apoptotic, Tumorigenic and Metastatic Potential of Hsp27 (HspB1) and αB-crystallin (HspB5): Emerging Targets for the Development of New Anti-Cancer Therapeutic Strategies

  2007cites this paper
• Differential expression of heat shock protein mRNAs under in vivo glutathione depletion in the mouse retina.

  2007cites this paper
• Activation of Protein Kinase D1 in Mast Cells in Response to Innate, Adaptive, and Growth Factor Signals1

  2007cites this paper