BACKGROUND Information on the molecular basis underlying organic anion and cation transport in renal tubules has expanded in recent years with the identification and characterization of numerous transporters. However, little is known about the regulation of this transport. METHODS Both English and Russian language studies dealing with the regulation of organic ion transport by the kidney have been reviewed. RESULTS This review summarizes the literature on the physiological and pharmacological aspects of the regulation of organic ion transport, linking this information where possible to underlying transport mechanisms. Current models of the tubular secretion of organic anions and cations are reviewed. Factors that inhibit or enhance tubular secretion of xenobiotics are described, and their influence on proximal tubule cell transport and function is discussed. Important roles for substrate stimulation, the adrenergic nervous system, numerous hormones, P-glycoprotein, and protein kinase C activity have been identified. CONCLUSIONS Despite considerable advances in the understanding of basic transport pathways and mechanisms involved in the tubular secretion of organic compounds, there is still relatively little information on the regulation of this transport. Studies combining the techniques of integrative and cell physiology and molecular biology will provide significant new insights into the pathways regulating the tubular transport of these compounds.
Regulation of renal tubular secretion of organic compounds.
Efim B. Berkhin,Michael H. Humphreys
Published 2001 in Kidney International
ABSTRACT
PUBLICATION RECORD
- Publication year
2001
- Venue
Kidney International
- Publication date
Unknown publication date
- Fields of study
Medicine, Chemistry
- Identifiers
- External record
- Source metadata
Semantic Scholar, PubMed
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CLAIMS
CONCEPTS
- adrenergic nervous system
The catecholamine-driven signaling system that acts through adrenergic receptors.
- hormones
Endocrine signaling molecules that circulate in the body and modulate target-cell function.
- organic anion transport
Transport of negatively charged organic solutes across renal tubular cell membranes.
- organic cation transport
Transport of positively charged organic solutes across renal tubular cell membranes.
- p-glycoprotein
A membrane transporter protein associated with efflux of diverse compounds from cells.
- protein kinase c activity
The signaling activity of protein kinase C enzymes that phosphorylate target proteins.
- renal tubular secretion of organic compounds
The kidney tubular process that moves organic molecules from the blood into the tubular lumen for excretion.
Aliases: tubular secretion of organic compounds
- substrate stimulation
A regulatory effect in which exposure to a transported substrate alters the activity of a transport system.
REFERENCES
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