Breaking barriers to novel analgesic drug development

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Nature reviews. Drug discovery

• Publication date

  2017-06-09

• Fields of study

  Medicine

• Identifiers
  DOI 10.1038/nrd.2017.87PMID 28596533PMCID PMC5675565
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A Review of the Theoretical and Biological Understanding of the Nocebo and Placebo Phenomena.

  2017cited by this paper
• The Potential Role of Sensory Testing, Skin Biopsy, and Functional Brain Imaging as Biomarkers in Chronic Pain Clinical Trials: IMMPACT Considerations.

  2017cited by this paper
• A nontoxic pain killer designed by modeling of pathological receptor conformations

  2017cited by this paper
• A tale of 2 ADFs: differences in the effectiveness of abuse-deterrent formulations of oxymorphone and oxycodone extended-release drugs

  2016cited by this paper
• Structure-based discovery of opioid analgesics with reduced side effects

  2016cited by this paper
• Pharmacodynamic comparison of LY3023703, a novel microsomal prostaglandin e synthase 1 inhibitor, with celecoxib

  2016cited by this paper
• Patient phenotyping in clinical trials of chronic pain treatments: IMMPACT recommendations

  2016cited by this paper
• Opioid Abuse in Chronic Pain--Misconceptions and Mitigation Strategies.

  2016cited by this paper
• Positive emotions and brain reward circuits in chronic pain

  2016cited by this paper
• Potassium channels in neuropathic pain: advances, challenges, and emerging ideas

  2016cited by this paper
• Identification and Characterization of Novel Microsomal Prostaglandin E Synthase-1 Inhibitors for Analgesia

  2016cited by this paper
• (420) NEO6860, a novel modality selective TRPV1 antagonist: results from a phase I, double-blind, placebo-controlled study in healthy subjects.

  2016cited by this paper
• Kv5, Kv6, Kv8, and Kv9 subunits: No simple silent bystanders

  2016cited by this paper
• Decreased diversion by doctor-shopping for a reformulated extended release oxycodone product (OxyContin).

  2016cited by this paper
• Effect of endocannabinoid degradation on pain: role of FAAH polymorphisms in experimental and postoperative pain in women treated for breast cancer

  2016cited by this paper
• The Role of Psychosocial Processes in the Development and Maintenance of Chronic Pain.

  2016cited by this paper
• Pharmacological reversal of a pain phenotype in iPSC-derived sensory neurons and patients with inherited erythromelalgia

  2016cited by this paper
• AAPT Diagnostic Criteria for Chronic Cancer Pain Conditions

  2016cited by this paper
• Towards a mechanism-based approach to pain diagnosis

  2016cited by this paper
• The effect of an abuse‐deterrent opioid formulation (OxyContin) on opioid abuse‐related outcomes in the postmarketing setting

  2016cited by this paper
• Pain intensity rating training: results from an exploratory study of the ACTTION PROTECCT system

  2016cited by this paper
• Truncated mu opioid GPCR variant involvement in opioid-dependent and opioid-independent pain modulatory systems within the CNS

  2016cited by this paper
• A novel orvinol analog, BU08028, as a safe opioid analgesic without abuse liability in primates

  2016cited by this paper
• Safety, Tolerability and Pharmacokinetics of FAAH Inhibitor V158866: A Double-Blind, Randomised, Placebo-Controlled Phase I Study in Healthy Volunteers

  2016cited by this paper
• TRPV1: A Target for Rational Drug Design

  2016cited by this paper
• Single Residue Substitutions That Confer Voltage-Gated Sodium Ion Channel Subtype Selectivity in the NaV1.7 Inhibitory Peptide GpTx-1.

  2016cited by this paper
• Medicinal Chemistry, Pharmacology, and Potential Therapeutic Benefits of Cannabinoid CB2 Receptor Agonists.

  2016cited by this paper
• Discovery of Aryl Sulfonamides as Isoform-Selective Inhibitors of NaV1.7 with Efficacy in Rodent Pain Models.

  2016cited by this paper
• Peripheral neuropathic pain: a mechanism-related organizing principle based on sensory profiles

  2016cited by this paper
• A randomized, phase 2 study investigating TRV130, a biased ligand of the &mgr;-opioid receptor, for the intravenous treatment of acute pain

  2016cited by this paper
• When Is Osteonecrosis Not Osteonecrosis?: Adjudication of Reported Serious Adverse Joint Events in the Tanezumab Clinical Development Program

  2016cited by this paper
• The Emerging Role of the Cannabinoid Receptor Family in Peripheral and Neuro-immune Interactions.

  2016cited by this paper
• Early Repeated Administration of CXCR4 Antagonist AMD3100 Dose-Dependently Improves Neuropathic Pain in Rats After L5 Spinal Nerve Ligation

  2016cited by this paper
• TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action

  2016cited by this paper
• Neuroimmunity: Physiology and Pathology.

  2016cited by this paper
• Voltage gated sodium channels as drug discovery targets

  2015cited by this paper
• Safety, Tolerability and Pharmacokinetic and Pharmacodynamic Learnings from a Double-Blind, Randomized, Placebo-Controlled, Sequential Group First-in-Human Study of the TRPV1 Antagonist, JNJ-38893777, in Healthy Men

  2015cited by this paper
• A Randomized, Double-Blind, Placebo-Controlled, Crossover Study of the T-Type Calcium Channel Blocker ABT-639 in an Intradermal Capsaicin Experimental Pain Model in Healthy Adults.

  2015cited by this paper
• Activation of peripheral KCNQ channels relieves gout pain

  2015cited by this paper
• Sodium channels and pain.

  2015cited by this paper
• The Physiology, Pathology, and Pharmacology of Voltage-Gated Calcium Channels and Their Future Therapeutic Potential

  2015cited by this paper
• δ Subunit‐containing GABAA receptors are preferred targets for the centrally acting analgesic flupirtine

  2015cited by this paper
• Targeting voltage-gated calcium channels in neurological and psychiatric diseases

  2015cited by this paper
• NaV1.9: a sodium channel linked to human pain

  2015cited by this paper
• Increased excitability of medium‐sized dorsal root ganglion neurons by prolonged interleukin‐1β exposure is K+ channel dependent and reversible

  2015cited by this paper
• The Lysophosphatidylinositol Receptor GPR55 Modulates Pain Perception in the Periaqueductal Gray

  2015cited by this paper
• Exploring the role of tanezumab as a novel treatment for the relief of neuropathic pain.

  2015cited by this paper
• Modulation of Closed−State Inactivation in Kv2.1/Kv6.4 Heterotetramers as Mechanism for 4−AP Induced Potentiation

  2015cited by this paper
• (421) CR845, a novel peripherally-acting kappa opioid receptor agonist, has low abuse potential compared with pentazocine

  2015cited by this paper
• Different immune cells mediate mechanical pain hypersensitivity in male and female mice

  2015cited by this paper
• Restoring the spinal pain gate: GABA(A) receptors as targets for novel analgesics.

  2015cited by this paper
• Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis.

  2015cited by this paper
• A systematic review of the efficacy and general safety of antibodies to NGF in the treatment of OA of the hip or knee.

  2015cited by this paper
• Calcium Channel CaVα₁ Splice Isoforms - Tissue Specificity and Drug Action.

  2015cited by this paper
• Assay sensitivity of pain intensity versus pain relief in acute pain clinical trials: ACTTION systematic review and meta-analysis.

  2015cited by this paper
• The G Protein–Biased κ-Opioid Receptor Agonist RB-64 Is Analgesic with a Unique Spectrum of Activities In Vivo

  2015cited by this paper
• Attenuation of morphine antinociceptive tolerance by cannabinoid CB1 and CB2 receptor antagonists

  2015cited by this paper
• Two-pore domain potassium channels: potential therapeutic targets for the treatment of pain

  2015cited by this paper
• Crystal Structures of mPGES-1 Inhibitor Complexes Form a Basis for the Rational Design of Potent Analgesic and Anti-Inflammatory Therapeutics.

  2015cited by this paper
• CONTINUING EDUCATION IN HONOR OF NORMAN TRIEGER, DMD, MD Alpha-2 Adrenergic Receptor Agonists: A Review of Current Clinical Applications

  2015cited by this paper
• Alpha‐Adrenoceptor Modulation in Central Nervous System Trauma: Pain, Spasms, and Paralysis – An Unlucky Triad

  2015cited by this paper
• Endoplasmic reticulum stress in the peripheral nervous system is a significant driver of neuropathic pain

  2015cited by this paper
• Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation.

  2015cited by this paper
• Electrophysiological characterization of activation state-dependent Cav2 channel antagonist TROX-1 in spinal nerve injured rats

  2015cited by this paper
• Antinociceptive Efficacy of Retigabine in the Monosodium Lodoacetate Rat Model for Osteoarthritis Pain

  2015cited by this paper
• The family of K2P channels: salient structural and functional properties

  2015cited by this paper
• G protein-gated inwardly rectifying potassium channel subunits 1 and 2 are down-regulated in rat dorsal root ganglion neurons and spinal cord after peripheral axotomy

  2015cited by this paper
• Inhibition of Inflammatory and Neuropathic Pain by Targeting a Mu Opioid Receptor/Chemokine Receptor5 Heteromer (MOR-CCR5).

  2015cited by this paper
• Preclinical Characterization of the FAAH Inhibitor JNJ-42165279.

  2015cited by this paper
• The prescription opioid and heroin crisis: a public health approach to an epidemic of addiction.

  2015cited by this paper
• Emerging potassium channel targets for the treatment of pain

  2015cited by this paper
• A randomized double-blind, placebo-, and active-controlled study of T-type calcium channel blocker ABT-639 in patients with diabetic peripheral neuropathic pain

  2015cited by this paper
• Full Fatty Acid Amide Hydrolase Inhibition Combined with Partial Monoacylglycerol Lipase Inhibition: Augmented and Sustained Antinociceptive Effects with Reduced Cannabimimetic Side Effects in Mice

  2015cited by this paper
• G9a Is Essential for Epigenetic Silencing of K+ Channel Genes in Acute-to-Chronic Pain Transition

  2015cited by this paper
• Slack Channels Expressed in Sensory Neurons Control Neuropathic Pain in Mice

  2015cited by this paper
• A Randomized, Placebo-controlled Trial of the Analgesic Efficacy and Safety of the p38 MAP Kinase Inhibitor, Losmapimod, in Patients With Neuropathic Pain From Lumbosacral Radiculopathy

  2015cited by this paper
• Ensuring transparency and minimization of methodologic bias in preclinical pain research: PPRECISE considerations

  2015cited by this paper
• Mediation of opioid analgesia by a truncated 6-transmembrane GPCR.

  2015cited by this paper
• Opioid and chemokine receptor crosstalk: a promising target for pain therapy?

  2015cited by this paper
• Heterologous expression of NaV1.9 chimeras in various cell systems

  2015cited by this paper
• Endogenous opioids contribute to insensitivity to pain in humans and mice lacking sodium channel Nav1.7

  2015cited by this paper
• The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase

  2015cited by this paper
• Reduction of Neuropathic and Inflammatory Pain through Inhibition of the Tetrahydrobiopterin Pathway.

  2015cited by this paper
• Mechanisms underlying clinical efficacy of Angiotensin II type 2 receptor (AT2R) antagonist EMA401 in neuropathic pain: clinical tissue and in vitro studies

  2015cited by this paper
• Stromal cell-derived CCL2 drives neuropathic pain states through myeloid cell infiltration in injured nerve.

  2015cited by this paper
• Abuse-deterrent opioid formulations: part of a public health strategy to reverse the opioid epidemic.

  2015cited by this paper
• Modulation of the TRPV1 channel: current clinical trials and recent patents with focus on neurological conditions.

  2014cited by this paper
• Sodium channel genes in pain-related disorders: phenotype-genotype associations and recommendations for clinical use.

  2014cited by this paper
• Olfactory exposure to males, including men, causes stress and related analgesia in rodents

  2014cited by this paper
• Long‐term safety and effectiveness of tanezumab as treatment for chronic low back pain

  2014cited by this paper
• Mechanistic insights into the analgesic efficacy of A-1264087, a novel neuronal Ca(2+) channel blocker that reduces nociception in rat preclinical pain models.

  2014cited by this paper
• Changes in prevalence of prescription opioid abuse after introduction of an abuse-deterrent opioid formulation.

  2014cited by this paper
• Src family kinases involved in CXCL12-induced loss of acute morphine analgesia.

  2014cited by this paper
• Reward and motivation in pain and pain relief

  2014cited by this paper
• Recent progress in sodium channel modulators for pain.

  2014cited by this paper
• Transient Receptor Potential Channels as Drug Targets: From the Science of Basic Research to the Art of Medicine

  2014cited by this paper
• Bupivacaine‐induced cellular entry of QX‐314 and its contribution to differential nerve block

  2014cited by this paper
• Opening paths to novel analgesics: the role of potassium channels in chronic pain

  2014cited by this paper
• Targeting the minor pocket of C5aR for the rational design of an oral allosteric inhibitor for inflammatory and neuropathic pain relief

  2014cited by this paper
• Inhibitors of voltage-gated sodium channel Nav1.7: patent applications since 2010.

  2014cited by this paper

• Lipid metabolic suppression accompanies an immunometabolic signature in the spinal cord during chronic neuropathic pain

  2026cites this paper
• Mimicking opioid analgesia in cortical pain circuits

  2026cites this paper
• A paradigm shift in analgesic discovery: from rodent to human models

  2026cites this paper
• TRPV1: from structure to function—a multidimensional target for therapeutic advances

  2026cites this paper
• Targeting TRPA1 with Novel Synthetic Compounds Based on Different Scaffolds to Reduce Acute and Chronic Pain.

  2026cites this paper
• Small molecules induces dorsal root ganglion satellite glial cells to differentiate into sensory neuron-like cells.

  2026cites this paper
• Sexually Dimorphic Neuroimmune Pathways in Chronic Pain: A Comprehensive Systematic Review of Cellular and Molecular Mechanisms.

  2026cites this paper
• Circadian rhythmicity and biopsychosocial characteristics influence opioid use in chronic low back pain

  2025cites this paper
• Exploring the antinociceptive activity and toxicological profile of Zn(valp)2Bipy: a promising molecule in pain research

  2025cites this paper
• Molecule-rich solutions for achieving novel non-opioid analgesics.

  2025cites this paper
• Spatiotemporal Imaging of Extra-/Intracellular Ion Concentrations by Multifrequency Complex Electrical Impedance Tomography (mfc-EIT)

  2025cites this paper
• Human microphysiological model of dorsal root ganglion-spinal cord dorsal horn circuitry recapitulates opioid induced effects

  2025cites this paper
• Spatiotemporal neuromodulation via reversible and photothermal-gated DNA nanochannels

  2025cites this paper
• Tuina Alleviates Neuropathic Pain in CCI Rats by Regulating the TRPV4-CaMKII Signaling Pathway in Dorsal Root Ganglion

  2025cites this paper
• Liraglutide and denatonium benzoate attenuate T2DM-induced metabolic, neurological, and testicular changes in rats: Targeting oxidative stress, inflammation, and BCRP transporter

  2025cites this paper
• Multi-network dynamical structure of the human brain in the setting of chronic pain: a coordinate-based meta-analysis

  2025cites this paper
• Editorial: Pharmacological advances to treat pathological pain

  2025cites this paper
• Development of a Novel Benzodiazepine to Delineate Peripheral GABA-A Signaling Mechanisms in Visceral Pain Syndromes

  2025cites this paper
• Identification of Genes for Improving Cold Sensitivity in Nerve-Damaged Rats Via Lumbar Sympathectomy Using Poly(A)-seq.

  2025cites this paper
• Allosteric modulation and direct activation of glycine receptors by a tricyclic sulfonamide

  2025cites this paper
• Quantitative Analysis of the Active Metabolite of VX-150 Using UPLC-MS/MS: A Preclinical Pharmacokinetic Study in Rats.

  2025cites this paper
• Phenolate-based bioactive compounds: Design, delivery and biomedical applications

  2025cites this paper
• A molecular map of the human spinal dorsal and ventral horn defines arrangement of neuronal types and glial sex differences

  2025cites this paper
• Enhancing clinical translation of analgesics for neuropathic pain: a systematic review and meta-analysis on the role of non-evoked pain assessment in preclinical trials

  2025cites this paper
• Individual risk factors associated with post-traumatic trigeminal neuropathy following endodontic procedures: a systematic review.

  2025cites this paper
• Alcohol Use Disorder-Associated Pain: Clinical and Preclinical Evidence.

  2025cites this paper
• 12/15-lipoxygenases mediate toll-like receptor 4-dependent nociplastic pain hypersensitivity in female mice.

  2025cites this paper
• Non-Inferiority Study of Two Capsaicin Formulations for Painful Diabetic Neuropathy

  2025cites this paper
• An orally bioavailable MrgprX1-positive allosteric modulator alleviates certain neuropathic pain-related behaviors in humanized mice.

  2025cites this paper
• Discovery and development of an oral analgesic targeting the α2B adrenoceptor

  2025cites this paper
• Nicorandil Repurposing in Orofacial Pain: Preclinical Findings in Adult Zebrafish

  2025cites this paper
• Mechanism of human α3β GlyR regulation by intracellular M3/M4 loop phosphorylation and 2,6-di-tert-butylphenol interaction

  2025cites this paper
• Dual Mechanisms of the Diazepine-Benzimidazole Derivative, DAB-19, in Modulating Glutamatergic Neurotransmission

  2025cites this paper
• Comprehensive Proteomic Profiling of Human Nav1.7-Interacting Proteins Reveals Conserved Regulatory Networks Involved in Nociceptive Signaling

  2025cites this paper
• Rational Design Biased Compounds against μ‑Opioid Receptor.

  2025cites this paper
• Review of nonpharmacological interventions for delaying the effects of cerebral neuropathy caused by diabetes

  2025cites this paper
• Preclinical assay of the effects of lacosamide, pregabalin, and tapentadol on the rat N1 spinal somatosensory evoked potential

  2025cites this paper
• Anti-inflammatory and antioxidant activities of a dibenzoylmethane derivative in experimental models of inflammation and pain

  2025cites this paper
• Ferroptosis in pain: evidence, challenges, and opportunities

  2025cites this paper
• WERF Endometriosis Phenome and Biobanking Harmonisation Project for Experimental Models in Endometriosis Research (EPHect-EM-Pain): methods to assess pain behaviour in rodent models of endometriosis

  2025cites this paper
• Functional MRI following sensory stimulation in rat monosodium iodoacetate model of osteoarthritis pain as a tool for drug therapy discovery

  2025cites this paper
• Voltage-gated sodium channels in excitable cells as drug targets

  2025cites this paper
• Plasticity of Mouse Dorsal Root Ganglion Neurons by Innate Immune Activation Is Influenced by Electrophysiological Activity

  2024cites this paper
• Potent painkiller from spider venom antagonizes P2X3 receptors without dysgeusia.

  2024cites this paper
• A Novel Quaternary Ammonium N-Propylamiodarone Bromide Provides Long-Lasting Analgesia Against Corneal Pain

  2024cites this paper
• The cannabinoid CB2 agonist LY2828360 suppresses neuropathic pain behavior and attenuates morphine tolerance and conditioned place preference in rats.

  2024cites this paper
• P2X3 and P2X2/3 Receptors Inhibition Produces a Consistent Analgesic Efficacy: A Systematic Review and Meta-Analysis of Preclinical Studies.

  2024cites this paper
• Development and characterization of pyridyl carboxamides as potent and highly selective Nav1.8 inhibitors.

  2024cites this paper
• Research Progress of Opioid Analgesics

  2024cites this paper
• Macrophage/microglia-producing transient increase of platelet-activating factor is involved in neuropathic pain

  2024cites this paper
• State-Dependent Inhibition of Nav1.8 Sodium Channels by VX-150 and VX-548

  2024cites this paper
• Directions for analgesic development

  2024cites this paper
• Long-term optical imaging of the spinal cord in awake behaving mice

  2024cites this paper
• Analgesic Effect of Human Placenta Hydrolysate on CFA-Induced Inflammatory Pain in Mice

  2024cites this paper
• Tuina alleviates neuropathic pain through regulate the activation of microglia and the secretion of inflammatory cytokine in spinal cord.

  2024cites this paper
• IUPHAR Editorial: Emerging Targets for the Treatment of Pain: Moving towards non-addicting therapeutics and New Preclinical Directions.

  2024cites this paper
• MP-13, a novel chimeric peptide of morphiceptin and pepcan-9, produces potent antinociception with limited side effects.

  2024cites this paper
• Spatial transcriptomics combined with single-nucleus RNA sequencing reveals glial cell heterogeneity in the human spinal cord

  2024cites this paper
• Cannabinoid CB2 receptors in primary sensory neurons are implicated in CB2 agonist-mediated suppression of paclitaxel-induced neuropathic nociception and sexually-dimorphic sparing of morphine tolerance

  2024cites this paper
• Strategies for developing μ opioid receptor agonists with reduced adverse effects.

  2024cites this paper
• Strategies for Measuring Non-Evoked Pain in Preclinical Models of Neuropathic Pain: Systematic Review.

  2024cites this paper
• Effects of pH on opioid receptor activation and implications for drug design

  2024cites this paper
• Mechanism of human α3β GlyR modulation in inflammatory pain and 2, 6-DTBP interaction

  2024cites this paper
• Using automated patch clamp electrophysiology platforms in ion channel drug discovery: an industry perspective

  2024influential citation
• Analgesic and Anti-inflammatory Effects of Montelukast in Chicks

  2024cites this paper
• Digging deeper into pain: an ethological behavior assay correlating well-being in mice with human pain experience

  2024cites this paper
• 12/15-Lipoxygenases mediate neuropathic-like pain hypersensitivity in female mice

  2024cites this paper
• Design, Synthesis, and In Vivo Evaluation of a New Series of Indole-Chalcone Hybrids as Analgesic and Anti-Inflammatory Agents

  2024cites this paper
• Effects of educational attainment on comorbidity of pain and depression in Chinese older adults

  2024cites this paper
• Opioid and Cannabinoid Systems in Pain: Emerging Molecular Mechanisms and Use in Clinical Practice, Health, and Fitness

  2024cites this paper
• Mimicking opioid analgesia in cortical pain circuits

  2024cites this paper
• An overview of drug‐induced sodium channel blockade and changes in cardiac conduction: Implications for drug safety

  2024cites this paper
• A historical perspective and recent advances on the evolution of the relationship between acute and chronic pain and cardiovascular disease.

  2024cites this paper
• Prolonged Corneal Analgesia Without Impairing Wound Healing Using a Novel Quaternary Ammonium N-Propylamiodarone Bromide

  2023cites this paper
• Peripheral mechanisms of peripheral neuropathic pain

  2023cites this paper
• Neuropathic pain; what we know and what we should do about it

  2023influential citation
• What’s New in Neuropathy?

  2023cites this paper
• Spatial transcriptomics and single-nucleus RNA sequencing reveal a transcriptomic atlas of adult human spinal cord

  2023cites this paper
• Spontaneous activity in peripheral sensory nerves: a systematic review

  2023cites this paper
• Single-nucleus transcriptomic atlas of glial cells in human dorsal root ganglia

  2023cites this paper
• Nociceptin Receptor-Related Agonists as Safe and Non-addictive Analgesics

  2023cites this paper
• What should be the entry pain intensity criteria for chronic pain clinical trials? An IMMPACT update.

  2023cites this paper
• Oxycodone: A Current Perspective on Its Pharmacology, Abuse, and Pharmacotherapeutic Developments

  2023cites this paper
• Potential analgesic effects of psychedelics on select chronic pain conditions: A survey study

  2023cites this paper
• Digging deeper into pain – an ethological behavior assay correlating well-being in mice with human pain experience

  2023cites this paper
• Scalable generation of sensory neurons from human pluripotent stem cells

  2023cites this paper
• Inhibition of NKCC1 in spinal dorsal horn and dorsal root ganglion results in alleviation of neuropathic pain in rats with spinal cord contusion

  2023cites this paper
• Uncovering protein-protein interactions of the human sodium channel Nav1.7

  2023cites this paper
• FXYD2 antisense oligonucleotide provides an efficient approach for long-lasting relief of chronic peripheral pain

  2023cites this paper
• The core of maintaining neuropathic pain: Crosstalk between glial cells and neurons (neural cell crosstalk at spinal cord)

  2023cites this paper
• Network pharmacological analysis to reveal the mechanism governing the effect of Qin Xi Tong on osteoarthritis and rheumatoid arthritis

  2023cites this paper
• Solving an Old Puzzle: Elucidation and Evaluation of the Binding Mode of Salvinorin A at the Kappa Opioid Receptor

  2023cites this paper
• The Known Biology of Neuropathic Pain and Its Relevance to Pain Management

  2023cites this paper
• Investigation of the Analgesic Properties L-759,633 and SER 601 in Experimental Neuropathic Pain Model in Rats and their Comparison with Pregabalin

  2023cites this paper
• Molecular mechanisms of pain in acute pancreatitis: recent basic research advances and therapeutic implications

  2023cites this paper
• An orally available Cav2.2 calcium channel inhibitor for the treatment of neuropathic pain

  2023cites this paper
• Targeting sensory neuron GPCRs for peripheral neuropathic pain.

  2023cites this paper
• Long-term optical imaging of the spinal cord in awake, behaving animals

  2023cites this paper
• A Novel Bifunctional μOR Agonist and σ1R Antagonist with Potent Analgesic Responses and Reduced Adverse Effects.

  2023cites this paper
• Angiotensin II type 2 receptor signalling as a pain target: Bench, bedside and back-translation

  2023cites this paper