The α2δ-1-NMDA Receptor Complex Is Critically Involved in Neuropathic Pain Development and Gabapentin Therapeutic Actions

SUMMARY α2δ-1, commonly known as a voltage-activated Ca2+ channel subunit, is a binding site of gabapentinoids used to treat neuropathic pain and epilepsy. However, it is unclear how α2δ-1 contributes to neuropathic pain and gabapentinoid actions. Here, we show that Cacna2d1 overexpression potentiates presynaptic and postsynaptic NMDAR activity of spinal dorsal horn neurons to cause pain hypersensitivity. Conversely, Cacna2d1 knockdown or ablation normalizes synaptic NMDAR activity increased by nerve injury. α2δ-1 forms a heteromeric complex with NMDARs in rodent and human spinal cords. The α2δ-1-NMDAR interaction predominantly occurs through the C terminus of α2δ-1 and promotes surface trafficking and synaptic targeting of NMDARs. Gabapentin or an α2δ-1 C terminus-interfering peptide normalizes NMDAR synaptic targeting and activity increased by nerve injury. Thus, α2δ-1 is an NMDAR-interacting protein that increases NMDAR synaptic delivery in neuropathic pain. Gabapentinoids reduce neuropathic pain by inhibiting forward trafficking of α2δ-1-NMDAR complexes.

• Publication year

  2018

• Venue

  Cell Reports

• Publication date

  2018-02-27

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.celrep.2018.02.021PMID 29490268PMCID 5873963
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2014cited by this paper
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  2013cited by this paper
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  2012cited by this paper
• alpha2delta expression sets presynaptic calcium channel abundance and release probability

  2012cited by this paper
• Glutamate transporter dysfunction associated with nerve injury-induced pain in mice.

  2012cited by this paper
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  2012cited by this paper
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  2012cited by this paper
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  2012cited by this paper
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  2011cited by this paper
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  2011cited by this paper
• Quantitative proteomics of the Cav2 channel nano-environments in the mammalian brain

  2010cited by this paper
• MHC class I modulates NMDA receptor function and AMPA receptor trafficking

  2010cited by this paper
• Evidence that pregabalin reduces neuropathic pain by inhibiting the spinal release of glutamate

  2010cited by this paper
• Recommendations for the pharmacological management of neuropathic pain: an overview and literature update.

  2010cited by this paper
• Gabapentin receptor alpha2delta-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis.

  2009cited by this paper
• Targeted disruption of the voltage-dependent calcium channel alpha2/delta-1-subunit.

  2009cited by this paper
• Aminopyridines Potentiate Synaptic and Neuromuscular Transmission by Targeting the Voltage-activated Calcium Channel β Subunit*♦

  2009cited by this paper
• The Increased Trafficking of the Calcium Channel Subunit α2δ-1 to Presynaptic Terminals in Neuropathic Pain Is Inhibited by the α2δ Ligand Pregabalin

  2009cited by this paper
• Pharmacological disruption of calcium channel trafficking by the α2δ ligand gabapentin

  2008cited by this paper
• Treatment of inflammatory and neuropathic pain by uncoupling Src from the NMDA receptor complex

  2008cited by this paper
• The regulation of dendritic arbor development and plasticity by glutamatergic synaptic input: a review of the synaptotrophic hypothesis

  2008cited by this paper
• Immunostaining of rat brain, spinal cord, sensory neurons and skeletal muscle for calcium channel alpha2-delta (alpha2-delta) type 1 protein.

  2008cited by this paper
• Functional biology of the alpha(2)delta subunits of voltage-gated calcium channels.

  2007cited by this paper
• Excitatory interneurons dominate sensory processing in the spinal substantia gelatinosa of rat

  2007cited by this paper
• Functional biology of the α 2 δ subunits of voltage-gated calcium channels

  2007cited by this paper
• Identification of the alpha2-delta-1 subunit of voltage-dependent calcium channels as a molecular target for pain mediating the analgesic actions of pregabalin.

  2006cited by this paper
• Identification of the (cid:1) 2 - (cid:2) -1 subunit of voltage-dependent calcium channels as a molecular target for pain mediating the analgesic actions of pregabalin

  2006cited by this paper
• The metal-ion-dependent adhesion site in the Von Willebrand factor-A domain of alpha2delta subunits is key to trafficking voltage-gated Ca2+ channels.

  2005cited by this paper
• Distinct Roles of Group III Metabotropic Glutamate Receptors in Control of Nociception and Dorsal Horn Neurons in Normal and Nerve-Injured Rats

  2005cited by this paper
• Gabapentin fails to alter P/Q‐type Ca2+ channel‐mediated synaptic transmission in the hippocampus in vitro

  2005cited by this paper
• NMDA Receptor Subunit-Dependent [Ca2+] Signaling in Individual Hippocampal Dendritic Spines

  2005cited by this paper
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  2005cited by this paper
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  2005cited by this paper
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  2005cited by this paper
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  2005cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2003cited by this paper
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  2001cited by this paper
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  2001cited by this paper
• Calcium Channel α2δ Subunits—Structure and Gabapentin Binding

  2001cited by this paper
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  2001cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1996cited by this paper
• Quantitative assessment of tactile allodynia in the rat paw.

  1994cited by this paper
• Evidence for presynaptic N-methyl-D-aspartate autoreceptors in the spinal cord dorsal horn.

  1994cited by this paper
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  1994cited by this paper
• Gabapentin actions on ligand- and voltage-gated responses in cultured rodent neurons.

  1993cited by this paper
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  1992cited by this paper
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  1992cited by this paper

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  2023cites this paper
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  2023cites this paper
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