The role of inflammation in cancer of the esophagus

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Expert Review of Gastroenterology & Hepatology

• Publication date

  2014-08-20

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1586/17474124.2014.913478PMID 24857183
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Statin use is associated with reduced risk of histologic subtypes of esophageal cancer: a nested case-control analysis.

  2014cited by this paper
• STAT3 expression, activity and functional consequences of STAT3 inhibition in esophageal squamous cell carcinomas and Barrett’s adenocarcinomas

  2014cited by this paper
• Could Signal Transducer and Activator of Transcription 3 be a Therapeutic Target in Obesity-Related Gastrointestinal Malignancy?

  2014cited by this paper
• The esophagitis to adenocarcinoma sequence; the role of inflammation.

  2014cited by this paper
• Circulating inflammatory cytokines and adipokines are associated with increased risk of Barrett's esophagus: a case-control study.

  2014cited by this paper
• Statins and Aspirin for Chemoprevention in Barrett's Esophagus: Results of a Cost-Effectiveness Analysis

  2013cited by this paper
• The genomic landscape of oesophagogastric junctional adenocarcinoma

  2013cited by this paper
• Do proton pump inhibitors protect against cancer progression in GERD?

  2013cited by this paper
• Metabolic signatures of esophageal cancer: NMR-based metabolomics and UHPLC-based focused metabolomics of blood serum.

  2013cited by this paper
• Molecular mechanisms of chemopreventive phytochemicals against gastroenterological cancer development.

  2013influential reference
• Dendritic cells in Barrett's esophagus carcinogenesis: an inadequate microenvironment for antitumor immunity?

  2013cited by this paper
• Does the Incidence of Adenocarcinoma of the Esophagus and Gastric Cardia Continue to Rise in the Twenty-First Century?—a SEER Database Analysis

  2013cited by this paper
• Reduced esophageal cancer incidence in statin users, particularly with cyclo-oxygenase inhibition.

  2013cited by this paper
• Role of aspirin in chemoprevention of esophageal adenocarcinoma: A meta‐analysis

  2013cited by this paper
• TNFα and IL-17 cooperatively stimulate glucose metabolism and growth factor production in human colorectal cancer cells

  2013cited by this paper
• Dietary antioxidants and risk of Barrett's esophagus and adenocarcinoma of the esophagus in an Australian population

  2013cited by this paper
• Proton pump inhibitors reduce the risk of neoplastic progression in patients with Barrett's esophagus.

  2013cited by this paper
• Defining a positive circumferential resection margin in oesophageal cancer and its implications for adjuvant treatment

  2013cited by this paper
• Central adiposity is associated with increased risk of esophageal inflammation, metaplasia, and adenocarcinoma: a systematic review and meta-analysis.

  2013cited by this paper
• Role of endothelial cell metabolism in vessel sprouting.

  2013cited by this paper
• Association between markers of obesity and progression from Barrett's esophagus to esophageal adenocarcinoma.

  2013cited by this paper
• The effects of obesity on oesophageal function, acid exposure and the symptoms of gastro‐oesophageal reflux disease

  2013cited by this paper
• Barrett's esophagus: cancer and molecular biology

  2013cited by this paper
• Esophagogastric cancer after bariatric surgery: systematic review of the literature.

  2013cited by this paper
• The nuclear factor kappa B signaling pathway: integrating metabolism with inflammation.

  2012cited by this paper
• Targeting the intrinsic inflammatory pathway: honokiol exerts proapoptotic effects through STAT3 inhibition in transformed Barrett's cells.

  2012cited by this paper
• IGF-1 and Its Receptor in Esophageal Cancer: Association with Adenocarcinoma and Visceral Obesity

  2012cited by this paper
• Aberrant p53 protein expression is associated with an increased risk of neoplastic progression in patients with Barrett's oesophagus

  2012cited by this paper
• Mitochondrial localization of TIGAR under hypoxia stimulates HK2 and lowers ROS and cell death

  2012cited by this paper
• Bile acid and inflammation activate gastric cardia stem cells in a mouse model of Barrett-like metaplasia.

  2012cited by this paper
• Gastrointestinal adenocarcinomas of the esophagus, stomach, and colon exhibit distinct patterns of genome instability and oncogenesis.

  2012cited by this paper
• Role of the insulin‐like growth factor 1 axis and visceral adiposity in oesophageal adenocarcinoma

  2012cited by this paper
• Inflammation and Barrett's carcinogenesis.

  2012cited by this paper
• Barrett’s to Oesophageal Cancer Sequence: A Model of Inflammatory-Driven Upper Gastrointestinal Cancer

  2012cited by this paper
• Inflammation‐mediated genomic instability: roles of activation‐induced cytidine deaminase in carcinogenesis

  2012cited by this paper
• Comparative genomic analysis of esophageal adenocarcinoma and squamous cell carcinoma.

  2012cited by this paper
• Non-Smad signaling pathways

  2011cited by this paper
• Nonsteroidal anti-inflammatory drugs and statins have chemopreventative effects in patients with Barrett's esophagus.

  2011cited by this paper
• MicroRNA prognostic signature for nodal metastases and survival in esophageal adenocarcinoma.

  2011cited by this paper
• NF-κB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration

  2011cited by this paper
• Genomic evolution in Barrett’s adenocarcinoma cells: critical roles of elevated hsRAD51, homologous recombination and Alu sequences in the genome

  2011cited by this paper
• Cancer-related inflammation and Barrett's carcinogenesis: interleukin-6 and STAT3 mediate apoptotic resistance in transformed Barrett's cells.

  2011cited by this paper
• Hallmarks of cancer: the next generation.

  2011cited by this paper
• HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells

  2011cited by this paper
• Acid reflux and oesophageal cancer.

  2011cited by this paper
• Visceral obesity, metabolic syndrome, insulin resistance and cancer

  2011cited by this paper
• Bile acid-induced expression of activation-induced cytidine deaminase during the development of Barrett's oesophageal adenocarcinoma.

  2011cited by this paper
• Interleukin 6 enhances glycolysis through expression of the glycolytic enzymes hexokinase 2 and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3.

  2010cited by this paper
• Leptin and gastro‐intestinal malignancies

  2010cited by this paper
• Treatment for Barrett's oesophagus.

  2010cited by this paper
• Connection between inflammation and carcinogenesis in gastrointestinal tract: focus on TGF-beta signaling.

  2010cited by this paper
• Stat3: linking inflammation to epithelial cancer - more than a "gut" feeling?

  2010cited by this paper
• Adipose tissue as an endocrine organ.

  2010cited by this paper
• Imaging , Diagnosis , Prognosis Inflammatory and MicroRNA Gene Expression as Prognostic Classifier of Barrett ' s-Associated Esophageal Adenocarcinoma

  2010cited by this paper
• Chronic Inflammation in Obesity and the Metabolic Syndrome

  2010cited by this paper
• Deletion at Fragile Sites Is a Common and Early Event in Barrett's Esophagus

  2010cited by this paper
• MMP-1 is a (pre-)invasive factor in Barrett-associated esophageal adenocarcinomas and is associated with positive lymph node status

  2010cited by this paper
• Nitric oxide-mediated invasion in Barrett's high-grade dysplasia and adenocarcinoma.

  2010cited by this paper
• Q‐FISH analysis of telomere and chromosome instability in the oesophagus with and without squamous cell carcinoma in situ

  2010cited by this paper
• Genomic instability in patients with Barrett's esophagus.

  2010cited by this paper
• Associations between leptin and adiponectin receptor upregulation, visceral obesity and tumour stage in oesophageal and junctional adenocarcinoma

  2010cited by this paper
• STATs in cancer inflammation and immunity: a leading role for STAT3

  2009cited by this paper
• Enteral Nutrition Enriched With Eicosapentaenoic Acid (EPA) Preserves Lean Body Mass Following Esophageal Cancer Surgery: Results of a Double-Blinded Randomized Controlled Trial

  2009cited by this paper
• HIF-1alpha protein expression is associated with the environmental inflammatory reaction in Barrett's metaplasia.

  2009cited by this paper
• In benign Barrett's epithelial cells, acid exposure generates reactive oxygen species that cause DNA double-strand breaks.

  2009cited by this paper
• Chemoprevention of oesophageal cancer and the AspECT trial.

  2009influential reference
• Inflammation, microenvironment, and the immune system in cancer progression.

  2009cited by this paper
• Inflammation and esophageal carcinogenesis.

  2009cited by this paper
• Esophageal cancer.

  2008cited by this paper
• Incidence of adenocarcinoma of the esophagus among white Americans by sex, stage, and age.

  2008influential reference
• Barrett Esophagus: Prevalence of Central Adiposity, Metabolic Syndrome, and a Proinflammatory State

  2008cited by this paper
• p53 regulates glucose metabolism through an IKK-NF-κB pathway and inhibits cell transformation

  2008cited by this paper
• Statins Inhibit Proliferation and Induce Apoptosis in Barrett's Esophageal Adenocarcinoma Cells

  2008cited by this paper
• Increasing expression of hypoxia-inducible proteins in the Barrett's metaplasia–dysplasia–adenocarcinoma sequence

  2007cited by this paper
• UC Irvine UC Irvine Previously Published Works Title Reactive oxygen species : a breath of life or death ?

  2007cited by this paper
• Central adiposity and risk of Barrett's esophagus.

  2007cited by this paper
• Activation of the Interleukin-6/STAT3 Antiapoptotic Pathway in Esophageal Cells by Bile Acids and Low pH: Relevance to Barrett's Esophagus

  2007cited by this paper
• Deoxycholic acid at neutral and acid pH, is genotoxic to oesophageal cells through the induction of ROS: The potential role of anti-oxidants in Barrett's oesophagus.

  2007cited by this paper
• Reactive Oxygen Species: A Breath of Life or Death?

  2007cited by this paper
• Immunohistochemical study of nuclear factor-&kgr;B activity and interleukin-8 abundance in oesophageal adenocarcinoma; a useful strategy for monitoring these biomarkers

  2007cited by this paper
• microRNAs as oncogenes and tumor suppressors.

  2007cited by this paper
• Elevated tumour interleukin-1b is associated with systemic inflammation: a marker of reduced survival in gastro-oesophageal cancer

  2006cited by this paper
• Overexpression of TGF‐β1 in esophageal (Barrett's) adenocarcinoma is associated with advanced stage of disease and poor prognosis

  2006cited by this paper
• Chromosomal Instability in Barrett's Esophagus Is Related to Telomere Shortening

  2006cited by this paper
• Genomic Instability in Precancerous Lesions before Inactivation of Tumor Suppressors p53 and APC in Patients

  2006cited by this paper
• Gastric acid suppression and risk of oesophageal and gastric adenocarcinoma: a nested case control study in the UK

  2006cited by this paper
• MicroRNA signatures in human cancers

  2006cited by this paper
• What aspects of body fat are particularly hazardous and how do we measure them?

  2006cited by this paper
• Improving surveillance for Barrett's oesophagus: AspECT and BOSS trials provide an evidence base

  2006cited by this paper
• MicroRNAs as oncogenes and tumor suppressors.

  2005cited by this paper
• Obesity Is an Independent Risk Factor for GERD Symptoms and Erosive Esophagitis

  2005cited by this paper
• Proinflammatory Cytokine and Nuclear Factor Kappa-B Expression along the Inflammation–Metaplasia–Dysplasia–Adenocarcinoma Sequence in the Esophagus

  2005cited by this paper
• COX2 expression, angiogenesis, proliferation and survival in Barrett's cancer.

  2005cited by this paper
• Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB

  2005cited by this paper
• Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB.

  2005cited by this paper
• Impaired transforming growth factor β signalling in Barrett’s carcinogenesis due to frequent SMAD4 inactivation

  2005cited by this paper
• Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms

  2004cited by this paper
• Telomere length assessment in tissue sections by quantitative FISH: Image analysis algorithms

  2004cited by this paper
• Tumors and inflammatory infiltrates: Friends or foes?

  2004cited by this paper
• Impact of the Biliary Diversion Procedure on Carcinogenesis in Barrett's Esophagus Surgically Induced by Duodenoesophageal Reflux in Rats

  2004cited by this paper

• Tertiary lymphoid structures correlate with reduced recurrence risk and enhanced antitumor immunity in esophageal squamous cell carcinoma with pathologic non-complete response to neoadjuvant chemoimmunotherapy

  2026cites this paper
• Decoding intratumoral cyclooxygenase-2 signaling through multi-omics: insights from esophageal cancer and beyond

  2025cites this paper
• CD45-PET is a robust, non-invasive tool for imaging inflammation

  2025cites this paper
• Cholelithiasis and cholecystectomy increase the risk of gastroesophageal reflux disease and Barrett’s esophagus

  2024cites this paper
• Predictive model for acute radiation esophagitis in esophageal carcinoma based on prognostic nutritional index and systemic inflammatory index and its application

  2024cites this paper
• Clinical Value of Mean Platelet Volume to Platelet Ratio (MPR) in Distinguishing Mass-Forming Chronic Pancreatitis and Pancreatic Cancer

  2023cites this paper
• Lactobacillus sp. Facilitate the Repair of DNA Damage Caused by Bile-Induced Reactive Oxygen Species in Experimental Models of Gastroesophageal Reflux Disease

  2023cites this paper
• Cancer-associated Macrophage-like Cells in Patients with Non-metastatic Adenocarcinoma of the Esophagus - Cytomorphological Heterogeneity

  2023cites this paper
• A Paradoxical Effect of Interleukin-32 Isoforms on Cancer

  2022cites this paper
• Targeting Chronic Inflammation of the Digestive System in Cancer Prevention: Modulators of the Bioactive Sphingolipid Sphingosine-1-Phosphate Pathway

  2022cites this paper
• Sinomenine Derivatives: Synthesis, Antitumor Activity, and Apoptotic Induction in MCF‐7 Cells via IL‐6/PI3K/Akt/NF‐κB Signaling Pathway

  2022cites this paper
• The Impact of Perioperative Fluid Balance on Postoperative Complications after Esophagectomy for Esophageal Cancer

  2022cites this paper
• Barrett's esophagus: The pathomorphological and molecular genetic keystones of neoplastic progression

  2021cites this paper
• Visceral Obesity, Metabolic Syndrome, and Esophageal Adenocarcinoma

  2021cites this paper
• Effect of the Rehabilitation Program, ReStOre, on Serum Biomarkers in a Randomized Control Trial of Esophagogastric Cancer Survivors

  2021cites this paper
• Esophageal Cancer Associated Immune Genes as Biomarkers for Predicting Outcome in Upper Gastrointestinal Tumors

  2021cites this paper
• Hypoxia and its impact on the tumour microenvironment of gastroesophageal cancers

  2021cites this paper
• The Omentum in Obesity-Associated Cancer: A Hindrance to Effective Natural Killer Cell Migration towards Tumour Which Can Be Overcome by CX3CR1 Antagonism

  2021cites this paper
• Tumors of the Gastrointestinal System Including the Pancreas

  2020cites this paper
• Investigation of IL-4, IL-10, and HVEM polymorphisms with esophageal squamous cell carcinoma: a case–control study involving 1929 participants

  2020cites this paper
• Esophageal Microenvironment: From Precursor Microenvironment to Premetastatic Niche

  2020cites this paper
• Human esophageal myofibroblasts increase squamous epithelial thickness via paracrine mechanisms in an in vitro model of gastroesophageal reflux disease

  2020cites this paper
• Local and Systemic Interleukin-32 in Esophageal, Gastric, and Colorectal Cancers: Clinical and Diagnostic Significance

  2020cites this paper
• The G-Protein Coupled Formyl Peptide Receptors and Their Role in the Progression of Digestive Tract Cancer

  2020cites this paper
• A Higher Dietary Inflammatory Index Score Is Associated With a Higher Risk of Breast Cancer Among Chinese Women: A Case–Control Study

  2020cites this paper
• Esophageal Microenvironment: From Precursor Microenvironment to Premetastatic Niche

  2020cites this paper
• Glucocorticoid receptor and serum‐ and glucocorticoid‐induced kinase‐1 in esophageal adenocarcinoma and adjacent Barrett's esophagus

  2020cites this paper
• Clinical and prognostic significance of preoperative lymphocyte-monocyte ratio, neutrophil-lymphocyte ratio and neutrophil-monocyte ratio on esophageal squamous cell carcinoma patients

  2020cites this paper
• Will a Proton Pump Inhibitor and an Aspirin Keep the Doctor Away for Patients With Barrett's Esophagus?

  2019cites this paper
• Finding esophageal cancer : could initial blood cell counts tell us ?

  2019cites this paper
• Interleukin-32: Frenemy in cancer?

  2019cites this paper
• Barrett oesophagus

  2019cites this paper
• Jie Du Tong Ye San Prevents N-Nitrosomethylbenzylamine-Induced Esophageal Carcinogenesis via Inhibition of Inflammation and Proliferation

  2019cites this paper
• Baseline neutrophil-lymphocyte ratio holds no prognostic value for esophageal and junctional adenocarcinoma in patients treated with neoadjuvant chemotherapy.

  2018cites this paper
• Dietary inflammatory index and risk of oesophageal cancer in Xinjiang Uyghur Autonomous Region, China

  2018cites this paper
• The arachidonic acid metabolism protein-protein interaction network and its expression pattern in esophageal diseases.

  2018cites this paper
• Cellular and clinicopathological features of the IL-33/ST2 axis in human esophageal squamous cell carcinomas

  2018cites this paper
• Orchestration of immune checkpoints in tumor immune contexture and their prognostic significance in esophageal squamous cell carcinoma

  2018cites this paper
• Dietary in fl ammatory index and risk of oesophageal cancer in Xinjiang Uyghur Autonomous Region , China

  2018cites this paper
• Potential role of P2X7R in esophageal squamous cell carcinoma proliferation

  2017cites this paper
• Dietary in fl ammatory index and risk of re fl ux oesophagitis , Barrett ’ s oesophagus and oesophageal adenocarcinoma : a population-based case – control study

  2017cites this paper
• Dietary inflammatory index and risk of reflux oesophagitis, Barrett's oesophagus and oesophageal adenocarcinoma: a population-based case-control study.

  2017cites this paper
• Hamburg-Glasgow classification: preoperative staging by combination of disseminated tumour load and systemic inflammation in oesophageal carcinoma

  2017cites this paper
• Cross-talk among metabolic parameters, esophageal microbiota, and host gene expression following chronic exposure to an obesogenic diet

  2017cites this paper
• Molecular interplay of pro-inflammatory transcription factors and non-coding RNAs in esophageal squamous cell carcinoma

  2017cites this paper
• Interleukin-17A promotes esophageal adenocarcinoma cell invasiveness through ROS-dependent, NF-κB-mediated MMP-2/9 activation.

  2017cites this paper
• Effects of a multimodal rehabilitation programme on inflammation and oxidative stress in oesophageal cancer survivors: the ReStOre feasibility study

  2017cites this paper
• Examining the connectivity between different cellular processes in the Barrett tissue microenvironment.

  2016cites this paper
• Prechemotherapy neutrophil : lymphocyte ratio is superior to the platelet : lymphocyte ratio as a prognostic indicator for locally advanced esophageal squamous cell cancer treated with neoadjuvant chemotherapy.

  2016cites this paper
• Diet-related inflammation and oesophageal cancer by histological type: a nationwide case–control study in Sweden

  2016cites this paper
• Circulating Tumor Cells in the Adenocarcinoma of the Esophagus

  2016cites this paper
• Mechanisms of esophageal adenocarcinoma formation and approaches to chemopreventive intervention.

  2016influential citation
• Investigation into mitochondrial function and energy metabolism and their connectivity with protumourigenic cellular proceses in Barrett's oesophagus

  2016influential citation
• Obesity and increased risk of esophageal adenocarcinoma

  2015cites this paper
• The Role of Energy Metabolism in Driving Disease Progression in Inflammatory, Hypoxic and Angiogenic Microenvironments

  2015cites this paper
• Dietary inflammatory index and risk of esophageal squamous cell cancer in a case–control study from Italy

  2015cites this paper
• Is Campylobacter to esophageal adenocarcinoma as Helicobacter is to gastric adenocarcinoma?

  2015cites this paper
• Dietary Inflammatory Index and Risk of Esophageal Squamous Cell Cancer in a Case-Control Study from Iran

  2015cites this paper
• Possible contribution of chronic inflammation in the induction of cancer in rheumatic diseases.

  2014cites this paper
• World Journal of Gastrointestinal Oncology

  year unknowncites this paper