Structural basis for induced fit mechanisms in DNA recognition by the Pdx1 homeodomain.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Biochemistry

• Publication date

  2007-02-23

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1021/BI060969LPMID 17315980
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Molecular flexibility in protein-DNA interactions.

  2006cited by this paper
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  2006cited by this paper
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  2005cited by this paper
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  2005cited by this paper
• The chordate ParaHox cluster.

  2005cited by this paper
• Modulating Hox gene functions during animal body patterning

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• Role of intrinsic DNA binding specificity in defining target genes of the mammalian transcription factor PDX1.

  2004cited by this paper
• Structure of HoxA9 and Pbx1 bound to DNA: Hox hexapeptide and DNA recognition anterior to posterior.

  2003cited by this paper
• Insights into nonspecific binding of homeodomains from a structure of MATα2 bound to DNA

  2003cited by this paper
• Pancreas duodenum homeobox-1 regulates pancreas development during embryogenesis and islet cell function in adulthood.

  2002cited by this paper
• Interchange of DNA-binding modes in the deformed and ultrabithorax homeodomains: a structural role for the N-terminal arm.

  2002cited by this paper
• Changing homeodomain residues 2 and 3 of Hoxa1 alters its activity in a cell-type and enhancer dependent manner.

  2002cited by this paper
• The role of transcription factors in maturity-onset diabetes of the young.

  2002cited by this paper
• Crystal structure of the Msx-1 homeodomain/DNA complex.

  2001cited by this paper
• Functional consequences of mutations in the MODY4 gene (IPF1) and coexistence with MODY3 mutations

  2001cited by this paper
• PDX:PBX complexes are required for normal proliferation of pancreatic cells during development.

  2001cited by this paper
• Molecular evolution of the homeodomain family of transcription factors.

  2001cited by this paper
• Pancreatic duodenal homeobox–1, PDX-1, a major regulator of beta cell identity and function

  2001cited by this paper
• The Homeodomain of PDX-1 Mediates Multiple Protein-Protein Interactions in the Formation of a Transcriptional Activation Complex on the Insulin Promoter

  2000cited by this paper
• Pancreatic Homeodomain Transcription Factor IDX1/IPF1 Expressed in Developing Brain Regulates Somatostatin Gene Transcription in Embryonic Neural Cells*

  2000cited by this paper
• Transcription Factor BETA2 Acts Cooperatively with E2A and PDX1 to Activate the Insulin Gene Promoter*

  2000cited by this paper
• Missense mutations in the insulin promoter factor-1 gene predispose to type 2 diabetes.

  1999cited by this paper
• Functional and Cooperative Interactions between the Homeodomain PDX1, Pbx, and Prep1 Factors on the Somatostatin Promoter*

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  1999cited by this paper
• Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation.

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  1998cited by this paper
• The Abd-B-like Hox Homeodomain Proteins Can Be Subdivided by the Ability to Form Complexes with Pbx1a on a Novel DNA Target*

  1997cited by this paper
• Early-onset type-ll diabetes mellitus (MODY4) linked to IPF1

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• Distinct HOX N-terminal Arm Residues Are Responsible for Specificity of DNA Recognition by HOX Monomers and HOX·PBX Heterodimers*

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• Hepatocyte nuclear factor 3beta is involved in pancreatic beta-cell-specific transcription of the pdx-1 gene

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  1996cited by this paper
• Pbx modulation of Hox homeodomain amino-terminal arms establishes different DNA-binding specificities across the Hox locus

  1996cited by this paper
• Conservation and diversification in homeodomain-DNA interactions: a comparative genetic analysis.

  1996cited by this paper
• Cooperative interactions between HOX and PBX proteins mediated by a conserved peptide motif

  1995cited by this paper
• DNA bending by the a1 and alpha 2 homeodomain proteins from yeast.

  1995cited by this paper
• High resolution crystal structure of a paired (Pax) class cooperative homeodomain dimer on DNA.

  1995cited by this paper
• The hexapeptide LFPWMR in Hoxb-8 is required for cooperative DNA binding with Pbx1 and Pbx2 proteins.

  1995cited by this paper
• The pancreatic islet factor STF-1 binds cooperatively with Pbx to a regulatory element in the somatostatin promoter: importance of the FPWMK motif and of the homeodomain

  1995cited by this paper
• Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins.

  1995cited by this paper
• The specificity of homeotic gene function

  1995cited by this paper
• Hox proteins have different affinities for a consensus DNA site that correlate with the positions of their genes on the hox cluster

  1994cited by this paper
• Differential DNA-binding specificity of the engrailed homeodomain: the role of residue 50.

  1994cited by this paper
• IDX‐1: a new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene.

  1994cited by this paper
• Functional differences between HOX proteins conferred by two residues in the homeodomain N-terminal arm

  1994cited by this paper
• The degree of variation in DNA sequence recognition among four Drosophila homeotic proteins.

  1994cited by this paper
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  1994cited by this paper
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  1994cited by this paper
• CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice.

  1994cited by this paper
• Insulin expression in pancreatic islet cells relies on cooperative interactions between the helix loop helix factor E47 and the homeobox factor STF-1.

  1994cited by this paper
• Nuclear magnetic resonance spectroscopy of a DNA complex with the uniformly 13C-labeled Antennapedia homeodomain and structure determination of the DNA-bound homeodomain.

  1993cited by this paper
• Functional specificity of the Antennapedia homeodomain.

  1993cited by this paper
• Ectopic expression and function of the Antp and Scr homeotic genes: the N terminus of the homeodomain is critical to functional specificity.

  1993cited by this paper
• Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells.

  1993cited by this paper
• Mapping functional specificity in the Dfd and Ubx homeo domains.

  1992cited by this paper
• NMR structure determination reveals that the homeodomain is connected through a flexible linker to the main body in the Drosophila Antennapedia protein.

  1992cited by this paper
• DNA binding specificity of homeodomains.

  1991cited by this paper
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  1991cited by this paper
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  1991cited by this paper
• Functional dissection of Ultrabithorax proteins in D. melanogaster.

  1990cited by this paper
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  1989cited by this paper
• The definition of generalized helicoidal parameters and of axis curvature for irregular nucleic acids.

  1988cited by this paper

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