Stability elements in the LRP6 cytoplasmic tail confer efficient signalling upon DIX-dependent polymerization

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Journal of Cell Science

• Publication date

  2010-05-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1242/jcs.067546PMID 20388731PMCID PMC2858023
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Proximal events in Wnt signal transduction

  2009cited by this paper
• Wnt/beta-catenin signaling: components, mechanisms, and diseases.

  2009cited by this paper
• Inhibition of GSK3 Phosphorylation of β-Catenin via Phosphorylated PPPSPXS Motifs of Wnt Coreceptor LRP6

  2009influential reference
• The role of the Ser/Thr cluster in the phosphorylation of PPPSP motifs in Wnt coreceptors.

  2009cited by this paper
• LRP6 transduces a canonical Wnt signal independently of Axin degradation by inhibiting GSK3's phosphorylation of β-catenin

  2008influential reference
• Direct Inhibition of GSK3β by the Phosphorylated Cytoplasmic Domain of LRP6 in Wnt/β-Catenin Signaling

  2008influential reference
• Wnt3a and Dkk1 regulate distinct internalization pathways of LRP6 to tune the activation of beta-catenin signaling.

  2008influential reference
• Wnt Induces LRP6 Signalosomes and Promotes Dishevelled-Dependent LRP6 Phosphorylation

  2007influential reference
• Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions

  2007influential reference
• Dynamic recruitment of axin by Dishevelled protein assemblies

  2007influential reference
• The DIX domain of Dishevelled confers Wnt signaling by dynamic polymerization

  2007influential reference
• Regulated proteolytic processing of LRP6 results in release of its intracellular domain

  2007cited by this paper
• The Low Density Lipoprotein Receptor-related Protein 6 Interacts with Glycogen Synthase Kinase 3 and Attenuates Activity*

  2006influential reference
• Caveolin Is Necessary for Wnt-3a-Dependent Internalization of LRP6 and Accumulation of β-Catenin

  2006cited by this paper
• Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin.

  2006cited by this paper
• Wnt/beta-catenin signaling in development and disease.

  2006influential reference
• Casein kinase 1 γ couples Wnt receptor activation to cytoplasmic signal transduction

  2005influential reference
• A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation

  2005influential reference
• Dishevelled (Dvl-2) activates canonical Wnt signalling in the absence of cytoplasmic puncta

  2005influential reference
• Interaction between LRP5 and Frat1 Mediates the Activation of the Wnt Canonical Pathway*

  2005cited by this paper
• Role of the intracellular domains of LRP5 and LRP6 in activating the Wnt canonical pathway

  2005influential reference
• The Wnt signalling effector Dishevelled forms dynamic protein assemblies rather than stable associations with cytoplasmic vesicles

  2005influential reference
• Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction.

  2005cited by this paper
• Truncated mutants of the putative Wnt receptor LRP6/Arrow can stabilize β-catenin independently of Frizzled proteins

  2004influential reference
• Wnt signals across the plasma membrane to activate the β-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP

  2004cited by this paper
• The Wnt signaling pathway in development and disease.

  2004cited by this paper
• A mechanism for Wnt coreceptor activation.

  2004influential reference
• Zebrafish prickle, a modulator of noncanonical Wnt/Fz signaling, regulates gastrulation movements.

  2003cited by this paper
• Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled.

  2003cited by this paper
• The Roles of APC and Axin Derived from Experimental and Theoretical Analysis of the Wnt Pathway

  2003cited by this paper
• A role of Dishevelled in relocating Axin to the plasma membrane during wingless signaling.

  2003influential reference
• Wg/Wnt signal can be transmitted through arrow/LRP5,6 and Axin independently of Zw3/Gsk3beta activity.

  2003influential reference
• Structural basis for recruitment of glycogen synthase kinase 3β to the axin—APC scaffold complex

  2003cited by this paper
• Wnt pathway activation in mesothelioma: evidence of Dishevelled overexpression and transcriptional activity of beta-catenin.

  2003cited by this paper
• Second Cysteine-rich Domain of Dickkopf-2 Activates Canonical Wnt Signaling Pathway via LRP-6 Independently of Dishevelled*

  2002cited by this paper
• Proteolytic Processing of Low Density Lipoprotein Receptor-related Protein Mediates Regulated Release of Its Intracellular Domain*

  2002cited by this paper
• LDL-receptor-related protein 6 is a receptor for Dickkopf proteins

  2001influential reference
• Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway.

  2001influential reference
• LDL-receptor-related proteins in Wnt signal transduction

  2000cited by this paper
• arrow encodes an LDL-receptor-related protein essential for Wingless signalling

  2000influential reference
• Negative regulation of Wingless signaling by D-axin, a Drosophila homolog of axin.

  1999influential reference
• DIX Domains of Dvl and Axin Are Necessary for Protein Interactions and Their Ability To Regulate β-Catenin Stability

  1999cited by this paper
• A Heptad Motif of Leucine Residues Found in Membrane Proteins Can Drive Self-assembly of Artificial Transmembrane Segments*

  1999cited by this paper
• Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC−/− Colon Carcinoma

  1997cited by this paper
• Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF.

  1997cited by this paper
• Dimerisation of the glycophorin A transmembrane segment in membranes probed with the ToxR transcription activator.

  1996cited by this paper

• Wnt signalosome assembly is governed by conformational flexibility of Axin and by the AP2 clathrin adaptor

  2025cites this paper
• The Actin regulator Mena promotes Wnt signalosome endocytosis and Wnt signalling

  2025cites this paper
• The emerging role of receptor trafficking in signalosome formation and sustained long-term Wnt/β-catenin signaling

  2025cites this paper
• Anti-resonance in developmental signaling regulates cell fate decisions

  2025cites this paper
• Crosstalk between CAFs and tumour cells in head and neck cancer

  2024cites this paper
• Exploring DIX-DIX Homo- and Hetero-Oligomers in Wnt Signaling with AlphaFold2

  2024cites this paper
• RSPO3 induced by Helicobacter pylori extracts promotes gastric cancer stem cell properties through the GNG7/β‐catenin signaling pathway

  2024cites this paper
• Oncogenic signaling-mediated regulation of chromatin during tumorigenesis

  2023cites this paper
• A single-component, light-assisted uncaging switch for endoproteolytic release

  2023cites this paper
• A rationally designed optochemogenetic switch for activating canonical Wnt signaling

  2023cites this paper
• Vitamin B6 is governed by the local compartmentalization of metabolic enzymes during growth

  2023cites this paper
• Dishevelled: An emerging therapeutic oncogene in human cancers.

  2023cites this paper
• A comprehensive insight into the correlation between ncRNAs and the Wnt/β-catenin signalling pathway in gastric cancer pathogenesis

  2023cites this paper
• Wnt/β-catenin signaling inhibitors.

  2023cites this paper
• Dysregulation of cellular membrane homeostasis as a crucial modulator of cancer risk

  2022cites this paper
• Signaling pathways of adipose stem cell-derived exosomes promoting muscle regeneration

  2022cites this paper
• Dishevelled phase separation promotes Wnt signalosome assembly and destruction complex disassembly

  2022cites this paper
• MicroRNAs regulating Wnt signaling pathway in colorectal cancer: biological implications and clinical potentials

  2022cites this paper
• Superresolution microscopy localizes endogenous Dvl2 to Wnt signaling-responsive biomolecular condensates

  2022cites this paper
• Biofunctional nanodot arrays in living cells uncover synergistic co-condensation of Wnt signalodroplets

  2022cites this paper
• Protein proximity networks and functional evaluation of the casein kinase 1 gamma family reveal unique roles for CK1γ3 in WNT signaling

  2022cites this paper
• Targeting Epigenetic Modifiers of Tumor Plasticity and Cancer Stem Cell Behavior

  2022cites this paper
• Bufalin Suppresses Colorectal Cancer Cells by the Blockade of Canonical Wnt Signaling Pathway

  2022cites this paper
• DACT3 has a tumor‐inhibiting role in acute myeloid leukemia via the suppression of Wnt/β‐catenin signaling by DVL2

  2022cites this paper
• SiNiSan alleviates liver injury by promoting hepatic stem cell differentiation via Wnt/β-catenin signaling pathway.

  2022cites this paper
• Protein proximity networks and functional evaluation of the Casein Kinase 1 γ family reveals unique roles for CK1γ3 in WNT signaling

  2021cites this paper
• Tweaking EMT and MDR dynamics to constrain triple-negative breast cancer invasiveness by EGFR and Wnt/β-catenin signaling regulation

  2021cites this paper
• A guide-tag system controlling client enrichment into Y15 peptide-based granules for an in-cell protein recruitment assay.

  2021cites this paper
• The Interaction between microRNAs and the Wnt/β-Catenin Signaling Pathway in Osteoarthritis

  2021cites this paper
• Regulation of the Low-Density Lipoprotein Receptor-Related Protein LRP6 and Its Association With Disease: Wnt/β-Catenin Signaling and Beyond

  2021cites this paper
• Zooming in on the WNT/CTNNB1 Destruction Complex: Functional Mechanistic Details with Implications for Therapeutic Targeting.

  2021cites this paper
• Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer

  2021cites this paper
• Volumetric Compression Induces Intracellular Crowding to Control Intestinal Organoid Growth via Wnt/β-Catenin Signaling.

  2021cites this paper
• Optogenetic control of the canonical Wnt signaling pathway during Xenopus laevis embryonic development.

  2021cites this paper
• optoLRP6 Illuminates Wnt Signaling In Early Embryo Development.

  2021cites this paper
• Targeting leukemia stem cells in T-cell acute lymphoblastic leukemia (T-ALL)

  2021cites this paper
• WNT5a in Colorectal Cancer: Research Progress and Challenges

  2021cites this paper
• Activated ALK Cooperates with N-Myc via Wnt/β-Catenin Signaling to Induce Neuroendocrine Prostate Cancer

  2021cites this paper
• Targeting cancer stem cell pathways for cancer therapy

  2020cites this paper
• CMAR_A_252232 3981..3993

  2020cites this paper
• Volumetric Compression Induces Intracellular Crowding to Control Intestinal Organoid Growth via Wnt/β-Catenin Signaling.

  2020cites this paper
• Wnt signaling recruits KIF2A to the spindle to ensure chromosome congression and alignment during mitosis

  2020cites this paper
• KLHL22 Regulates the EMT and Proliferation in Colorectal Cancer Cells in Part via the Wnt/β-Catenin Signaling Pathway

  2020cites this paper
• Wnt signalling pathway in bladder cancer.

  2020cites this paper
• Inhibition of the Wnt Signalling Pathway: An Avenue to Control Breast Cancer Aggressiveness

  2020cites this paper
• WNT/β-catenin pathway activation via Wnt1 overexpression and Axin1 downregulation correlates with cadherin-catenin complex disruption and increased lymph node involvement in micropapillary-predominant lung adenocarcinoma

  2020cites this paper
• Canonical WNT pathway is activated in the airway epithelium in chronic obstructive pulmonary disease

  2020cites this paper
• Interplay Between Ion Channels and the Wnt/β-Catenin Signaling Pathway in Cancers

  2020cites this paper
• THE RELATIONSHIP BETWEEN WNT (WINGLESS/INT) PATHWAYS REACTIVE OXYGEN SPECIES (ROS) AND CANCER

  2019cites this paper
• WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop

  2019cites this paper
• The Wnt signaling pathway: a potential therapeutic target against cancer

  2019cites this paper
• Wnt canonical pathway activates macropinocytosis and lysosomal degradation of extracellular proteins

  2019cites this paper
• Deciphering the Role of WNT Signaling in Metabolic Syndrome–Linked Alzheimer’s Disease

  2019cites this paper
• Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex

  2019cites this paper
• Investigating the Role of Wnt Signalling and Identifying of Novel Fitness Genes in Glioblastoma

  2019cites this paper
• Designing cell function: assembly of synthetic gene circuits for cell biology applications

  2018cites this paper
• Interaction between Wnt/β-catenin and RAS-ERK pathways and an anti-cancer strategy via degradations of β-catenin and RAS by targeting the Wnt/β-catenin pathway

  2018cites this paper
• Supramolecular assembly of the beta-catenin destruction complex and the effect of Wnt signaling on its localization, molecular size, and activity in vivo

  2018cites this paper
• RHBDF1 regulates APC‐mediated stimulation of the epithelial‐to‐mesenchymal transition and proliferation of colorectal cancer cells in part via the Wnt/&bgr;‐catenin signalling pathway

  2018cites this paper
• Functional link between plasma membrane spatiotemporal dynamics, cancer biology, and dietary membrane-altering agents

  2018cites this paper
• Therapeutic potential of targeting the Wnt/β‐catenin pathway in the treatment of pancreatic cancer

  2018cites this paper
• Integrating regulatory mechanisms of Wnt signaling in development and tissue homeostasis

  2017cites this paper
• Constitutive scaffolding of multiple Wnt enhanceosome components by Legless/BCL9

  2017cites this paper
• A Comparative Perspective on Wnt/β-Catenin Signalling in Cell Fate Determination.

  2017cites this paper
• Membrane Targeting of Disheveled Can Bypass the Need for Arrow/LRP5

  2017cites this paper
• The phosphatase Pgam5 antagonizes Wnt/β-Catenin signaling in embryonic anterior-posterior axis patterning

  2017cites this paper
• Gtpbp2 is a positive regulator of Wnt signaling and maintains low levels of the Wnt negative regulator Axin

  2016cites this paper
• Inhibition of disheveled-2 resensitizes cisplatin-resistant lung cancer cells through down-regulating Wnt/β-catenin signaling.

  2016cites this paper
• Generating Cellular Diversity and Spatial Form: Wnt Signaling and the Evolution of Multicellular Animals.

  2016cites this paper
• Wnt signaling in cancer

  2016cites this paper
• Essential role of the Dishevelled DEP domain in a Wnt-dependent human-cell-based complementation assay

  2016influential citation
• Wnt Signalosome Assembly by DEP Domain Swapping of Dishevelled

  2016cites this paper
• Silencing dishevelled‐1 sensitizes paclitaxel‐resistant human ovarian cancer cells via AKT/GSK‐3β/β‐catenin signalling

  2015cites this paper
• Spatio-temporal Model of Endogenous ROS and Raft-Dependent WNT/Beta-Catenin Signaling Driving Cell Fate Commitment in Human Neural Progenitor Cells

  2015cites this paper
• The evolving roles of canonical WNT signaling in stem cells and tumorigenesis: Implications in targeted cancer therapies

  2015cites this paper
• Disinhibition of the HECT E3 ubiquitin ligase WWP2 by polymerized Dishevelled

  2015cites this paper
• Ras-activated Dsor1 promotes Wnt signaling in Drosophila development

  2015cites this paper
• Regulation of endogenous transmembrane receptors through optogenetic Cry2 clustering

  2015cites this paper
• Maternal Wnt/STOP signaling promotes cell division during early Xenopus embryogenesis

  2015cites this paper
• Endocytosis and signaling during development.

  2014cites this paper
• 14‐3‐3 and β‐catenin are secreted on extracellular vesicles to activate the oncogenic Wnt pathway

  2014cites this paper
• Signalosome assembly by domains undergoing dynamic head-to-tail polymerization.

  2014cites this paper
• Wnt Signaling in Skin Development, Homeostasis,

  2014cites this paper
• In vivo analysis of formation and endocytosis of the Wnt/β-Catenin signaling complex in zebrafish embryos

  2014cites this paper
• Dynamic Regulation of Mammalian Cell Signaling through Optical Protein Clustering

  2014influential citation
• Mitotic wnt signaling promotes protein stabilization and regulates cell size.

  2014cites this paper
• New insights into the regulation of Axin function in canonical Wnt signaling pathway

  2014influential citation
• The role of canonical and non-canonical WNT signalling pathways in load induced cartilage degradation

  2014cites this paper
• Optogenetic protein clustering and signaling activation in mammalian cells

  2013cites this paper
• Carboxypeptidase E: a negative regulator of the canonical Wnt signaling pathway

  2013cites this paper
• LRP6 exerts non-canonical effects on Wnt signaling during neural tube closure.

  2013cites this paper
• Ubiquitin & Wnt: The diverse roles of ubiquitin in canonical Wnt signalling

  2013cites this paper
• LRP 6 exerts non-canonical effects on Wnt signaling during neural tube closure

  2013cites this paper
• DURING NEURAL TUBE CLOSURE

  2013cites this paper
• Frizzled and LRP5/6 receptors for Wnt/β-catenin signaling.

  2012cites this paper
• Wnt/beta-Catenin Signaling and Small Molecule Inhibitors

  2012cites this paper
• Cortical localization of APC2 plays a role in actin organization but not in Wnt signaling in Drosophila

  2011cites this paper
• Transmembrane Protein 198 Promotes LRP6 Phosphorylation and Wnt Signaling Activation

  2011influential citation
• Mechanisms of Wnt signaling: from embryonic stem cells to dopaminergic neurons

  2011cites this paper
• Functional dissection of phosphorylation of Disheveled in Drosophila.

  2011cites this paper