Inactivation of Rv2525c, a Substrate of the Twin Arginine Translocation (Tat) System of Mycobacterium tuberculosis, Increases β-Lactam Susceptibility and Virulence

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Journal of Bacteriology

• Publication date

  2006-09-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/JB.00631-06PMID 16952959PMCID PMC1595485
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• The Transcriptional Responses of Mycobacterium tuberculosis to Inhibitors of Metabolism

  2004influential reference
• The complete genomic sequence of Nocardia farcinica IFM 10152.

  2004cited by this paper
• A glycolipid of hypervirulent tuberculosis strains that inhibits the innate immune response

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• Comparative mycobacterial genomics as a tool for drug target and antigen discovery

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  2002influential reference
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  2002cited by this paper
• Resazurin Microtiter Assay Plate: Simple and Inexpensive Method for Detection of Drug Resistance in Mycobacterium tuberculosis

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  2001cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
• Growth Rate of Mycobacteria in Mice as an Unreliable Indicator of Mycobacterial Virulence

  1999cited by this paper
• Survival of mice infected with Mycobacterium smegmatis containing large DNA fragments from Mycobacterium tuberculosis.

  1999cited by this paper
• Antimycobacterial Activities of Isoxyl and New Derivatives through the Inhibition of Mycolic Acid Synthesis

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• Overlapping functions of components of a bacterial Sec‐independent protein export pathway

  1998cited by this paper
• An Essential Component of a Novel Bacterial Protein Export System with Homologues in Plastids and Mitochondria*

  1998cited by this paper
• Erratum: Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence

  1998cited by this paper
• Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence

  1998cited by this paper
• Efficient allelic exchange and transposon mutagenesis in Mycobacterium tuberculosis.

  1997influential reference
• Can penicillins and other beta-lactam antibiotics be used to treat tuberculosis?

  1995cited by this paper
• The complete general secretory pathway in gram-negative bacteria.

  1993cited by this paper
• Proteins released from Mycobacterium tuberculosis during growth

  1991cited by this paper

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  2020cites this paper
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  2019cites this paper
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  2017cites this paper
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  2016cites this paper
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• Inactivation of the Mycobacterium tuberculosis fadB4 gene results in increased virulence in host cell and mice.

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• A novel drug discovery concept for tuberculosis: inhibition of bacterial and host cell signalling.

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• 19 The Mycobacterial Heparin-Binding Hemagglutinin: a Virulence Factor and Antigen Useful for Diagnostics and Vaccine Development

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