The integrity of cholinergic basal forebrain neurons depends on expression of Nkx2‐1

No abstract is available for this paper.

• Publication year

  2011

• Venue

  European Journal of Neuroscience

• Publication date

  2011-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/j.1460-9568.2011.07890.xPMID 22098391PMCID PMC3486784
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Centrality of Striatal Cholinergic Transmission in Basal Ganglia Function

  2011cited by this paper
• The Progenitor Zone of the Ventral Medial Ganglionic Eminence Requires Nkx2-1 to Generate Most of the Globus Pallidus But Few Neocortical Interneurons

  2010cited by this paper
• Origin and Molecular Specification of Globus Pallidus Neurons

  2010influential reference
• Sex differences in water maze performance and cortical neurotrophin levels of LHX7 null mutant mice.

  2009cited by this paper
• Ongoing expression of Nkx2.1 in the postnatal mouse forebrain: potential for understanding NKX2.1 haploinsufficiency in humans?

  2009influential reference
• LIM homeodomain transcription factor-dependent specification of bipotential MGE progenitors into cholinergic and GABAergic striatal interneurons

  2009cited by this paper
• The requirement of Nkx2-1 in the temporal specification of cortical interneuron subtypes.

  2008influential reference
• NKX2.1 specifies cortical interneuron fate by activating Lhx6

  2008influential reference
• Homeobox genes in vertebrate forebrain development and disease

  2008cited by this paper
• Postmitotic Nkx2-1 controls the migration of telencephalic interneurons by direct repression of guidance receptors.

  2008influential reference
• Fate mapping Nkx2.1‐lineage cells in the mouse telencephalon

  2008cited by this paper
• Histogenetic compartments of the mouse centromedial and extended amygdala based on gene expression patterns during development

  2008cited by this paper
• Delineation of Multiple Subpallial Progenitor Domains by the Combinatorial Expression of Transcriptional Codes

  2007influential reference
• Benign hereditary chorea revisited: A journey to understanding

  2007cited by this paper
• Thyroid-specific enhancer-binding protein/NKX2.1 is required for the maintenance of ordered architecture and function of the differentiated thyroid.

  2006influential reference
• TTF-1, a homeodomain-containing transcription factor, regulates feeding behavior in the rat hypothalamus.

  2006cited by this paper
• Neurotrophin-regulated signalling pathways

  2006cited by this paper
• Deletion of the Ttf1 Gene in Differentiated Neurons Disrupts Female Reproduction without Impairing Basal Ganglia Function

  2006cited by this paper
• Brain cholinergic vulnerability: relevance to behavior and disease.

  2005cited by this paper
• The temporal and spatial origins of cortical interneurons predict their physiological subtype.

  2005cited by this paper
• Transient overexpression of the 5-HT1A receptor impairs water-maze but not hole-board performance.

  2005cited by this paper
• Adult mouse brain gene expression patterns bear an embryologic imprint.

  2005cited by this paper
• Nonsense mutation in TITF1 in a Portuguese family with benign hereditary chorea

  2005cited by this paper
• Loss of forebrain cholinergic neurons and impairment in spatial learning and memory in LHX7‐deficient mice

  2005influential reference
• The Basal Ganglia

  2004cited by this paper
• CHAPTER 18 – Basal Ganglia

  2004cited by this paper
• Intracellular Lucifer Yellow staining and electron microscopy of neurones in slices of fixed epitumourous human cortical tissue

  2004cited by this paper
• Aberrant trajectory of ascending dopaminergic pathway in mice lacking Nkx2.1.

  2003cited by this paper
• TTF-1, a Homeodomain-containing Transcription Factor, Participates in the Control of Body Fluid Homeostasis by Regulating Angiotensinogen Gene Transcription in the Rat Subfornical Organ*

  2003cited by this paper
• The mouse brain in stereotaxic coordinates

  2003cited by this paper
• The cholinergic basal forebrain system during development and its influence on cognitive processes: important questions and potential answers.

  2003influential reference
• Fischer 344 and wistar rats differ in anxiety and habituation but not in water maze performance.

  2002influential reference
• Choreoathetosis, hypothyroidism, and pulmonary alterations due to human NKX2-1 haploinsufficiency.

  2002cited by this paper
• Complete Deletion of the Neurotrophin Receptor p75NTRLeads to Long-Lasting Increases in the Number of Basal Forebrain Cholinergic Neurons

  2002influential reference
• Molecular mechanisms underlying cell fate specification in the developing telencephalon.

  2002cited by this paper
• Mutations in TITF-1 are associated with benign hereditary chorea.

  2002cited by this paper
• Partial deficiency of thyroid transcription factor 1 produces predominantly neurological defects in humans and mice.

  2002cited by this paper
• Nerve growth factor signaling, neuroprotection, and neural repair.

  2001cited by this paper
• Pallial and subpallial derivatives in the embryonic chick and mouse telencephalon, traced by the expression of the genes Dlx‐2, Emx‐1, Nkx‐2.1, Pax‐6, and Tbr‐1

  2000cited by this paper
• Neurotrophins: key regulators of cell fate and cell shape in the vertebrate nervous system.

  2000cited by this paper
• Origin and Molecular Specification of Striatal Interneurons

  2000influential reference
• Domain‐restricted expression of two glutamic acid decarboxylase genes in midgestation mouse embryos

  2000cited by this paper
• Acetylcholine-mediated modulation of striatal function.

  2000cited by this paper
• Regional expression of a gene encoding a neuron-specific Na(+)-dependent inorganic phosphate cotransporter (DNPI) in the rat forebrain.

  2000cited by this paper
• Loss of Nkx2.1 homeobox gene function results in a ventral to dorsal molecular respecification within the basal telencephalon: evidence for a transformation of the pallidum into the striatum.

  1999influential reference
• Neurotrophins and synaptic plasticity.

  1999cited by this paper
• Basal Ganglia

  1998cited by this paper
• Region‐specific activation of microglial cells in the rat septal complex following fimbria‐fornix transection

  1998cited by this paper
• Sexually dimorphic responses to neonatal basal forebrain lesions in mice: I. Behavior and neurochemistry.

  1998cited by this paper
• Competitive Signaling Between TrkA and p75 Nerve Growth Factor Receptors Determines Cell Survival

  1998cited by this paper
• GABAergic and other noncholinergic basal forebrain neurons, together with cholinergic neurons, project to the mesocortex and isocortex in the rat

  1997cited by this paper
• Development of cholinergic and GABAergic neurons in the rat medial septum: Effect of target removal in early postnatal development

  1997cited by this paper
• Genetic variation in the morphology of the septo‐hippocampal cholinergic and GABAergic system in mice. I. Cholinergic and GABAergic markers

  1996cited by this paper
• Genetic variation in the morphology of the septo‐hippocampal cholinergic and GABAergic systems in mice: II. Morpho‐behavioral correlations

  1996cited by this paper
• The T/ebp null mouse: thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary.

  1996influential reference
• Development of cholinergic and GABAergic neurons in the rat medial septum: Different onset of choline acetyltransferase and glutamate decarboxylase mRNA expression

  1996influential reference
• Expression of NGF and NT3 mRNAs in Hippocampal Interneurons Innervated by the GABAergic Septohippocampal Pathway

  1996cited by this paper
• Fate of GABAergic septohippocampal neurons after fimbria‐fornix transection as revealed by in situ hybridization for glutamate decarboxylase mRNA and parvalbumin immunocytochemistry

  1995cited by this paper
• Regulation of TrkA and ChAT expression in developing rat basal forebrain: evidence that both exogenous and endogenous NGF regulate differentiation of cholinergic neurons

  1995cited by this paper
• p75 and Trk: a two-receptor system.

  1995cited by this paper
• Neurotrophins and Neuronal Plasticity

  1995influential reference
• TrkA‐immunoreactive profiles in the central nervous system: Colocalization with neurons containing p75 nerve growth factor receptor, choline acetyltransferase, and serotonin

  1994cited by this paper
• Brain-derived neurotrophic factor promotes differentiation of striatal GABAergic neurons.

  1994cited by this paper
• The neurotrophic factor concept: a reexamination

  1993influential reference
• Fine structure of rat septohippocampal neurons: I. Identification of septohippocampal projection neurons by retrograde tracing combined with electron microscopic immunocytochemistry and intracellular staining

  1992cited by this paper
• Fine structure of rat septohippocampal neurons: II. A time course analysis following axotomy

  1992cited by this paper
• Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator

  1991cited by this paper
• GABAergic septohippocampal neurons contain parvalbumin.

  1989cited by this paper
• The cholinergic nuclei of the basal forebrain of the rat: normal structure, development and experimentally induced degeneration.

  1987cited by this paper
• Nerve growth factor increases choline acetyltransferase activity in developing basal forebrain neurons.

  1986cited by this paper
• The Rat nervous system

  1985cited by this paper
• NGF-mediated increase of choline acetyltransferase (ChAT) in the neonatal rat forebrain: evidence for a physiological role of NGF in the brain?

  1983cited by this paper
• Cholinergic innervation of cortex by the basal forebrain: Cytochemistry and cortical connections of the septal area, diagonal band nuclei, nucleus basalis (Substantia innominata), and hypothalamus in the rhesus monkey

  1983influential reference
• Identification of central cholinergic neurons containing both choline acetyltransferase and acetylcholinesterase and of central neurons containing only acetylcholinesterase

  1983influential reference
• The development of the septal region in the rat. I. Neurogenesis examined with 3H‐thymidine autoradiography

  1979cited by this paper
• Behavior and neurochemistry.

  1961cited by this paper

• Generation of human nucleus basalis organoids with functional nbM-cortical cholinergic projections in transplanted assembloids.

  2025cites this paper
• Brain Abnormalities in Young Single- and Double-Heterozygote Mice for Both Nkx2-1- and Pax8-Null Mutations

  2024cites this paper
• Streamlined Full-Length Total RNA Sequencing of Paraformaldehyde-Fixed Brain Tissues

  2024cites this paper
• Striatal cholinergic interneuron development in models of DYT1 dystonia

  2024cites this paper
• Maintenance of neuronal fate and transcriptional identity

  2023cites this paper
• Neuronal Transplantation for Alzheimer’s Disease and Prospects for Generating Exogenic Neurons as a Source of Cells for Implantation

  2023cites this paper
• A versatile viral toolkit for functional discovery in the nervous system

  2022cites this paper
• Working memory, attention and planning abilities in NKX2.1-related chorea.

  2021cites this paper
• Analysis of Islet‐1, Nkx2.1, Pax6, and Orthopedia in the forebrain of the sturgeon Acipenser ruthenus identifies conserved prosomeric characteristics

  2021cites this paper
• PBX1 acts as terminal selector for olfactory bulb dopaminergic neurons

  2020cites this paper
• Pharmacological interrogation of TrkA-mediated mechanisms in hippocampal-dependent memory consolidation

  2019cites this paper
• Regulation of cholinergic basal forebrain development, connectivity, and function by neurotrophin receptors

  2019cites this paper
• Transcriptional control of lung alveolar type 1 cell development and maintenance by NK homeobox 2-1

  2019cites this paper
• Stem Cells as Potential Targets of Polyphenols in Multiple Sclerosis and Alzheimer's Disease

  2018cites this paper
• Immunohistochemical Biomarkers in Thyroid Pathology

  2018cites this paper
• Developmental specification of forebrain cholinergic neurons.

  2017cites this paper
• NKX2-1 Is Required in the Embryonic Septum for Cholinergic System Development, Learning, and Memory

  2017cites this paper
• A Non-Canonical Role for Choline Acetyltransferase in Chromatin Organization and the Response to Beta-Amyloid

  2016cites this paper
• Transcription Factors in Schizophrenia: A Current View of Genetic Aspects

  2016cites this paper
• A Role for the Transcription Factor Nk2 Homeobox 1 in Schizophrenia: Convergent Evidence from Animal and Human Studies

  2016influential citation
• Distinct Developmental Origins Manifest in the Specialized Encoding of Movement by Adult Neurons of the External Globus Pallidus

  2015cites this paper
• ESC-Derived Basal Forebrain Cholinergic Neurons Ameliorate the Cognitive Symptoms Associated with Alzheimer’s Disease in Mouse Models

  2015cites this paper
• Alterations of synaptic plasticity and network functions in APP and APLP-deficient mice

  2015cites this paper
• Prototypic and Arkypallidal Neurons in the Dopamine-Intact External Globus Pallidus

  2015cites this paper
• GluN2B-Containing NMDA Receptors Promote Glutamate Synapse Development in Hippocampal Interneurons

  2014cites this paper
• Maintenance of postmitotic neuronal cell identity

  2014cites this paper
• Impaired selenoprotein expression in brain triggers striatal neuronal loss leading to co-ordination defects in mice.

  2014cites this paper
• Characterization of Human 82-kDa Choline Acetyltransferase expression in a newly developed Transgenic Mouse Model

  2014cites this paper
• Regulation of expression and cellular release of acetylcholinesterase

  2013cites this paper
• The role of Ten-m3 in the development of the mouse thalamostriatal pathway

  2013cites this paper
• All-cause and disease-specific mortality and morbidity in patients with congenital hypothyroidism treated since the neonatal period: a national population-based study.

  2013cites this paper
• Functional inactivation of thyroid transcription factor-1 in PCCl3 thyroid cells.

  2012cites this paper
• A postnatal function for Nkx2‐1 in basal forebrain integrity (Commentary on Magno et al.)

  2011cites this paper