Is the chemical gate of connexins voltage sensitive? Behavior of Cx32 wild-type and mutant channels.

No abstract is available for this paper.

• Publication year

  1999

• Venue

  American Journal of Physiology - Cell Physiology

• Publication date

  1999-06-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1152/ajpcell.1999.276.6.C1361PMID 29597660
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Chemical Gating of Heteromeric and Heterotypic Gap Junction Channels

  1998cited by this paper
• Connexin32 Mutations Associated with X-Linked Charcot–Marie–Tooth Disease Show Two Distinct Behaviors: Loss of Function and Altered Gating Properties

  1998cited by this paper
• Molecular dissection of a basic COOH-terminal domain of Cx32 that inhibits gap junction gating sensitivity.

  1998cited by this paper
• Inhibition of endosome fusion by wortmannin persists in the presence of activated Rab5.

  1998cited by this paper
• Positive charges of the initial C-terminus domain of Cx32 inhibit gap junction gating sensitivity to CO2.

  1997influential reference
• Connexin domains relevant to the chemical gating of gap junction channels.

  1997cited by this paper
• Long-chain n-alkanols and arachidonic acid interfere with the Vm-sensitive gating mechanism of gap junction channels

  1997cited by this paper
• Three-dimensional structure of the gap junction connexon.

  1997cited by this paper
• Two distinct gating mechanisms in gap junction channels: CO2-sensitive and voltage-sensitive.

  1997cited by this paper
• Intramolecular interactions mediate pH regulation of connexin43 channels.

  1996cited by this paper
• PH regulation of connexin43: molecular analysis of the gating particle.

  1996cited by this paper
• Connexin 32/38 chimeras suggest a role for the second half of inner loop in gap junction gating by low pH.

  1996cited by this paper
• Connections with connexins: the molecular basis of direct intercellular signaling.

  1996cited by this paper
• CHAPTER 24 – Molecular Models of Channel Interaction and Gating in Gap Junctions

  1994cited by this paper
• Point mutations of the connexin32 (GJB1) gene in X-linked dominant Charcot-Marie-Tooth neuropathy.

  1994cited by this paper
• Opposite voltage gating polarities of two closely related onnexins

  1994influential reference
• A structural basis for the unequal sensitivity of the major cardiac and liver gap junctions to intracellular acidification: the carboxyl tail length.

  1993cited by this paper
• Connexin mutations in X-linked Charcot-Marie-Tooth disease.

  1993cited by this paper
• Gap junctions formed by connexins 26 and 32 alone and in combination are differently affected by applied voltage.

  1991cited by this paper
• Gating properties of connexin32 cell—cell channels and their mutants expressed in Xenopusoocytes

  1991cited by this paper
• Cell-to-cell communication and the control of growth.

  1990cited by this paper
• Molecular cloning of cDNA for rat liver gap junction protein

  1986cited by this paper
• Equilibrium properties of a voltage-dependent junctional conductance

  1981cited by this paper

• Calcium Role in Gap Junction Channel Gating: Direct Electrostatic or Calmodulin-Mediated?

  2024cites this paper
• Gap Junction Channel Regulation: A Tale of Two Gates—Voltage Sensitivity of the Chemical Gate and Chemical Sensitivity of the Fast Voltage Gate

  2024influential citation
• Calmodulin-Connexin Partnership in Gap Junction Channel Regulation-Calmodulin-Cork Gating Model

  2021influential citation
• Calmodulin-Cork Model of Gap Junction Channel Gating—One Molecule, Two Mechanisms

  2020influential citation
• Calmodulin-Mediated Regulation of Gap Junction Channels

  2020influential citation
• References

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• Targeting a moonlighting function of aldolase induces apoptosis in cancer cells

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• Functional asymmetry and plasticity of electrical synapses interconnecting neurons through a 36-state model of gap junction channel gating

  2017cites this paper
• Stochastic Model of Gap Junctions Exhibiting Rectification and Multiple Closed States of Slow Gates.

  2016cites this paper
• Putative Pore-lining Residues and Intracellular Magnesium Influence Connexin50 Unitary Gap Junction Channel Conductance

  2016cites this paper
• Structural basis for the selective permeability of channels made of communicating junction proteins.

  2013cites this paper
• Intracellular Matrix Remodeling and Cardiac Function in Ischemia–Reperfusion Injury

  2013cites this paper
• Der epigastrisch adipokutane Lappen am Tiermodell zur Evaluierung der ischämischen Präkonditionierung

  2009cites this paper
• Mitochondrial Involvement in Cardiac Apoptosis During Ischemia and Reperfusion: Can We Close the Box?

  2009cites this paper
• Endothelial cytoskeletal elements are critical for flow-mediated dilation in human coronary arterioles

  2008cites this paper
• Connexin43 behaviour in cardiac myocytes exposed to ischaemia and hypoxia

  2007cites this paper
• Mitochondria and Their Role in Ischemia/Reperfusion Injury

  2007cites this paper
• Unusual Slow Gating of Gap Junction Channels in Oocytes Expressing Connexin32 or Its COOH-Terminus Truncated Mutant

  2007cites this paper
• Interactions of connexins with other membrane channels and transporters.

  2007cites this paper
• Interplay between Cystic Fibrosis Transmembrane Regulator and Gap Junction Channels Made of Connexins 45, 40, 32 and 50 Expressed in Oocytes

  2006cites this paper
• Inversion of both gating polarity and CO2 sensitivity of voltage gating with D3N mutation of Cx50.

  2005cites this paper
• Diazoxide-induced respiratory inhibition – a putative mitochondrial KATP channel independent mechanism of pharmacological preconditioning

  2005cites this paper
• Functional Interaction Between CFTR and Cx45 Gap Junction Channels Expressed in Oocytes

  2005cites this paper
• In vivo protective effects of urocortin on ischemia-reperfusion injury in rat heart via free radical mechanisms.

  2005cites this paper
• Protective Effects of Resveratrol against Ischemia-Reperfusion

  2005cites this paper
• Putative endogenous mediators of preconditioning‐induced ischemic tolerance in rat brain identified by genomic and proteomic analysis

  2004cites this paper
• Opposite Cx32 and Cx26 Voltage-Gating Response to CO2 Reflects Opposite Voltage-Gating Polarity

  2004cites this paper
• CO2 Sensitivity of Voltage Gating and Gating Polarity of GapJunction Channels—Connexin40 and its COOH-Terminus-Truncated Mutant

  2004cites this paper
• Effects of volatile anesthetics on cardiac ion channels

  2004cites this paper
• NEW INSIGHT INTO THE SIGNALLING PATHWAYS OF HEAT STRESS‐INDUCED MYOCARDIAL PRECONDITIONING: PROTEIN KINASE Cε TRANSLOCATION AND HEAT SHOCK PROTEIN 27 PHOSPHORYLATION

  2004cites this paper
• KATP channel openers: Structure‐activity relationships and therapeutic potential

  2004cites this paper
• Chemical gating of gap junction channels; roles of calcium, pH and calmodulin.

  2004influential citation
• Gap junction channel gating.

  2004cites this paper
• The Voltage Gates of Connexin Channels are Sensitive to CO2

  2003cites this paper
• Is the Voltage Gate of Connexins CO2-sensitive? Cx45 Channels and Inhibition of Calmodulin Expression

  2003cites this paper
• Activation of p38 Kinase in the Gerbil Hippocampus Showing Ischemic Tolerance

  2003cites this paper
• Mitochondrial Sources of H2O2 Generation Play a Key Role in Flow-Mediated Dilation in Human Coronary Resistance Arteries

  2003cites this paper
• Gating properties of gap junction channels assembled from connexin43 and connexin43 fused with green fluorescent protein.

  2001cites this paper
• Emerging issues of connexin channels: biophysics fills the gap

  2001cites this paper
• Selective pharmacological agents implicate mitochondrial but not sarcolemmal K(ATP) channels in ischemic cardioprotection.

  2000cites this paper
• Calmodulin Directly Gates Gap Junction Channels*

  2000cites this paper
• Slow Gating of Gap Junction Channels and Calmodulin

  2000cites this paper
• Adenosine A(1) receptor induced delayed preconditioning in rabbits: induction of p38 mitogen-activated protein kinase activation and Hsp27 phosphorylation via a tyrosine kinase- and protein kinase C-dependent mechanism.

  2000cites this paper
• Do Modulators of the Mitochondrial KATP Channel Change the Function of Mitochondria in Situ?*

  2000cites this paper
• Calmodulin-connexin colocolization and direct role of calmodulin in gap junction channel gating

  2000cites this paper
• Ischemic preconditioning in isolated cells.

  2000cites this paper
• Myocardial K(ATP) channels in preconditioning.

  2000cites this paper
• Chapter 13: Behavior of Chemical and Slow Voltage-Sensitive Gates of Connexin Channels: The “Cork” Gating Hypothesis

  1999cites this paper
• Chapter 12: Mechanistic Differences Between Chemical and Electrical Gating of Gap Junctions

  1999cites this paper