Stem Cells as Potential Targets of Polyphenols in Multiple Sclerosis and Alzheimer's Disease

Alzheimer's disease (AD) and multiple sclerosis are major neurodegenerative diseases, which are characterized by the accumulation of abnormal pathogenic proteins due to oxidative stress, mitochondrial dysfunction, impaired autophagy, and pathogens, leading to neurodegeneration and behavioral deficits. Herein, we reviewed the utility of plant polyphenols in regulating proliferation and differentiation of stem cells for inducing brain self-repair in AD and multiple sclerosis. Firstly, we discussed the genetic, physiological, and environmental factors involved in the pathophysiology of both the disorders. Next, we reviewed various stem cell therapies available and how they have proved useful in animal models of AD and multiple sclerosis. Lastly, we discussed how polyphenols utilize the potential of stem cells, either complementing their therapeutic effects or stimulating endogenous and exogenous neurogenesis, against these diseases. We suggest that polyphenols could be a potential candidate for stem cell therapy against neurodegenerative disorders.

• Publication year

  2018

• Venue

  BioMed Research International

• Publication date

  2018-07-12

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1155/2018/1483791PMID 30112360PMCID 6077677
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Clusterin

  2019cited by this paper
• Effective combination of methylprednisolone and interferon β-secreting mesenchymal stem cells in a model of multiple sclerosis.

  2018cited by this paper
• Nicotine Augments the Beneficial Effects of Mesenchymal Stem Cell-based Therapy in Rat Model of Multiple Sclerosis

  2018cited by this paper
• Human mesenchymal factors induce rat hippocampal‐ and human neural stem cell dependent oligodendrogenesis

  2018cited by this paper
• Anti-inflammatory Activity of Extra Virgin Olive Oil Polyphenols: Which Role in the Prevention and Treatment of Immune-Mediated Inflammatory Diseases?

  2018cited by this paper
• Fluvoxamine stimulates oligodendrogenesis of cultured neural stem cells and attenuates inflammation and demyelination in an animal model of multiple sclerosis

  2017cited by this paper
• Targeting the TLR4 signaling pathway by polyphenols: A novel therapeutic strategy for neuroinflammation.

  2017cited by this paper
• Celecoxib‐induced inhibition of neurogenesis in fetal frontal cortex is attenuated by curcumin via Wnt/&bgr;‐catenin pathway

  2017cited by this paper
• A green tea polyphenol epigallocatechin‐3‐gallate enhances neuroregeneration after spinal cord injury by altering levels of inflammatory cytokines

  2017cited by this paper
• Inhibition of the transforming growth factor-β/SMAD cascade mitigates the anti-neurogenic effects of the carbamate pesticide carbofuran

  2017cited by this paper
• Scalable Production of iPSC-Derived Human Neurons to Identify Tau-Lowering Compounds by High-Content Screening

  2017cited by this paper
• Presenilin-1 mutations and Alzheimer’s disease

  2017cited by this paper
• Epigallocatechin gallate induces extracellular degradation of amyloid β-protein by increasing neprilysin secretion from astrocytes through activation of ERK and PI3K pathways.

  2017cited by this paper
• Adaptive human immunity drives remyelination in a mouse model of demyelination

  2017cited by this paper
• GD1a Overcomes Inhibition of Myelination by Fibronectin via Activation of Protein Kinase A: Implications for Multiple Sclerosis

  2017cited by this paper
• Defective expression of apoptosis‐related molecules in multiple sclerosis patients is normalized early after autologous haematopoietic stem cell transplantation

  2017cited by this paper
• Protective effects of a green tea polyphenol, epigallocatechin-3-gallate, against sevoflurane-induced neuronal apoptosis involve regulation of CREB/BDNF/TrkB and PI3K/Akt/mTOR signalling pathways in neonatal mice.

  2017cited by this paper
• Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer’s disease

  2017cited by this paper
• Multiple Sclerosis Patient-Specific Primary Neurons Differentiated from Urinary Renal Epithelial Cells via Induced Pluripotent Stem Cells

  2016cited by this paper
• Alzheimer Disease

  2016cited by this paper
• Differential responses of Trans-Resveratrol on proliferation of neural progenitor cells and aged rat hippocampal neurogenesis

  2016cited by this paper
• Remyelination Is Correlated with Regulatory T Cell Induction Following Human Embryoid Body-Derived Neural Precursor Cell Transplantation in a Viral Model of Multiple Sclerosis

  2016cited by this paper
• Treatment of multiple sclerosis by transplantation of neural stem cells derived from induced pluripotent stem cells

  2016cited by this paper
• Investigation on the Role of BDNF in the Benefits of Blueberry Extracts for the Improvement of Learning and Memory in Alzheimer’s Disease Mouse Model

  2016cited by this paper
• Survival and Functionality of Human Induced Pluripotent Stem Cell‐Derived Oligodendrocytes in a Nonhuman Primate Model for Multiple Sclerosis

  2016cited by this paper
• Mesenchymal Stem Cells Preserve Working Memory in the 3xTg-AD Mouse Model of Alzheimer’s Disease

  2016cited by this paper
• Loss of galectin‐3 decreases the number of immune cells in the subventricular zone and restores proliferation in a viral model of multiple sclerosis

  2016cited by this paper
• Mfn2 is Required for Mitochondrial Development and Synapse Formation in Human Induced Pluripotent Stem Cells/hiPSC Derived Cortical Neurons

  2016cited by this paper
• Safety and efficacy of hematopoietic stem cells mobilization in patients with multiple sclerosis

  2016cited by this paper
• Evaluation of AD-MSC (adipose-derived mesenchymal stem cells) as a vehicle for IFN-β delivery in experimental autoimmune encephalomyelitis.

  2016cited by this paper
• Accelerated generation of oligodendrocyte progenitor cells from human induced pluripotent stem cells by forced expression of Sox10 and Olig2

  2016cited by this paper
• Neural Stem Cells Engineered to Express Three Therapeutic Factors Mediate Recovery from Chronic Stage CNS Autoimmunity

  2016cited by this paper
• Resveratrol: A Potential Hippocampal Plasticity Enhancer

  2016cited by this paper
• Prox1 Is Required for Oligodendrocyte Cell Identity in Adult Neural Stem Cells of the Subventricular Zone

  2016influential reference
• Epigenetic Modulation of Human Induced Pluripotent Stem Cell Differentiation to Oligodendrocytes

  2016cited by this paper
• Oligodendroglial TNFR2 Mediates Membrane TNF-Dependent Repair in Experimental Autoimmune Encephalomyelitis by Promoting Oligodendrocyte Differentiation and Remyelination

  2016cited by this paper
• Induced pluripotent stem cells in Alzheimer’s disease: applications for disease modeling and cell-replacement therapy

  2016cited by this paper
• Evaluation of patients with multiple sclerosis using reverse nutech functional score and expanded disability status scale after human embryonic stem cell therapy

  2016cited by this paper
• Mesenchymal stem cells engineered to express selectin ligands and IL-10 exert enhanced therapeutic efficacy in murine experimental autoimmune encephalomyelitis.

  2016cited by this paper
• Adipose‐derived mesenchymal stem cells modulate the immune response in chronic experimental autoimmune encephalomyelitis model

  2016cited by this paper
• The polyphenols resveratrol and epigallocatechin-3-gallate restore the severe impairment of mitochondria in hippocampal progenitor cells from a Down syndrome mouse model.

  2016cited by this paper
• Resveratrol augments therapeutic efficiency of mouse bone marrow mesenchymal stem cell‐based therapy in experimental autoimmune encephalomyelitis

  2016cited by this paper
• Dynamin-related Protein 1 Inhibition Mitigates Bisphenol A-mediated Alterations in Mitochondrial Dynamics and Neural Stem Cell Proliferation and Differentiation*

  2016cited by this paper
• Developmental Origin of Oligodendrocyte Lineage Cells Determines Response to Demyelination and Susceptibility to Age-Associated Functional Decline

  2016cited by this paper
• Conditioned Medium from the Stem Cells of Human Exfoliated Deciduous Teeth Ameliorates Experimental Autoimmune Encephalomyelitis

  2016cited by this paper
• Rapamycin Augments Immunomodulatory Properties of Bone Marrow-Derived Mesenchymal Stem Cells in Experimental Autoimmune Encephalomyelitis

  2016cited by this paper
• Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015

  2016cited by this paper
• Resveratrol Promotes Remyelination in Cuprizone Model of Multiple Sclerosis: Biochemical and Histological Study

  2016cited by this paper
• Resveratrol counteracts lipopolysaccharide-induced depressive-like behaviors via enhanced hippocampal neurogenesis

  2016cited by this paper
• Protein‐Induced Pluripotent Stem Cells Ameliorate Cognitive Dysfunction and Reduce Aβ Deposition in a Mouse Model of Alzheimer's Disease

  2016cited by this paper
• PI3K/AKT Signaling Pathway Is Essential for Survival of Induced Pluripotent Stem Cells

  2016cited by this paper
• Bisphenol-A Mediated Inhibition of Hippocampal Neurogenesis Attenuated by Curcumin via Canonical Wnt Pathway

  2016cited by this paper
• Immunological correlates of favorable long-term clinical outcome in multiple sclerosis patients after autologous hematopoietic stem cell transplantation.

  2016cited by this paper
• Activation of Autophagic Flux against Xenoestrogen Bisphenol-A-induced Hippocampal Neurodegeneration via AMP kinase (AMPK)/Mammalian Target of Rapamycin (mTOR) Pathways*

  2015cited by this paper
• Association of nonmyeloablative hematopoietic stem cell transplantation with neurological disability in patients with relapsing-remitting multiple sclerosis.

  2015cited by this paper
• Modulation of neurotrophic signaling pathways by polyphenols

  2015cited by this paper
• R47H Variant of TREM2 Associated With Alzheimer Disease in a Large Late-Onset Family: Clinical, Genetic, and Neuropathological Study.

  2015cited by this paper
• Autophagy-related protein 7 deficiency in amyloid β (Aβ) precursor protein transgenic mice decreases Aβ in the multivesicular bodies and induces Aβ accumulation in the Golgi.

  2015cited by this paper
• Inhibition of Gli1 mobilizes endogenous neural stem cells for remyelination

  2015cited by this paper
• Activation of endogenous neural stem cells for multiple sclerosis therapy

  2015cited by this paper
• Elucidating molecular phenotypes caused by the SORL1 Alzheimer's disease genetic risk factor using human induced pluripotent stem cells.

  2015cited by this paper
• Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer’s disease and multiple sclerosis

  2015cited by this paper
• Resveratrol Pretreatment Decreases Ischemic Injury and Improves Neurological Function Via Sonic Hedgehog Signaling After Stroke in Rats

  2015cited by this paper
• Demyelination Causes Adult CNS Progenitors to Revert to an Immature State and Express Immune Cues That Support Their Migration

  2015cited by this paper
• Fyn inhibition rescues established memory and synapse loss in Alzheimer mice

  2015cited by this paper
• Role of vitamin D in regulating the neural stem cells of mouse model with multiple sclerosis.

  2015cited by this paper
• Possible role of resveratrol targeting estradiol and neprilysin pathways in lipopolysaccharide model of Alzheimer disease.

  2015cited by this paper
• Association of Brain DNA methylation in SORL1, ABCA7, HLA-DRB5, SLC24A4, and BIN1 with pathological diagnosis of Alzheimer disease.

  2015cited by this paper
• An elevated level of circulating galanin promotes developmental expression of myelin basic protein in the mouse brain.

  2015cited by this paper
• Immunomodulatory characteristics of mesenchymal stem cells and their role in the treatment of multiple sclerosis.

  2015cited by this paper
• Adult Mammalian Neural Stem Cells and Neurogenesis: Five Decades Later.

  2015cited by this paper
• GDF-15 Secreted from Human Umbilical Cord Blood Mesenchymal Stem Cells Delivered Through the Cerebrospinal Fluid Promotes Hippocampal Neurogenesis and Synaptic Activity in an Alzheimer's Disease Model

  2015cited by this paper
• Resveratrol-induced SIRT1 activation promotes neuronal differentiation of human bone marrow mesenchymal stem cells.

  2015cited by this paper
• Beneficial effects of bone marrow-derived mesenchymal stem cell transplantation in a non-immune model of demyelination.

  2015cited by this paper
• (-)-Epigallocatechin-3-gallate attenuates cognitive deterioration in Alzheimer's disease model mice by upregulating neprilysin expression.

  2015cited by this paper
• Protective effect of bone marrow mesenchymal stem cells on PC12 cells apoptosis mediated by TAG1.

  2015cited by this paper
• Nicotinic acetylcholine receptors mediate donepezil‐induced oligodendrocyte differentiation

  2015cited by this paper
• Treatment Efficacy of NGF Nanoparticles Combining Neural Stem Cell Transplantation on Alzheimer’s Disease Model Rats

  2015cited by this paper
• Mesenchymal stem cells in multiple sclerosis - translation to clinical trials

  2015cited by this paper
• Neuroprotective effects of a polyphenolic white grape juice extract in a mouse model of experimental autoimmune encephalomyelitis.

  2015cited by this paper
• Administration of embryonic stem cell-derived thymic epithelial progenitors expressing MOG induces antigen-specific tolerance and ameliorates experimental autoimmune encephalomyelitis.

  2015cited by this paper
• Quercetin promotes neurite growth through enhancing intracellular cAMP level and GAP-43 expression.

  2015cited by this paper
• Programming Hippocampal Neural Stem/Progenitor Cells into Oligodendrocytes Enhances Remyelination in the Adult Brain after Injury.

  2015cited by this paper
• Antibody-mediated neutralization of myelin-associated EphrinB3 accelerates CNS remyelination

  2015cited by this paper
• Neural Stem Cell Transplant-Induced Effect on Neurogenesis and Cognition in Alzheimer Tg2576 Mice Is Inhibited by Concomitant Treatment with Amyloid-Lowering or Cholinergic α7 Nicotinic Receptor Drugs

  2015cited by this paper
• ESC-Derived Basal Forebrain Cholinergic Neurons Ameliorate the Cognitive Symptoms Associated with Alzheimer’s Disease in Mouse Models

  2015cited by this paper
• Neuro-peptide treatment with Cerebrolysin improves the survival of neural stem cell grafts in an APP transgenic model of Alzheimer disease.

  2015cited by this paper
• Fibroblast Growth Factor-2 Enhanced The Recruitment of Progenitor Cells and Myelin Repair in Experimental Demyelination of Rat Hippocampal Formations

  2015cited by this paper
• Effects of CD2-associated protein deficiency on amyloid-β in neuroblastoma cells and in an APP transgenic mouse model

  2015cited by this paper
• Mesenchymal Stem Cells as a Source of Schwann Cells: Their Anticipated Use in Peripheral Nerve Regeneration

  2015cited by this paper
• Autologous hematopoietic stem cell transplantation in progressive severe multiple sclerosis

  2015cited by this paper
• Non-steroidal anti-inflammatory drug indometacin enhances endogenous remyelination

  2015cited by this paper
• Human neural stem cells alleviate Alzheimer-like pathology in a mouse model

  2015cited by this paper
• Cell surface glycan engineering of neural stem cells augments neurotropism and improves recovery in a murine model of multiple sclerosis.

  2015cited by this paper
• Latent tri-lineage potential of adult hippocampal neural stem cells revealed by Nf1 inactivation

  2015cited by this paper
• Neuroprotective Effects of Transplanted Mesenchymal Stromal Cells-derived Human Umbilical Cord Blood Neural Progenitor Cells in EAE.

  2015cited by this paper
• Aberrant Lipid Metabolism in the Forebrain Niche Suppresses Adult Neural Stem Cell Proliferation in an Animal Model of Alzheimer's Disease.

  2015cited by this paper
• Myelin repair in vivo is increased by targeting oligodendrocyte precursor cells with nanoparticles encapsulating leukaemia inhibitory factor (LIF)

  2015cited by this paper
• Role of Environmental Contaminants in the Etiology of Alzheimer's Disease: A Review

  2015cited by this paper
• Ganglioside-Dependent Neural Stem Cell Proliferation in Alzheimer’s Disease Model Mice

  2015cited by this paper

• Amelioration of pain and adjuvant-induced arthritis by syringic acid via modulation of behavioral parameters and inflammatory mediators i.e. TNF-α, Interleukins, MCP-1, NF-kB and COX-2

  2025cites this paper
• Catechin hydrate induces GFAP expression and astrocyte branch elongation in rat neural stem cells

  2025cites this paper
• Plant-based flavonoids and their nanoparticles: Latest arsenal against Alzheimer’s disease

  2025cites this paper
• CLU polymorphisms and plasma clusterin levels in patients with multiple sclerosis: association with disability scores, progression rate and fingolimod therapy

  2025cites this paper
• (Poly)phenols and Multiple Sclerosis: Results from an Observational Cross-Sectional Study

  2025cites this paper
• The Effect of Polyphenols on Cellular and Isolated Proteasomes

  2024cites this paper
• Effects of multiple treatments with stem cell therapy in patients with multiple sclerosis.

  2024cites this paper
• Application and Mechanisms of Internet-Based Cognitive Behavioral Therapy (iCBT) in Improving Psychological State in Cancer Patients

  2023cites this paper
• Natural Phenolic Compounds with Neuroprotective Effects.

  2023cites this paper
• Stem cells in the treatment of Alzheimer's disease - Promises and pitfalls.

  2023cites this paper
• Research Progress of Flavonoid Chinese Herbal Extract Monomers in Multiple Sclerosis

  2022cites this paper
• Effects of Polyphenols on Oxidative Stress, Inflammation, and Interconnected Pathways during Spinal Cord Injury

  2022cites this paper
• Polyphenols as potential enhancers of stem cell therapy against neurodegeneration

  2022cites this paper
• The relationship of early- and late-onset Alzheimer’s disease genes with COVID-19

  2022cites this paper
• Mesenchymal stem cell therapy: A review of clinical trials for multiple sclerosis

  2022cites this paper
• Comparing the Effects of Concord Grape (Vitis labrusca L.) Puree, Juice, and Pomace on Intestinal Morphology, Functionality, and Bacterial Populations In Vivo (Gallus gallus)

  2022cites this paper
• Nutritional interventions for the prevention and treatment of neurological disorders such as anxiety, bipolar disorder, depression, epilepsy, multiple sclerosis, and schizophrenia

  2022cites this paper
• The relationships between neuroglial and neuronal changes in Alzheimer’s disease, and the related controversies II: gliotherapies and multimodal therapy

  2022cites this paper
• Dietary Polyphenols in Metabolic and Neurodegenerative Diseases: Molecular Targets in Autophagy and Biological Effects

  2021cites this paper
• Luteolin Modulates Neural Stem Cells Fate Determination: In vitro Study on Human Neural Stem Cells, and in vivo Study on LPS-Induced Depression Mice Model

  2021cites this paper
• Immunological responses and anti-tumor effects of HPV16/18 L1-L2-E7 multiepitope fusion construct along with curcumin and nanocurcumin in C57BL/6 mouse model.

  2021cites this paper
• Klotho Pathways, Myelination Disorders, Neurodegenerative Diseases, and Epigenetic Drugs

  2020cites this paper
• Dietary Polyphenols in Metabolic Diseases and Neurodegeneration: Molecular Targets on Autophagy and Biological Effects

  2020cites this paper
• Governing Issues in Nanoscale Systems and Their Potential for Improving the Therapeutic Application of Phytoconstituents

  2020cites this paper
• Notch pathway up-regulation via curcumin mitigates bisphenol-A (BPA) induced alterations in hippocampal oligodendrogenesis.

  2020cites this paper
• Nanomedicine against Alzheimer's and Parkinson's disease.

  2020cites this paper
• Dendrosomal nanocurcumin promotes remyelination through induction of oligodendrogenesis in experimental demyelination animal model

  2020cites this paper
• Neuroprotective effects of Syringic acid against aluminium chloride induced oxidative stress mediated neuroinflammation in rat model of Alzheimer's disease

  2020cites this paper
• Safety and efficacy of stem cell therapy for treatment of neural damage in patients with multiple sclerosis.

  2019cites this paper
• “Polyphenolic-food” Effects on Brain Health (Human Data review)

  2019cites this paper