Dual roles of yes-associated protein (YAP) in colorectal cancer

Yes-associated protein (YAP) is a downstream effector molecule of a newly emerging tumour suppressor pathway called the Hippo pathway. YAP is a transcriptional co-activator and mis-expressed in various cancers, including colorectal cancer (CRC). Accumulating studies show that the high expression of nuclear YAP is linked with tumour progression and decreased survival. Nuclear YAP can interact with other transcription factors to promote cancer cell proliferation, apoptosis, metastasis and maintenance of stemness. Therefore, YAP has the potential to be a tumour biomarker or therapeutic target for CRC. However, recently, a number of studies have supported a contradictory role for YAP as a tumour suppressor, demonstrating inhibition of the tumorigenesis of CRC, involvement in promoting cell apoptosis, and inhibiting the maintenance of intestinal stem cells and inflammatory activity. In these studies, high expression of YAP was highly correlated with worse survival in CRC. In this review, we will comprehensively summarize and analyse these paradoxical reports, and discuss both the oncogenic and tumour suppressor functions of YAP in the differential status of CRC progression. Further investigation into the mechanisms responsible for the dual function of YAP will be of great value in the prevention, early diagnosis, and therapy of CRC.

• Publication year

  2017

• Venue

  OncoTarget

• Publication date

  2017-08-11

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.18632/oncotarget.20155PMID 29088905PMCID 5650460
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cancer screening in the United States, 2018: A review of current American Cancer Society guidelines and current issues in cancer screening

  2018cited by this paper
• Colorectal Carcinoma: A General Overview and Future Perspectives in Colorectal Cancer

  2017cited by this paper
• Colorectal cancer statistics, 2017

  2017cited by this paper
• YAP–IL-6ST autoregulatory loop activated on APC loss controls colonic tumorigenesis

  2017cited by this paper
• Furin promotes epithelial-mesenchymal transition in pancreatic cancer cells via Hippo-YAP pathway.

  2017cited by this paper
• YAP/TAZ-Mediated Upregulation of GAB2 Leads to Increased Sensitivity to Growth Factor-Induced Activation of the PI3K Pathway.

  2017cited by this paper
• A TIAM Double Hit to Oppose YAP/TAZ.

  2017cited by this paper
• Co-activation of STAT3 and YES-Associated Protein 1 (YAP1) Pathway in EGFR-Mutant NSCLC

  2017influential reference
• MiR-590-5p, a density-sensitive microRNA, inhibits tumorigenesis by targeting YAP1 in colorectal cancer.

  2017cited by this paper
• Clinical and biological significance of circulating tumor cells, circulating tumor DNA, and exosomes as biomarkers in colorectal cancer

  2017cited by this paper
• Cancer statistics, 2017

  2017cited by this paper
• Morin impedes Yap nuclear translocation and fosters apoptosis through suppression of Wnt/&bgr;‐catenin and NF‐&kgr;B signaling in Mst1 overexpressed HepG2 cells

  2017cited by this paper
• YAP/TAZ link cell mechanics to Notch signalling to control epidermal stem cell fate

  2017influential reference
• Endothelin Promotes Colorectal Tumorigenesis by Activating YAP/TAZ.

  2017cited by this paper
• MARK4 inhibits Hippo signaling to promote proliferation and migration of breast cancer cells

  2017cited by this paper
• Expression of Yes-associated protein 1 and its clinical significance in ovarian serous cystadenocarcinoma

  2017cited by this paper
• Expenditure and financial burden for the diagnosis and treatment of colorectal cancer in China: a hospital-based, multicenter, cross-sectional survey

  2017cited by this paper
• Wnt signaling promotes androgen-independent prostate cancer cell proliferation through up-regulation of the hippo pathway effector YAP.

  2017cited by this paper
• SAV1 represses the development of human colorectal cancer by regulating the Akt‐mTOR pathway in a YAP‐dependent manner

  2017cited by this paper
• TIAM1 Antagonizes TAZ/YAP Both in the Destruction Complex in the Cytoplasm and in the Nucleus to Inhibit Invasion of Intestinal Epithelial Cells

  2017influential reference
• Identification of a novel YAP–14-3-3ζ negative feedback loop in gastric cancer

  2017cited by this paper
• Ovatodiolide suppresses colon tumorigenesis and prevents polarization of M2 tumor-associated macrophages through YAP oncogenic pathways

  2017cited by this paper
• Elevation of YAP promotes the epithelial‐mesenchymal transition and tumor aggressiveness in colorectal cancer

  2017cited by this paper
• The Hippo pathway in tissue homeostasis and regeneration

  2017cited by this paper
• Repression of YAP by NCTD disrupts NSCLC progression

  2016cited by this paper
• G-protein-coupled receptors mediate ω-3 PUFAs-inhibited colorectal cancer by activating the Hippo pathway

  2016cited by this paper
• Mechanisms of Hippo pathway regulation

  2016cited by this paper
• Hippo/YAP signaling pathway is involved in osteosarcoma chemoresistance

  2016cited by this paper
• Mitochondrial DNA depletion causes decreased ROS production and resistance to apoptosis

  2016cited by this paper
• Muscle contraction is required to maintain the pool of muscle progenitors via YAP and NOTCH during fetal myogenesis

  2016cited by this paper
• IQGAP1 Binds to Yes-associated Protein (YAP) and Modulates Its Transcriptional Activity *

  2016influential reference
• Clinicopathological and prognostic significance of Yes-associated protein expression in hepatocellular carcinoma and hepatic cholangiocarcinoma

  2016cited by this paper
• YAP induces cisplatin resistance through activation of autophagy in human ovarian carcinoma cells

  2016cited by this paper
• ZO-2 silencing induces renal hypertrophy through a cell cycle mechanism and the activation of YAP and the mTOR pathway

  2016cited by this paper
• Effectiveness of screening colonoscopy in reducing the risk of death from right and left colon cancer: a large community-based study

  2016cited by this paper
• YAP/TAZ at the Roots of Cancer.

  2016cited by this paper
• LKB1 inhibits the proliferation of gastric cancer cells by suppressing the nuclear translocation of Yap and β-catenin.

  2016cited by this paper
• Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration

  2016cited by this paper
• YB-1 is elevated in medulloblastoma and drives proliferation in Sonic hedgehog - dependent cerebellar granule neuron progenitor cells and medulloblastoma cells

  2016cited by this paper
• Angiomotin promotes the malignant potential of colon cancer cells by activating the YAP-ERK/PI3K-AKT signaling pathway.

  2016cited by this paper
• An evolutionarily conserved negative feedback mechanism in the Hippo pathway reflects functional difference between LATS1 and LATS2

  2016cited by this paper
• Overuse of colorectal cancer screening services in the United States and its implications

  2016cited by this paper
• Yap1 plays a protective role in suppressing free fatty acid-induced apoptosis and promoting beta-cell survival

  2016cited by this paper
• TGF-β Targets the Hippo Pathway Scaffold RASSF1A to Facilitate YAP/SMAD2 Nuclear Translocation.

  2016cited by this paper
• Interaction of the EGF Receptor and the Hippo Pathway in the Diabetic Kidney.

  2016cited by this paper
• G-protein-coupled receptors mediate ω-3 PUFAs-inhibited colorectal cancer by activating the Hippo pathway

  2016cited by this paper
• HIPPO-Integrin-linked Kinase Cross-Talk Controls Self-Sustaining Proliferation and Survival in Pulmonary Hypertension.

  2016cited by this paper
• siRNA targeting YAP gene inhibits gastric carcinoma growth and tumor metastasis in SCID mice

  2016cited by this paper
• Niche Appropriation by Drosophila Intestinal Stem Cell Tumors

  2015cited by this paper
• miR675 upregulates long noncoding RNA H19 through activating EGR1 in human liver cancer

  2015cited by this paper
• Circulating tumor DNA to monitor treatment response and detect acquired resistance in patients with metastatic melanoma

  2015cited by this paper
• The Hippo Coactivator YAP1 Mediates EGFR Overexpression and Confers Chemoresistance in Esophageal Cancer

  2015cited by this paper
• The Hippo/YAP pathway interacts with EGFR signaling and HPV oncoproteins to regulate cervical cancer progression

  2015cited by this paper
• Alterations in the NF2/LATS1/LATS2/YAP Pathway in Schwannomas

  2015cited by this paper
• IL‐33 facilitates oncogene‐induced cholangiocarcinoma in mice by an interleukin‐6‐sensitive mechanism

  2015cited by this paper
• Proton-sensing GPCR-YAP Signalling Promotes Cell Proliferation and Survival

  2015influential reference
• A gp130–Src–YAP module links inflammation to epithelial regeneration

  2015cited by this paper
• Activation of Yes-Associated Protein in Low-Grade Meningiomas Is Regulated by Merlin, Cell Density, and Extracellular Matrix Stiffness

  2015cited by this paper
• Role of physical activity and diet after colorectal cancer diagnosis.

  2015cited by this paper
• Rectal and colon cancer: Not just a different anatomic site.

  2015cited by this paper
• Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer.

  2015cited by this paper
• Microenvironment rigidity modulates responses to the HER2 receptor tyrosine kinase inhibitor lapatinib via YAP and TAZ transcription factors

  2015cited by this paper
• VGLL4 inhibits EMT in part through suppressing Wnt/β-catenin signaling pathway in gastric cancer

  2015cited by this paper
• The emerging roles of YAP and TAZ in cancer

  2015cited by this paper
• Prognostic Value of Yes-Associated Protein 1 (YAP1) in Various Cancers: A Meta-Analysis

  2015cited by this paper
• YAP Is a Critical Inducer of SOCS3, Preventing Reactive Astrogliosis

  2015cited by this paper
• Genetic architecture of colorectal cancer

  2015cited by this paper
• Global cancer statistics, 2012

  2015cited by this paper
• Yap1 promotes the survival and self-renewal of breast tumor initiating cells via inhibiting Smad3 signaling

  2015cited by this paper
• Deregulation of the Hippo pathway in soft-tissue sarcoma promotes FOXM1 expression and tumorigenesis

  2015cited by this paper
• A role for the transducer of the Hippo pathway, TAZ, in the development of aggressive types of endometrial cancer

  2015cited by this paper
• Up-regulation of matrix metalloproteinases in a mouse model of chemically induced colitis-associated cancer: the role of microRNAs

  2015cited by this paper
• Clinical Implication of Colorectal Cancer Stem Cells: Still Has a Long Way to Go

  2015cited by this paper
• YAP activation protects urothelial cell carcinoma from treatment-induced DNA damage

  2015cited by this paper
• A hairpin within YAP mRNA 3'UTR functions in regulation at post-transcription level.

  2015cited by this paper
• Inflammation‐induced S100A8 activates Id3 and promotes colorectal tumorigenesis

  2015cited by this paper
• A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis

  2015cited by this paper
• The Hippo pathway in colorectal cancer.

  2015cited by this paper
• Biliary repair and carcinogenesis are mediated by IL-33-dependent cholangiocyte proliferation.

  2014cited by this paper
• Tead2 expression levels control the subcellular distribution of Yap and Taz, zyxin expression and epithelial–mesenchymal transition

  2014cited by this paper
• A peptide mimicking VGLL4 function acts as a YAP antagonist therapy against gastric cancer.

  2014cited by this paper
• Hippo signalling directs intestinal fate

  2014cited by this paper
• Yap1 Is Required for Endothelial to Mesenchymal Transition of the Atrioventricular Cushion*

  2014cited by this paper
• The cellular story of dishevelleds

  2014cited by this paper
• The Hippo transducer YAP1 transforms activated satellite cells and is a potent effector of embryonal rhabdomyosarcoma formation.

  2014cited by this paper
• Identification, Mechanism of Action, and Antitumor Activity of a Small Molecule Inhibitor of Hippo, TGF-β, and Wnt Signaling Pathways

  2014cited by this paper
• Induction of Cancer Stem Cell Properties in Colon Cancer Cells by Defined Factors

  2014cited by this paper
• Polyomavirus Small t Antigen Interacts with Yes-Associated Protein To Regulate Cell Survival and Differentiation

  2014cited by this paper
• Expression of Hippo Pathway in Colorectal Cancer

  2014cited by this paper
• LPS Induced miR-181a Promotes Pancreatic Cancer Cell Migration via Targeting PTEN and MAP2K4

  2014cited by this paper
• Hippo/YAP pathway for targeted therapy.

  2014cited by this paper
• Dual role of YAP and TAZ in renewal of the intestinal epithelium

  2014cited by this paper
• Expression of Yes-associated protein (YAP) in breast phyllodes tumor.

  2014cited by this paper
• YAP forms autocrine loops with the ERBB pathway to regulate ovarian cancer initiation and progression

  2014cited by this paper
• YAP1 acts as oncogenic target of 11q22 amplification in multiple cancer subtypes

  2014cited by this paper
• The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease

  2014cited by this paper
• Significant Association of Oncogene YAP1 with Poor Prognosis and Cetuximab Resistance in Colorectal Cancer Patients

  2014cited by this paper
• The clinically used photosensitizer Verteporfin (VP) inhibits YAP-TEAD and human retinoblastoma cell growth in vitro without light activation.

  2014influential reference
• KRAS and YAP1 converge to regulate EMT and tumor survival.

  2014cited by this paper
• Stretch-activated ion channel Piezo1 directs lineage choice in human neural stem cells

  2014cited by this paper

• Homer condensates orchestrate YAP-Wnt signaling crosstalk downstream of the Crumbs polarity complex

  2026cites this paper
• Oncofetal Reprogramming: A New Frontier in Cancer Therapy Resistance

  2026cites this paper
• Yes-associated protein plays oncogenic roles in human sporadic colorectal adenomas

  2025cites this paper
• Co-exposure to low levels of DEHP, procymidone, Cd2+, Pb2+, and 1-nitropyrene may damage mouse ovary and uterus via Hippo pathway and circPVT1.

  2025cites this paper
• Comparing the malignant properties of parental and a knock-in version of HCT116 cell line expressing the CDK2-mutant of eukaryotic elongation factor 2 (eEF2)

  2025cites this paper
• Evaluation of Potential Candidate Genes in the Differentiation of Neoplastic and Non-neoplastic Conditions of Endometrium

  2025cites this paper
• The possible correlation between miR-762, Hippo signaling pathway, TWIST1, and SMAD3 in lung cancer and chronic inflammatory diseases

  2024cites this paper
• Targeting Androgen, Thyroid Hormone, and Vitamin A and D Receptors to Treat Prostate Cancer

  2024cites this paper
• Regulation of Tumor Microenvironment through YAP/TAZ under Tumor Hypoxia

  2024cites this paper
• Molecular Interactions of Selective Agonists and Antagonists with the Retinoic Acid Receptor γ

  2024cites this paper
• Integrating cutting-edge technologies: AI, IoT, blockchain and nanotechnology for enhanced diagnosis and treatment of colorectal cancer - A review

  2023cites this paper
• Deciphering the involvement of the Hippo pathway co-regulators, YAP/TAZ in invadopodia formation and matrix degradation

  2022cites this paper
• Recent insight into the role and therapeutic potential of YAP/TAZ in gastrointestinal cancers.

  2022cites this paper
• Functions of Yes-association protein (YAP) in cancer progression and anticancer therapy resistance

  2022cites this paper
• Mechanobiology of Colorectal Cancer

  2022cites this paper
• The Hippo Signaling Core Components YAP and TAZ as New Prognostic Factors in Lung Cancer

  2022cites this paper
• Noncanonical HIPPO/MST Signaling via BUB3 and FOXO Drives Pulmonary Vascular Cell Growth and Survival

  2022cites this paper
• Long noncoding RNA DLEU2 affects the proliferative and invasive ability of colorectal cancer cells

  2021cites this paper
• Inhibition of zinc finger protein 367 exerts a tumor suppressive role in colorectal cancer by affecting the activation of oncogenic YAP1 signaling

  2021cites this paper
• YAP1 and PRDM14 converge to promote cell survival and tumorigenesis.

  2021cites this paper
• Artificial intelligence in colorectal cancer management

  2021cites this paper
• lncRNA cytoskeleton regulator RNA (CYTOR): Diverse functions in metabolism, inflammation and tumorigenesis, and potential applications in precision oncology

  2021cites this paper
• Adenomatous polyposis coli in cancer and therapeutic implications

  2021cites this paper
• Hippo-YAP signaling in digestive system tumors.

  2021cites this paper
• P 4 HA 2-induced prolyl hydroxylation suppresses YAP 1-mediated prostate cancer cell migration , 1 invasion , and metastasis 2

  2021cites this paper
• Down-regulation of miR-195 in Colorectal Adenocarcinoma Cancer

  2021cites this paper
• Role of exosomal long non-coding RNAs in colorectal cancer

  2021cites this paper
• Analysis the role of miR-195 in Colorectal Adenocarcinoma Cancer

  2021cites this paper
• P4HA2-induced prolyl hydroxylation suppresses YAP1-mediated prostate cancer cell migration, invasion, and metastasis

  2021cites this paper
• Increased Cytoplasmic Yes-associated Protein (YAP) Expression in Mismatch Repair Protein: Proficient Colorectal Cancer With High-grade Tumor Budding and Reduced Autophagy Activity.

  2020cites this paper
• PLCε knockdown prevents serine/glycine metabolism and proliferation of prostate cancer by suppressing YAP.

  2020cites this paper
• Verteporfin induced SUMOylation of YAP1 in endometrial cancer.

  2020cites this paper
• FGF15 improves outcomes after brain dead donor liver transplantation with steatotic and non-steatotic grafts in rats.

  2020cites this paper
• Pharmacogenomics of 5-fluorouracil in colorectal cancer: review and update

  2020cites this paper
• The emerging role of super enhancer-derived noncoding RNAs in human cancer

  2020cites this paper
• Double Negativity for Expression of YAP1 and CDX2 Defines an Aggressive Type of Colitis-associated Cancer

  2020cites this paper
• lncRNA USP2-AS1 promotes colon cancer progression by modulating Hippo/YAP1 signaling.

  2020cites this paper
• Platelet-derived growth factor-BB mediates pancreatic cancer malignancy via regulation of the Hippo/Yes-associated protein signaling pathway

  2020cites this paper
• Application of artificial intelligence to the diagnosis and therapy of colorectal cancer.

  2020cites this paper
• Pharmacogenomics of 5-fluorouracil in colorectal cancer: review and update

  2020cites this paper
• Loss of Yes-associated Protein Represents an Aggressive Subtype of Colorectal Cancer

  2019cites this paper
• Blockade of YAP alleviates hepatic fibrosis through accelerating apoptosis and reversion of activated hepatic stellate cells

  2019cites this paper
• New Insights into the Roles of Yes-Associated Protein (YAP1) in Colorectal Cancer Development and Progression

  2019cites this paper
• Role of Muscarinic Acetylcholine Signaling in Gastrointestinal Cancers

  2019cites this paper
• Tumor necrosis factor-inducible gene 6 reprograms hepatic stellate cells into stem-like cells, which ameliorates liver damage in mouse.

  2019cites this paper
• Overexpression of the long non-coding RNA BLACAT1 promotes cell proliferation and invasion in colorectal cancer

  2019cites this paper
• Up-regulation of THY1 attenuates interstitial pulmonary fibrosis and promotes lung fibroblast apoptosis during acute interstitial pneumonia by blockade of the WNT signaling pathway

  2019cites this paper
• Searching for the link; mechanisms underlying liver regeneration and recurrence of colorectal liver metastasis post partial hepatectomy

  2019cites this paper
• Identification of Cross Talk between FoxM1 and RASSF1A as a Therapeutic Target of Colon Cancer

  2019cites this paper
• Up-regulation of LINC00467 promotes the tumourigenesis in colorectal cancer

  2019cites this paper
• Définir de nouvelles cibles thérapeutiques pour l´hépatite alcoolique : nécessité d´une approche translationnelle

  2019cites this paper
• DUSP10 Is a Regulator of YAP1 Activity Promoting Cell Proliferation and Colorectal Cancer Progression

  2019cites this paper
• The role of free‐fatty acid receptor‐4 (FFA4) in human cancers and cancer cell lines

  2018cites this paper
• Upregulated plasmacytoma variant translocation 1 promotes cell proliferation, invasion and metastasis in colorectal cancer

  2018cites this paper
• CircPVT1: a bridge linking Hippo pathway and human cancers.

  2018cites this paper
• Dual role of YAP: oncoprotein and tumor suppressor.

  2018cites this paper
• Two-edged sword: how activation of the "proto-oncogene" yes-associated protein 1 in lung squamous cell carcinoma can surprisingly inhibit tumor growth.

  2018cites this paper
• The emerging landscape of lncRNAs in diabetic nephropathy

  2018cites this paper
• CCNA2 acts as a novel biomarker in regulating the growth and apoptosis of colorectal cancer

  2018cites this paper
• Loss of HACE1 promotes colorectal cancer cell migration via upregulation of YAP1

  2018cites this paper
• Aberrant Promoter Methylation of YAP Gene and its Subsequent Downregulation in Indian Breast Cancer Patients

  2018cites this paper
• Reconstruction of the genome-scale co-expression network for the Hippo signaling pathway in colorectal cancer

  2018cites this paper
• Metastasis-associated lung adenocarcinoma transcript 1 regulates tumor progression: old wine in a new bottle.

  2018cites this paper