A novel crosstalk between the tumor suppressors ING1 and ING2 regulates androgen receptor signaling

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Journal of molecular medicine

• Publication date

  2016-06-16

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1007/s00109-016-1440-1PMID 27305909
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The tumor suppressor ING1b is a novel corepressor for the androgen receptor and induces cellular senescence in prostate cancer cells.

  2016cited by this paper
• Cancer statistics, 2015

  2015cited by this paper
• Supraphysiological androgen levels induce cellular senescence in human prostate cancer cells through the Src-Akt pathway

  2014cited by this paper
• Nuclear ING2 expression is reduced in osteosarcoma.

  2014cited by this paper
• A natural androgen receptor antagonist induces cellular senescence in prostate cancer cells.

  2014cited by this paper
• ING1 and ING2: multifaceted tumor suppressor genes

  2013influential reference
• ING1 induces apoptosis through direct effects at the mitochondria

  2013cited by this paper
• Ing1 functions in DNA demethylation by directing Gadd45a to H3K4me3.

  2013cited by this paper
• Overexpression of the VSSC‐associated CAM, beta‐2, enhances LNCaP cell metastasis associated behavior

  2012cited by this paper
• Sodium butyrate induces cellular senescence in neuroblastoma and prostate cancer cells

  2011cited by this paper
• Pro-senescence therapy for cancer treatment

  2011cited by this paper
• Erratum: Gene expression alterations by conditional knockout of androgen receptor in adult sertoli cells of Utp14bjsd/jsd (jsd) mice (Biology of Reproduction (2010) 83, (759-766) DOI: 10.1095/biolreprod.110.085472)

  2011cited by this paper
• Gene expression alterations by conditional knockout of androgen receptor in adult Sertoli cells of Utp14b jsd/jsd (jsd) mice.

  2011cited by this paper
• Targeted Disruption of Ing2 Results in Defective Spermatogenesis and Development of Soft-Tissue Sarcomas

  2010cited by this paper
• Senescence in tumours: evidence from mice and humans

  2010cited by this paper
• Gene Expression Alterations by Conditional Knockout of Androgen Receptor in Adult Sertoli Cells of Utp14bjsd/jsd (jsd) Mice1

  2010cited by this paper
• ING2 controls the G1 to S-phase transition by regulating p21 expression

  2010cited by this paper
• Sumoylation of ING2 regulates the transcription mediated by Sin3A

  2010cited by this paper
• The ING gene family in the regulation of cell growth and tumorigenesis

  2009cited by this paper
• TScratch: a novel and simple software tool for automated analysis of monolayer wound healing assays.

  2009cited by this paper
• Cellular senescence in vivo: a barrier to tumorigenesis.

  2008cited by this paper
• ING1a expression increases during replicative senescence and induces a senescent phenotype

  2008cited by this paper
• A novel ING2 isoform, ING2b, synergizes with ING2a to prevent cell cycle arrest and apoptosis

  2008cited by this paper
• Expression profiles of mRNA transcript variants encoding the human inhibitor of growth tumor suppressor gene family in normal and neoplastic tissues.

  2008cited by this paper
• The tumor suppressors p33ING1 and p33ING2 interact with alien in vivo and enhance alien-mediated gene silencing.

  2007cited by this paper
• Integrative molecular concept modeling of prostate cancer progression

  2007cited by this paper
• Deletion of p37Ing1 in mice reveals a p53-independent role for Ing1 in the suppression of cell proliferation, apoptosis, and tumorigenesis.

  2007influential reference
• Integrative molecular concept modeling of prostate cancer progression

  2007cited by this paper
• Androgen receptor structural and functional elements: role and regulation in prostate cancer.

  2007cited by this paper
• Infertility with defective spermatogenesis and steroidogenesis in male mice lacking androgen receptor in Leydig cells

  2007cited by this paper
• Leucine zipper‐like domain is required for tumor suppressor ING2‐mediated nucleotide excision repair and apoptosis

  2006cited by this paper
• Bioenergetics and the formation of mitochondrial reactive oxygen species.

  2006cited by this paper
• Androgens induce prostate cancer cell proliferation through mammalian target of rapamycin activation and post-transcriptional increases in cyclin D proteins.

  2006cited by this paper
• Targeted disruption of the mouse ing1 locus results in reduced body size, hypersensitivity to radiation and elevated incidence of lymphomas

  2006influential reference
• Direct, androgen receptor-mediated regulation of the FKBP5 gene via a distal enhancer element.

  2006cited by this paper
• ING2 Regulates the Onset of Replicative Senescence by Induction of p300-Dependent p53 Acetylation

  2005cited by this paper
• Nuclear hormone receptor co-repressors.

  2005cited by this paper
• Phylogenetic analysis of the ING family of PHD finger proteins.

  2005cited by this paper
• Integrative genomic and proteomic analysis of prostate cancer reveals signatures of metastatic progression.

  2005cited by this paper
• Gene expression profiling identifies clinically relevant subtypes of prostate cancer.

  2004cited by this paper
• ONCOMINE: a cancer microarray database and integrated data-mining platform.

  2004cited by this paper
• Antiandrogen-induced cell death in LNCaP human prostate cancer cells

  2003cited by this paper
• Transcriptional silencing of zinc finger protein 185 identified by expression profiling is associated with prostate cancer progression.

  2003cited by this paper
• Gene expression correlates of clinical prostate cancer behavior.

  2002cited by this paper
• Human cell lines engineered for tetracycline‐regulated expression of tumor suppressor candidate genes from a frequently affected chromosomal region, 3p21

  2002cited by this paper
• Activation of mouse Pi-class glutathione S-transferase gene by Nrf2(NF-E2-related factor 2) and androgen.

  2002cited by this paper
• Role of chaperones in nuclear translocation and transactivation of steroid receptors

  2001cited by this paper
• Selective DNA binding by the androgen receptor as a mechanism for hormone-specific gene regulation.

  2001cited by this paper
• A new mathematical model for relative quantification in real-time RT-PCR.

  2001cited by this paper
• The role of the androgen receptor in the development and progression of prostate cancer.

  1999cited by this paper
• Suppression of the novel growth inhibitor p33ING1 promotes neoplastic transformation

  1996cited by this paper
• A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

  1995cited by this paper
• Characterization of two cis-acting DNA elements involved in the androgen regulation of the probasin gene.

  1993cited by this paper
• Cancer statistics

  1989cited by this paper
• Mechanism of induction of mouse kidney alcohol dehydrogenase by androgen. Androgen-induced stimulation of transcription of the Adh-1 gene.

  1988cited by this paper
• Androgen regulation of murine beta-glucuronidase expression: identification and characterization of a nonresponse variant.

  1988cited by this paper
• Printed in U.S.A. Copyright © 1998 by The Endocrine Society Identification of Androgen-Regulated Genes in Mouse Kidney by Representational Difference Analysis and Random Arbitrarily Primed Polymerase Chain Reaction*

  year unknowncited by this paper

• The intricate interplay between circadian rhythm, androgen signaling, hormone therapy, and cellular senescence in prostate cancer

  2025cites this paper
• Functional circuits of LYL1 controlled by supraphysiological androgen in prostate cancer cells to regulate cell senescence

  2024cites this paper
• Prognostic significance of ING3 expression in patients with cancer: A systematic review and meta-analysis

  2023cites this paper
• Inhibitor of Growth Factors Regulate Cellular Senescence

  2022cites this paper
• The natural compound atraric acid suppresses androgen-regulated neo-angiogenesis of castration-resistant prostate cancer through angiopoietin 2

  2022cites this paper
• Epigenetic Coregulation of Androgen Receptor Signaling.

  2022cites this paper
• Molecular mechanisms of inhibitor of growth (ING) family members in health and malignancy

  2022cites this paper
• Androgen-Induced MIG6 Regulates Phosphorylation of Retinoblastoma Protein and AKT to Counteract Non-Genomic AR Signaling in Prostate Cancer Cells

  2022cites this paper
• ING Tumour Suppressors and ING Splice Variants as Coregulators of the Androgen Receptor Signalling in Prostate Cancer

  2021influential citation
• Antithetic hTERT Regulation by Androgens in Prostate Cancer Cells: hTERT Inhibition Is Mediated by the ING1 and ING2 Tumor Suppressors

  2021cites this paper
• A Novel Splice Variant of the Inhibitor of Growth 3 Lacks the Plant Homeodomain and Regulates Epithelial–Mesenchymal Transition in Prostate Cancer Cells

  2021cites this paper
• The androgen receptor—lncRNASAT1-AKT-p15 axis mediates androgen-induced cellular senescence in prostate cancer cells

  2021cites this paper
• Tumour Suppressors and ING Splice Variants as Coregulators of the Androgen Receptor Signalling in Prostate

  2021influential citation
• Mechanisms of Androgen Receptor Agonist- and Antagonist-Mediated Cellular Senescence in Prostate Cancer

  2020cites this paper
• Interleukin-23 Represses the Level of Cell Senescence Induced by the Androgen Receptor Antagonists Enzalutamide and Darolutamide in Castration-Resistant Prostate Cancer Cells

  2020cites this paper
• Senolytic compounds control a distinct fate of androgen receptor agonist- and antagonist-induced cellular senescent LNCaP prostate cancer cells

  2020cites this paper
• Analyse protéomique des réseaux de signalisation du récepteur aux androgènes modulés par l'Enzalutamide dans le cancer de la prostate résistant à la castration

  2019cites this paper
• Hsp70 and gama-Semino protein as possible prognostic marker of prostate cancer.

  2018cites this paper
• Down-regulation of miR-500 and miR-628 suppress non-small cell lung cancer proliferation, migration and invasion by targeting ING1.

  2018cites this paper
• Up-regulated MiR-27-3p promotes the G1-S phase transition by targeting inhibitor of growth family member 5 in osteosarcoma.

  2018cites this paper
• 1987 Hsp70 and gama-Semino protein as possible prognostic marker of prostate cancer

  year unknowncites this paper