Neurochemical alterations of the brain in bipolar disorder and their implications for pathophysiology: a systematic review of the in vivo proton magnetic resonance spectroscopy findings.

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Progress in Neuro-psychopharmacology and Biological Psychiatry

• Publication date

  2006-08-30

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1016/J.PNPBP.2006.03.012PMID 16677749
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Magnetic resonance spectroscopy: neurochemistry and treatment effects in affective disorders.

  2025cited by this paper
• Review of 1H magnetic resonance spectroscopy findings in major depressive disorder: a meta-analysis.

  2006cited by this paper
• 1H magnetic resonance spectroscopy investigation of the dorsolateral prefrontal cortex in bipolar disorder patients.

  2005cited by this paper
• Mitochondrial dysfunction in bipolar disorder: evidence from magnetic resonance spectroscopy research

  2005cited by this paper
• Brain metabolic alterations in medication-free patients with bipolar disorder.

  2004cited by this paper
• New insights help define the pathophysiology of bipolar affective disorder: neuroimaging and neuropathology findings.

  2004cited by this paper
• Hippocampal neurochemical pathology in patients at first episode of affective psychosis: a proton magnetic resonance spectroscopic imaging study.

  2004cited by this paper
• Neuroimaging studies in bipolar children and adolescents.

  2004cited by this paper
• Neurobiological Findings in Bipolar II Disorder Compared with Findings in Bipolar I Disorder

  2004cited by this paper
• Neurochemical predictors of response to pharmacologic treatments for bipolar disorder

  2004cited by this paper
• Brain choline concentrations may not be altered in euthymic bipolar disorder patients chronically treated with either lithium or sodium valproate

  2004cited by this paper
• Lithium and valproic acid treatment effects on brain chemistry in bipolar disorder.

  2004cited by this paper
• Corpus callosum signal intensity in patients with bipolar and unipolar disorder

  2004cited by this paper
• Chronic treatment with lithium, but not sodium valproate, increases cortical N-acetyl-aspartate concentrations in euthymic bipolar patients

  2003cited by this paper
• Brain Imaging Studies in Mood and Anxiety Disorders

  2003cited by this paper
• Decreased N-acetylaspartate in children with familial bipolar disorder.

  2003cited by this paper
• Lower concentration of hippocampal N-acetylaspartate in familial bipolar I disorder.

  2003cited by this paper
• Acute mania is accompanied by elevated glutamate/glutamine levels within the left dorsolateral prefrontal cortex

  2003cited by this paper
• Neuronal pathology in the hippocampal area of patients with bipolar disorder: a study with proton magnetic resonance spectroscopic imaging.

  2003cited by this paper
• Proton magnetic resonance spectroscopy of bipolar disorder versus intermittent explosive disorder in children and adolescents.

  2003cited by this paper
• Proton magnetic resonance spectroscopy of the frontal lobe and cerebellar vermis in children with a mood disorder and a familial risk for bipolar disorders.

  2003cited by this paper
• Mood disorders: treatment-induced changes in brain neurochemistry and structure.

  2002cited by this paper
• Frontal lobe differences in bipolar disorder as determined by proton MR spectroscopy.

  2002cited by this paper
• Chronic treatment with both lithium and sodium valproate may normalize phosphoinositol cycle activity in bipolar patients

  2002cited by this paper
• Increased thalamic N-acetylaspartate in male patients with familial bipolar I disorder.

  2001cited by this paper
• Reductions in neuronal and glial density characterize the dorsolateral prefrontal cortex in bipolar disorder.

  2001cited by this paper
• Decreased Anterior Cingulate Myo-inositol/Creatine Spectroscopy Resonance with Lithium Treatment in Children with Bipolar Disorder

  2001cited by this paper
• Glia: listening and talking to the synapse

  2001cited by this paper
• Postmortem studies in mood disorders indicate altered numbers of neurons and glial cells.

  2000cited by this paper
• Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders.

  2000cited by this paper
• Choline, myo-inositol and mood in bipolar disorder: a proton magnetic resonance spectroscopic imaging study of the anterior cingulate cortex.

  2000cited by this paper
• Lithium increases N-acetyl-aspartate in the human brain: in vivo evidence in support of bcl-2's neurotrophic effects?

  2000cited by this paper
• Functions of N‐Acetyl‐l‐Aspartate and N‐Acetyl‐l‐Aspartylglutamate in the Vertebrate Brain

  2000cited by this paper
• Proton MR spectroscopy in children with bipolar affective disorder: preliminary observations.

  2000cited by this paper
• Glutamate receptors in glia: new cells, new inputs and new functions.

  2000cited by this paper
• Temporal dissociation between lithium-induced changes in frontal lobe myo-inositol and clinical response in manic-depressive illness.

  1999cited by this paper
• Quantitative proton magnetic resonance spectroscopy of the bilateral frontal lobes in patients with bipolar disorder

  1999cited by this paper
• Quantitative proton magnetic resonance spectroscopy of the basal ganglia in patients with affective disorders

  1998cited by this paper
• Magnetic resonance spectroscopy in affective disorders.

  1998cited by this paper
• Decreased dorsolateral prefrontal N-acetyl aspartate in bipolar disorder.

  1998cited by this paper
• Proton magnetic resonance spectroscopy of the lenticular nuclei in bipolar I affective disorder

  1998cited by this paper
• Glial reduction in the subgenual prefrontal cortex in mood disorders.

  1998cited by this paper
• Choline-containing compounds detected by proton magnetic resonance spectroscopy in the basal ganglia in bipolar disorder.

  1996cited by this paper
• Axonal injury and membrane alterations in Alzheimer's disease suggested by in vivo proton magnetic resonance spectroscopic imaging

  1994cited by this paper
• Proton mrs of the basal ganglia in bipolar disorder

  1994cited by this paper
• Proton mrs of the basal ganglia in major depression

  1994cited by this paper
• Evidence for irnnairment of energy metabofism in vivo in Huntington's disease using localized 1H NMR spectroscopy

  1993cited by this paper
• Evidence for impairment of energy metabolism in vivo in Huntington's disease using localized 1H NMR spectroscopy.

  1993cited by this paper
• The human brain resonance of choline-containing compounds is similar in patients receiving lithium treatment and controls: an in vivo proton magnetic resonance spectroscopy study.

  1992cited by this paper
• Proton magnetic resonance spectroscopy of the brain in schizophrenic and affective patients

  1992cited by this paper
• Brain imaging in affective disorders

  1991cited by this paper

• Lithium effects in the frontolimbic circuitry: a systematic review of neuroimaging findings in bipolar disorder

  2026cites this paper
• Decreased levels of N-Acetylaspartyglutamate, myo-inositol, and syllo-inositol, in cortical brain regions of women exposed to adverse childhood experiences.

  2026cites this paper
• Mitochondrial Transplantation in Animal Models of Psychiatric Disorders: A Novel Approach to Psychiatric Treatment

  2025cites this paper
• Identification of candidate genes associated with bipolar disorder by whole-exome sequencing of a Chinese multi-affected pedigree

  2025cites this paper
• Neuromarkers in bipolar disorder: A narrative review bridging neuroscience and clinical practice

  2025cites this paper
• A pilot study of a ketogenic diet in bipolar disorder: clinical, metabolic and magnetic resonance spectroscopy findings

  2025cites this paper
• Lithium-induced neuroprotection in bipolar disorder: Translational insights into cytoskeletal and proteomic mechanisms

  2025cites this paper
• Mitochondrial respiration in patients with bipolar disorder: Can mitochondrial respiratory control ratios serve as state and/or trait markers?

  2025cites this paper
• Biochemical abnormalities in basal ganglia and cognitive dysfunction in bipolar disorder comorbid with attention-deficit/hyperactivity disorder patients: A proton magnetic resonance spectroscopy study.

  2025cites this paper
• A Magnetic Resonance Spectroscopy Study on Polarity Subphenotypes in Bipolar Disorder

  2024cites this paper
• Changes in the medial prefrontal cortex metabolites after 6 months of medication therapy for patients with bipolar disorder: A 1H‐MRS study

  2024cites this paper
• Posterior cingulate and medial prefrontal excitation-inhibition balance in euthymic bipolar disorder.

  2024cites this paper
• MIR218 polygenic risk score is associated with cognitive function and neurochemical metabolites among patients with depressed bipolar disorders.

  2024cites this paper
• Cortical thickness alterations are associated with astrocytes and excitatory neuron-specific transcriptome signatures in pediatric bipolar disorder.

  2023cites this paper
• A Pilot Study of a Ketogenic Diet in Bipolar Disorder: Clinical, Metabolomic and Magnetic Resonance Spectroscopy Outcomes

  2023cites this paper
• The Cerebellum’s Role in Affective Disorders: The Onset of Its Social Dimension

  2023cites this paper
• Progress of depression mechanism based on Omics method.

  2023cites this paper
• Brain temperature as an indicator of neuroinflammation induced by typhoid vaccine: Assessment using whole-brain magnetic resonance spectroscopy in a randomised crossover study

  2022cites this paper
• Magnetic Resonance Spectroscopy in Bipolar Disorder

  2022cites this paper
• Neuroprogression in bipolar disorder

  2022cites this paper
• Elevated choline in dorsolateral prefrontal cortex of lithium responders with bipolar I disorder.

  2022cites this paper
• In Vivo 13C Magnetic Resonance Spectroscopy for Assessing Brain Biochemistry in Health and Disease

  2022cites this paper
• Are mGluR2/3 Inhibitors Potential Compounds for Novel Antidepressants?

  2022cites this paper
• Antidepressant chronotherapeutics normalizes prefrontal 1H-MRS glutamate in bipolar depression.

  2022cites this paper
• Brain Imaging Changes in Patients Recovered From COVID-19: A Narrative Review

  2022cites this paper
• Glutamate and N-Acetylaspartate Alterations Observed in Early Phase Psychosis: A Systematic Review of Proton Magnetic Resonance Spectroscopy Studies.

  2022cites this paper
• Altered neurometabolite levels in the brains of patients with depression: A systematic analysis of magnetic resonance spectroscopy studies.

  2022cites this paper
• Brain spectroscopic measures of glutamatergic and neuronal metabolism and glial activation influence white matter integrity in bipolar depression.

  2022cites this paper
• Brain Imaging of Reward Dysfunction in Unipolar and Bipolar Disorders

  2021cites this paper
• The Neurometabolic Basis of Mood Instability: The Parvalbumin Interneuron Link—A Systematic Review and Meta-Analysis

  2021cites this paper
• Neuroanatomical Findings in Bipolar Disorder

  2021cites this paper
• Functional Connectome in Bipolar Disorder

  2021cites this paper
• Ventromedial prefrontal cortex/anterior cingulate cortex Glx, glutamate, and GABA levels in medication-free major depressive disorder

  2021cites this paper
• Imaging Glutamatergic and GABAergic Abnormalities in Mood Disorders

  2021cites this paper
• Effects of Lithium on Brain Structure in Bipolar Disorder

  2021cites this paper
• Imaging Genetic and Epigenetic Markers in Mood Disorders

  2021cites this paper
• Targeting metabotropic glutamate receptors for the treatment of depression and other stress-related disorders.

  2021cites this paper
• Neuroimaging Studies of Effects of Psychotherapy in Depression

  2021cites this paper
• Brain Imaging and the Mechanisms of Antidepressant Action

  2021cites this paper
• Magnetic Resonance Spectroscopy Investigations of Bioenergy and Mitochondrial Function in Mood Disorders

  2021cites this paper
• Brain Imaging Methods in Mood Disorders

  2021cites this paper
• Weight gain as a risk factor for progressive neurochemical abnormalities in first episode mania patients: a longitudinal magnetic resonance spectroscopy study

  2021cites this paper
• Anterior cingulate cortex neurometabolites in bipolar disorder are influenced by mood state and medication: A meta-analysis of 1H-MRS studies.

  2021cites this paper
• Resting-State Functional Connectivity in Unipolar Depression

  2021cites this paper
• Functional Near-Infrared Spectroscopy Studies in Mood Disorders

  2021cites this paper
• fMRI Neurofeedback as Treatment for Depression

  2021cites this paper
• An Overview of Machine Learning Applications in Mood Disorders

  2021cites this paper
• Impaired mitochondrial bioenergetics in psychiatric disorders

  2021cites this paper
• Neuroanatomical Findings in Unipolar Depression and the Role of the Hippocampus

  2021cites this paper
• Neuroimaging Biomarkers in Pediatric Mood Disorders

  2021cites this paper
• Magnetoencephalography Studies in Mood Disorders

  2021cites this paper
• Molecular Imaging of Dopamine and Antipsychotics in Bipolar Disorder

  2021cites this paper
• Neuroimaging Brain Inflammation in Mood Disorders

  2021cites this paper
• Neurometabolic alterations in bipolar disorder with anxiety symptoms: A proton magnetic resonance spectroscopy study of the prefrontal whiter matter.

  2021cites this paper
• Electrophysiological Biomarkers for Mood Disorders

  2021cites this paper
• Evaluation of The Psychiatric Research Output From Turkey Via Web Of Science Database: A Bibliometric Analysis

  2020cites this paper
• Altered brain creatine cycle metabolites in bipolar I disorder with childhood abuse: A 1H magnetic resonance spectroscopy study.

  2020cites this paper
• Prolonged functional cerebral asymmetry as a consequence of dysfunctional parvocellular paraventricular hypothalamic nucleus signaling: An integrative model for the pathophysiology of bipolar disorder.

  2020cites this paper
• Altered neurochemistry in the anterior white matter of bipolar children and adolescents: a multivoxel 1H MRS study

  2020cites this paper
• Proinflammatory Cytokines Predict Brain Metabolite Concentrations in the Anterior Cingulate Cortex of Patients With Bipolar Disorder

  2020cites this paper
• Lithium and the Interplay Between Telomeres and Mitochondria in Bipolar Disorder

  2020cites this paper
• Investigating the effects of ebselen, a potential new lithium mimetic, on glutamate transmission

  2020cites this paper
• Specificity and Continuity of Schizophrenia and Bipolar Disorder: Relation to 
Biomarkers

  2019cites this paper
• Mitochondrial Dysfunction in Blood Platelets of Patients with Manic Episode of Bipolar Disorder.

  2019cites this paper
• Disturbances of mitochondrial parameters to distinguish patients with depressive episode of bipolar disorder and major depressive disorder

  2019cites this paper
• The glutamatergic system and astrocytic impairment in rat hippocampus: a comparative study of underlying etiology and pathophysiology of depression.

  2019cites this paper
• Evidence for perturbed metabolic patterns in bipolar disorder subjects associated with lithium responsiveness.

  2019cites this paper
• Monosodium glutamate influences depressive behavior of two age groups of mice in forced swimming test: Vitamin B6 could remedy the situation

  2019cites this paper
• Altered biochemical metabolism and its lateralization in the cortico-striato-cerebellar circuit of unmedicated bipolar II depression.

  2019cites this paper
• Mitochondrial Involvement in Mental Disorders: Energy Metabolism and Genetic and Environmental Factors.

  2019cites this paper
• At Physiologically Relevant Concentrations, Valproic Acid and Lithium Carbonate Reduce Oxidative Stress in Human Astrocytoma Cells

  2019cites this paper
• Integrated Metabolomics and Proteomics Analysis Revealed Second Messenger System Disturbance in Hippocampus of Chronic Social Defeat Stress Rat

  2019cites this paper
• Clinical Findings Documenting Cellular and Molecular Abnormalities of Glia in Depressive Disorders

  2018cites this paper
• Biochemical abnormalities in basal ganglia and executive dysfunction in acute- and euthymic-episode patients with bipolar disorder: A proton magnetic resonance spectroscopy study.

  2018cites this paper
• Associations between executive function impairment and biochemical abnormalities in bipolar disorder with suicidal ideation.

  2018cites this paper
• Choline Compounds of the Frontal Lobe and Temporal Glutamatergic System in Bipolar and Schizophrenia Proton Magnetic Resonance Spectroscopy Study

  2018cites this paper
• Distinctive Neuroanatomical Substrates for Depression in Bipolar Disorder versus Major Depressive Disorder

  2018cites this paper
• The Effects of the Gsk-3 Inhıbıtor Tdzd-8 on Bıpolar-Lıke Behavıoral Phenotype Induced by Hıgh Fructose Corn Syrup Consumptıon in Adolescent Rats

  2018cites this paper
• Mitochondrial Involvement in Mental Disorders; Energy Metabolism, Genetic, and Environmental Factors.

  2018cites this paper
• Analysis of rat brain lipids and metabolites after antidepressant drug treatment

  2018cites this paper
• Chapter 10 Neuroplasticity in Bipolar Disorder : Insights from Neuroimaging

  2018cites this paper
• 9 Neurotransmission in Mood Disorders

  2018cites this paper
• A urinary metabolomics (GC-MS) strategy to evaluate the antidepressant-like effect of chlorogenic acid in adrenocorticotropic hormone-treated rats

  2018cites this paper
• Proton magnetic resonance spectroscopy changes after lithium treatment. Systematic review

  2018cites this paper
• A model of the mitochondrial basis of bipolar disorder.

  2017cites this paper
• Mitochondrial Dysfunctions in Bipolar Disorder: Effect of the Disease and Pharmacotherapy.

  2017cites this paper
• From direct to indirect lithium targets: a comprehensive review of omics data.

  2017cites this paper
• Magnetic Resonance Spectroscopy and its Clinical Applications: A Review.

  2017cites this paper
• Biological hypotheses and biomarkers of bipolar disorder

  2017cites this paper
• Neuroplasticity in Bipolar Disorder: Insights from Neuroimaging

  2017cites this paper
• Metabotropic glutamate receptors as emerging research targets in bipolar disorder.

  2017cites this paper
• Ultra-High-Field Magnetic Resonance Spectroscopy in Psychiatry

  2017cites this paper
• Molecular Mechanisms of Bipolar Disorder: Progress Made and Future Challenges

  2017cites this paper
• Neurochemical alterations in anterior cingulate cortex in bipolar disorder: a proton magnetic resonance spectroscopy study (1H-MRS).

  2016cites this paper
• Evaluation of neuron-glia integrity by in vivo proton magnetic resonance spectroscopy: Implications for psychiatric disorders.

  2016cites this paper
• Proteomics strategies for bipolar disorder evaluation: From sample preparation to validation.

  2016cites this paper
• Neurodevelopmental origins of bipolar disorder: iPSC models.

  2016cites this paper
• The identification of metabolic disturbances in the prefrontal cortex of the chronic restraint stress rat model of depression.

  2016cites this paper
• Areas of controversy in neuroprogression in bipolar disorder

  2016cites this paper
• Quantification by the fast Padé transform of magnetic resonance spectroscopic data encoded at 1.5 T: implications for brain tumor diagnostics

  2016cites this paper