Targeting metastasis-initiating cells through the fatty acid receptor CD36

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Nature

• Publication date

  2016-12-07

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/nature20791PMID 27974793
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Genetic alterations in fatty acid transport and metabolism genes are associated with metastatic progression and poor prognosis of human cancers

  2016cited by this paper
• Mesenchymal Cancer Cell-Stroma Crosstalk Promotes Niche Activation, Epithelial Reversion, and Metastatic Colonization

  2015cited by this paper
• Neutrophils support lung colonization of metastasis-initiating breast cancer cells

  2015cited by this paper
• Enhanced MAF Oncogene Expression and Breast Cancer Bone Metastasis

  2015cited by this paper
• Microenvironment in metastasis: roadblocks and supportive niches.

  2015cited by this paper
• Therapy-induced tumour secretomes promote resistance and tumour progression

  2015cited by this paper
• Distinct EMT programs control normal mammary stem cells and tumour-initiating cells

  2015cited by this paper
• EMT Program is Dispensable for Metastasis but Induces Chemoresistance in Pancreatic Cancer

  2015cited by this paper
• EMT is not required for lung metastasis but contributes to chemoresistance

  2015cited by this paper
• Elevated free fatty acid uptake via CD36 promotes epithelial-mesenchymal transition in hepatocellular carcinoma

  2015cited by this paper
• In Vivo Imaging Reveals Extracellular Vesicle-Mediated Phenocopying of Metastatic Behavior

  2015cited by this paper
• TGF-β promotes heterogeneity and drug resistance in squamous cell carcinoma.

  2015cited by this paper
• Structure-function of CD36 and importance of fatty acid signal transduction in fat metabolism.

  2014cited by this paper
• Metastatic stem cells: sources, niches, and vital pathways.

  2014cited by this paper
• Cancer-secreted miR-105 destroys vascular endothelial barriers to promote metastasis.

  2014cited by this paper
• The tumour-induced systemic environment as a critical regulator of cancer progression and metastasis

  2014cited by this paper
• Analysis of tumor- and stroma-supplied proteolytic networks reveals a brain metastasis-promoting role for cathepsin S

  2014cited by this paper
• Serpins promote cancer cell survival and vascular co-option in brain metastasis.

  2014cited by this paper
• UC Office of the President Recent Work Title Cancer-secreted miR-105 destroys vascular endothelial barriers to promote metastasis

  2014cited by this paper
• The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells

  2014cited by this paper
• Rewiring of an Epithelial Differentiation Factor, miR-203, to Inhibit Human Squamous Cell Carcinoma Metastasis

  2014cited by this paper
• A novel method for monitoring tumor proliferation in vivo using fluorescent dye DiD

  2014cited by this paper
• Cancer Stem Cell‐Specific Scavenger Receptor CD36 Drives Glioblastoma Progression

  2014cited by this paper
• Selection of bone metastasis seeds by mesenchymal signals in the primary tumor stroma.

  2013cited by this paper
• Comprehensive molecular portraits of human breast tumours

  2013cited by this paper
• Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

  2013cited by this paper
• VEGF targets the tumour cell

  2013cited by this paper
• Molecular Basis of Antiangiogenic Thrombospondin-1 Type 1 Repeat Domain Interactions With CD36

  2013cited by this paper
• Dependency of colorectal cancer on a TGF-β-driven program in stromal cells for metastasis initiation.

  2012cited by this paper
• Analysis of Marker-Defined HNSCC Subpopulations Reveals a Dynamic Regulation of Tumor Initiating Properties

  2012cited by this paper
• Comprehensive molecular portraits of human breast tumors

  2012cited by this paper
• Epithelial-mesenchymal transition can suppress major attributes of human epithelial tumor-initiating cells.

  2012cited by this paper
• Comparative Studies of Vertebrate Platelet Glycoprotein 4 (CD36)

  2012cited by this paper
• The PSA(-/lo) prostate cancer cell population harbors self-renewing long-term tumor-propagating cells that resist castration.

  2012cited by this paper
• Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

  2012cited by this paper
• The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data.

  2012cited by this paper
• Cancer stem cells in squamous cell carcinoma switch between two distinct phenotypes that are preferentially migratory or proliferative.

  2011cited by this paper
• A Perspective on Cancer Cell Metastasis

  2011cited by this paper
• Macrophage binding to receptor VCAM-1 transmits survival signals in breast cancer cells that invade the lungs.

  2011cited by this paper
• Pathogenic Role of Scavenger Receptor CD36 in the Metabolic Syndrome and Diabetes

  2011cited by this paper
• Metabolic fuels: regulating fluxes to select mix

  2011cited by this paper
• Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth

  2011cited by this paper
• VCAM-1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging α4β1-positive osteoclast progenitors.

  2011cited by this paper
• Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs

  2011cited by this paper
• Use of BODIPY (493/503) to Visualize Intramuscular Lipid Droplets in Skeletal Muscle

  2011cited by this paper
• Biological and molecular heterogeneity of breast cancers correlates with their cancer stem cell content.

  2010cited by this paper
• Accurate Expression Profiling of Very Small Cell Populations

  2010cited by this paper
• Membrane fatty acid transporters as regulators of lipid metabolism: implications for metabolic disease.

  2010cited by this paper
• Adipose acyl-CoA synthetase-1 directs fatty acids toward beta-oxidation and is required for cold thermogenesis.

  2010cited by this paper
• A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth.

  2010cited by this paper
• Mouse models of human AML accurately predict chemotherapy response.

  2009cited by this paper
• ELDA: extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays.

  2009cited by this paper
• Isolation and culture of epithelial stem cells.

  2009cited by this paper
• Gene Expression Omnibus ( GEO ) : Microarray data storage , submission , retrieval , and analysis

  2008cited by this paper
• Sensitivity of Squamous Cell Carcinoma Lymph Node Metastases to Herpes Oncolytic Therapy

  2008cited by this paper
• Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma

  2007cited by this paper
• Stem cell patterns in cell lines derived from head and neck squamous cell carcinoma.

  2007cited by this paper
• Activation of CD36 inhibits and induces regression of inflammatory corneal neovascularization.

  2006cited by this paper
• Fibroblasts in cancer

  2006cited by this paper
• OP9 mouse stromal cells rapidly differentiate into adipocytes: characterization of a useful new model of adipogenesis Published, JLR Papers in Press, November 30, 2005

  2006cited by this paper
• Trans-arachidonic acids generated during nitrative stress induce a thrombospondin-1–dependent microvascular degeneration

  2005cited by this paper
• From the Cover: Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

  2005cited by this paper
• Lipid metabolic enzymes: emerging drug targets for the treatment of obesity

  2004cited by this paper
• Bioconductor: open software development for computational biology and bioinformatics

  2004cited by this paper
• Exploration, normalization, and summaries of high density oligonucleotide array probe level data.

  2003cited by this paper
• Characterizing gene sets with FuncAssociate

  2003cited by this paper
• An orthotopic nude mouse model of oral tongue squamous cell carcinoma.

  2002cited by this paper
• Defective Uptake and Utilization of Long Chain Fatty Acids in Muscle and Adipose Tissues of CD36 Knockout Mice*

  2000cited by this paper
• Muscle-specific Overexpression of FAT/CD36 Enhances Fatty Acid Oxidation by Contracting Muscle, Reduces Plasma Triglycerides and Fatty Acids, and Increases Plasma Glucose and Insulin*

  1999cited by this paper
• Controlling the false discovery rate: a practical and powerful approach to multiple testing

  1995cited by this paper

• CD36 enhances sensitivity of triple negative breast cancer cells to palmitate-induced ferroptosis

  2026cites this paper
• Metabolic crosstalk in the metastatic prostate cancer-bone microenvironment: mechanism, detection and therapeutic strategies.

  2026cites this paper
• Lipid metabolic alterations in cancer: common pathophysiology with cardiovascular disease.

  2026cites this paper
• Targeting Fatty Acids in Liver Cancer: Molecular Insights and Drug Approaches.

  2026cites this paper
• Autophagy in cancer-associated fibroblasts: its role in gastrointestinal cancers.

  2026cites this paper
• Nutritional modulation of metabolic signaling within the tumor microenvironment for cancer therapy.

  2026cites this paper
• Rethinking mitochondria as a target for cancer therapy.

  2026cites this paper
• Lipids grease the chain of cancer progression.

  2026cites this paper
• Metabolic reprogramming in cancer: signaling pathways and therapeutic targets.

  2026cites this paper
• Cancer Metabolism and Its Historical & Molecular Foundations: An Overview

  2026cites this paper
• Restoring Antitumor Immunity by Reprogramming Abnormal Lipid Metabolism in the Tumor Microenvironment Using Irisin-Manganese Co-loaded Nanoparticles.

  2026cites this paper
• Lipidomics in Melanoma: Insights into Disease Progression and Therapeutical Targets

  2026cites this paper
• CDK13 drives clear cell renal carcinoma through METTL16-mediated m6A modification of ACLY mRNA.

  2026cites this paper
• Spatially resolved multiomics reveals the self-enforcing property of the leading-edge multicellular ecosystem of head and neck cancer.

  2026cites this paper
• Metadherin with Stromal-Immune Cues Drives CD36-Dependent Lipid Reprogramming and Metastasis in Triple-Negative Breast Cancer: Insights from a Hetero-Spheroid Model.

  2026cites this paper
• The impact of lipid metabolism remodeling in the tumor microenvironment on angiogenesis.

  2026cites this paper
• Fatty acid and cysteine metabolic interplay regulate ferroptosis and highlight xCT as a selenium-chrysin target in breast carcinoma.

  2026cites this paper
• The dual role of CD36 in cancer: from lipid metabolism to tumor microenvironment regulation

  2025cites this paper
• Long-Chain Fatty Acids Alter Estrogen Receptor Expression in Breast Cancer Cells

  2025cites this paper
• Distinct lipidomic profiles in breast cancer cell lines relate to proliferation and EMT phenotypes.

  2025cites this paper
• New mechanistic understanding of FXR agonist Vonafexor: inducing sublethal damage of HBV-positive liver cancer cells via promoting anti-tumor immunity

  2025cites this paper
• NPR1 Promotes Lipid Droplet Lipolysis to Enhance Mitochondrial Oxidative Phosphorylation and Fuel Gastric Cancer Metastasis

  2025cites this paper
• Lipids: Driving Forces in the Underlying Biology of Carcinogenesis.

  2025cites this paper
• Oxidized Low-Density Lipoprotein as a Potential Target for Enhancing Immune Checkpoint Inhibitor Therapy in Microsatellite-Stable Colorectal Cancer

  2025cites this paper
• The Landscape of Cancer Metabolism as a Therapeutic Target

  2025cites this paper
• Decoding the CD36-Centric Axis in Gastric Cancer: Insights into Lipid Metabolism, Obesity, and Hypercholesterolemia

  2025cites this paper
• Metabolic hallmarks of trastuzumab resistance

  2025cites this paper
• Metabolic Adaptations in Cancer Progression: Optimization Strategies and Therapeutic Targets

  2025cites this paper
• Lipid metabolic reprogramming in colorectal cancer: mechanisms and therapeutic strategies

  2025cites this paper
• Mitochondrial glutathione import enables breast cancer metastasis via integrated stress response signaling.

  2025cites this paper
• Lipid metabolism in cancer stem cells: reprogramming, mechanisms, crosstalk, and therapeutic approaches

  2025cites this paper
• Identification of new selective CD36 inhibitors to potentiate HER2-targeted therapy in HER2-positive breast cancer

  2025cites this paper
• Lipid Metabolism in Gastrointestinal Malignancies: Exploring Dysregulation, Biomarkers, and Treatment Strategies

  2025cites this paper
• Ubiquitination in lipid metabolism reprogramming: implications for pediatric solid tumors

  2025cites this paper
• In vivo CRISPR activation screen identifies acyl-CoA-binding protein as a driver of bone metastasis.

  2025cites this paper
• Tumor acidosis supports cancer cell lipid uptake via a rapid, transporter-independent mechanism.

  2025cites this paper
• Cross-Talk Between Cancer and Its Cellular Environment—A Role in Cancer Progression

  2025cites this paper
• CD36 promotes iron accumulation and dysfunction in CD8+ T cells via the p38-CEBPB-TfR1 axis in early-stage hepatocellular carcinoma

  2025cites this paper
• The Role of Glycolipids and their Toxicity in the Context of Nanomaterials and Nanoparticles: A Review of the Literature.

  2025cites this paper
• Increased fatty acid delivery by tumor endothelium promotes metastatic outgrowth

  2025cites this paper
• The regulatory role and mechanism of energy metabolism and immune response in head and neck cancer

  2025cites this paper
• Loss of fatty acid-binding protein 7 promotes B16F10 melanoma metastasis

  2025cites this paper
• Fatty acid metabolism: The crossroads in intestinal homeostasis and tumor.

  2025cites this paper
• PLT012, a Humanized CD36-Blocking Antibody, Is Effective for Unleashing Antitumor Immunity Against Liver Cancer and Liver Metastasis.

  2025cites this paper
• A novel 68Ga-labeled cyclic peptide: A potential radiotracer for PET imaging of CD36-positive cancers.

  2025cites this paper
• The Metabolic Landscape of Cancer Stem Cells: Insights and Implications for Therapy

  2025cites this paper
• Acetylation-induced degradation of ECHS1 enhances BCAA accumulation and proliferation in KRAS-mutant colorectal cancer

  2025cites this paper
• Targeting metabolic reprogramming to overcome immune tolerance in melanoma immunotherapy

  2025cites this paper
• Modified Lipid Particle Recognition: A Link Between Atherosclerosis and Cancer?

  2025cites this paper
• CD36 as a marker of acute myeloid leukemia prognosis: A systematic review

  2025cites this paper
• Impact of fat distribution and muscle on survival in overweight and obese breast cancer patients.

  2025cites this paper
• CD18 and CD36 expression in neutrophils from tumors and tumor-draining lymph nodes: implications for metastasis in oral squamous cell carcinoma

  2025cites this paper
• Preclinical models in the study of lymph node metastasis

  2025cites this paper
• Ferroptosis in immune cells: Implications for tumor immunity and cancer therapy.

  2025cites this paper
• Exploring the molecular mechanisms of comorbidity between thyroid cancer and breast cancer through multi-omics data

  2025cites this paper
• Aldo-keto Reductase 1B10 (AKR1B10) Suppresses Sensitivity of Ferroptosis in TNBC by Activating the AKT/GSK3β/Nrf2/GPX4 Axis.

  2025cites this paper
• Cancer progression through the lens of age-induced metabolic reprogramming

  2025cites this paper
• The Impact of Obesity and Lipids on Cancer: Insights into Mechanisms and Potential Interventions.

  2025cites this paper
• Fatty acid metabolic reprogramming in the tumor microenvironment: Unraveling mechanisms and therapeutic prospects

  2025cites this paper
• Analyzing the Blueprint: Exploring the Molecular Profile of Metastasis and Therapeutic Resistance

  2025cites this paper
• Metabolic adaptations in cancer progression.

  2025cites this paper
• Linking mitochondria, fatty acids, and hematopoietic stem cell expansion during infection: implications for aging and metabolic diseases

  2025cites this paper
• Targeting lipid metabolism in acute myeloid leukemia: biological insights and therapeutic opportunities

  2025cites this paper
• Energy metabolism in health and diseases

  2025cites this paper
• Lipid Metabolism in Breast Cancer: From Basic Research to Clinical Application

  2025cites this paper
• Study on the Mechanism of Solasonine Inhibiting the Proliferation of Oral Squamous Cell Carcinoma Based on Lipidomics.

  2025cites this paper
• Discovery and in vitro characterization of a human anti-CD36 scFv

  2025cites this paper
• Targeting PCSK9, through an innovative cVLP-based vaccine, enhanced the therapeutic activity of a cVLP-HER2 vaccine in a preclinical model of HER2-positive mammary carcinoma

  2025cites this paper
• Normal and melanoma skin visualized, quantified and compared by in vivo photoacoustic imaging

  2025cites this paper
• PPARα-mediated lipid metabolism reprogramming supports anti-EGFR therapy resistance in head and neck squamous cell carcinoma

  2025cites this paper
• Cell fusion as a driver of metastasis: re-evaluating an old hypothesis in the age of cancer heterogeneity

  2025cites this paper
• Reprogramming of fatty acid metabolism: a hidden force regulating the occurrence and progression of cholangiocarcinoma

  2025cites this paper
• Anti‐Tumor Strategies Targeting Nutritional Deprivation: Challenges and Opportunities

  2025cites this paper
• Discovery of Fatty Acid Translocase CD36-Targeting Near-Infrared Fluorescent Probe Enables Visualization and Imaging-Guided Surgery for Glioma.

  2025cites this paper
• Metabolic Objectives and Trade-Offs: Inference and Applications

  2025cites this paper
• Oxidative Stress and Reprogramming of Lipid Metabolism in Cancers

  2025cites this paper
• An Insight into Prognostic Impact of TIPE2 & CD36 Immunohistochemical Expression in Urothelial Carcinoma

  2025cites this paper
• Proteomic meta-analysis unveils new frontiers for biomarkers research in pancreatic carcinoma

  2025cites this paper
• Fatty acid uptake activates an AXL–CAV1–β-catenin axis to drive melanoma progression

  2025cites this paper
• Lipid metabolic reprograming: the unsung hero in breast cancer progression and tumor microenvironment

  2025cites this paper
• Molecular Underpinnings of Brain Metastases

  2025cites this paper
• Modulating lipid metabolism by nanoparticles (NPs)-mediated ACSL3 silencing to inhibit hepatocellular carcinoma growth and metastasis

  2025cites this paper
• RORγ Bridges Cancer-Driven Lipid Dysmetabolism and Myeloid Immunosuppression

  2025cites this paper
• CAD manipulates tumor intrinsic DHO/UBE4B/NF-κB pathway and fuels macrophage cross-talk, promoting hepatocellular carcinoma metastasis.

  2025cites this paper
• Lactobacillus johnsonii-derived leucic acid promotes fatty acid absorption and deposition by targeting CD36

  2025cites this paper
• Effects of candidate genes on milk fat synthesis in ruminants: A meta-analysis.

  2025cites this paper
• FAO-fueled OXPHOS and NRF2-mediated stress resilience in MICs drive lymph node metastasis

  2025cites this paper
• CD36-mediated endocytosis of proteolysis-targeting chimeras.

  2025cites this paper
• Stromal lipid species dictate melanoma metastasis and tropism

  2025cites this paper
• Multi-omic features and clustering phenotypes of circulating tumor cells associated with metastasis and clinical outcomes.

  2025cites this paper
• Palmitic acid and palmitoylation in cancer: Understanding, insights, and challenges

  2025influential citation
• Rewiring lipid metabolism to enhance immunotherapy efficacy in melanoma: a frontier in cancer treatment

  2025cites this paper
• Circadian rhythm and aryl hydrocarbon receptor crosstalk in bone marrow adipose tissue and implications in leukemia

  2025cites this paper
• Molecular Targets of Oxidative Stress: Focus on Nuclear Factor Erythroid 2–Related Factor 2 Function in Leukemia and Other Cancers

  2025cites this paper
• The correlation between obesity and the occurrence and development of breast cancer

  2025cites this paper
• Unveiling fatty acid subtypes: immunometabolic interplay and therapeutic opportunities in gastric cancer

  2025cites this paper
• High CD36 expression in the tumor microenvironmental vasculature correlates with unfavorable overall survival in high grade serous ovarian cancer

  2025cites this paper
• RAN potentiates nuclear export of phosphorylated AMPK, reshaping lipid metabolism and impairing immune efficacy in lung adenocarcinoma

  2025cites this paper
• The role and mechanism of fatty acid oxidation in cancer drug resistance

  2025cites this paper
• CD36 enrichment in HER2-positive mesenchymal stem cells drives therapy refractoriness in breast cancer

  2025cites this paper