Nonsteroidal aromatase inhibitors: Recent advances

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Medicinal research reviews (Print)

• Publication date

  2002-05-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1002/med.10010PMID 11933021
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Aromatase inhibitors — mechanisms for non-steroidal inhibitors

  2004cited by this paper
• Pharmacological profiles of exemestane and formestane, steroidal aromatase inhibitors used for treatment of postmenopausal breast cancer

  2004cited by this paper
• Pharmacological and clinical profile of anastrozole

  2004cited by this paper
• Steroid hormone receptors in breast cancer management

  2004cited by this paper
• Fadrozole and letrozole in advanced breast cancer: Clinical and biochemical effects

  2004cited by this paper
• Aromatase inhibitors: past, present and future.

  2001cited by this paper
• Evaluation of the mechanism of aromatase cytochrome P450. A site-directed mutagenesis study.

  2001influential reference
• Chalcones are potent inhibitors of aromatase and 17beta-hydroxysteroid dehydrogenase activities.

  2001cited by this paper
• Endocrine therapy in the treatment of metastatic breast cancer.

  2001cited by this paper
• Aromatase regulation and breast cancer

  2001cited by this paper
• The selective estrogen enzyme modulator (SEEM) in breast cancer.

  2001cited by this paper
• Chalcones are potent inhibitors of aromatase and 17β-hydroxysteroid dehydrogenase activities

  2001cited by this paper
• Recent advances in the clinical application of aromatase inhibitors.

  2001cited by this paper
• Aromatase inhibition by an 11,13-dihydroderivative of a sesquiterpene lactone.

  2001cited by this paper
• Aromatase inhibitors in the treatment and prevention of breast cancer.

  2001cited by this paper
• A new class of nonsteroidal aromatase inhibitors: design and synthesis of chromone and xanthone derivatives and inhibition of the P450 enzymes aromatase and 17 alpha-hydroxylase/C17,20-lyase.

  2001influential reference
• 1-imidazolyl(alkyl)-substituted di- and tetrahydroquinolines and analogues: syntheses and evaluation of dual inhibitors of thromboxane A(2) synthase and aromatase.

  2000cited by this paper
• Complete Estrogen Blockade for the Treatment of Metastatic and Early Stage Breast Cancer

  2000cited by this paper
• Aromatase as a therapeutic target in endometriosis.

  2000cited by this paper
• Synthesis of new potent and selective aromatase inhibitors based on long-chained diarylalkylimidazole and diarylalkyltriazole molecule skeletons.

  2000cited by this paper
• New aromatase inhibitors. Synthesis and biological activity of aryl-substituted pyrrolizine and indolizine derivatives.

  2000cited by this paper
• Aromatase inhibitors and their application in breast cancer treatment*.

  2000cited by this paper
• The role of local estrogen biosynthesis in males and females.

  2000cited by this paper
• Role of aromatase in sex steroid action.

  2000cited by this paper
• Linking CoMFA and protein homology models of enzyme-inhibitor interactions: an application to non-steroidal aromatase inhibitors.

  2000influential reference
• Exemestane in advanced breast cancer

  2000cited by this paper
• Is There a Growing Role for Endocrine Therapy in the Treatment of Breast Cancer?

  2000cited by this paper
• Comparison of estrogen concentrations, estrone sulfatase and aromatase activities in normal, and in cancerous, human breast tissues.

  2000cited by this paper
• Role of the heme active site and protein environment in structure, spectra, and function of the cytochrome p450s.

  2000cited by this paper
• A yeast screen system for aromatase inhibitors and ligands for androgen receptor: yeast cells transformed with aromatase and androgen receptor.

  1999cited by this paper
• Inhibition of Aromatase (P450Arom) by some 1‐(Benzofuran‐2‐ylmethyl)imidazoles

  1999cited by this paper
• Aromatase Inhibitors in the Treatment of Postmenopausal Breast Cancer

  1999cited by this paper
• Aromatase and gynecomastia.

  1999cited by this paper
• Aromatase and its inhibitors.

  1999cited by this paper
• Aromatase inhibitors in relation to other forms of endocrine therapy for breast cancer.

  1999cited by this paper
• Use of aromatase inhibitors in precocious puberty.

  1999cited by this paper
• Neuroactive steroids: mechanisms of action and neuropsychopharmacological perspectives.

  1999cited by this paper
• The third-generation non-steroidal aromatase inhibitors: a review of their clinical benefits in the second-line hormonal treatment of advanced breast cancer.

  1999cited by this paper
• New selective nonsteroidal aromatase inhibitors: synthesis and inhibitory activity of 2,3 or 5-(alpha-azolylbenzyl)-1H-indoles.

  1999cited by this paper
• MR 20492 and MR 20494: two indolizinone derivatives that strongly inhibit human aromatase.

  1999cited by this paper
• 1-[(Benzofuran-2-yl)phenylmethyl]-triazoles and -tetrazoles - potent competitive inhibitors of aromatase.

  1999cited by this paper
• Comparative molecular field analysis of non-steroidal aromatase inhibitors: an extended model for two different structural classes.

  1998cited by this paper
• Aromatase and 17beta-hydroxysteroid dehydrogenase inhibition by flavonoids.

  1998cited by this paper
• Ab initio calculations on iron-porphyrin model systems for intermediates in the oxidative cycle of cytochrome P450s

  1998cited by this paper
• Molecular basis of the inhibition of human aromatase (estrogen synthetase) by flavone and isoflavone phytoestrogens: A site-directed mutagenesis study.

  1998cited by this paper
• New insights into the regulation and function of brain estrogen synthase (aromatase).

  1998cited by this paper
• In situ aromatization enhances breast tumor estradiol levels and cellular proliferation.

  1998cited by this paper
• Intratumoral aromatase in human breast, endometrial, and ovarian malignancies.

  1998cited by this paper
• Design and synthesis of a new type of non steroidal human aromatase inhibitors.

  1998cited by this paper
• Anastrozole

  1998cited by this paper
• Aromatase inhibitors in advanced breast cancer: mechanism of action and clinical implications.

  1998cited by this paper
• Evidence for new non-steroidal human aromatase inhibitors and comparison with equine aromatase inhibition for an understanding of the mammalian active site

  1998cited by this paper
• Medicinal Chemistry: Enantioselectivity of Some 1‐(Benzofuran‐2‐yl)‐1‐(1‐H‐imidazol‐1‐yl) Alkanes as Inhibitors of P450Arom

  1998cited by this paper
• Mimicking Cytochrome P-450 2B4 and Aromatase: Aromatization of a Substrate Analogue by a Peroxo Fe(III) Porphyrin Complex

  1998cited by this paper
• Letrozole. A review of its use in postmenopausal women with advanced breast cancer.

  1998cited by this paper
• Aromatase inhibitors.

  1998cited by this paper
• Studies on aromatase inhibitors. II. Synthesis and biological evaluation of 1-amino-1H-1,2,4-triazole derivatives.

  1997cited by this paper
• Studies on aromatase inhibitors. III. Synthesis and biological evaluation of [(4-bromobenzyl)(4-cyanophenyl)amino]azoles and their azine analogs.

  1997cited by this paper
• Binding characteristics of aromatase inhibitors and phytoestrogens to human aromatase.

  1997cited by this paper
• Three-dimensional structure of NADPH-cytochrome P450 reductase: prototype for FMN- and FAD-containing enzymes.

  1997cited by this paper
• Studies on aromatase inhibitors. IV. Synthesis and biological evaluation of N,N-disubstituted-5-aminopyrimidine derivatives.

  1997cited by this paper
• Aromatase expression in health and disease.

  1997cited by this paper
• Synthesis and In Vitro Evaluation of 3‐(1‐Azolylmethyl)‐1H‐indoles and 3‐(1‐Azolyl‐1‐phenylmethyl)‐1H‐indoles as Inhibitors of P450 arom

  1997cited by this paper
• Vorozole

  1997cited by this paper
• A novel activity for a group of sesquiterpene lactones: inhibition of aromatase

  1997cited by this paper
• The mechanism of a P-450 enzyme-aromatase; a molecular modelling perspective for the removal of the C(19) methyl and aromatisation of the steroid A ring.

  1997cited by this paper
• Binding characteristics of seven inhibitors of human aromatase: a site-directed mutagenesis study.

  1996cited by this paper
• Development of Steroidal and Nonsteroidal Inhibitors of Aromatase for the Treatment of Hormone-Dependent Breast Cancer

  1996cited by this paper
• Comparative molecular field analysis of non-steroidal aromatase inhibitors related to fadrozole

  1996cited by this paper
• Inhibition of aromatase.

  1996cited by this paper
• Cytochrome P450 2: peroxidative reactions of diversozymes.

  1996cited by this paper
• Studies on aromatase inhibitors. I. Synthesis and biological evaluation of 4-amino-4H-1,2,4-triazole derivatives.

  1996cited by this paper
• Synthesis and Evaluation of Azole‐Substituted Tetrahydronaphthalenes as Inhibitors of P450 arom, P450 17, and P450 TxA2

  1996cited by this paper
• Tetrahydronaphthalenes: influence of heterocyclic substituents on inhibition of steroid enzymes P450 arom and P450 17.

  1996cited by this paper
• Pyridyl-substituted tetrahydrocyclopropa[a]naphthalenes: highly active and selective inhibitors of P450 arom.

  1995cited by this paper
• A molecular model for the interaction between vorozole and other non-steroidal inhibitors and human cytochrome P450 19 (P450 aromatase).

  1995cited by this paper
• Synthesis and biological evaluation of imidazole based compounds as cytochrome P-450 inhibitors.

  1995cited by this paper
• Pyridyl‐Substituted Tetrahydrocyclopropa(a)naphthalenes: Highly Active and Selective Inhibitors of P450 arom.

  1995cited by this paper
• A three‐dimensional model of aromatase cytochrome P450

  1995cited by this paper
• Prevention of experimental hepatic metastasis with thromboxne synthase inhibitor

  1995cited by this paper
• Mutagenesis study at a postulated hydrophobic region near the active site of aromatase cytochrome P450.

  1994cited by this paper
• Aromatase inhibitors. Syntheses and structure-activity studies of novel pyridyl-substituted indanones, indans, and tetralins.

  1994influential reference
• Aromatase cytochrome P450, the enzyme responsible for estrogen biosynthesis.

  1994cited by this paper
• Crystal structure and refinement of cytochrome P450terp at 2.3 A resolution.

  1994cited by this paper
• Crystal structure of hemoprotein domain of P450BM-3, a prototype for microsomal P450's.

  1993cited by this paper
• Aromatase inhibitors: synthesis, biological activity, and binding mode of azole-type compounds.

  1993influential reference
• Functional domains of human aromatase cytochrome P450 characterized by linear alignment and site-directed mutagenesis.

  1993cited by this paper
• Studies on the mechanism of aromatase and other cytochrome P450 mediated deformylation reactions.

  1993cited by this paper
• Mechanistic studies on aromatase and related C-C bond cleaving P-450 enzymes.

  1993influential reference
• A detailed molecular model for human aromatase.

  1993cited by this paper
• Structure-activity relationships and binding model of novel aromatase inhibitors.

  1993cited by this paper
• Substituted 1-[benzofuran-2-yl)-phenylmethyl]-imidazoles as potent inhibitors of aromatase in vitro and in female rats in vivo.

  1993cited by this paper
• Structure-function relationships of human aromatase cytochrome P-450 using molecular modeling and site-directed mutagenesis.

  1991cited by this paper
• Theoretical studies on the mechanism of conversion of androgens to estrogens by aromatase.

  1991cited by this paper
• New aromatase inhibitors. Synthesis and biological activity of pyridyl-substituted tetralone derivatives.

  1991cited by this paper
• Tumour cell proliferation by thromboxane A2: a receptor-mediated event.

  1991cited by this paper
• Conversion of a 3-desoxysteroid to 3-desoxyestrogen by human placental aromatase.

  1990cited by this paper
• Stable expression of human aromatase complementary DNA in mammalian cells: a useful system for aromatase inhibitor screening.

  1990cited by this paper
• R 76713 and enantiomers: selective, nonsteroidal inhibitors of the cytochrome P450-dependent oestrogen synthesis.

  1990cited by this paper
• Highly selective inhibition of estrogen biosynthesis by CGS 20267, a new non-steroidal aromatase inhibitor.

  1990cited by this paper

• Prospective evaluation of CYP19A1-mediated aromatase inhibitors for ER+ breast cancers by ultra-high performance liquid chromatography tandem mass spectrometry supported by in silico methods

  2025cites this paper
• Small molecule inhibitors for treating breast cancer: drug analysis based on the pathogenesis of breast cancer.

  2025cites this paper
• Aromatase inhibitors for the treatment of breast cancer: An overview (2019-2023).

  2024cites this paper
• Enantio- and Diastereoselective Copper-Catalyzed Borylative Coupling of Styrenes and Azadienes.

  2024cites this paper
• Design and synthesis new indole-based aromatase/iNOS inhibitors with apoptotic antiproliferative activity

  2024cites this paper
• Addition of sulfonylphthalides to para-quinone methides: Selective 1,6-additions and oxidative annulations.

  2023cites this paper
• Phytochemicals with Chemopreventive Activity Obtained from the Thai Medicinal Plant Mammea siamensis (Miq.) T. Anders.: Isolation and Structure Determination of New Prenylcoumarins with Inhibitory Activity against Aromatase

  2022cites this paper
• Silver Triflate Catalyzed Domino Reactions of o ‐Alkynylanilines: An Approach Toward Unsymmetrical Diarylacetates and Triarylmethanes

  2022cites this paper
• Synthesis of New Pyrimidine‐Triazole Derivatives and Investigation of Their Anticancer Activities

  2022cites this paper
• Aromatic or Hetero-aromatic Directly Attached Tri and Tetrasubstituted Methanes: New Chemical Entities as Anti-infectives.

  2022cites this paper
• 1,2,3,4-Tetrahydroisoquinoline (THIQ) as privileged scaffold for anticancer de novo drug design

  2021cites this paper
• 1,6-Addition of 1,2,3-NH triazoles to para-quinone methides: Facile access to highly selective N1 and N2 substituted triazoles.

  2021cites this paper
• Microwave-Assisted Copper Catalysis of α-Difluorinated gem-Diol toward Difluoroalkyl Radical for Hydrodifluoroalkylation of para-Quinone Methides.

  2020cites this paper
• The comparison of the effect of different inhibitors on aromatase enzyme effective in the breast cancer by molecular docking method

  2020cites this paper
• Effective anti-aromatase therapy to battle against estrogen-mediated breast cancer: Comparative SAR/QSAR assessment on steroidal aromatase inhibitors.

  2020cites this paper
• Synthesis of aza‐diarylmethines via 1,6‐conjugate addition/aromatization of para ‐quinone methides and isatin catalyzed by Et 3 N

  2020cites this paper
• Catalyst-free 1,6-conjugate addition of indoles and 4-hydroxycoumarins to para-quinone methides: synthesis of unsymmetrical triarylmethanes.

  2020cites this paper
• Visible-Light-Enabled C-H Functionalization by a Direct Hydrogen Atom Transfer Uranyl Photocatalyst.

  2020cites this paper
• Catalytic asymmetric 1,4-type Friedel–Crafts (hetero)arylations of 1-azadienes: the highly enantioselective syntheses of chiral hetero-triarylmethanes

  2020cites this paper
• Aromatase inhibitors: Role in postmenopausal breast cancer.

  2020cites this paper
• Metal-Free C-B Bond Cleavage: An Acid Catalyzed Three-Component Reaction Construction of Imidazole-Containing Triarylmethanes.

  2019cites this paper
• Modulation of aromatase by natural compounds—A pharmacophore guided molecular modelling simulations

  2019cites this paper
• A new approach to access difluoroalkylated diarylmethanes via visible-light photocatalytic cross-coupling reactions.

  2018cites this paper
• Photophysics and Photochemistry of Conformationally Restricted Triarylmethanes: Application as Photoredox Catalysts

  2018cites this paper
• Computational Exploration of New Non-Steroidal Chemo-types as Human Aromatase Inhibitors

  2018cites this paper
• Conformationally Restricted Triarylmethanes: Synthesis, Photophysical Studies, and Applications

  2018cites this paper
• Aromatase inhibitory activity of 1,4-naphthoquinone derivatives and QSAR study

  2017cites this paper
• Comprehensive and Automated Linear Interaction Energy Based Binding-Affinity Prediction for Multifarious Cytochrome P450 Aromatase Inhibitors

  2017cites this paper
• Investigation of antiaromatase activity using hepatic microsomes of Nile tilapia (Oreochromis niloticus).

  2017cites this paper
• Bifunctional Amine‐Squaramide Catalyzed Friedel–Crafts Alkylation Based on ortho‐Quinone Methides in Oil‐Water Phases: Enantioselective Synthesis of Triarylmethanes

  2017cites this paper
• Direct access to α,α′-diarylated ketones through N-heterocyclic carbene-catalyzed 1,6-addition of aromatic aldehydes to para-quinone methides

  2017cites this paper
• Synthesis of Indolizine‐Containing Diaryl‐ and Triarylmethanes through a Cu‐Catalyzed Domino Cyclization of 2‐(2‐Enynyl)pyridines

  2017cites this paper
• Combating breast cancer with non-steroidal aromatase inhibitors (NSAIs): Understanding the chemico-biological interactions through comparative SAR/QSAR study.

  2017cites this paper
• Chiral Brønsted acid-catalyzed alkylation of C3-substituted indoles with o-hydroxybenzyl alcohols: highly enantioselective synthesis of diarylindol-2-ylmethanes and evaluation on their cytotoxicity

  2016cites this paper
• Bi(OTf)3 Catalyzed Solvent Free Approach to Unsymmetrical Diaryl(2‐indolyl)methanes Through 1,6‐Conjugate Addition of 3‐Substituted Indoles to para‐Quinone Methides.

  2016cites this paper
• 1,6‐Addition Arylation of para‐Quinone Methides: An Approach to Unsymmetrical Triarylmethanes

  2016cites this paper
• Correction: Xie, H.; et al. 3D QSAR Studies, Pharmacophore Modeling and Virtual Screening on a Series of Steroidal Aromatase Inhibitors. Int. J. Mol. Sci. 2014, 15, 20927–20947

  2015cites this paper
• Prediction of aromatase inhibitory activity using the efficient linear method (ELM)

  2015cites this paper
• Chiral Brønsted acid-catalyzed Friedel-Crafts alkylation of electron-rich arenes with in situ-generated ortho-quinone methides: highly enantioselective synthesis of diarylindolylmethanes and triarylmethanes.

  2015cites this paper
• Ligand- and Structure-Based Drug Design of Non-Steroidal Aromatase Inhibitors (NSAIs) in Breast Cancer

  2015cites this paper
• Expedient Access to Unsymmetrical Diarylindolylmethanes through Palladium-Catalyzed Domino Electrophilic Cyclization-Extended Conjugate Addition Approach.

  2015cites this paper
• Recent developments in steroidal and nonsteroidal aromatase inhibitors for the chemoprevention of estrogen-dependent breast cancer.

  2015cites this paper
• Inhibition of Cytochrome P450 Enzymes

  2015cites this paper
• Anticancer Drugs That Modulate Hormone Action

  2015cites this paper
• Flavones: an important scaffold for medicinal chemistry.

  2014cites this paper
• Investigation of aromatase inhibitory activity of metal complexes of 8-hydroxyquinoline and uracil derivatives

  2014influential citation
• Pharmacophore modeling, virtual screening, and 3D-QSAR studies on a series of non-steroidal aromatase inhibitors

  2014cites this paper
• Ru(II)-catalyzed selective C-H amination of xanthones and chromones with sulfonyl azides: synthesis and anticancer evaluation.

  2014cites this paper
• 3D QSAR Studies, Pharmacophore Modeling and Virtual Screening on a Series of Steroidal Aromatase Inhibitors

  2014cites this paper
• Investigation of fluorinated and bifunctionalized 3-phenylchroman-4-one (isoflavanone) aromatase inhibitors.

  2014cites this paper
• Nonsteroidal aromatase inhibitors for the treatment of breast cancer: an update.

  2014cites this paper
• Enantioselective synthesis of triarylmethanes by chiral imidodiphosphoric acids catalyzed Friedel-Crafts reactions.

  2014cites this paper
• Prachayasittikul et al

  2014influential citation
• Synthetic approach towards trisubstituted methanes and a chiral tertiary α-hydroxyaldehyde, a possible intermediate for tetrasubstituted methanes

  2013cites this paper
• Pharmacophore based 3D-QSAR study of biphenyl derivatives as nonsteroidal aromatase inhibitors in JEG-3 cell lines.

  2013cites this paper
• Design, synthesis, and structure-activity relationships of azolylmethylpyrroloquinolines as nonsteroidal aromatase inhibitors.

  2013cites this paper
• Computational methods for the design of potent aromatase inhibitors

  2013cites this paper
• Steroidal pyrazolines evaluated as aromatase and quinone reductase-2 inhibitors for chemoprevention of cancer.

  2012cites this paper
• Development of a new class of aromatase inhibitors: design, synthesis and inhibitory activity of 3-phenylchroman-4-one (isoflavanone) derivatives.

  2012cites this paper
• Neoflavonoids and Tetrahydroquinolones as Possible Cancer Chemopreventive Agents

  2012cites this paper
• Synthesis and aromatase inhibitory activity of some new 16E-arylidenosteroids.

  2012cites this paper
• Diversity and substrate specificity in the structures of steroidogenic cytochrome P450 enzymes.

  2012cites this paper
• Design, synthesis and antiproliferative activity of urocanic-chalcone hybrid derivatives

  2011cites this paper
• Suppression of Tumor Necrosis Factor-α-Induced Nuclear Factor κB Activation and Aromatase Activity by Capsaicin and Its Analog Capsazepine

  2011cites this paper
• Design, synthesis, and biological evaluation of callophycin A and analogues as potential chemopreventive and anticancer agents.

  2011cites this paper
• Aromatase and Dual Aromatase-Steroid Sulfatase Inhibitors from the Letrozole and Vorozole Templates

  2011cites this paper
• Hybrid dual aromatase-steroid sulfatase inhibitors with exquisite picomolar inhibitory activity.

  2011cites this paper
• A powerful combination of computational methods on the road toward potent non-steroidal inhibitors of steroidogenic enzymes involved in hormone-dependent diseases

  2010cites this paper
• Modeling of diarylalkyl‐imidazole and diarylalkyl‐triazole derivatives as potent aromatase inhibitors for treatment of hormone‐dependent cancer

  2010cites this paper
• Pharmacophore modeling strategies for the development of novel nonsteroidal inhibitors of human aromatase (CYP19).

  2010cites this paper
• Design, synthesis, and biological evaluation of resveratrol analogues as aromatase and quinone reductase 2 inhibitors for chemoprevention of cancer.

  2010cites this paper
• Circular dichroism in drug discovery and development: an abridged review

  2010cites this paper
• Bicyclic Derivatives of the Potent Dual Aromatase–Steroid Sulfatase Inhibitor 2‐Bromo‐4‐{[(4‐cyanophenyl)(4H‐1,2,4‐triazol‐4‐yl)amino]methyl}phenylsulfamate: Synthesis, SAR, Crystal Structure, and in vitro and in vivo Activities

  2010cites this paper
• Cinchona alkaloid-catalyzed asymmetric trifluoromethylation of alkynyl ketones with trimethylsilyl trifluoromethane.

  2010cites this paper
• Highly potent first examples of dual aromatase-steroid sulfatase inhibitors based on a biphenyl template.

  2010cites this paper
• Reinvestigation of the synthesis and evaluation of [N-methyl-(11)C]vorozole, a radiotracer targeting cytochrome P450 aromatase.

  2009cites this paper
• Fast three dimensional pharmacophore virtual screening of new potent non-steroid aromatase inhibitors.

  2009cites this paper
• Practical catalytic asymmetric synthesis of diaryl-, aryl heteroaryl-, and diheteroarylmethanols.

  2009cites this paper
• Natural products as aromatase inhibitors.

  2008cites this paper
• CYP19 (aromatase): exploring the scaffold flexibility for novel selective inhibitors.

  2008cites this paper
• From nonsteroidal aromatase inhibitors to multifunctional drug candidates: classic and innovative strategies for the treatment of breast cancer.

  2008cites this paper
• Chiral aromatase and dual aromatase-steroid sulfatase inhibitors from the letrozole template: synthesis, absolute configuration, and in vitro activity.

  2008cites this paper
• Non‐Steroidal Aromatase Inhibitors Based on a Biphenyl Scaffold: Synthesis, in vitro SAR, and Molecular Modelling

  2008cites this paper
• Acute and chronic effects of testosterone and 4-hydroxyandrostenedione to the crustacean Daphnia magna.

  2008cites this paper
• A computational study of the substrate conversion and selective inhibition of aldosterone synthase

  2008cites this paper
• Practical Syntheses of Enantiomerically Pure N‐Acetylbenzhydrylamines

  2007cites this paper
• Imidazolylmethylbenzophenones as highly potent aromatase inhibitors.

  2007cites this paper
• Endocrine Modulating Agents

  2007cites this paper
• Construction of 3D models of the CYP11B family as a tool to predict ligand binding characteristics

  2007cites this paper
• Synthesis and biological evaluation of (+/-)-abyssinone II and its analogues as aromatase inhibitors for chemoprevention of breast cancer.

  2007cites this paper
• Synthesis and biological activity of 7-phenyl-6,9-dihydro-3H-pyrrolo[3,2-f]quinolin-9-ones: a new class of antimitotic agents devoid of aromatase activity.

  2006cites this paper
• Aromatáza jako cíl v antihormonální léčbě

  2006cites this paper
• Lead optimization providing a series of flavone derivatives as potent nonsteroidal inhibitors of the cytochrome P450 aromatase enzyme.

  2006cites this paper
• Functional interaction of nitrogenous organic bases with cytochrome P450: a critical assessment and update of substrate features and predicted key active-site elements steering the access, binding, and orientation of amines.

  2006cites this paper
• Pharmacophore Modeling and in Silico Screening for New P450 19 (Aromatase) Inhibitors

  2006cites this paper
• Three‐dimensional model of the human aromatase enzyme and density functional parameterization of the iron‐containing protoporphyrin IX for a molecular dynamics study of heme‐cysteinato cytochromes

  2006cites this paper
• Xanthone derivatives: new insights in biological activities.

  2005cites this paper
• Synthesis and in vitro and in vivo antitumor activity of 2-phenylpyrroloquinolin-4-ones.

  2005cites this paper
• A letrozole-based dual aromatase-sulphatase inhibitor with in vivo activity.

  2005cites this paper
• An easy access to unsymmetric trisubstituted methane derivatives (TRSMs)

  2005cites this paper