Mechanisms underlying recoupling of eNOS by HMG-CoA reductase inhibition in a rat model of streptozotocin-induced diabetes mellitus.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Atherosclerosis

• Publication date

  2008-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.ATHEROSCLEROSIS.2007.10.003PMID 18061195PMCID PMC2889614
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Age-Dependent Impairment of Endothelial Progenitor Cells Is Corrected by Growth Hormone Mediated Increase of Insulin-Like Growth Factor-1

  2007influential reference
• Telmisartan improves vascular function and reduces platelet activation in rats with streptozotocin-induced diabetes mellitus.

  2007cited by this paper
• Endothelial Nitric Oxide Synthase Uncoupling Impairs Endothelial Progenitor Cell Mobilization and Function in Diabetes

  2007cited by this paper
• Proteasome-Dependent Degradation of Guanosine 5-Triphosphate Cyclohydrolase I Causes Tetrahydrobiopterin Deficiency in Diabetes Mellitus

  2007cited by this paper
• Role of Reduced Lipoic Acid in the Redox Regulation of Mitochondrial Aldehyde Dehydrogenase (ALDH-2) Activity

  2007cited by this paper
• Bone marrow molecular alterations after myocardial infarction: Impact on endothelial progenitor cells.

  2006cited by this paper
• Endothelial Nitric Oxide Synthase in Vascular Disease: From Marvel to Menace

  2006cited by this paper
• Uncoupling of Endothelial Nitric Oxidase Synthase by Hypochlorous Acid: Role of NAD(P)H Oxidase–Derived Superoxide and Peroxynitrite

  2006cited by this paper
• Serial Review : The Role of Oxidative Stress in Diabetes mellitus Serial Review

  2006cited by this paper
• Tetrahydrobiopterin and Cardiovascular Disease

  2006cited by this paper
• 5-Methyltetrahydrofolate Rapidly Improves Endothelial Function and Decreases Superoxide Production in Human Vessels: Effects on Vascular Tetrahydrobiopterin Availability and Endothelial Nitric Oxide Synthase Coupling

  2006cited by this paper
• Oxidative stress and diabetic cardiovascular complications.

  2006cited by this paper
• Endothelial nitric oxide synthase dysfunction in diabetic mice: importance of tetrahydrobiopterin in eNOS dimerisation

  2005cited by this paper
• Dysregulation of the endothelial nitric oxide synthase-soluble guanylate cyclase pathway is normalized by insulin in the aorta of diabetic rat.

  2005cited by this paper
• Delivery of exogenous tetrahydrobiopterin (BH4) to cells of target organs: role of salvage pathway and uptake of its precursor in effective elevation of tissue BH4.

  2005cited by this paper
• Differential effects of diabetes on the expression of the gp91phox homologues nox1 and nox4.

  2005cited by this paper
• Circulating endothelial progenitor cells are reduced in peripheral vascular complications of type 2 diabetes mellitus.

  2005cited by this paper
• CD14+CD34low Cells With Stem Cell Phenotypic and Functional Features Are the Major Source of Circulating Endothelial Progenitors

  2005cited by this paper
• CD14+CD34low Cells With Stem Cell Phenotypic and Functional Features Are the Major Source of Circulating Endothelial Progenitors

  2005influential reference
• Measurement of NAD(P)H oxidase-derived superoxide with the luminol analogue L-012.

  2004cited by this paper
• The effect of high glucose on NO and O2- through endothelial GTPCH1 and NADPH oxidase.

  2004cited by this paper
• Atorvastatin Prevents End-Organ Injury in Salt-Sensitive Hypertension: Role of eNOS and Oxidant Stress

  2004cited by this paper
• Circulating endothelial progenitor cells, vascular function, and cardiovascular risk.

  2003cited by this paper
• HMG-CoA Reductase Inhibitor Increases GTP Cyclohydrolase I mRNA and Tetrahydrobiopterin in Vascular Endothelial Cells

  2003cited by this paper
• Tetrahydrobiopterin-dependent preservation of nitric oxide-mediated endothelial function in diabetes by targeted transgenic GTP-cyclohydrolase I overexpression.

  2003cited by this paper
• Role for peroxynitrite in the inhibition of prostacyclin synthase in nitrate tolerance.

  2003cited by this paper
• HMG-CoA Reductase Inhibitors Reduce Senescence and Increase Proliferation of Endothelial Progenitor Cells via Regulation of Cell Cycle Regulatory Genes

  2003cited by this paper
• Interactions of Peroxynitrite, Tetrahydrobiopterin, Ascorbic Acid, and Thiols

  2003influential reference
• Visualizing Superoxide Production in Normal and Diabetic Rat Islets of Langerhans*

  2003cited by this paper
• Statin enhances cytokine-mediated induction of nitric oxide synthesis in vascular smooth muscle cells.

  2002cited by this paper
• Mechanisms of Increased Vascular Superoxide Production in Human Diabetes Mellitus: Role of NAD(P)H Oxidase and Endothelial Nitric Oxide Synthase

  2002cited by this paper
• Oxidation of the zinc-thiolate complex and uncoupling of endothelial nitric oxide synthase by peroxynitrite.

  2002cited by this paper
• Xanthine oxidase is involved in free radical production in type 1 diabetes: protection by allopurinol.

  2002cited by this paper
• High glucose via peroxynitrite causes tyrosine nitration and inactivation of prostacyclin synthase that is associated with thromboxane/prostaglandin H(2) receptor-mediated apoptosis and adhesion molecule expression in cultured human aortic endothelial cells.

  2002cited by this paper
• Increase in Circulating Endothelial Progenitor Cells by Statin Therapy in Patients With Stable Coronary Artery Disease

  2001cited by this paper
• ERRATA

  2001cited by this paper
• Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site.

  2001cited by this paper
• HMG-CoA reductase inhibitor mobilizes bone marrow--derived endothelial progenitor cells.

  2001cited by this paper
• Mechanisms Underlying Endothelial Dysfunction in Diabetes Mellitus

  2001influential reference
• HMG-CoA Reductase Inhibitors Improve Endothelial Dysfunction in Normocholesterolemic Hypertension via Reduced Production of Reactive Oxygen Species

  2001cited by this paper
• HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI 3-kinase/Akt pathway.

  2001cited by this paper
• Beneficial effects of alpha-lipoic acid and ascorbic acid on endothelium-dependent, nitric oxide-mediated vasodilation in diabetic patients: relation to parameters of oxidative stress.

  2001cited by this paper
• Vasodilator-Stimulated Phosphoprotein Serine 239 Phosphorylation as a Sensitive Monitor of Defective Nitric Oxide/cGMP Signaling and Endothelial Dysfunction

  2000influential reference
• Transcriptional and posttranscriptional regulation of endothelial nitric oxide synthase expression by hydrogen peroxide.

  2000cited by this paper
• The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals.

  2000cited by this paper
• Effect of atorvastatin on endothelium-dependent constrictor factors in dyslipidemic rabbits.

  2000cited by this paper
• Prostaglandin endoperoxide‐dependent vasospasm in bovine coronary arteries after nitration of prostacyclin synthase

  1999cited by this paper
• Validation of lucigenin as a chemiluminescent probe to monitor vascular superoxide as well as basal vascular nitric oxide production.

  1999cited by this paper
• Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors.

  1998cited by this paper
• Post-transcriptional Regulation of Endothelial Nitric Oxide Synthase mRNA Stability by Rho GTPase*

  1998cited by this paper
• Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone.

  1996cited by this paper
• Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus.

  1996cited by this paper

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  2020cites this paper
• The Peroxisome Proliferator-Activated Receptor-Gamma Coactivator-1α–Heme Oxygenase 1 Axis, a Powerful Antioxidative Pathway with Potential to Attenuate Diabetic Cardiomyopathy

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• Targeting oxidative stress and anti-oxidant defence in diabetic kidney disease

  2020cites this paper
• Modulation of Nitric Oxide Bioavailability Attenuates Ischemia-Reperfusion Injury in Type II Diabetes.

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• Clinically relevant endothelial nitric oxide synthase polymorphisms and their impact on drug response

  2020cites this paper
• Brahma-Related Gene 1 Deficiency in Endothelial Cells Ameliorates Vascular Inflammatory Responses in Mice

  2020cites this paper
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  2019cites this paper
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• Preparation, characterization, and pharmacodynamics of insulin-loaded fumaryl diketopiperazine microparticle dry powder inhalation

  2019cites this paper
• Reactive Oxygen Comes of Age: Mechanism-Based Therapy of Diabetic End-Organ Damage.

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• Inducible Nitric Oxide Synthase and L-Arginine Optimizes Nitric Oxide Bioavailability in Ischemic Tissues Under Diabetes Mellitus Type 1.

  2019cites this paper
• Inhalation exposure to cigarette smoke induces endothelial nitric oxide synthase uncoupling and enhances vascular collagen deposition in streptozotocin-induced diabetic rats.

  2019cites this paper
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  2019cites this paper
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  2015cites this paper
• The Role of Endothelial Dysfunction in Aortic Aneurysms.

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• eNOS uncoupling in cardiovascular diseases--the role of oxidative stress and inflammation.

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