A Critical Function of Th17 Proinflammatory Cells in the Development of Atherosclerotic Plaque in Mice

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Journal of Immunology

• Publication date

  2010-11-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.1000116PMID 20952673PMCID PMC12230985
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Th17/Treg functional imbalance during atherogenesis in ApoE(-/-) mice.

  2010cited by this paper
• Interleukin-17 and Interferon-γ Are Produced Concomitantly by Human Coronary Artery–Infiltrating T Cells and Act Synergistically on Vascular Smooth Muscle Cells

  2009cited by this paper
• Inhibition of IL-17A Attenuates Atherosclerotic Lesion Development in ApoE-Deficient Mice1

  2009cited by this paper
• Loss of SOCS3 expression in T cells reveals a regulatory role for interleukin-17 in atherosclerosis

  2009cited by this paper
• The Th17/Treg imbalance in patients with acute coronary syndrome.

  2008cited by this paper
• The multifaceted contributions of leukocyte subsets to atherosclerosis: lessons from mouse models

  2008cited by this paper
• Innocuous IFNγ induced by adjuvant-free antigen restores normoglycemia in NOD mice through inhibition of IL-17 production

  2008cited by this paper
• Micro-ultrasound imaging assessment of carotid plaque characteristics in apolipoprotein-E knockout mice.

  2008cited by this paper
• Exacerbation of Antigen-Induced Arthritis in IFN-γ-Deficient Mice As a Result of Unrestricted IL-17 Response1

  2007cited by this paper
• IL‐23 and the Th17 pathway promote inflammation and impair antifungal immune resistance

  2007cited by this paper
• Transforming growth factor-beta induces development of the T(H)17 lineage.

  2006cited by this paper
• TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells.

  2006cited by this paper
• Cytokines in atherosclerosis: pathogenic and regulatory pathways.

  2006cited by this paper
• Adoptive Transfer of CD4+ T Cells Reactive to Modified Low-Density Lipoprotein Aggravates Atherosclerosis

  2006cited by this paper
• Regulatory T cells

  2006cited by this paper
• Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

  2006cited by this paper
• The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells.

  2006cited by this paper
• A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

  2005cited by this paper
• Induction of cartilage damage by overexpression of T cell interleukin-17A in experimental arthritis in mice deficient in interleukin-1.

  2005cited by this paper
• IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

  2005cited by this paper
• Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

  2005cited by this paper
• Interferon-gamma produced by bone marrow-derived cells attenuates atherosclerotic lesion formation in LDLR-deficient mice.

  2004cited by this paper
• Regulatory T cells: friend or foe in immunity to infection?

  2004cited by this paper
• IL-17, Produced by Lymphocytes and Neutrophils, Is Necessary for Lipopolysaccharide-Induced Airway Neutrophilia: IL-15 as a Possible Trigger

  2003cited by this paper
• Influence of Interferon-&ggr; on the Extent and Phenotype of Diet-Induced Atherosclerosis in the LDLR-Deficient Mouse

  2003cited by this paper
• The role of interleukin-4 and interleukin-12 in the progression of atherosclerosis in apolipoprotein E-deficient mice.

  2003cited by this paper
• Interleukin-4 Deficiency Decreases Atherosclerotic Lesion Formation in a Site-Specific Manner in Female LDL Receptor−/− Mice

  2002cited by this paper
• Effect of Immune Deficiency on Lipoproteins and Atherosclerosis in Male Apolipoprotein E-Deficient Mice

  2001cited by this paper
• Atherosclerosis The Road Ahead

  2001cited by this paper
• Induction of Rapid Atherogenesis by Perivascular Carotid Collar Placement in Apolipoprotein E–Deficient and Low-Density Lipoprotein Receptor–Deficient Mice

  2001influential reference
• T Helper—Cell Phenotype Regulates Atherosclerosis in Mice Under Conditions of Mild Hypercholesterolemia

  2001cited by this paper
• Regulatory T cells: key controllers of immunologic self-tolerance.

  2000cited by this paper
• Exogenous interferon-gamma enhances atherosclerosis in apolipoprotein E-/- mice.

  2000cited by this paper
• Transfer of CD4+ T Cells Aggravates Atherosclerosis in Immunodeficient Apolipoprotein E Knockout Mice

  2000cited by this paper
• Exogenous interferon-γ enhances atherosclerosis in apolipoprotein E-/- mice

  2000cited by this paper
• Atherosclerosis : Vascular biology

  2000cited by this paper
• The role of interleukin 12 in the development of atherosclerosis in ApoE-deficient mice.

  1999cited by this paper
• Homocysteine and atherosclerosis.

  1999cited by this paper
• IL-17 is produced by some proinflammatory Th1/Th0 cells but not by Th2 cells.

  1999cited by this paper
• Vascular endothelium, hemodynamic forces, and atherogenesis.

  1999cited by this paper
• IFN-gamma potentiates atherosclerosis in ApoE knock-out mice.

  1997cited by this paper
• Decreased atherosclerosis in mice deficient in both macrophage colony-stimulating factor (op) and apolipoprotein E.

  1995cited by this paper
• Homocysteine and Atherosclerosis

  1993cited by this paper
• Variation in susceptibility to atherosclerosis among inbred strains of mice.

  1985cited by this paper

• The Statin Floor Effect: a Mechanistic Framework for Residual Cardiovascular Risk.

  2026cites this paper
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  2025cites this paper
• IL-17 as a Therapeutic Target in Cardiovascular Diseases: Mechanistic Insights and Translational Opportunities.

  2025cites this paper
• How lactate and lactylation shape the immunity system in atherosclerosis (Review)

  2025cites this paper
• Adult thymectomy is associated with increased mortality risk from cancer but not cardiovascular disease

  2025cites this paper
• Imbalance of T cell subsets: a core event that mediates the progression of T2DM and its complications

  2025cites this paper
• Systemic Inflammation Mediates the Association Between Blood Trihalomethane Concentrations and Cardiovascular Disease in U.S. Individuals Over 45: Insights from NHANES 2005–2012

  2025cites this paper
• T cell cholesterol transport links intestinal immune responses to dietary lipid absorption.

  2025cites this paper
• Sparstolonin B and Curcumin alleviate atherogenesis by modulating T helper 17-stromal cell interactions associated with interleukin-17 receptor A (IL-17RA) - transforming growth factor-β-activated kinase 1 (TAK1) - nuclear factor-kappa B (NF-κB) signaling.

  2025cites this paper
• PCSK6 ablation in blood circulating cells increases atherosclerotic burden, but improves plaque stability by activating Th17-smooth muscle cell modulatory axis.

  2025cites this paper
• The role of immune cells in different stages of atherosclerosis

  2024cites this paper
• Oxidized low‐density lipoproteins impair the pro‐atherosclerotic effect of granulocyte‐macrophage‐colony‐stimulating factor‐producing T helper cells on macrophages

  2024cites this paper
• Inflammation and all-cause mortality in patients undergoing peritoneal dialysis

  2024cites this paper
• The Impact of Interleukin-17 Inhibitors on Major Adverse Cardiovascular Events in Psoriasis or Psoriatic Arthritis Patients Naive to Biologic Agents: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

  2024cites this paper
• The roles of lncRNAs in Th17-associated diseases, with special focus on JAK/STAT signaling pathway

  2023cites this paper
• Asthma and Carotid Artery Plaques.

  2023cites this paper
• Th17 Cells and IL-17A in Ischemic Stroke

  2023cites this paper
• IL-17A induces valvular endothelial inflammation and aggravates calcific aortic valve disease.

  2023cites this paper
• Molecular mechanisms and therapeutic perspectives of peroxisome proliferator‐activated receptor α agonists in cardiovascular health and disease

  2023cites this paper
• Small molecule inhibitors of RORγt for Th17 regulation in inflammatory and autoimmune diseases

  2023cites this paper
• Interleukin‐4 and Interleukin‐17 are associated with coronary artery disease

  2023cites this paper
• New Biomarkers (Endocan, Interleukin-17, and Thrombospondin-4) for the Diagnosis, Assessment of Severity, and Follow-Up of Peripheral Arterial Disease

  2023cites this paper
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  2023cites this paper
• Circulating Th17/Treg as a promising biomarker for patients with rheumatoid arthritis in indicating comorbidity with atherosclerotic cardiovascular disease

  2023cites this paper
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  2022cites this paper
• Interleukin-27 Ameliorates Atherosclerosis in ApoE−/− Mice through Regulatory T Cell Augmentation and Dendritic Cell Tolerance

  2022cites this paper
• To Explore the Key Active Compounds and Therapeutic Mechanism of Guizhi Gancao Decoction in Coronary Heart Disease by Network Pharmacology and Molecular Docking

  2022cites this paper
• Psoriasis and Cardiometabolic Diseases: Shared Genetic and Molecular Pathways

  2022cites this paper
• Research progress on Th17 and T regulatory cells and their cytokines in regulating atherosclerosis

  2022cites this paper
• Pseudolycorine chloride ameliorates Th17 cell-mediated central nervous system autoimmunity by restraining myeloid-derived suppressor cell expansion

  2022influential citation
• Inhibition of IL17A Using an Affibody Molecule Attenuates Inflammation in ApoE-Deficient Mice

  2022cites this paper
• Identification of heterogeneous subsets of aortic interleukin-17A-expressing CD4+ T cells in atherosclerotic mice

  2022cites this paper
• Interleukin-38 in atherosclerosis.

  2022cites this paper
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  2022cites this paper
• Therapeutic strategies targeting inflammation and immunity in atherosclerosis: how to proceed?

  2022cites this paper
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  2022cites this paper
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  2022cites this paper
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  2021cites this paper
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  2021cites this paper
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  2021cites this paper
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  2021cites this paper
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• The roles of immune cells in atherosclerotic calcification

  2021cites this paper
• How the immune system shapes atherosclerosis: roles of innate and adaptive immunity

  2021cites this paper
• Inflammatory basis of atherosclerosis: modulation by sex hormones.

  2021cites this paper
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  2020cites this paper
• Comparative immunohistochemical and morphometric research of interleukin-17 in various atherosclerotic lesions in human

  2020cites this paper
• Distinct inflammatory mediator patterns in young black and white adults: The African-predict study.

  2020cites this paper
• Heterogeneity of T Cells in Atherosclerosis Defined by Single-Cell RNA-Sequencing and Cytometry by Time of Flight

  2020cites this paper
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  2020cites this paper
• Friend or foe of innate lymphoid cells in inflammation‐associated cardiovascular disease

  2020cites this paper
• Immunological mechanisms underlying sterile inflammation in the pathogenesis of atherosclerosis: potential sites for intervention

  2020cites this paper
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  2019cites this paper
• Pathogenesis of Accelerated Atherosclerosis and Vascular Injury in Systemic Lupus Erythematosus

  2019cites this paper
• Immunometabolic and Cellular Traits in Cardiovascular Disease

  2019cites this paper
• Systemic effects of IL-17 in inflammatory arthritis

  2019cites this paper
• Effects of Interleukin 17A Inhibition on Myocardial Deformation and Vascular Function in Psoriasis.

  2019cites this paper
• Immunität und Entzündung bei Arteriosklerose

  2019cites this paper
• Immunobiology of Atherosclerosis: A Complex Net of Interactions

  2019cites this paper
• Analysis of interleukin-17 and interleukin-18 levels in animal models of atherosclerosis

  2019cites this paper
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  2019cites this paper
• Chapter 2 Cytokines and Immune Responses in Murine Atherosclerosis

  2019cites this paper
• Interleukin 17A exacerbates atherosclerosis by promoting fatty acid-binding protein 4-mediated ER stress in macrophages.

  2019cites this paper
• Role of interleukin‐17 in acute myocardial infarction

  2019cites this paper
• Macrophages and T cells in atherosclerosis: a translational perspective.

  2019cites this paper
• Immunity and Inflammation in Atherosclerosis

  2019cites this paper
• MicroRNA-381 reduces inflammation and infiltration of macrophages in polymyositis via downregulating HMGB1.

  2018cites this paper
• Systemic Inflammation and Cardiovascular Comorbidity in Psoriasis Patients: Causes and Consequences

  2018cites this paper
• The pleiotropic role of interleukin-17 in atherosclerosis.

  2018cites this paper
• Heat shock proteins and cardiovascular disease.

  2018cites this paper
• T‐Cell‐Intrinsic Receptor Interacting Protein 2 Regulates Pathogenic T Helper 17 Cell Differentiation

  2018cites this paper
• Atlas of the Immune Cell Repertoire in Mouse Atherosclerosis Defined by Single-Cell RNA-Sequencing and Mass Cytometry

  2018cites this paper
• Anti-Inflammatory Treatment

  2018cites this paper
• Interleukin 17, inflammation, and cardiovascular risk in patients with psoriasis

  2018cites this paper
• Unstable Angina is a syndrome correlated to Th17 inflammatory disorder

  2018cites this paper
• Vaccination to Prevent Cardiovascular Disease

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• Rebamipide ameliorates atherosclerosis by controlling lipid metabolism and inflammation

  2017cites this paper
• [Subpopulation Composition of CD4+ T-lymphocytes as Factor Contributing to the Progression of Atherosclerosis of Carotid Arteries].

  2017cites this paper
• Target Identification and Characterization in Transgenic Cardiovascular Disease Models of Atherosclerosis and Heart Failure

  2017cites this paper
• The ontogeny of inflammatory macrophages and monocyte-derived dendritic cells

  2017cites this paper
• Non-coding RNA regulation of T cell biology: Implications for age-associated cardiovascular diseases.

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• The immunology of atherosclerosis

  2017cites this paper
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  2017cites this paper
• Effects of Interleukin 17 on the cardiovascular system.

  2017cites this paper
• Impact of environmental factors on alloimmunity and transplant fate

  2017cites this paper
• IL-17-differentiated macrophages secrete pro-inflammatory cytokines in response to oxidized low-density lipoprotein

  2017cites this paper
• Regulatory T Cell Immunity in Atherosclerosis.

  2017cites this paper
• The regulation of immune cells by Lactobacilli: a potential therapeutic target for anti-atherosclerosis therapy

  2017cites this paper
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  2017cites this paper
• Inflammation The link between traditional risk factors and atherogenesis

  2017cites this paper
• Interleukin 17A in atherosclerosis - Regulation and pathophysiologic effector function.

  2017cites this paper
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  2017cites this paper
• The Impact of IL-17 in Atherosclerosis.

  2017cites this paper
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  2017cites this paper
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