SCIENCE@home

Mesenchymal-endothelial-transition contributes to cardiac neovascularization

Eric Ubil,Jinzhu Duan,I. Pillai,M. Rosa-Garrido,Yong Wu,Francesca Bargiacchi,Yan Lu,Seta Stanbouly,Jie Huang,M. Rojas,T. Vondriska,E. Stefani,Arjun Deb

Published 2014 in Nature

ABSTRACT

Endothelial cells contribute to a subset of cardiac fibroblasts by undergoing endothelial-to-mesenchymal transition, but whether cardiac fibroblasts can adopt an endothelial cell fate and directly contribute to neovascularization after cardiac injury is not known. Here, using genetic fate map techniques, we demonstrate that cardiac fibroblasts rapidly adopt an endothelial-cell-like phenotype after acute ischaemic cardiac injury. Fibroblast-derived endothelial cells exhibit anatomical and functional characteristics of native endothelial cells. We show that the transcription factor p53 regulates such a switch in cardiac fibroblast fate. Loss of p53 in cardiac fibroblasts severely decreases the formation of fibroblast-derived endothelial cells, reduces post-infarct vascular density and worsens cardiac function. Conversely, stimulation of the p53 pathway in cardiac fibroblasts augments mesenchymal-to-endothelial transition, enhances vascularity and improves cardiac function. These observations demonstrate that mesenchymal-to-endothelial transition contributes to neovascularization of the injured heart and represents a potential therapeutic target for enhancing cardiac repair.

PUBLICATION RECORD

CITATION MAP

EXTRACTION MAP

CLAIMS

  • No claims are published for this paper.

CONCEPTS

  • No concepts are published for this paper.

REFERENCES

Showing 1-46 of 46 references · Page 1 of 1

CITED BY

Showing 1-100 of 352 citing papers · Page 1 of 4

1234
Next