Insulin stimulation of hepatic triacylglycerol secretion and the etiology of insulin resistance.

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Journal of NutriLife

• Publication date

  2001-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/JN/131.8.2074PMID 11481396
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The fourth Musketeer — from Alexandre Dumas to Claude Bernard

  2006cited by this paper
• Prolonged inhibition of muscle carnitine palmitoyltransferase-1 promotes intramyocellular lipid accumulation and insulin resistance in rats.

  2001cited by this paper
• Preferential channeling of energy fuels toward fat rather than muscle during high free fatty acid availability in rats.

  2001cited by this paper
• Pravastatin and the Development of Diabetes Mellitus: Evidence for a Protective Treatment Effect in the West of Scotland Coronary Prevention Study

  2001cited by this paper
• A switch in the direction of the effect of insulin on the partitioning of hepatic fatty acids for the formation of secreted triacylglycerol occurs in vivo, as predicted from studies with perfused livers.

  2000cited by this paper
• Dietary habits and nutritional status in adolescents over Europe. An overview of current studies in the Nordic countries

  2000cited by this paper
• Insulin-treated Zucker diabetic fatty rats retain the hypertriglyceridemia associated with obesity.

  2000cited by this paper
• Postprandial apolipoprotein B48-and B100-containing lipoproteins in type 2 diabetes: do statins have a specific effect on triglyceride metabolism?

  2000cited by this paper
• Glucose-stimulated insulin secretion suppresses hepatic triglyceride-rich lipoprotein and apoB production.

  2000cited by this paper
• Relationship between altered postprandial lipemia and insulin resistance in normolipidemic and normoglucose tolerant obese patients

  2000cited by this paper
• Postprandial lipemia after short-term variation in dietary fat and carbohydrate.

  2000cited by this paper
• The post‐prandial state and cardiovascular disease: relevance to diabetes mellitus

  2000cited by this paper
• Use of in vivo and in vitro techniques for the study of the effects of insulin on hepatic triacylglycerol secretion in different insulinaemic states.

  2000cited by this paper
• Mechanisms of Hepatic Very Low Density Lipoprotein Overproduction in Insulin Resistance

  2000cited by this paper
• Insulin stimulates triacylglycerol secretion by perfused livers from fed rats but inhibits it in livers from fasted or insulin-deficient rats implications for the relationship between hyperinsulinaemia and hypertriglyceridaemia.

  1999cited by this paper
• Malonyl-CoA, fuel sensing, and insulin resistance.

  1999cited by this paper
• Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study

  1999cited by this paper
• Malonyl-CoA, fuel sensing, and insulin resistance.

  1999cited by this paper
• The malonyl-CoA-long-chain acyl-CoA axis in the maintenance of mammalian cell function.

  1999cited by this paper
• Glucose control guidelines: current concepts.

  1998cited by this paper
• Effects of insulin and acipimox on VLDL1 and VLDL2 apolipoprotein B production in normal subjects.

  1998cited by this paper
• Hepatic and whole-body fat synthesis in humans during carbohydrate overfeeding.

  1997cited by this paper
• Do high carbohydrate diets prevent the development or attenuate the manifestations (or both) of syndrome X? A viewpoint strongly against

  1997cited by this paper
• Contributions of de novo synthesis of fatty acids to total VLDL-triglyceride secretion during prolonged hyperglycemia/hyperinsulinemia in normal man.

  1996cited by this paper
• Effects of a 48-h Fat Infusion on Insulin Secretion and Glucose Utilization

  1995cited by this paper
• Interaction between free fatty acids and insulin in the acute control of very low density lipoprotein production in humans.

  1995cited by this paper
• Decreasing triglyceride by gemfibrozil therapy does not affect the glucoregulatory or antilipolytic effect of insulin in nondiabetic subjects with mild hypertriglyceridemia.

  1995cited by this paper
• Why Do Low-Fat High-Carbohydrate Diets Accentuate Postprandial Lipemia in Patients With NIDDM?

  1995cited by this paper
• Insulin regulation of triacylglycerol-rich lipoprotein synthesis and secretion.

  1994cited by this paper
• Role of insulin resistance in human disease (syndrome X): an expanded definition.

  1993cited by this paper
• Effects of Acute Hyperinsulinemia on VLDL Triglyceride and VLDL ApoB Production in Normal Weight and Obese Individuals

  1993cited by this paper
• Altering Triglyceride Concentrations Changes Insulin-Glucose Relationships in Hypertriglyceridemic Patients: Double-Blind Study With Gemfibrozil With Implications for Atherosclerosis

  1991cited by this paper
• Influence of Dietary Fat Composition on Development of Insulin Resistance in Rats: Relationship to Muscle Triglyceride and ω-3 Fatty Acids in Muscle Phospholipid

  1991cited by this paper
• Insulin resistance and action in hypertriglyceridemia.

  1991cited by this paper
• The assessment of hepatic and peripheral insulin sensitivity in hypertriglyceridemia.

  1990cited by this paper
• Short- and longer-term regulation of very-low-density lipoprotein secretion by insulin, dexamethasone and lipogenic substrates in cultured hepatocytes. A biphasic effect of insulin.

  1988cited by this paper
• Effects of flow rate and insulin on triacylglycerol secretion by perfused rat liver.

  1988cited by this paper
• Failure of insulin to stimulate lipogenesis and triacylglycerol secretion in perfused livers from rats adapted to dietary fish oil.

  1987cited by this paper
• Atherosclerosis: an insulin-dependent disease?

  1986cited by this paper
• Effect of in vivo plasma insulin levels on the relationship between perfusate free fatty acid concentration and triglyceride secretion by perfused rat livers.

  1984cited by this paper
• Hyperinsulinemia and in vivo very-low-density lipoprotein-triglyceride kinetics.

  1984cited by this paper
• Effect of In Vivo Plasma Insulin Levels on the Relationship between Perfusate Free Fatty Acid Concentration and Triglyceride Secretion by Perfused Rat Livers

  1984cited by this paper
• Investigations into the direct effects of insulin on hepatic ketogenesis, lipoprotein secretion and pyruvate dehydrogenase activity.

  1984cited by this paper
• Regulation of 3-hydroxybutyrate formation and secretion of very-low-density-lipoprotein triacylglycerol by perfused livers from fed and starved rats.

  1982cited by this paper
• Resistance to Insulin but Not to Glucagon in Lean Human Hypertriglyceridemics

  1980cited by this paper
• Effects of anti-insulin serum, insulin, and glucose on output of triglycerides and on ketogenesis by the perfused rat liver.

  1976cited by this paper
• Reappraisal of the role of insulin in hypertriglyceridemia.

  1974cited by this paper
• The immediate effects of insulin and fructose on the metabolism of the perfused liver. Changes in lipoprotein secretion, fatty acid oxidation and esterification, lipogenesis and carbohydrate metabolism.

  1972cited by this paper
• Regulation of Fat Metabolism in the Liver

  1967cited by this paper

• The effect of the keto diet on lipid profile with type two diabetic patients

  2024cites this paper
• Honokiol affects the composition of gut microbiota and the metabolism of lipid and bile acid in methionine-choline deficiency diet-induced NASH mice

  2023cites this paper
• Differences in protein expression, at the basal state and at 2 h of insulin infusion, in muscle biopsies from healthy Arab men with high or low insulin sensitivity measured by hyperinsulinemic euglycemic clamp

  2023cites this paper
• Secretory Phospholipase A2s in Insulin Resistance and Metabolism

  2021cites this paper
• Modulating Glycaemia with Cereal Products

  2021cites this paper
• Etlik Piliç Karma Yemlerinde Farklı Yağ Kaynağı Kullanımının Büyüme Performansı ve Serum Lipit Konsantrasyonuna Etkisi

  2020cites this paper
• Genetic Polymorphisms Complicate COVID-19 Therapy: Pivotal Role of HO-1 in Cytokine Storm

  2020cites this paper
• Diabetes Mellituslu Hastalarda Podolojik Açıdan Ayak Değerlendirmesi

  2019cites this paper
• Effects of different foods on blood glucose and lipid in type 2 diabetes mellitus in a rat model.

  2018cites this paper
• Starchy foods in the prevention of type 2 diabetes mellitus: Effects of food structure and composition on starch digestibility and the postprandial metabolic response

  2018influential citation
• Chronic hyperinsulinemia contributes to insulin resistance under dietary restriction in association with altered lipid metabolism in Zucker diabetic fatty rats.

  2017cites this paper
• Modulatory effects of rice bran and its oil on lipid metabolism in insulin resistance rats

  2017cites this paper
• Effects of Ready-to-Eat-Cereals on Key Nutritional and Health Outcomes: A Systematic Review

  2016cites this paper
• Zagrożenia zdrowotne związane ze stosowaniem syropu wysokofruktozowego w produkcji żywności

  2016cites this paper
• BIOCHEMICAL EVALUATION OF LIPID PROFILE IN METABOLIC SYNDROME

  2016cites this paper
• Application of an In Vivo Hepatic Triacylglycerol Production Method in the Setting of a High-Fat Diet in Mice

  2016cites this paper
• A cellular model to study drug-induced liver injury in nonalcoholic fatty liver disease: Application to acetaminophen.

  2016cites this paper
• The structure of wheat bread influences the postprandial metabolic response in healthy men.

  2015cites this paper
• A novel partial agonist of PPARγ with excellent effect on insulin resistance and type 2 diabetes

  2015cites this paper
• A Novel Partial Agonist of Peroxisome Proliferator-Activated Receptor γ with Excellent Effect on Insulin Resistance and Type 2 Diabetes

  2015cites this paper
• Nutritional factors influencing the development of the Metabolic Syndrome

  2015cites this paper
• Loranthus micranthus Leaves Extract Attenuates Risk Factors of Cardiovascular Disease in Fructose Fed Rats

  2014cites this paper
• Refeeding and metabolic syndromes: two sides of the same coin

  2014cites this paper
• The Māori Kai semi-quantitative food frequency questionnaire: relative validity and reliability for assessing usual sugar intakes in New Zealand East Coast Māori

  2014cites this paper
• The prevention and control the type-2 diabetes by changing lifestyle and dietary pattern

  2014cites this paper
• cAMP response element binding protein H mediates fenofibrate-induced suppression of hepatic lipogenesis

  2013cites this paper
• Effect of an L-carnitine-containing peritoneal dialysate on insulin sensitivity in patients treated with CAPD: a 4-month, prospective, multicenter randomized trial.

  2013cites this paper
• Fructose: A Key Factor in the Development of Metabolic Syndrome and Hypertension

  2013cites this paper
• Hepatic triacylglycerol synthesis and secretion: DGAT2 as the link between glycaemia and triglyceridaemia.

  2013cites this paper
• Laboratory Diagnostics of Dyslipidemia : From Cholesterol to Apolipoproteins

  2013cites this paper
• Possible modulation of FAS and PTP-1B signaling in ameliorative potential of Bombax ceiba against high fat diet induced obesity

  2013cites this paper
• Long-term high fructose and saturated fat diet affects plasma fatty acid profile in rats

  2012cites this paper
• Effects of hyperinsulinemia on lipoprotein lipase, angiopoietin-like protein 4, and glycosylphosphatidylinositol-anchored high-density lipoprotein binding protein 1 in subjects with and without type 2 diabetes mellitus.

  2012cites this paper
• Factors predicting progression of chronic kidney disease in IgA nephropathy

  2012cites this paper
• Apolipoprotein A-I, apolipoprotein B, and apolipoprotein B/apolipoprotein A-I ratio: reference intervals compared with values in different pathophysiological conditions from the FINRISK 2007 study.

  2011cites this paper
• A Combination of (ω–3) Polyunsaturated Fatty Acids, Polyphenols and L-Carnitine Reduces the Plasma Lipid Levels and Increases the Expression of Genes Involved in Fatty Acid Oxidation in Human Peripheral Blood Mononuclear Cells and HepG2 Cells

  2011cites this paper
• Upregulation of PPARγ by Aegle marmelos Ameliorates Insulin Resistance and β‐cell Dysfunction in High Fat Diet Fed‐Streptozotocin Induced Type 2 Diabetic Rats

  2011cites this paper
• Evidence That Diacylglycerol Acyltransferase 1 (DGAT1) Has Dual Membrane Topology in the Endoplasmic Reticulum of HepG2 Cells

  2011cites this paper
• Dietary Breads and Impact on Postprandial Parameters

  2011cites this paper
• Physiological functions of iso-type short-chain fatty acid and omega 3 polyunsaturated fatty acids containing oil in obese OLETF rats.

  2010cites this paper
• Relationship between Carnitine, Fatty Acids and Insulin Resistance

  2010cites this paper
• Genetics of metabolic syndrome and related traits

  2010cites this paper
• Influência do tempo de exposição à obesidade sobre a função cardíaca de ratos

  2010cites this paper
• Chronic consumption of fructose rich soft drinks alters tissue lipids of rats

  2010cites this paper
• Protective effect of Clerodendron glandulosum extract against experimentally induced metabolic syndrome in rats

  2010cites this paper
• Facteurs métaboliques de risque cardio-vasculaire : interaction entre les régimes alimentaires et les polymorphismes de gènes impliqués dans le métabolisme des lipides

  2010cites this paper
• Preventing Diet Induced Disease: Bioavailable Nutrient-Rich, Low-Energy-Dense Diets

  2009cites this paper
• Leptin augments the acute suppressive effects of insulin on hepatic very low-density lipoprotein production in rats.

  2009cites this paper
• Overexpression of apolipoprotein A5 in mice is not protective against body weight gain and aberrant glucose homeostasis.

  2009cites this paper
• Westernized-like-diet-fed rats: effect on glucose homeostasis, lipid profile, and adipocyte hormones and their modulation by rosiglitazone and glimepiride.

  2009cites this paper
• Overweight and obesity in students of a dental college of Karachi: lifestyle influence and measurement by an appropriate anthropometric index.

  2009cites this paper
• Glycemic Index, Glycemic Load: New Evidence for a Link with Acne

  2009cites this paper
• Glycemic index, glycemic load, wellness and beauty: the state of the art.

  2009cites this paper
• The expression of type III hyperlipoproteinemia: involvement of lipolysis genes

  2009cites this paper
• Hypothesis: could excessive fructose intake and uric acid cause type 2 diabetes?

  2009cites this paper
• A pilot study to determine the short-term effects of a low glycemic load diet on hormonal markers of acne: a nonrandomized, parallel, controlled feeding trial.

  2008cites this paper
• The Liver, Glucose Homeostasis, and Insulin Action in Type 2 Diabetes Mellitus

  2008cites this paper
• Alterations in plasma and tissue lipids associated with obesity and metabolic syndrome.

  2008cites this paper
• Effects of Fructose and/or Fat in the Diet on Developing the Type 2 Diabetic-like Syndrome in CD-1 Mice

  2008cites this paper
• como factores de riesgo para enfermedad cardiovascular

  2008cites this paper
• Carbohydrate restriction and cardiovascular risk

  2008cites this paper
• Beneficial effects of ketogenic diet in obese diabetic subjects

  2007cites this paper
• Is later obesity programmed in utero?

  2007cites this paper
• Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease.

  2007cites this paper
• Measuring insulin sensitivity and the effect of alternative dietary interventions and exercise on metabolic control

  2007cites this paper
• The fructose nation.

  2007cites this paper
• Biological factors related to the possible genotoxicity of simple carbohydrates in the rat colon

  2007cites this paper
• Insulinorresistencia e hiperinsulinemiacomo factores de riesgo para enfermedad cardiovascular

  2007cites this paper
• Lipid and lipoprotein dysregulation in insulin resistant states.

  2006cites this paper
• Effect of exercise on postprandial lipemia in men with hypertriglyceridemia

  2006cites this paper
• The atherogenic potential of dietary carbohydrate.

  2006cites this paper
• The etiology of hypertension in the metabolic syndrome part two: the gene-environment interaction.

  2006cites this paper
• Amelioration of obesity and glucose intolerance in high-fat-fed C57BL/6 mice by anthocyanins and ursolic acid in Cornelian cherry (Cornus mas).

  2006cites this paper
• Nutritional strategies for patients with obesity and the metabolic syndrome

  2006cites this paper
• Programming of Obesity—Experimental Evidence

  2006cites this paper
• Long Term Effects of Ketogenic Diet in Obese Subjects with High Cholesterol Level

  2006cites this paper
• Dietary conjugated linoleic acid alleviates nonalcoholic fatty liver disease in Zucker (fa/fa) rats.

  2005cites this paper
• Hyperthyroidism impairs pancreatic beta cell adaptations to late pregnancy and maternal liporegulation in the rat

  2005cites this paper
• Effects of bisphenol-A (BPA), dibutylphtalate (DBP), benzophenone-2 (BP2), procymidone (Proc), and linurone (Lin) on fat tissue, a variety of hormones and metabolic parameters: a 3 months comparison with effects of estradiol (E2) in ovariectomized (ovx) rats.

  2005cites this paper
• The effectiveness of structured food pattern advice for achievement of macronutrient targets in nutrition intervention

  2005cites this paper
• Fructose, insulin resistance, and metabolic dyslipidemia

  2005cites this paper
• Mitochondrial Glycerol-3-phosphate Acyltransferase-1 Is Essential in Liver for the Metabolism of Excess Acyl-CoAs*

  2005cites this paper
• Origins and evolution of the Western diet: health implications for the 21st century.

  2005cites this paper
• Hypothesis: fructose-induced hyperuricemia as a causal mechanism for the epidemic of the metabolic syndrome

  2005cites this paper
• Biochemical and Molecular Actions of Nutrients Dietary Conjugated Linoleic Acid Alleviates Nonalcoholic Fatty Liver Disease in Zucker ( fa / fa ) Rats 1

  2004cites this paper
• Oxidative Stress in Nonalcoholic Fatty Liver Disease: Pathogenesis and Antioxidant Therapies

  2004cites this paper
• Fetal Nutrition and Adult Disease: Programming of Chronic Disease through Fetal Exposure to Undernutrition

  2004cites this paper
• Effect of exercise timing on postprandial lipemia in hypertriglyceridemic men.

  2004cites this paper
• Adiponectin, the missing link in insulin resistance and obesity.

  2004cites this paper
• Lipid-Induced Insulin Resistance in the Liver

  2004cites this paper
• Potential role of peroxisome proliferator-activated receptor-alpha in the modulation of glucose-stimulated insulin secretion.

  2004cites this paper
• Lipoprotein metabolism in obesity and diabetes: insights from stable isotope kinetic studies in humans.

  2003cites this paper
• Polyunsaturated fatty acids reduce insulin and very low density lipoprotein levels in broiler chickens.

  2003cites this paper
• Hyperinsulinemic diseases of civilization: more than just Syndrome X.

  2003cites this paper
• Structural differences between rye and wheat breads but not total fiber content may explain the lower postprandial insulin response to rye bread.

  2003cites this paper
• Nutritional therapy of impaired glucose tolerance and diabetes mellitus.

  2002cites this paper
• Insulin Stimulation of Hepatic Triacylglycerol Secretion in the Insulin‐Replete State

  2002cites this paper
• Interaction between growth hormone and insulin in the regulation of lipoprotein metabolism in the rat.

  2002cites this paper
• Acne vulgaris: a disease of Western civilization.

  2002cites this paper
• Differential effects of fenofibrate or simvastatin treatment of rats on hepatic microsomal overt and latent diacylglycerol acyltransferase activities.

  2002cites this paper