Mucin synthesis. UDP-GlcNAc:GalNAc-R beta 3-N-acetylglucosaminyltransferase and UDP-GlcNAc:GlcNAc beta 1-3GalNAc-R (GlcNAc to GalNAc) beta 6-N-acetylglucosaminyltransferase from pig and rat colon mucosa.

No abstract is available for this paper.

• Publication year

  1985

• Venue

  Biochemistry

• Publication date

  1985-04-09

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1021/BI00329A010PMID 3160388
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mucin synthesis. The action of pig gastric mucosal UDP-GlcNAc:Gal beta 1-3(R1)GalNAc-R2 (GlcNAc to Gal) beta 3-N-acetylglucosaminyltransferase on high molecular weight substrates.

  1984cited by this paper
• Immunochemical studies on blood groups. Purification and characterization of radioactive 3H-reduced di- to hexasaccharides produced by alkaline beta-elimination-borohydride 3H reduction of Smith degraded blood group A active glycoproteins.

  1984cited by this paper
• Aglycon specificity of fetal calf liver and ovine and porcine submaxillary gland α‐N‐acetylgalactosaminide α2→6 sialyltransferase

  1983cited by this paper
• Mucin synthesis. III. UDP-GlcNAc:Gal beta 1-3(GlcNAc beta 1-6)GalNAc-R (GlcNAc to Gal) beta 3-N-acetylglucosaminyltransferase, an enzyme in porcine gastric mucosa involved in the elongation of mucin-type oligosaccharides.

  1983cited by this paper
• Aglycon specificity of fetal calf liver and ovine and porcine submaxillary gland alpha-N-acetylgalactosaminide alpha 2 leads to 6 sialyltransferase.

  1983cited by this paper
• Structures of the major oligosaccharides from a human rectal adenocarcinoma glycoprotein.

  1983cited by this paper
• The separation by liquid chromatography (under elevated pressure) of phenyl, benzyl, and O-nitrophenyl glycosides of oligosaccharides. Analysis of substrates and products for four N-acetyl-D-glucosaminyl-transferases involved in mucin synthesis.

  1983cited by this paper
• Synthesis of benzyl 2-acetamido-3-O- and -6-O-(2-acetamido-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-alpha -D-galactopyranoside.

  1983cited by this paper
• Synthesis of benzyl 2-acetamido-3-O- and -6-O-(2-acetamido-2-deoxy-β-d-glucopyranosyl)-2-deoxy-α-d-galactopyranoside

  1983cited by this paper
• Mucin synthesis. III. UDP-GlcNAc:Galβ1-3(GlcNAcβ1-6)GalNAc-R (GlcNAc to Gal) β3-N-acetylglucosaminyltransferase, an enzyme in porcine gastric mucosa involved in the elongation of mucin-type oligosaccharides

  1983cited by this paper
• Separation of acidic oligosaccharides by liquid chromatography: application to analysis of sugar chains of glycoproteins.

  1982cited by this paper
• Product-identification and substrate-specificity studies of the GDP-l-fucose: 2-acetamido-2-deoxy-β-d-glucoside (fuc→asn-linked GlcNAc) 6-α-l-fucosyltransferase in a golgi-rich fraction from porcine liver☆

  1982cited by this paper
• Primary-structure determination of fourteen neutral oligosaccharides derived from bronchial-mucus glycoproteins of patients suffering from cystic fibrosis, employing 500-MHz 1H-NMR spectroscopy.

  1982cited by this paper
• Product-identification and substrate-specificity studies of the GDP-L-fucose:2-acetamido-2-deoxy-beta-D-glucoside (FUC goes to Asn-linked GlcNAc) 6-alpha-L-fucosyltransferase in a Golgi-rich fraction from porcine liver.

  1982cited by this paper
• Determination of glycopeptide primary structure by 360-MHz proton magnetic resonance spectroscopy.

  1981cited by this paper
• Studies on bonnet monkey cervical mucus. The effect of proteases on mucus glycoproteins of Macaca radiata.

  1981cited by this paper
• Structural analysis of hexa- to octa-saccharide fractions isolated from sheep gastric-glycoproteins having blood-group I and i activities

  1981cited by this paper
• Mucin synthesis. II. Substrate specificity and product identification studies on canine submaxillary gland UDP-GlcNAc:Gal beta 1-3GalNAc(GlcNAc leads to GalNAc) beta 6-N-acetylglucosaminyltransferase.

  1980cited by this paper
• Isolation and characterization of oligosaccharides from rat colonic mucus glycoprotein.

  1980cited by this paper
• Mucin synthesis. I. Detection in canine submaxillary glands of an N-acetylglucosaminyltransferase which acts on mucin substrates.

  1980cited by this paper
• Structures of the acidic oligosaccharides isolated from rat sublingual glycoprotein.

  1978cited by this paper
• beta-Galactosidase from bovine testes.

  1978cited by this paper
• Structure of some oligosaccharides derived from rat-intestinal glycoproteins.

  1978cited by this paper
• Immunochemical studies on blood groups. Purification, chemical and immunochemical properties of blood group-active glycoproteins from horse gastric mucosae.

  1976cited by this paper
• Determination of aminosugar linkages in glycolipids by methylation. Aminosugar linkages of ceramide pentasaccharides of rabbit erythrocytes and of Forssman antigen.

  1973cited by this paper
• Sialic acids. 13. A uridine diphosphate D-galactose: mucin galactosyltransferase from porcine submaxillary gland.

  1971cited by this paper
• Synthesis of 2-Acetamido-2-deoxy-3-O-(β-D-galactopyranosyl)-α-D-galactose

  1965cited by this paper
• Nucleoside Polyphosphates. XI.1 An Improved General Method for the Synthesis of Nucleotide Coenzymes. Syntheses of Uridine-5', Cytidine-5' and Guanosine-5' Diphosphate Derivatives

  1961cited by this paper
• Protein measurement with the Folin phenol reagent.

  1951cited by this paper

• Mucins as anti-cancer targets: perspectives of the glycobiologist

  2021cites this paper
• Mucin-Type O-Glycans: Biosynthesis and Functions

  2021cites this paper
• Glycosylation pathways of human corneal and conjunctival epithelial cell mucins.

  2018cites this paper
• Biochemical and functional characterization of glycosylation-associated mutational landscapes in colon cancer

  2016cites this paper
• The Role of Ion Channels in Airway Mucus Hypersecretion in Asthma

  2015cites this paper
• Identification of a Novel Protein Binding Motif within the T-synthase for the Molecular Chaperone Cosmc*

  2014cites this paper
• Acceptor specificities and selective inhibition of recombinant human Gal- and GlcNAc-transferases that synthesize core structures 1, 2, 3 and 4 of O-glycans.

  2013cites this paper
• Structural Glycobiology: Applications in Cancer Research

  2012cites this paper
• Mucin O-glycan branching enzymes: structure, function, and gene regulation.

  2011cites this paper
• Location, location, location: new insights into O-GalNAc protein glycosylation.

  2011cites this paper
• Biosynthesis of Complex Mucin-Type O -Glycans

  2010cites this paper
• Leukosialin, a major sialoglycoprotein defining leucocyte differentiation.

  2007cites this paper
• 2.04 – 1H NMR Structural-Reporter-Group Concepts in Carbohydrate Analysis

  2007cites this paper
• 3.03 – Biosynthesis of Mucin-Type O-Glycans

  2007cites this paper
• Detection of glycosyltransferases in the golden hamster (Mesocricetus auratus) oviduct and evidence for the regulation of O-glycan biosynthesis during the estrous cycle.

  2005cites this paper
• Core 3 synthase is down-regulated in colon carcinoma and profoundly suppresses the metastatic potential of carcinoma cells.

  2005cites this paper
• Production and Use of Mammalian Glycosyltransferases

  2004cites this paper
• Soluble human core 2 beta6-N-acetylglucosaminyltransferase C2GnT1 requires its conserved cysteine residues for full activity.

  2003cites this paper
• Glycodynamics of mucin biosynthesis in gastrointestinal tumor cells.

  2003cites this paper
• Molecular Cloning and Characterization of a Novel UDP-GlcNAc:GalNAc-peptide β1,3-N-Acetylglucosaminyltransferase (β3Gn-T6), an Enzyme Synthesizing the Core 3 Structure of O-Glycans*

  2002cites this paper
• Several polylactosamine-modifying glycosyltransferases also use internal GalNAcbeta1-4GlcNAc units of synthetic saccharides as acceptors.

  2002cites this paper
• Nouvelle n-acetylglucosamine transferase, acide nucleique codant cette enzyme, anticorps dirige contre cette enzyme et utilisation de l'enzyme pour diagnostiquer un cancer ou une tumeur

  2002cites this paper
• Biosynthesis and function of beta 1,6 branched mucin-type glycans.

  2001cites this paper
• Pathways of Mucin O-Glycosylation in Normal and Malignant Rat Colonic Epithelial Cells Reveal a Mechanism for Cancer-Associated Sialyl-Tn Antigen Expression

  2001cites this paper
• Analysis of p-nitrophenyl N-acetyl-_-d-galactosaminide-induced oligosaccharides

  2001cites this paper
• Biosynthesis and function of β 1,6 branched mucin-type glycans

  2001cites this paper
• Differentiation-dependent glycosylation of gp190, an oncofetal crypt cell antigen expressed by Caco-2 cells

  2000cites this paper
• The joys of HexNAc. The synthesis and function of N-andO-glycan branches

  2000cites this paper
• Enzymes and proteins containing manganese: an overview.

  2000cites this paper
• Enzymatic in vitro synthesis of I-branches of mammalian polylactosamines: generation of scaffolds for multiple selectin-binding saccharide determinants

  2000cites this paper
• O-linked chain glycosyltransferases.

  2000cites this paper
• Pathways of O-glycan biosynthesis in cancer cells.

  1999cites this paper
• 3.04 – Glycosyltransferases Involved in the Synthesis of Ser/Thr-GalNAc O-Glycans

  1999cites this paper
• Control of O-Glycan Branch Formation

  1999cites this paper
• UDP-GlcNAc:Galbeta1-->3GalNAc (GlcNAc to GalNAc) beta1-->6N-acetylglucosaminyltransferase holds a key role on the control of CD15s expression in human pre-B lymphoid cell lines.

  1999cites this paper
• Control of O-Glycan Branch Formation

  1999cites this paper
• Sugars And Proteins: Why They Get It Together

  1998cites this paper
• And What About O-Linked Sugars?

  1998cites this paper
• Single Glycosyltransferase, Core 2 β1→6-N-acetylglucosaminyltransferase, Regulates Cell Surface Sialyl-Lex Expression Level in Human Pre-B Lymphocytic Leukemia Cell Line KM3 Treated with Phorbolester*

  1998cites this paper
• Enzymatic basis for sialyl-Tn expression in human colon cancer cells

  1998cites this paper
• Neutral core oligosaccharides of bovine submaxillary mucin--use of lead tetraacetate in the cold for establishing branch positions.

  1998cites this paper
• Glycoproteins and Their Relationship to Human Disease

  1998cites this paper
• Biosynthesis and functions of O-glycans and regulation of mucin antigen expression in cancer.

  1997cites this paper
• Activity of UDP-GlcNAc:GlcNAc beta 1-->6(GlcNAc beta 1-->2) Man alpha 1-->R[GlcNAc to Man] beta 1-->4N-acetylglucosaminyltransferase VI (GnT VI) from the ovaries of Oryzias latipes (Medaka fish).

  1997cites this paper
• Glycosylation patterns in mucus glycoproteins

  1997cites this paper
• Activity of UDP-GlcNAc:GlcNAcβ1→6(GlcNAcβ1→2) Manα1→R[GlcNAc to Man]β1→4N- Acetylglucosaminyltransferase VI (GnT VI) from the Ovaries ofOryzias latipes(Medaka Fish)☆☆☆

  1997cites this paper
• Biosynthesis of O-Glycans

  1997cites this paper
• Expression of stable human O-glycan core 2 beta-1,6-N-acetylglucosaminyltransferase in Sf9 insect cells.

  1997cites this paper
• Pilot scale expression and purification of soluble protein A tagged beta 1,6N-acetylglucosaminyltransferase in CHO cells.

  1997cites this paper
• Organization of the human beta-1,2-N-acetylglucosaminyltransferase I gene (MGAT1), which controls complex and hybrid N-glycan synthesis.

  1997cites this paper
• Different Fate of a Single Reporter Protein Containing KDEL or KKXX Targeting Signals Stably Expressed in Mammalian Cells (*)

  1996cites this paper
• Mechanisms underlying aberrant glycosylation of MUC1 mucin in breast cancer cells.

  1995cites this paper
• Chapter 5 Biosynthesis 3. Biosynthesis of O-Glycans of the N-Acetylgalactosamine-α-Ser/Thr Linkage Type

  1995cites this paper
• The human UDP‐N‐Acetylglucosamine:α‐6‐d‐Mannoside‐β‐1,2‐N‐Acetylglucosaminyltransferase II Gene (MGAT2)

  1995cites this paper
• Synthesis of the building blocks N ?-Fmoc-O-[?-D-Ac3GalN3 p-(1?3)-?-D-Ac2GalN3 p]-Thr-OPfp and N ?-Fmoc-O-[?-D-Ac3GalN3 p-(1?6)-?-D-Ac2GalN3 p]-Thr-OPfp and their application in the solid phase glycopeptide synthesis of core 5 and core 7 mucin O-glycopeptides

  1995cites this paper
• The human UDP-N-acetylglucosamine: alpha-6-D-mannoside-beta-1,2- N-acetylglucosaminyltransferase II gene (MGAT2). Cloning of genomic DNA, localization to chromosome 14q21, expression in insect cells and purification of the recombinant protein.

  1995cites this paper
• Substrate specificity and inhibition of UDP-GlcNAc:GlcNAc beta 1-2Man alpha 1-6R beta 1,6-N-acetylglucosaminyltransferase V using synthetic substrate analogues.

  1995cites this paper
• Synthesis of O-glycan core 3: characterization of UDP-GlcNAc: GalNAc-R beta 3-N-acetyl-glucosaminyltransferase activity from colonic mucosal tissues and lack of the activity in human cancer cell lines.

  1995cites this paper
• Carbohydrate-deficient glycoprotein syndrome type II. An autosomal recessive N-acetylglucosaminyltransferase II deficiency different from typical hereditary erythroblastic multinuclearity, with a positive acidified-serum lysis test (HEMPAS).

  1995cites this paper
• Biochemistry and Oncology of Sialoglycoproteins

  1995cites this paper
• Insertion intoAspergillus nidulans of functional UDP-GlcNAc: α3-d-mannoside β-1,2-N-acetylglucosaminyltransferase I, the enzyme catalysing the first committed step from oligomannose to hybrid and complex N-glycans

  1995cites this paper
• Characterization of a novel mucin sulphotransferase activity synthesizing sulphated O-glycan core 1,3-sulphate-Gal beta 1-3GalNAc alpha-R.

  1995cites this paper
• Substrate specificity and inhibition of UDP-GlcNAc:GlcNAcβ1-2Manα1-6R β1,6-N-acetylglucosaminyltransferase V using synthetic substrate analogues

  1995cites this paper
• UDPgalactose:glycoprotein-N-acetyl-D-galactosamine 3-beta-D-galactosyltransferase activity synthesizing O-glycan core 1 is controlled by the amino acid sequence and glycosylation of glycopeptide substrates.

  1994cites this paper
• Inhibition of UDP-GlcNAc:Gal beta 1-3GalNAc-R (GlcNAc to GalNAc) beta 6-N-acetylglucosaminyltransferase from acute myeloid leukaemia cells by photoreactive nitrophenyl substrate derivatives.

  1994cites this paper
• Expression of recombinant rabbit UDP-GlcNAc: alpha 3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I catalytic domain in Sf9 insect cells.

  1994cites this paper
• Expression of recombinant rabbit UDP-GlcNAc:α3-d-mannoside β-1,2-N-acetylglucosaminyltransferase I catalytic domain in Sf9 insect cells

  1994cites this paper
• O-glycan biosynthesis in human colorectal adenoma cells during progression to cancer.

  1994cites this paper
• Blood group antigens on human erythrocytes-distribution, structure and possible functions.

  1994cites this paper
• Two different glycosyltransferase defects that result in GalNAc alpha-O-peptide (Tn) expression.

  1994cites this paper
• 4 – Glycopeptide Synthesis

  1994cites this paper
• Alterations of O-glycan biosynthesis in human colon cancer tissues.

  1994cites this paper
• Processing O-glycan core 1, Gal beta 1-3GalNAc alpha-R. Specificities of core 2, UDP-GlcNAc: Gal beta 1-3 GalNAc-R(GlcNAc to GalNAc) beta 6-N-acetylglucosaminyltransferase and CMP-sialic acid: Gal beta 1-3GalNAc-R alpha 3-sialyltransferase.

  1993cites this paper
• ProcessingO-glycan core 1, Galβ1-3GalNAcα-R. Specificities of core 2, UDP-GlcNAc: Galβ1-3GalNAc-R(GlcNAc to GalNAc) β6-N-acetylglucosaminyltransferase and CMP-sialic acid:Galβ1-3GalNAc-R α3-sialyltransferase

  1993cites this paper
• Clinical aspects of glycoprotein biosynthesis.

  1993cites this paper
• Preferred conformations and dynamics of five core structures of mucin typeO-glycans determined by NMR spectroscopy and force field calculations

  1993cites this paper
• Isolation and structural characterization of novel sialylated oligosaccharide-alditols from respiratory-mucus glycoproteins of a patient suffering from bronchiectasis.

  1993cites this paper
• Expression of the developmental I antigen by a cloned human cDNA encoding a member of a beta-1,6-N-acetylglucosaminyltransferase gene family.

  1993cites this paper
• Structures of sulfated oligosaccharides in human trachea mucin glycoproteins

  1993cites this paper
• Oligosaccharide structures of mucins secreted by the human colonic cancer cell line CL.16E.

  1992cites this paper
• Mucin oligosaccharide biosynthesis in human colonic cancerous tissues and cell lines

  1992cites this paper
• Mucins: structure, function, and role in pulmonary diseases.

  1992cites this paper
• Control of glycoprotein synthesis: substrate specificity of rat liver UDP-GlcNAc:Manα3R β2-N-acetylglucosaminyl-transferase I using synthetic substrate analogues

  1992cites this paper
• Control of O-glycan synthesis: specificity and inhibition of O-glycan core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 3-galactosyltransferase from rat liver.

  1992cites this paper
• The broad diversity of neutral and sialylated oligosaccharides derived from human salivary mucins.

  1992cites this paper
• Biosynthesis and oligosaccharide structure of human CD8 glycoprotein expressed in a rat epithelial cell line.

  1992cites this paper
• Control of glycoprotein synthesis: substrate specificity of rat liver UDP-GlcNAc:Man alpha 3R beta 2-N-acetylglucosaminyltransferase I using synthetic substrate analogues.

  1992cites this paper
• Control of glycoprotein synthesis. Characterization of (1-->4)-N-acetyl-beta-D-glucosaminyltransferases acting on the alpha-D-(1-->3)- and alpha-D-(1-->6)-linked arms of N-linked oligosaccharides.

  1992cites this paper
• Mucin biosynthesis revisited. The enzymatic transfer of Gal in beta 1,3 linkage to the GalNAc moiety of the core structure R1-GlcNAc beta 1,6GalNAc alpha-O-R2.

  1992cites this paper
• Expression cloning of a cDNA encoding UDP-GlcNAc:Gal beta 1-3-GalNAc-R (GlcNAc to GalNAc) beta 1-6GlcNAc transferase by gene transfer into CHO cells expressing polyoma large tumor antigen.

  1992cites this paper
• Control of glycoprotein synthesis. Characterization of (1 → 4)-N-acetyl-β-d-glucosaminyltransferases acting on the α-d-(1 → 3)- and α-d-(1 → 6)-linked arms of N-linked oligosaccharides☆

  1992cites this paper
• Bausteine von Oligosacchariden. CII: Synthese von modifizierten Derivaten der 2-Acetamido-2-desoxy-D-galactose zur Untersuchung der Substratspezifität der Core-1-β3-Gal-transferase und der Core-3-β3-GlcNAc-transferase der Biosynthese von O-Glycoproteinen

  1992cites this paper
• High-Resolution 1H-Nuclear Magnetic Resonance Spectroscopy of Oligosaccharide-Alditols Released from Mucin-Type O-Glycoproteins

  1992cites this paper
• Bausteine von Oligosacchariden, CIII. Synthese von modifizierten Derivaten des Disaccharides β‐D‐Gal‐(1 → 3)‐α‐D‐GalNAc zur Untersuchung der Substratspezifität der Core‐2‐β6‐GlcNAc‐Transferase und α‐3‐Sialyltransferase der Biosynthese von O‐Glycoproteinen

  1992cites this paper
• Altered O-glycan synthesis in lymphocytes from patients with Wiskott- Aldrich syndrome

  1991cites this paper
• Aberrant O-linked oligosaccharide biosynthesis in lymphocytes and platelets from patients with the Wiskott-Aldrich syndrome.

  1991cites this paper
• Isolation and structural characterization of novel neutral oligosaccharide-alditols from respiratory-mucus glycoproteins of a patient suffering from bronchiectasis. 1. Structure of 11 oligosaccharides having the GlcNAc beta(1----3)Gal beta(1----4)GlcNAc beta(1----6)GalNAc-o1 structural element in co

  1991cites this paper
• Expression of aberrant O-glycans attached to leukosialin in differentiation-deficient HL-60 cells.

  1991cites this paper
• Increased UDP-GlcNAc:Gal beta 1-3GaLNAc-R (GlcNAc to GaLNAc) beta-1, 6-N-acetylglucosaminyltransferase activity in metastatic murine tumor cell lines. Control of polylactosamine synthesis.

  1991cites this paper
• Novel method for quantifying alpha(1----3)-L-fucosyltransferase activity in serum.

  1991cites this paper