Blood-Brain Barrier In Vitro Models and Their Application in Toxicology: The Report and Recommendations of ECVAM Workshop 491,2

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Alternatives to laboratory animals : ATLA

• Publication date

  2004-03-01

• Fields of study

  Medicine, Environmental Science

• Identifiers
  DOI 10.1177/026119290403200107PMID 15603552
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Development of an in vitro blood-brain barrier model-cytotoxicity of mercury and aluminum.

  2004cited by this paper
• Functional Clarification of MCT1-Mediated Transport of Monocarboxylic Acids at the Blood-Brain Barrier Using In Vitro Cultured Cells and In Vivo BUI Studies

  2004cited by this paper
• Tyrosine phosphatase inhibition induces loss of blood-brain barrier integrity by matrix metalloproteinase-dependent and -independent pathways.

  2004cited by this paper
• Biokinetic and Toxicodynamic Modelling and its Role in Toxicological Research and Risk Assessment

  2003cited by this paper
• Pharmacological investigations on lipopolysaccharide-induced permeability changes in the blood-brain barrier in vitro.

  2003cited by this paper
• Serum-derived factors weaken the barrier properties of cultured porcine brain capillary endothelial cells in vitro.

  2003cited by this paper
• Characterisation of the brain multidrug resistance protein (BMDP/ABCG2/BCRP) expressed at the blood-brain barrier.

  2003cited by this paper
• Refining In Vitro Neurotoxicity Testing — The Development of Blood–Brain Barrier Models

  2003cited by this paper
• Drug efflux transporters in the CNS.

  2003cited by this paper
• Lipids in blood-brain barrier models in vitro II: Influence of glial cells on lipid classes and lipid fatty acids

  2002cited by this paper
• Prediction of Drug Transport Through the Blood-Brain Barrier in Vivo: A Comparison Between Two in Vitro Cell Models

  2002cited by this paper
• Predicting Blood-Brain Barrier Permeability of Drugs: Evaluation of Different In Vitro Assays

  2002cited by this paper
• Bladder carcinoma cell line ECV304 is not a model system for endothelial cells

  2002cited by this paper
• Choroid Plexus Transporters for Drugs and Other Xenobiotics

  2002cited by this paper
• Assessment of blood-brain barrier penetration: in silico, in vitro and in vivo.

  2002cited by this paper
• Characteristic gene expression profile of primary human cerebral endothelial cells

  2002cited by this paper
• Alternative (Non-Animal) Methods for Chemicals Testing: Current Status and Future Prospects (A Report Prepared by ECVAM and the ECVAM WG on Chemicals)

  2002cited by this paper
• In Vitro Models of the Blood-Brain Barrier: When to Use Which?

  2002cited by this paper
• Expression and adhesive properties of basement membrane proteins in cerebral capillary endothelial cell cultures

  2002cited by this paper
• Drug transporters in the central nervous system: brain barriers and brain parenchyma considerations.

  2001cited by this paper
• Glucocorticoid and type 1 interferon interactions at the blood–brain barrier: relevance for drug therapies for multiple sclerosis

  2001cited by this paper
• P-glycoprotein efflux at the blood-brain barrier mediates differences in brain disposition and pharmacodynamics between two structurally related neurokinin-1 receptor antagonists.

  2001cited by this paper
• Establishment and functional characterization of an in vitro model of the blood-brain barrier, comprising a co-culture of brain capillary endothelial cells and astrocytes.

  2001cited by this paper
• *NO and oxyradical metabolism in new cell lines of rat brain capillary endothelial cells forming the blood-brain barrier.

  2001cited by this paper
• Recent Advances in the Development of Cell Culture Models for the Blood-Brain- and Blood-CSF-Barrier

  2001cited by this paper
• Porcine choroid plexus epithelial cells in culture: Regulation of barrier properties and transport processes

  2001cited by this paper
• Efflux transport systems for drugs at the blood-brain barrier and blood-cerebrospinal fluid barrier (Part 1).

  2001cited by this paper
• Neurotrophic and neuroprotective actions of estrogens and their therapeutic implications.

  2001cited by this paper
• Pluronic P85 enhances the delivery of digoxin to the brain: in vitro and in vivo studies.

  2001cited by this paper
• Conditionally immortalized cell lines as a new in vitro model for the study of barrier functions.

  2001cited by this paper
• Notch4 and Jagged-1 induce microvessel differentiation of rat brain endothelial cells.

  2000cited by this paper
• Empirical relations predicting human and rat tissue:air partition coefficients of volatile organic compounds.

  2000cited by this paper
• Blood—Brain Barrier Is Involved in the Efflux Transport of a Neuroactive Steroid, Dehydroepiandrosterone Sulfate, via Organic Anion Transporting Polypeptide 2

  2000cited by this paper
• Neural Induction of the Blood–Brain Barrier: Still an Enigma

  2000cited by this paper
• Neurons and ECM regulate occludin localization in brain endothelial cells

  2000cited by this paper
• Induction of blood-brain barrier properties in immortalized bovine brain endothelial cells by astrocytic factors.

  1999cited by this paper
• Estimation of systemic toxicity of acrylamide by integration of in vitro toxicity data with kinetic simulations.

  1999cited by this paper
• Receptor-mediated Transcytosis of Lactoferrin through the Blood-Brain Barrier*

  1999cited by this paper
• An Integrated Approach to the Prediction of Systemic Toxicity using Computer-based Biokinetic Models and Biological In vitro Test Methods: Overview of a Prevalidation Study Based on the ECITTS Project.

  1999cited by this paper
• ECV304 (endothelial) is really T24 (bladder carcinoma): Cell line cross-contamination at source

  1999cited by this paper
• The cell biology of the blood-brain barrier.

  1999cited by this paper
• In vitro model for evaluating drug transport across the blood-brain barrier.

  1999cited by this paper
• Demonstration of a Coupled Metabolism–Efflux Process at the Choroid Plexus as a Mechanism of Brain Protection Toward Xenobiotics

  1999cited by this paper
• Role of kinetics in acute lethality of nonreactive volatile organic compounds (VOCs).

  1998cited by this paper
• Inhibition of P-Glycoprotein: Rapid Assessment of Its Implication in Blood-Brain Barrier Integrity and Drug Transport to the Brain by an In Vitro Model of the Blood-Brain Barrier

  1998cited by this paper
• In vitro models of the blood-brain barrier.

  1998cited by this paper
• Immortalized mouse brain endothelial cells are ultrastructurally similar to endothelial cells and respond to astrocyte-conditioned medium

  1998cited by this paper
• Hydrocortisone reinforces the blood-brain barrier properties in a serum free cell culture system.

  1998cited by this paper
• Understanding the Physiology of the Blood-Brain Barrier: In Vitro Models.

  1998cited by this paper
• Development of immortalized human cerebromicrovascular endothelial cell line as an in vitro model of the human blood–brain barrier

  1997cited by this paper
• Bovine brain microvascular endothelial cells transfected with SV40-large T antigen: Development of an immortalized cell line to study pathophysiology of CNS disease

  1997cited by this paper
• A quantitative property-property relationship (QPPR) approach to estimate in vitro tissue-blood partition coefficients of organic chemicals in rats and humans

  1997cited by this paper
• The blood-brain barrier in neuroinflammatory diseases.

  1997cited by this paper
• Endothelin-1 as a Mediator of Endothelial Cell–Pericyte Interactions in Bovine Brain Capillaries

  1997cited by this paper
• Plasmodium falciparum: involvement of additional receptors in the cytoadherence of infected erythrocytes to microvascular endothelial cells.

  1996cited by this paper
• Studies of Plasmodium falciparum cytoadherence using immortalized human brain capillary endothelial cells.

  1996cited by this paper
• Establishment of the permanent microvascular endothelial cell line PBMEC/C1-2 from porcine brains.

  1996cited by this paper
• Receptor-mediated transcytosis of transferrin through blood-brain barrier endothelial cells.

  1996cited by this paper
• Characterization of the MDCK cell line for screening neurotoxicants.

  1996cited by this paper
• A tissue composition-based algorithm for predicting tissue:air partition coefficients of organic chemicals.

  1996cited by this paper
• SV40 large T immortalised cell lines of the rat blood-brain and blood-retinal barriers retain their phenotypic and immunological characteristics.

  1996cited by this paper
• Determination of Critical Cellular Neurotoxic Concentrations in Human Neuroblastoma (SH-SY5Y) Cell Cultures

  1995cited by this paper
• Drug transport to the brain: comparison between in vitro and in vivo models of the blood-brain barrier

  1995cited by this paper
• Induction of blood-brain barrier differentiation in a rat brain-derived endothelial cell line.

  1995cited by this paper
• Regulation of gamma‐glutamyl transpeptidase and alkaline phosphatase activities in immortalized rat brain microvessel endothelial cells

  1994cited by this paper
• Receptor‐Linked Hydrolysis of Phosphoinositides and Production of Prostacyclin in Cerebral Endothelial Cells

  1992cited by this paper
• [Functional involvement of P-glycoprotein in blood-brain barrier].

  1992cited by this paper
• Functional involvement of P-glycoprotein in blood-brain barrier.

  1992cited by this paper
• Physiological modelling of organic compounds.

  1991cited by this paper
• Immortalization of brain capillary endothelial cells with maintenance of structural characteristics of the blood-brain barrier endothelium

  1991cited by this paper
• Production of a transforming growth factor-beta-like growth factor by RSV-transformed rat cerebral microvascular endothelial cells.

  1991cited by this paper
• An Easier, Reproducible, and Mass‐Production Method to Study the Blood–Brain Barrier In Vitro

  1990cited by this paper
• Bovine Brain Endothelial Cells Express Tight Junctions and Monoamine Oxidase Activity in Long‐Term Culture

  1989cited by this paper

• BBB-Permeable PROTACs: Where Do We Stand?

  2026cites this paper
• Role of rosiglitazone in experimental Wistar rats model of neurodegeneration: Effect of peroxisome proliferator-activated receptors-γ as advanced glycation endproducts receptor of advanced glycation endproducts axis inhibitor

  2025cites this paper
• Bifunctional iRGD-Exo-DOX crosses the blood-brain barrier to target central nervous system lymphoma.

  2024cites this paper
• Refined Qingkailing protects the in vitro neurovascular unit against oxygen-glucose deprivation and re-oxygenation-induced injury.

  2023cites this paper
• A Microfluidic Multisize Spheroid Array for Multiparametric Screening of Anticancer Drugs and Blood–Brain Barrier Transport Properties

  2021cites this paper
• Human iPSC-Derived Blood-Brain Barrier Models: Valuable Tools for Preclinical Drug Discovery and Development?

  2020cites this paper
• Circulating MicroRNAs and Blood-Brain-Barrier Function in Breast Cancer Metastasis

  2020cites this paper
• Evaluation of the Influence of Astrocytes on In Vitro Blood–Brain Barrier Models

  2020cites this paper
• A mode-of-action ontology model for safety evaluation of chemicals: Outcome of a series of workshops on repeated dose toxicity.

  2019cites this paper
• Species-specific models in toxicology: in vitro epithelial barriers.

  2019cites this paper
• The effects of gold nanoparticles functionalized with ß-amyloid specific peptides on an in vitro model of blood-brain barrier.

  2017cites this paper
• [Modelling of the blood-brain barrier].

  2017cites this paper
• In vitro acute and developmental neurotoxicity screening: an overview of cellular platforms and high-throughput technical possibilities

  2016cites this paper
• A TEM protocol for quality assurance of in vitro cellular barrier models and its application to the assessment of nanoparticle transport mechanisms across barriers.

  2015cites this paper
• The blood-brain barrier: Structure, function and therapeutic approaches to cross it

  2014cites this paper
• Blood-brain barrier models and their relevance for a successful development of CNS drug delivery systems: a review.

  2014cites this paper
• Biological and medical applications of a brain-on-a-chip

  2014cites this paper
• Blood-brain barrier (BBB) toxicity and permeability assessment after L-(4-¹⁰Boronophenyl)alanine, a conventional B-containing drug for boron neutron capture therapy, using an in vitro BBB model.

  2014cites this paper
• In Vitro Approaches to Predictive Biokinetics

  2014cites this paper
• Blood–Brain Barrier In Vitro Models and Their Applications in Toxicology

  2014cites this paper
• A Stable and Reproducible Human Blood-Brain Barrier Model Derived from Hematopoietic Stem Cells

  2014cites this paper
• In Vivo Approaches to Assessing the Blood–Brain Barrier

  2013cites this paper
• Prevention of rt-PA induced blood-brain barrier component degradation by the poly(ADP-ribose)polymerase inhibitor PJ34 after ischemic stroke in mice.

  2013cites this paper
• High-throughput screening in traditional Chinese medicine-based drug discovery

  2013cites this paper
• Glial‐cell‐mediated re‐induction of the blood‐brain barrier phenotype in brain capillary endothelial cells: A differential gel electrophoresis study

  2013cites this paper
• Establishment of a simplified in vitro porcine blood–brain barrier model with high transendothelial electrical resistance

  2013cites this paper
• Proteomic Analysis of Plasma Membrane Proteins in an In Vitro Blood-Brain Barrier Model

  2012cites this paper
• Analysis of the proposed EU regulation concerning biocide products and its opportunities for alternative approaches and a toxicology for the 21st century

  2012cites this paper
• Brainpeps: the blood–brain barrier peptide database

  2012cites this paper
• Transferrin-conjugated boron nitride nanotubes: protein grafting, characterization, and interaction with human endothelial cells.

  2012cites this paper
• Nanotechnological advances for the delivery of CNS therapeutics.

  2012cites this paper
• Modelling the neurovascular unit and the blood-brain barrier with the unique function of pericytes.

  2011cites this paper
• Report from the EPAA workshop: in vitro ADME in safety testing used by EPAA industry sectors.

  2011cites this paper
• Modelling the Blood–Brain Barrier

  2011cites this paper
• Potential approaches for drug delivery to the brain: past, present, and future.

  2010cites this paper
• Biokinetic Modeling and in Vitro–in Vivo Extrapolations

  2010cites this paper
• The Blood – Brain Barrier and its Effect on Absorption and Distribution

  2010cites this paper
• Relevance of in vitro neurotoxicity testing for regulatory requirements: challenges to be considered.

  2010cites this paper
• New strategy for alerting central nervous system toxicity: Integration of blood-brain barrier toxicity and permeability in neurotoxicity assessment.

  2009cites this paper
• Twenty-First Century Challenges for In Vitro Neurotoxicity

  2009cites this paper
• An in vitro blood-brain barrier model for high throughput (HTS) toxicological screening.

  2008cites this paper
• The contribution of in vitro toxicity data in hazard and risk assessment: current limitations and future perspectives.

  2008cites this paper
• Alternative methods to safety studies in experimental animals: role in the risk assessment of chemicals under the new European Chemicals Legislation (REACH)

  2008influential citation
• Application of in vitro neurotoxicity testing for regulatory purposes: Symposium III summary and research needs.

  2008cites this paper
• Workgroup Report: Incorporating In Vitro Alternative Methods for Developmental Neurotoxicity into International Hazard and Risk Assessment Strategies

  2007cites this paper
• Automated Cell Cultivation on a Well-Plate

  2007cites this paper
• Effects of Bacterial Toxins on Endothelial Tight Junction In Vitro: A Mechanism-Based Investigation

  2007cites this paper
• The value of alternative testing for neurotoxicity in the context of regulatory needs.

  2006cites this paper
• Lab automation in cultivation of adherent cells

  2006cites this paper
• The Assessment of Repeated Dose Toxicity In Vitro: A Proposed Approach

  2006cites this paper
• Blood‐brain barrier‐specific properties of a human adult brain endothelial cell line

  2005cites this paper
• Modelos alternativos in vitro para el estudio y la evaluación de neurotoxicidad

  2005cites this paper
• The MAP kinase pathway mediates transcytosis induced by TNF‐α in an in vitro blood–brain barrier model

  2005cites this paper
• Prediction of blood-brain barrier permeation in drug discovery from in vivo, in vitro and in silico models.

  2004cites this paper