Androgen receptor structural and functional elements: role and regulation in prostate cancer.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Molecular Endocrinology

• Publication date

  2007-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1210/ME.2007-0223PMID 17636035
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Compartmentalization of androgen receptor protein–protein interactions in living cells

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• Nuclear receptor structure: implications for function.

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• A role of the amino-terminal (N) and carboxyl-terminal (C) interaction in binding of androgen receptor to chromatin.

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• Short hairpin RNA knockdown of the androgen receptor attenuates ligand-independent activation and delays tumor progression.

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• Interplay between two hormone-independent activation domains in the androgen receptor.

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• Ligand-specific allosteric regulation of coactivator functions of androgen receptor in prostate cancer cells.

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• Androgen axis in prostate cancer

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• Cancer Statistics, 2006

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• Ligand-independent Androgen Receptor Activity Is Activation Function-2-independent and Resistant to Antiandrogens in Androgen Refractory Prostate Cancer Cells*

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• The human androgen receptor AF1 transactivation domain: interactions with transcription factor IIF and molten-globule-like structural characteristics.

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• Biology of progressive, castration-resistant prostate cancer: directed therapies targeting the androgen-receptor signaling axis.

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• Structure and function of steroid receptor AF1 transactivation domains: induction of active conformations.

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• Recurrent Fusion of TMPRSS2 and ETS Transcription Factor Genes in Prostate Cancer

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• The Molecular Mechanisms of Coactivator Utilization in Ligand-dependent Transactivation by the Androgen Receptor*

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• Melanoma Antigen Gene Protein MAGE-11 Regulates Androgen Receptor Function by Modulating the Interdomain Interaction

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• Androgen receptor down regulation by small interference RNA induces cell growth inhibition in androgen sensitive as well as in androgen independent prostate cancer cells.

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• Structural Basis for Accommodation of Nonsteroidal Ligands in the Androgen Receptor*

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• Small-interfering RNA–induced androgen receptor silencing leads to apoptotic cell death in prostate cancer

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• Spatial and temporal recruitment of androgen receptor and its coactivators involves chromosomal looping and polymerase tracking.

  2005cited by this paper
• Membrane rafts as potential sites of nongenomic hormonal signaling in prostate cancer.

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• Structural basis for antagonism and resistance of bicalutamide in prostate cancer

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• Testosterone and Dihydrotestosterone Tissue Levels in Recurrent Prostate Cancer

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• Androgen receptor in prostate cancer.

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• Mechanisms of androgen-refractory prostate cancer.

  2004cited by this paper
• A novel inducible transactivation domain in the androgen receptor: implications for PRK in prostate cancer

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• Interrogating androgen receptor function in recurrent prostate cancer.

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• Activation of nuclear receptors: a perspective from structural genomics.

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• Is the Achilles' heel for prostate cancer therapy a gain of function in androgen receptor signaling?

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• BIOLOGY OF PROSTATESPECIFIC ANTIGEN

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• Androgen receptor mutations in androgen-independent prostate cancer: Cancer and Leukemia Group B Study 9663.

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• Structural basis for the glucocorticoid response in a mutant human androgen receptor (AR(ccr)) derived from an androgen-independent prostate cancer.

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• Disruption of androgen receptor function inhibits proliferation of androgen-refractory prostate cancer cells.

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• p300 and p300/cAMP-response Element-binding Protein-associated Factor Acetylate the Androgen Receptor at Sites Governing Hormone-dependent Transactivation*

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