Bioavailability, disposition, and dose-response effects of soy isoflavones when consumed by healthy women at physiologically typical dietary intakes.

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Journal of NutriLife

• Publication date

  2003-04-01

• Fields of study

  Agricultural and Food Sciences, Medicine, Chemistry

• Identifiers
  DOI 10.1093/JN/133.4.1027PMID 12672914
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Comparing the pharmacokinetics of daidzein and genistein with the use of 13C-labeled tracers in premenopausal women.

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• Evidence for lack of absorption of soy isoflavone glycosides in humans, supporting the crucial role of intestinal metabolism for bioavailability.

  2002cited by this paper
• The clinical importance of the metabolite equol-a clue to the effectiveness of soy and its isoflavones.

  2002cited by this paper
• Bioavailability of pure isoflavones in healthy humans and analysis of commercial soy isoflavone supplements.

  2001cited by this paper
• Interaction of Phytoestrogens with Estrogen Receptors α and β

  2001cited by this paper
• Interaction of phytoestrogens with estrogen receptors alpha and beta.

  2001cited by this paper
• Wheat bran and soy protein feeding do not alter urinary excretion of the isoflavan equol in premenopausal women.

  2001cited by this paper
• Urinary pharmacokinetics of the glucuronide and sulfate conjugates of genistein and daidzein.

  2000cited by this paper
• Isoflavone-rich soy protein isolate attenuates bone loss in the lumbar spine of perimenopausal women.

  2000cited by this paper
• Neither background diet nor type of soy food affects short-term isoflavone bioavailability in women.

  2000cited by this paper
• Soy isoflavone aglycones are absorbed faster and in higher amounts than their glucosides in humans.

  2000cited by this paper
• Interindividual Variation in Metabolism of Soy Isoflavones and Lignans: Influence of Habitual Diet on Equol Production by the Gut Microflora

  2000cited by this paper
• Dietary intake and sources of isoflavones among Japanese.

  1999cited by this paper
• A randomized trial comparing the effect of casein with that of soy protein containing varying amounts of isoflavones on plasma concentrations of lipids and lipoproteins.

  1999cited by this paper
• Urinary disposition of the soybean isoflavones daidzein, genistein and glycitein differs among humans with moderate fecal isoflavone degradation activity.

  1999cited by this paper
• Dietary isoflavones: biological effects and relevance to human health.

  1999cited by this paper
• Usual dietary consumption of soy foods and its correlation with the excretion rate of isoflavonoids in overnight urine samples among Chinese women in Shanghai.

  1999cited by this paper
• Serum levels and metabolic clearance of the isoflavones genistein and daidzein in hemodialysis patients.

  1999cited by this paper
• Pharmacokinetics of soybean isoflavones in plasma, urine and feces of men after ingestion of 60 g baked soybean powder (kinako).

  1998influential reference
• Phytoestrogens--what is the current knowledge?

  1998cited by this paper
• Mechanisms of action of the soy isoflavone genistein: emerging role for its effects via transforming growth factor beta signaling pathways.

  1998cited by this paper
• HPLC Analysis of Isoflavonoids and Other Phenolic Agents from Foods and from Human Fluids

  1998cited by this paper
• Isoflavonoid levels in spot urine are associated with frequency of dietary soy intake in a population-based sample of middle-aged and older Chinese in Singapore.

  1998cited by this paper
• Plasma and urinary kinetics of the isoflavones daidzein and genistein after a single soy meal in humans.

  1998influential reference
• The Effect of Dietary Soy Supplementation on Hot Flushes

  1998cited by this paper
• Urinary Equol Excretion with a Soy Challenge: Influence of Habitual Diet

  1998cited by this paper
• Phytoestrogens: the biochemistry, physiology, and implications for human health of soy isoflavones.

  1998cited by this paper
• Paradoxical effects of the phytoestrogen genistein on growth of estrogen-dependent human breast cancer cells in vitro and in vivo.

  1998cited by this paper
• Soy protein and isoflavones: their effects on blood lipids and bone density in postmenopausal women.

  1998cited by this paper
• Decreased serum total cholesterol concentration is associated with high intake of soy products in Japanese men and women.

  1998cited by this paper
• Isoflavone content of infant formulas and the metabolic fate of these phytoestrogens in early life.

  1998cited by this paper
• Sex and long-term soy diets affect the metabolism and excretion of soy isoflavones in humans.

  1998cited by this paper
• Short‐term Effects of Phytoestrogen‐rich Diet on Postmenopausal Women

  1997cited by this paper
• Urinary isoflavonoid excretion in humans is dose dependent at low to moderate levels of soy-protein consumption.

  1997cited by this paper
• Exposure of infants to phyto-oestrogens from soy-based infant formula.

  1997cited by this paper
• The chemopreventive properties of soy isoflavonoids in animal models of breast cancer

  1997cited by this paper
• Intestinal uptake and biliary excretion of the isoflavone genistein in rats.

  1997cited by this paper
• A diet high in wheat fiber decreases the bioavailability of soybean isoflavones in a single meal fed to women.

  1996cited by this paper
• Biological effects of isoflavones in young women: importance of the chemical composition of soyabean products

  1995cited by this paper
• Dietary soybean may be antiestrogenic in male mice.

  1995cited by this paper
• Phytoestrogens are partial estrogen agonists in the adult male mouse.

  1995cited by this paper
• Effect of genistein on in vitro and in vivo models of cancer.

  1995cited by this paper
• Rapid HPLC Analysis of Dietary Phytoestrogens from Legumes and from Human Urine

  1995cited by this paper
• Urinary isoflavonoid phytoestrogen and lignan excretion after consumption of fermented and unfermented soy products.

  1995cited by this paper
• Urinary lignan and isoflavonoid excretion in men and women consuming vegetable and soy diets.

  1995cited by this paper
• Daidzein is a more bioavailable soymilk isoflavone than is genistein in adult women.

  1994cited by this paper
• Biological effects of a diet of soy protein rich in isoflavones on the menstrual cycle of premenopausal women.

  1994cited by this paper
• Potential role of dietary isoflavones in the prevention of cancer.

  1994cited by this paper
• Genistein, daidzein, and their .beta.-glycoside conjugates: antitumor isoflavones in soybean foods from American and Asian diets

  1993cited by this paper
• Urinary excretion of lignans and isoflavonoid phytoestrogens in Japanese men and women consuming a traditional Japanese diet.

  1991cited by this paper
• Organic foods: consumer attitudes and use

  1989cited by this paper
• Diet and plasma androgens in postmenopausal vegetarian and omnivorous women and postmenopausal women with breast cancer.

  1989cited by this paper
• Genistein, a specific inhibitor of tyrosine-specific protein kinases.

  1987cited by this paper
• Urinary estrogen profile determination in young Finnish vegetarian and omnivorous women.

  1986cited by this paper
• Nonsteroidal estrogens of dietary origin: possible roles in hormone-dependent disease.

  1984cited by this paper
• Soya--a dietary source of the non-steroidal oestrogen equol in man and animals.

  1984cited by this paper
• Phytoestrogen content of processed soybean products

  1982cited by this paper
• The identification of the weak oestrogen equol [7-hydroxy-3-(4'-hydroxyphenyl)chroman] in human urine.

  1982cited by this paper

• The isoflavone metabolites, O-desmethylangolensin and (S)-equol, relax isolated arteries ex vivo and decrease arterial blood pressure in vivo.

  2026cites this paper
• Menopause care: alternatives to hormone replacement therapy

  2025cites this paper
• Replacing Hydrolyzed Soybean Meal with Recombinant β-Glucosidase Enhances Resistance to Clostridium perfringens in Broilers Through Immune Modulation

  2024cites this paper
• Soy-Based Tempeh as a Functional Food: Evidence for Human Health and Future Perspective.

  2024cites this paper
• Machine Learning-Based Analysis Reveals Triterpene Saponins and Their Aglycones in Cimicifuga racemosa as Critical Mediators of AMPK Activation

  2024cites this paper
• Exploring the Complex Mechanisms of Isoflavones: From Cell Bioavailability, to Cell Dynamics and Breast Cancer

  2024cites this paper
• The Role of Isoflavones in the Prevention of Breast Cancer and Prostate Cancer

  2023cites this paper
• Application of a skin and liver Chip2 microphysiological model to investigate the route‐dependent toxicokinetics and toxicodynamics of consumer‐relevant doses of genistein

  2023cites this paper
• Recapitulate genistein for topical applications including nanotechnology delivery

  2022cites this paper
• Dietary Freeze-Dried Flaxseed and Alfalfa Sprouts as Additional Ingredients to Improve the Bioactive Compounds and Reduce the Cholesterol Content of Hen Eggs

  2022cites this paper
• Bioactive ingredients of legumes

  2022cites this paper
• Dietary Isoflavone Aglycons from Soy Germ Pasta Improves Reproductive Performance of Aging Hens and Lowers Cholesterol Levels of Egg Yolk

  2022cites this paper
• Preventive Applications of Polyphenols in Dentistry—A Review

  2021cites this paper
• Adlercreutzia hattorii sp. nov., an equol non-producing bacterium isolated from human faeces.

  2021cites this paper
• Isoflavone biomarkers are inversely associated with atherosclerosis progression in adults: a prospective study.

  2021cites this paper
• BIOTECHNOLOGY OF SOYA MULTI-COMPONENT FUNCTIONAL INGREDIENTS

  2021cites this paper
• Use of Physiologically Based Pharmacokinetic Modeling to Predict Human Gut Microbial Conversion of Daidzein to S-Equol

  2021cites this paper
• The Antihypertensive Potential of Flavonoids from Chinese Herbal Medicine: A Review.

  2021cites this paper
• Interaction between apigenin and sodium deoxycholate with raloxifene: A potential risk for clinical practice.

  2021cites this paper
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  2020cites this paper
• Analysis of soy isoflavones in foods and biological fluids: An overview

  2020cites this paper
• Biotechnological aspects of obtaining fermented soybean products with increased phytoestrogenic activity

  2020cites this paper
• Adipocytes Under Environmental Assault: Targets for Obesity?

  2020cites this paper
• Targeting Abdominal Obesity and Its Complications with Dietary Phytoestrogens

  2020cites this paper
• Nutraceuticals in the Treatment of Pulmonary Arterial Hypertension

  2020cites this paper
• Estrogen receptors-β and serotonin mediate the antidepressant-like effect of an aqueous extract of pomegranate in ovariectomized rats.

  2020cites this paper
• Effect of Genistein on Cholesterol Metabolism-Related Genes in HepG2 Cell.

  2019cites this paper
• The association of urinary estrogen levels with urinary isoflavone levels: Difference between premenopausal women and postmenopausal women.

  2019cites this paper
• Effect of heat- and freeze-drying treatments on phytochemical content and fatty acid profile of alfalfa and flax sprouts.

  2019cites this paper
• (±)-Equol does not interact with genistein on estrogen-dependent breast tumor growth.

  2019cites this paper
• Health Effects and Safety of Soy and Isoflavones

  2019cites this paper
• Cytosine Methylation of Isoflavone Synthase Gene in the Genic Region Positively Regulates Its Expression and Isoflavone Biosynthesis in Soybean Seeds

  2019cites this paper
• Inhibition of Spermatogonia Formation on Little Wistar Rats

  2019cites this paper
• [Nutritional assessment and phytoestrogen exposure in a diet of students of the University of Costa Rica].

  2019cites this paper
• Optimal cut-off value for equol-producing status in women: The Japan Nurses’ Health Study urinary isoflavone concentration survey

  2018cites this paper
• Biomarkers of legume intake in human intervention and observational studies: a systematic review

  2018cites this paper
• ELISA for free S-equol in human urine.

  2018cites this paper
• Androgen receptor and soy isoflavones in prostate cancer ( Review )

  2018cites this paper
• Nutritional significance and health benefits of designer eggs

  2018cites this paper
• Androgen receptor and soy isoflavones in prostate cancer.

  2018cites this paper
• Determination of isoflavones from soy-milk, masoor and mung dal soups in Bangladeshi postmenopausal women

  2018influential citation
• Efficacy of feeding of soy fortified Shrikhand as functional food on thyroid hormone (T3, T4) and thyroid stimulating hormone (TSH) of rats

  2018cites this paper
• The history and basic science development of soy isoflavones

  2017cites this paper
• Hypoglycemic property of soy isoflavones from hypocotyl in Goto-Kakizaki diabetic rats

  2017cites this paper
• Chapter 11 – Oral Absorption Basics: Pathways and Physicochemical and Biological Factors Affecting Absorption

  2017cites this paper
• The Importance of Microbial and Enzymatic Bioconversions of Isoflavones in Bioactive Compounds

  2017cites this paper
• Regulation of Isoflavone Biosynthesis by miRNAs in Two Contrasting Soybean Genotypes at Different Seed Developmental Stages

  2017cites this paper
• Use of Phytoestrogens for the Treatment of Psychiatric Symptoms Associated with Menopause Transition

  2017cites this paper
• Deciphering Regulatory Mechanism(s) Underlying Isoflavone Biosynthesis and Accumulation in Soybean (Glycine max L.) Seeds

  2017cites this paper
• Genistein Ameliorates Fat Accumulation Through AMPK Activation in Fatty Acid-Induced BRL Cells.

  2017cites this paper
• ROLE OF THE SIX1 ONCOPROTEIN IN ENDOMETRIAL CANCER CAUSED BY NEONATAL XENOESTROGEN EXPOSURE

  2017influential citation
• Dietary Management of Skin Health: The Role of Genistein

  2017cites this paper
• Metabolism and health effects of phyto-estrogens

  2017cites this paper
• Genistein: mechanisms of action for a pleiotropic neuroprotective agent in stroke

  2017cites this paper
• New Insights Regarding the Potential Health Benefits of Isoflavones

  2017cites this paper
• Association between Dietary Share of Ultra-Processed Foods and Urinary Concentrations of Phytoestrogens in the US

  2017cites this paper
• Genistein crosses the bioartificial oviduct and alters secretion composition.

  2017cites this paper
• Endocrine disruption by dietary phyto-oestrogens: impact on dimorphic sexual systems and behaviours

  2016cites this paper
• Phytoestrogen consumption and risk for cognitive decline and dementia: With consideration of thyroid status and other possible mediators.

  2016cites this paper
• The Dietary Isoflavone Daidzein Reduces Expression of Pro-Inflammatory Genes through PPARα/γ and JNK Pathways in Adipocyte and Macrophage Co-Cultures

  2016cites this paper
• R-equol, a synthetic metabolite of the dietary estrogen daidzein, modulates the nongenomic estrogenic effects of 17β-estradiol in pituitary tumor cells

  2016cites this paper
• Kanamycin inhibits daidzein metabolism and abilities of the metabolites to prevent bone loss in ovariectomized mice

  2016cites this paper
• Bioavailability and delivery of nutraceuticals by nanoparticles

  2016cites this paper
• Alfalfa and flax sprouts supplementation enriches the content of bioactive compounds and lowers the cholesterol in hen egg

  2016influential citation
• Soy isoflavone exposure through all life stages accelerates 17β-estradiol-induced mammary tumor onset and growth, yet reduces tumor burden, in ACI rats

  2016cites this paper
• The effect of processing and formulation on the bioavailability of isoflavones from red clover

  2015cites this paper
• Red clover isoflavone metabolite bioavailability is decreased after fructooligosaccharide supplementation.

  2015cites this paper
• Interaction of Isoflavones with the BCRP/ABCG2 Drug Transporter.

  2015cites this paper
• The Role of Colonic Bacteria in the Metabolism of the Natural Isoflavone Daidzin to Equol

  2015cites this paper
• Bioavailability of Citrus Flavanones and Their Effect on Cardiovascular Health Biomarkers

  2015influential citation
• Current and Emerging Trends in the Formulation and Manufacture of Nutraceuticals and Functional Food Products

  2015cites this paper
• Soy and the soy isoflavone genistein promote adipose tissue development in male mice on a low-fat diet

  2015cites this paper
• Effect of simultaneous consumption of soymilk and coffee on the urinary excretion of isoflavones, chlorogenic acids and metabolites in healthy adults

  2015cites this paper
• Effects of Soy Phytoestrogens and New Zealand Functional Foods on Bone Health.

  2015cites this paper
• Dietary isoflavone daidzein promotes Tfam expression that increases mitochondrial biogenesis in C2C12 muscle cells.

  2015cites this paper
• Soy Isoflavones in Epidemiological Serum Samples: What are the Optimal Time Window and Concentration Cutoffs for Assignment of Equol Producer Status?

  2014cites this paper
• Pharmaco- and toxicokinetics of selected exogenous and endogenous estrogens: A review of the data and identification of knowledge gaps

  2014influential citation
• Soy but not bisphenol A (BPA) induces hallmarks of polycystic ovary syndrome (PCOS) and related metabolic co-morbidities in rats.

  2014cites this paper
• Phytoestrogens and cognitive function: a review.

  2014cites this paper
• Endocrine disrupting compounds affecting corticosteroid signaling pathways in Czech and Swiss waters: potential impact on fish.

  2014cites this paper
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  2014cites this paper
• Effect of synbiotic fermented milk on oral bioavailability of isoflavones in postmenopausal women

  2014cites this paper
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  2014cites this paper
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  2014cites this paper
• ENHANCED β-GALACTOSIDASE ACTIVITY IN PROBIOTICS FOR IMPROVED BIOCONVERSION OF SOY ISOFLAVONES IN DAIRY AND SOY- BASED YOGHURT A thesis submitted for the degree of DOCTOR of PHILOSOPHY

  2014cites this paper
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  2014cites this paper
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  2014cites this paper
• Soy Isoflavonoids as Nutraceutical for Human Health: An Update

  2014cites this paper
• In vivo dynamics of estrogen receptor activity: the ERE-Luc model.

  2014cites this paper
• Current and Emerging Trends in the Formulation and Manufacture of Nutraceuticals and Functional Food Products Alberta

  2014influential citation
• Absorption, distribution, metabolism, and excretion of isoflavonoids after soy intake.

  2014cites this paper
• [Soya isoflavones and evidences on cardiovascular protection].

  2014cites this paper
• Bioavailability of Flavonoids

  2014cites this paper
• Soy foods, isoflavones, and the health of postmenopausal women.

  2014cites this paper
• Large inter-individual variation in isoflavone plasma concentration limits use of isoflavone intake data for risk assessment

  2014cites this paper
• Food, Nutrition and Health

  2013cites this paper
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  2013cites this paper
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  2013cites this paper
• Iso fl avone metabolism in domestic cats ( Felis catus ): Comparison of plasma metabolites detected after ingestion of two different dietary forms of genistein and daidzein 1

  2013cites this paper
• Design and selection of soy breads used for evaluating isoflavone bioavailability in clinical trials.

  2013cites this paper