Homocysteine, vitamin B-12, and folic acid and the risk of cognitive decline in old age: the Leiden 85-Plus study.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  American Journal of Clinical Nutrition

• Publication date

  2005-10-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1093/AJCN/82.4.866PMID 16210718
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Early Alzheimer's disease.

  2004cited by this paper
• Move over ANOVA: progress in analyzing repeated-measures data and its reflection in papers published in the Archives of General Psychiatry.

  2004cited by this paper
• Effect of vitamins and aspirin on markers of platelet activation oxidative stress and homocysteine in people at high risk of dementia

  2003cited by this paper
• Accuracy of the 15‐item geriatric depression scale (GDS‐15) in a community sample of the oldest old

  2003cited by this paper
• Folic acid with or without vitamin B12 for cognition and dementia.

  2003cited by this paper
• Homocysteine, white matter hyperintensities, and cognition in healthy elderly people

  2003influential reference
• Effect of vitamins and aspirin on markers of platelet activation, oxidative stress and homocysteine in people at high risk of dementia

  2003cited by this paper
• Folic Acid Supplementation in Dementia: A Preliminary Report

  2003cited by this paper
• Clinical practice. Early Alzheimer's disease.

  2003cited by this paper
• Testing cognitive function in elderly populations: the PROSPER study

  2002cited by this paper
• Short-term folate, vitamin B-12 or vitamin B-6 supplementation slightly affects memory performance but not mood in women of various ages.

  2002cited by this paper
• Plasma Homocysteine as a Risk Factor for Dementia and Alzheimer's Disease

  2002cited by this paper
• Homocysteine and cognitive function in the elderly

  2002cited by this paper
• Plasma homocysteine as a risk factor for dementia and Alzheimer's disease.

  2002cited by this paper
• A Randomized, Double‐Blind, Placebo‐Controlled Study of Oral Vitamin B12 Supplementation in Older Patients with Subnormal or Borderline Serum Vitamin B12 Concentrations

  2002cited by this paper
• A high response is not essential to prevent selection bias: results from the Leiden 85-plus study.

  2002cited by this paper
• [The PROSPER Study (PROspective study of pravastatin in the elderly at risk)].

  2002cited by this paper
• Homocysteine and cognitive function in the elderly: The Rotterdam Scan Study

  2002cited by this paper
• Homocysteine and Cognitive Decline in Healthy Elderly

  2001cited by this paper
• Vitamin B12 and folate in relation to the development of Alzheimer’s disease

  2001cited by this paper
• Cobalamin supplementation improves cognitive and cerebral function in older, cobalamin-deficient persons.

  2001cited by this paper
• Vitamin B12 deficiency in dementia and cognitive impairment: the effects of treatment on neuropsychological function

  2000cited by this paper
• The design of a prospective study of Pravastatin in the Elderly at Risk (PROSPER). PROSPER Study Group. PROspective Study of Pravastatin in the Elderly at Risk.

  1999cited by this paper
• Diabetes mellitus and the risk of dementia

  1999cited by this paper
• Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease.

  1998cited by this paper
• Long-term postoperative cognitive dysfunction in the elderly ISPOCD1 study. ISPOCD investigators. International Study of Post-Operative Cognitive Dysfunction.

  1998cited by this paper
• Déficience en vitamine B12 et état démentiel : étude épidémiologique multicentrique et thérapeutique. Essai préliminaire

  1997cited by this paper
• Folate and cobalamin in psychiatric illness.

  1997cited by this paper
• Low folate levels in the cognitive decline of elderly patients and the efficacy of folate as a treatment for improving memory deficits.

  1997cited by this paper
• Dementia and subnormal levels of vitamin B12: Effects of replacement therapy on dementia

  1996cited by this paper
• CAN GERIATRICIANS MAINTAIN SEPARATE CONSULTATIVE AND PRIMARY CARE ROLES?

  1995cited by this paper
• Cognitive recovery with vitamin B12 therapy

  1994cited by this paper
• Serum Vitamin B12 Levels and Incidence of Dementia in a Healthy Elderly Population: A Report from the Bronx Longitudinal Aging Study

  1994cited by this paper
• High Prevalence of Cobalamin Deficiency in Elderly Outpatients

  1992cited by this paper
• Time Dependency of Cognitive Recovery with Cobalamin Replacement: Report or a Pilot Study

  1992cited by this paper
• “Mini-mental state”: A practical method for grading the cognitive state of patients for the clinician

  1975cited by this paper

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  2025cites this paper
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  2024cites this paper
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  2023cites this paper
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  2023cites this paper
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  2022cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
• Neurocognitive Dysfunctions in Iron Deficiency Patients

  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2018cites this paper
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  2018cites this paper
• Identifying Dietary Patterns Associated with Mild Cognitive Impairment in Older Korean Adults Using Reduced Rank Regression

  2018cites this paper
• The effects and potential mechanisms of folic acid on cognitive function: a comprehensive review

  2018cites this paper
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  2018influential citation
• B-Vitamin Intake and Biomarker Status in Relation to Cognitive Decline in Healthy Older Adults in a 4-Year Follow-Up Study

  2017cites this paper
• Sustainable Nutrition in a Changing World

  2017cites this paper
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  2017cites this paper
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  2017cites this paper
• “ Homocysteine-Induced Neurotoxicity and Oxidative Stress in Neuropsychiatric Disorders . ”

  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2015cites this paper
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  2015cites this paper
• Hyperhomocysteinemia is associated with vitamin B-12 deficiency: A cross-sectional study in a rural, elderly population of Shanxi China

  2015cites this paper
• Study of Serum Folic Acid and Vitamin B12 levels in Patients of Vascular Dementia

  2015cites this paper
• Implications of the folic acid fortification mandate on infant and child health

  2014cites this paper
• Diffusion tensor tractography and neuropsychological assessment in patients with vitamin B12 deficiency

  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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