History of Neural Stem Cell Research and Its Clinical Application

“Once development was ended…in the adult centers, the nerve paths are something fixed and immutable. Everything may die, nothing may be regenerated,” wrote Santiago Ramón y Cajal, a Spanish neuroanatomist and Nobel Prize winner and the father of modern neuroscience. This statement was the central dogma in neuroscience for a long time. However, in the 1960s, neural stem cells (NSCs) were discovered. Since then, our knowledge about NSCs has continued to grow. This review focuses on our current knowledge about NSCs and their surrounding microenvironment. In addition, the clinical application of NSCs for the treatment of various central nervous system diseases is also summarized.

• Publication year

  2016

• Venue

  Neurologia medico-chirurgica

• Publication date

  2016-02-16

• Fields of study

  Medicine, History

• Identifiers
  DOI 10.2176/nmc.ra.2015-0340PMID 26888043PMCID 4791305
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2015cited by this paper
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  2015cited by this paper
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  2015cited by this paper
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  2015cited by this paper
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  2015cited by this paper
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  2014cited by this paper
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  2013cited by this paper
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  2013cited by this paper
• Stem cell therapy: a clinical trial of stroke.

  2013cited by this paper
• Vector-Free and Transgene-Free Human iPS Cells Differentiate into Functional Neurons and Enhance Functional Recovery after Ischemic Stroke in Mice

  2013cited by this paper
• The role of the dentate gyrus in the formation of contextual representations

  2013cited by this paper
• Lumbar Intraspinal Injection of Neural Stem Cells in Patients with Amyotrophic Lateral Sclerosis: Results of a Phase I Trial in 12 Patients

  2012cited by this paper
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  2012cited by this paper
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  2012cited by this paper
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  2012cited by this paper
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  2012cited by this paper
• Intra-Arterial Bone Marrow Mononuclear Cells in Ischemic Stroke: A Pilot Clinical Trial

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  2012cited by this paper
• Amyotrophic lateral sclerosis.

  2012cited by this paper
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  2011cited by this paper
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  2011cited by this paper
• Protein-based human iPS cells efficiently generate functional dopamine neurons and can treat a rat model of Parkinson disease.

  2011cited by this paper
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  2011cited by this paper
• Autologous Mesenchymal Stem Cells in Chronic Stroke

  2011cited by this paper
• ES cell-derived renewable and functional midbrain dopaminergic progenitors

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  2011cited by this paper
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  2010cited by this paper
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• Huntington disease

  2010cited by this paper
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  2010cited by this paper
• Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats

  2010cited by this paper
• Coexistence of Quiescent and Active Adult Stem Cells in Mammals

  2010cited by this paper
• The Neural Stem Cell Line CTX0E03 Promotes Behavioral Recovery and Endogenous Neurogenesis After Experimental Stroke in a Dose-Dependent Fashion

  2009cited by this paper
• A patient with Huntington’s disease and long-surviving fetal neural transplants that developed mass lesions

  2009cited by this paper
• A safer stem cell: on guard against cancer

  2009cited by this paper
• Molecular and magnetic resonance imaging of human embryonic stem cell-derived neural stem cell grafts in ischemic rat brain.

  2009cited by this paper
• Functional Engraftment of the Medial Ganglionic Eminence Cells in Experimental Stroke Model

  2009cited by this paper
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  2009cited by this paper
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  2008cited by this paper
• Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons

  2008cited by this paper
• Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease

  2008cited by this paper
• Development of a human neural stem cell line for use in recovery from disability after stroke.

  2008cited by this paper
• Highly efficient and large-scale generation of functional dopamine neurons from human embryonic stem cells

  2008cited by this paper
• Neural stem cells confer unique pinwheel architecture to the ventricular surface in neurogenic regions of the adult brain.

  2008cited by this paper
• Recent developments in cholinesterases inhibitors for Alzheimer's disease treatment.

  2007cited by this paper
• Monocyte Chemoattractant Protein-1 Plays a Critical Role in Neuroblast Migration after Focal Cerebral Ischemia

  2007cited by this paper
• Therapeutic Benefit of Bone Marrow Stromal Cells Administered 1 Month after Stroke

  2007cited by this paper
• Neurological and functional recovery in human stroke are associated with peripheral blood CD34+ cell mobilization

  2007cited by this paper
• Behavioral improvement in a primate Parkinson's model is associated with multiple homeostatic effects of human neural stem cells

  2007cited by this paper
• In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state

  2007cited by this paper
• Direct reprogramming of genetically unmodified fibroblasts into pluripotent stem cells

  2007cited by this paper
• ALS: a disease of motor neurons and their nonneuronal neighbors.

  2006cited by this paper
• Neuronal differentiation of transplanted embryonic stem cell-derived precursors in stroke lesions of adult rats.

  2006cited by this paper
• Intracerebral Infusion of Glial Cell Line–Derived Neurotrophic Factor Promotes Striatal Neurogenesis After Stroke in Adult Rats

  2006cited by this paper
• Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.

  2006cited by this paper
• Stem cells for the treatment of neurological disorders

  2006cited by this paper
• A computational theory of hippocampal function, and empirical tests of the theory.

  2006cited by this paper
• Involvement of Matrix Metalloproteinase in Neuroblast Cell Migration from the Subventricular Zone after Stroke

  2006cited by this paper
• Review ALS: A Disease of Motor Neurons and Their Nonneuronal Neighbors

  2006cited by this paper
• A Neurovascular Niche for Neurogenesis after Stroke

  2006cited by this paper
• Administration of Hematopoietic Cytokines in the Subacute Phase After Cerebral Infarction Is Effective for Functional Recovery Facilitating Proliferation of Intrinsic Neural Stem/Progenitor Cells and Transition of Bone Marrow–Derived Neuronal Cells

  2006cited by this paper
• A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease

  2005cited by this paper
• Dopaminergic neurons generated from monkey embryonic stem cells function in a Parkinson primate model.

  2005cited by this paper
• Neurotransplantation for patients with subcortical motor stroke: a phase 2 randomized trial.

  2005cited by this paper
• Neurogenesis in Rats After Focal Cerebral Ischemia is Enhanced by Indomethacin

  2005cited by this paper
• Fate of immortalized human neuronal progenitor cells transplanted in rat spinal cord.

  2005cited by this paper
• Axonal growth of embryonic stem cell-derived motoneurons in vitro and in motoneuron-injured adult rats.

  2004cited by this paper
• Treatment of Stroke With Erythropoietin Enhances Neurogenesis and Angiogenesis and Improves Neurological Function in Rats

  2004cited by this paper
• Functional Properties of Motoneurons Derived from Mouse Embryonic Stem Cells

  2004cited by this paper
• Enhanced In Vitro Midbrain Dopamine Neuron Differentiation, Dopaminergic Function, Neurite Outgrowth, and 1-Methyl-4-Phenylpyridium Resistance in Mouse Embryonic Stem Cells Overexpressing Bcl-XL

  2004cited by this paper
• Transplanted human fetal neural stem cells survive, migrate, and differentiate in ischemic rat cerebral cortex.

  2004cited by this paper
• Migration patterns of subventricular zone cells in adult mice change after cerebral cortex injury.

  2004cited by this paper
• Cell therapy in Parkinson’s disease

  2004cited by this paper
• Stroke‐induced progenitor cell proliferation in adult spontaneously hypertensive rat brain: effect of exogenous IGF‐1 and GDNF

  2003cited by this paper
• Differential effects of learning on neurogenesis: learning increases or decreases the number of newly born cells depending on their birth date

  2003cited by this paper
• The Cholinergic Hypothesis of Age and Alzheimer's Disease-Related Cognitive Deficits: Recent Challenges and Their Implications for Novel Drug Development

  2003cited by this paper
• Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease

  2002cited by this paper
• Genetic engineering of mouse embryonic stem cells by Nurr1 enhances differentiation and maturation into dopaminergic neurons

  2002cited by this paper
• The distribution of structural neuropathology in pre-clinical Huntington's disease.

  2002cited by this paper
• Rat forebrain neurogenesis and striatal neuron replacement after focal stroke

  2002cited by this paper
• Neuronal replacement from endogenous precursors in the adult brain after stroke

  2002cited by this paper
• Directed differentiation of embryonic stem cells into motor neurons.

  2002cited by this paper
• Binge ethanol exposure decreases neurogenesis in adult rat hippocampus

  2002cited by this paper
• Transplantation of cultured human neuronal cells for patients with stroke.

  2001cited by this paper
• Cell therapy for Parkinson's disease.

  2001cited by this paper
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  2001cited by this paper
• Astrocytes Give Rise to New Neurons in the Adult Mammalian Hippocampus

  2001cited by this paper
• Neural progenitors from human embryonic stem cells

  2001cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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• Cell replacement therapies for central nervous system disorders

  2000cited by this paper
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  2000cited by this paper

• Characterization of Neural Stem Cells of the Human Embryonic Fetus Across Regions of the Central Nervous System and Through Standard Gestation Period Assessments

  2025cites this paper
• Advancements in Stem Cell Research for Effective Therapies Against Alzheimer’s Disease: Current Investigation and Future Insight

  2025cites this paper
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  2025cites this paper
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  2024cites this paper
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  2024cites this paper
• Interface‐Mediated Neurogenic Signaling: The Impact of Surface Geometry and Chemistry on Neural Cell Behavior for Regenerative and Brain–Machine Interfacing Applications

  2024cites this paper
• Age-associated declining of the regeneration potential of skeletal stem/progenitor cells

  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
• 100 plus years of stem cell research—20 years of ISSCR

  2022cites this paper
• Dental Pulp-Derived Stem Cells Reduce Inflammation, Accelerate Wound Healing and Mediate M2 Polarization of Myeloid Cells

  2022cites this paper
• NSC Physiological Features in Spinal Muscular Atrophy: SMN Deficiency Effects on Neurogenesis

  2022cites this paper
• Stem Cell-Based Therapies: What Interventional Radiologists Need to Know.

  2021cites this paper
• MiR-140-5p targets Prox1 to regulate the proliferation and differentiation of neural stem cells through the ERK/MAPK signaling pathway

  2021cites this paper
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  2021cites this paper
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  2021cites this paper
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• A review on stem cell therapy for neuropathic pain.

  2020cites this paper
• Epidermal growth factor‐immobilized surfaces for the selective expansion of neural progenitor cells derived from induced pluripotent stem cells

  2020cites this paper
• mRNA-Driven Generation of Transgene-Free Neural Stem Cells from Human Urine-Derived Cells

  2019cites this paper
• Spinal Cord Injury and Its Future Therapy - A Perspective

  2019cites this paper
• Hydrogel-Based Bioprocess for Scalable Manufacturing of Human Pluripotent Stem Cell-Derived Neural Stem Cells.

  2018cites this paper
• Cell therapies administered in the chronic phase after stroke: a meta-analysis examining safety and efficacy.

  2017cites this paper