LRP6 exerts non-canonical effects on Wnt signaling during neural tube closure.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Human Molecular Genetics

• Publication date

  2013-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/hmg/ddt277PMID 23773994PMCID PMC3792688
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2008cited by this paper
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  2005cited by this paper
• Neurulation in the cranial region – normal and abnormal

  2005cited by this paper
• Cdc42 - the centre of polarity

  2004cited by this paper
• Wnt Proteins Induce Dishevelled Phosphorylation via an LRP5/6- Independent Mechanism, Irrespective of Their Ability To Stabilize β-Catenin

  2004cited by this paper
• The Wnt signaling pathway in development and disease.

  2004cited by this paper
• β‐catenin signaling marks the prospective site of primitive streak formation in the mouse embryo

  2004cited by this paper
• A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling.

  2003cited by this paper
• Cdc42 regulates GSK-3β and adenomatous polyposis coli to control cell polarity

  2003cited by this paper
• Shroom induces apical constriction and is required for hingepoint formation during neural tube closure.

  2003cited by this paper
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• Activation of Gβγ signaling downstream of Wnt-11/Xfz7 regulates Cdc42 activity during Xenopus gastrulation

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• Role of beta-catenin in the developing cortical and hippocampal neuroepithelium.

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• Faculty Opinions recommendation of Cdc42 regulates GSK-3beta and adenomatous polyposis coli to control cell polarity.

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• Activation of Gbetagamma signaling downstream of Wnt-11/Xfz7 regulates Cdc42 activity during Xenopus gastrulation.

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• Mesd encodes an LRP5/6 chaperone essential for specification of mouse embryonic polarity.

  2003cited by this paper
• Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism.

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• Neural tube closure requires Dishevelled-dependent convergent extension of the midline

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  2002cited by this paper
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  2001cited by this paper
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  2001cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
• Crooked tail (Cd) models human folate-responsive neural tube defects.

  1999cited by this paper
• Abnormalities of floor plate, notochord and somite differentiation in the loop-tail (Lp) mouse: a model of severe neural tube defects.

  1998cited by this paper
• Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a.

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  1997cited by this paper
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  1995cited by this paper
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  1990cited by this paper
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  1987cited by this paper
• Surface modifications of neural epithelial cells during formation of the neural tube in the rat embryo.

  1972cited by this paper
• Neurulation in Xenopus laevis. An analysis and model based upon light and electron microscopy.

  1970cited by this paper
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  1967cited by this paper

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