An Epstein-Barr virus transformation-associated membrane protein interacts with src family tyrosine kinases

No abstract is available for this paper.

• Publication year

  1992

• Venue

  Journal of Virology

• Publication date

  1992-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/jvi.66.8.5161-5167.1992PMID 1321296PMCID PMC241398
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• An Epstein-Barr virus protein associated with cell growth transformation interacts with a tyrosine kinase

  1991influential reference
• The nature of Hodgkin and Reed-Sternberg cells, their association with EBV, and their relationship to anaplastic large-cell lymphoma.

  1991cited by this paper
• Tyrosine phosphorylation of components of the B-cell antigen receptors following receptor crosslinking.

  1991influential reference
• Anti-immunoglobulin stimulation of B lymphocytes activates src-related protein-tyrosine kinases.

  1991influential reference
• Association of B cell antigen receptor with protein tyrosine kinase Lyn.

  1991cited by this paper
• The B-cell antigen receptor complex.

  1991cited by this paper
• IgM antigen receptor complex contains phosphoprotein products of B29 and mb-1 genes.

  1991cited by this paper
• SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins.

  1991cited by this paper
• A second Epstein-Barr virus membrane protein (LMP2) is expressed in latent infection and colocalizes with LMP1

  1990cited by this paper
• Association between the PDGF receptor and members of the src family of tyrosine kinases.

  1990cited by this paper
• Binding of GAP to activated PDGF receptors.

  1990cited by this paper
• Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A.

  1990cited by this paper
• PDGF β-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex

  1990cited by this paper
• Molecular components of the B cell antigen receptor complex of class IgD differ partly from those of IgM.

  1990cited by this paper
• B lymphocyte antigen receptors (mIg) are non‐covalently associated with a disulfide linked, inducibly phosphorylated glycoprotein complex.

  1990influential reference
• Identification of Epstein-Barr virus terminal protein 1 (TP1) in extracts of four lymphoid cell lines, expression in insect cells, and detection of antibodies in human sera

  1990cited by this paper
• Phosphorylation of the PDGF receptor beta subunit creates a tight binding site for phosphatidylinositol 3 kinase.

  1990cited by this paper
• Stimulation of protein tyrosine phosphorylation by the B-lymphocyte antigen receptor

  1990cited by this paper
• Differences in glycoprotein complexes associated with IgM and IgD on normal murine B cells potentially enable transduction of different signals.

  1990cited by this paper
• Binding of SH2 domains of phospholipase C gamma 1, GAP, and Src to activated growth factor receptors.

  1990cited by this paper
• Epstein-Barr virus in nasal T-cell lymphomas in patients with lethal midline granuloma.

  1990cited by this paper
• Identification of the Epstein-Barr virus terminal protein gene products in latently infected lymphocytes

  1990cited by this paper
• Molecular components of the B-cell antigen receptor complex of the IgM class

  1990influential reference
• Tyrosine phosphorylation coupled to IgE receptor-mediated signal transduction and histamine release.

  1990cited by this paper
• Epstein-Barr virus latent membrane protein (LMP1) and nuclear proteins 2 and 3C are effectors of phenotypic changes in B lymphocytes: EBNA-2 and LMP1 cooperatively induce CD23

  1990cited by this paper
• Detection of ebv gene expression in reed‐sternberg cells of Hodgkin's disease

  1990cited by this paper
• Protein tyrosine phosphorylation is induced in murine B lymphocytes in response to stimulation with anti‐immunoglobulin.

  1990influential reference
• Characterization of the BNLF-1 oncogene of Epstein-Barr virus.

  1989cited by this paper
• Role of phosphatidylinositol kinase in PDGF receptor signal transduction.

  1989cited by this paper
• A survey of Epstein-Barr virus DNA in lymphoid tissue. Frequent detection in Hodgkin's disease.

  1989cited by this paper
• Association of p60fyn with middle tumor antigen in murine polyomavirus-transformed rat cells

  1989cited by this paper
• Demonstration of monoclonal EBV genomes in Hodgkin's disease and Ki-1-positive anaplastic large cell lymphoma by combined Southern blot and in situ hybridization.

  1989cited by this paper
• Molecular genetic analysis of lymphoid tumors arising after organ transplantation.

  1989cited by this paper
• Human immunodeficiency virus (HIV) and Epstein-Barr virus (EBV) antigens and genome in lymph nodes of HIV-positive patients affected by persistent generalized lymphadenopathy (PGL).

  1989cited by this paper
• Direct activation of the serine/threonine kinase activity of Raf-1 through tyrosine phosphorylation by the PDGF beta-receptor.

  1989cited by this paper
• Plasma cell malignancy in the acquired immune deficiency syndrome. Association with Epstein-Barr virus.

  1989cited by this paper
• Epstein-Barr virus latent membrane protein: induction of B-cell activation antigens and membrane patch formation does not require vimentin

  1989cited by this paper
• Two related Epstein-Barr virus membrane proteins are encoded by separate genes

  1989cited by this paper
• Expression of Epstein-Barr virus transformation-associated genes in tissues of patients with EBV lymphoproliferative disease.

  1989cited by this paper
• CD3-negative lymphoproliferative disease of granular lymphocytes containing Epstein-Barr viral DNA.

  1989cited by this paper
• High frequency of Epstein-Barr virus genome in HIV-positive patients with Hodgkin's disease.

  1989cited by this paper
• EGF induces tyrosine phosphorylation of phospholipase C-II: a potential mechanism for EGF receptor signaling.

  1989cited by this paper
• High frequency of Epstein-Barr virus genome in HIV-positive patients with Hodgkin's disease.

  1989cited by this paper
• The truncated form of the Epstein-Barr virus latent-infection membrane protein expressed in virus replication does not transform rodent fibroblasts

  1988cited by this paper
• The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck.

  1988cited by this paper
• Peptide antibodies to the human c‐fyn gene product demonstrate pp59c‐fyn is capable of complex formation with the middle‐T antigen of polyomavirus.

  1988cited by this paper
• Transformation of Balb 3T3 cells by the BNLF-1 gene of Epstein-Barr virus.

  1988cited by this paper
• A spliced Epstein‐Barr virus gene expressed in immortalized lymphocytes is created by circularization of the linear viral genome.

  1988cited by this paper
• Identification and characterization of p59fyn (a src‐like protein tyrosine kinase) in normal and polyoma virus transformed cells.

  1988cited by this paper
• Cellular proteins that associate with the middle and small T antigens of polyomavirus

  1988cited by this paper
• Potential positive and negative autoregulation of p60c-src by intermolecular autophosphorylation.

  1988cited by this paper
• Signal transduction from membrane to cytoplasm: growth factors and membrane-bound oncogene products increase Raf-1 phosphorylation and associated protein kinase activity.

  1988cited by this paper
• Epstein-Barr virus latent infection membrane protein alters the human B-lymphocyte phenotype: deletion of the amino terminus abolishes activity

  1988cited by this paper
• Analysis of the c-src gene product structure, abundance, and protein kinase activity in human neuroblastoma and glioblastoma cells.

  1987cited by this paper
• Tyrosine phosphorylation regulates the biochemical and biological properties of pp60c-src.

  1987cited by this paper
• Evidence for two distinct phosphatidylinositol kinases in fibroblasts. Implications for cellular regulation.

  1987cited by this paper
• Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity.

  1987cited by this paper
• Association of the polyomavirus middle-T antigen with c-yes protein

  1987cited by this paper
• An 81 kd protein complexed with middle T antigen and pp60c-src: a possible phosphatidylinositol kinase.

  1987cited by this paper
• Cell transformation by pp60c-src mutated in the carboxy-terminal regulatory domain.

  1987cited by this paper
• Activation and suppression of pp60c-src transforming ability by mutation of its primary sites of tyrosine phosphorylation.

  1987cited by this paper
• Mutations around the NG59 lesion indicate an active association of polyoma virus middle‐T antigen with pp60c‐src is required for cell transformation.

  1986cited by this paper
• Altered sites of tyrosine phosphorylation in pp60c-src associated with polyomavirus middle tumor antigen

  1986cited by this paper
• An EBV membrane protein expressed in immortalized lymphocytes transforms established rodent cells.

  1985cited by this paper
• Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation

  1985cited by this paper
• Nucleotide sequence of an mRNA transcribed in latent growth-transforming virus infection indicates that it may encode a membrane protein

  1984influential reference
• The complex of polyoma virus middle‐T antigen and pp60c‐src.

  1984cited by this paper
• Enhancement of cellular src gene product associated tyrosyl kinase activity following polyoma virus infection and transformation.

  1984cited by this paper
• A membrane protein encoded by Epstein-Barr virus in latent growth-transforming infection.

  1984influential reference
• Polyoma virus transforming protein associates with the product of the c-src cellular gene

  1983cited by this paper
• Transformation of rat cells by an altered polyoma virus genome expressing only the middle-T protein

  1981cited by this paper
• Malignant lymphoma in cottontop marmosets after inoculation with Epstein-Barr virus.

  1973cited by this paper

• Regulation mechanism of EBV-encoded EBER1 and LMP2A on YAP1 and the impact of YAP1 on the EBV infection status in EBV-associated gastric carcinoma

  2024cites this paper
• The regulatory role of protein phosphorylation in human gammaherpesvirus associated cancers

  2017cites this paper
• Manipulation of the host cell membrane by human γ-herpesviruses EBV and KSHV for pathogenesis

  2016cites this paper
• [Infectious and neoplasic complications after kidney transplantation].

  2016cites this paper
• Latent Membrane Protein 2 (LMP2).

  2015cites this paper
• Epstein Barr Virus Volume 2

  2015cites this paper
• Caractérisation structurale et fonctionnelle des interactions impliquant TFIIH et les domaines de transactivation viraux

  2014cites this paper
• Beta Interferon, and Viral Spread B, Induction of κ Regulates Activation of NF- An ITAM in a Nonenveloped Virus

  2014cites this paper
• Defining Immune Engagement Thresholds for In Vivo Control of Virus-Driven Lymphoproliferation

  2014influential citation
• Role of the Immunoreceptor Tyrosine-Based Activation Motif of Latent Membrane Protein 2A (LMP2A) in Epstein-Barr Virus LMP2A-Induced Cell Transformation

  2014cites this paper
• Fyn Kinase Is Required for Optimal Humoral Responses

  2013cites this paper
• Concurrent targeting of eicosanoid receptor 1/eicosanoid receptor 4 receptors and COX-2 induces synergistic apoptosis in Kaposi's sarcoma-associated herpesvirus and Epstein-Barr virus associated non-Hodgkin lymphoma cell lines.

  2013cites this paper
• An ITAM in a Nonenveloped Virus Regulates Activation of NF-κB, Induction of Beta Interferon, and Viral Spread

  2013cites this paper
• Viral-encoded genes and cancer

  2012cites this paper
• Virus-Mediated Cell Proliferation

  2012cites this paper
• Modulation of Autophagy-Like Processes by Tumor Viruses

  2012cites this paper
• Phosphorylation events during viral infections provide potential therapeutic targets

  2011cites this paper
• Dualité fonctionnelle de LMP1 : implication dans l’apoptose et la transformation cellulaire

  2011cites this paper
• Syk Activation of Phosphatidylinositol 3-Kinase/Akt Prevents HtrA2-dependent Loss of X-linked Inhibitor of Apoptosis Protein (XIAP) to Promote Survival of Epstein-Barr Virus+ (EBV+) B Cell Lymphomas*

  2011cites this paper
• Human Immunodeficiency Virus-Associated Malignancies

  2010cites this paper
• The role of host cell factors in the lytic reactivation of Kaposi's sarcoma-associated herpesvirus from latency

  2010cites this paper
• Hodgkin lymphoma transcription similar to those observed in Reed-Sternberg cells of Epstein-Barr Virus (EBV) LMP2A induces alterations in gene

  2010cites this paper
• C-Myc et lymphomagenèse dans les cellules B infectées par le virus d’Epstein-Barr

  2009influential citation
• The role of the microenvironment on the regulation of Epstein-Barr virus latent gene expression

  2009cites this paper
• Immune control of mammalian gamma-herpesviruses: lessons from murid herpesvirus-4.

  2009cites this paper
• An auto-regulatory loop for EBV LMP2A involves activation of Notch.

  2008cites this paper
• Multi-transmembrane protein K15 of Kaposi's sarcoma-associated herpesvirus targets Lyn kinase in the membrane raft and induces NFAT/AP1 activities

  2008cites this paper
• Systematic Mutagenesis of the Murine Gammaherpesvirus 68 M2 Protein Identifies Domains Important for Chronic Infection

  2008cites this paper
• Lessons from viruses: controlling the function of transmembrane proteins by interfering transmembrane helices.

  2008cites this paper
• Studies on Immune Regulation of Epstein-Barr Virus

  2008cites this paper
• EBV LMP2A provides a surrogate pre-B cell receptor signal through constitutive activation of the ERK/MAPK pathway.

  2008cites this paper
• The signaling pathways of Epstein-Barr virus-encoded latent membrane protein 2A (LMP2A) in latency and cancer

  2008cites this paper
• Rôle de la protéine LMP1 dans la balance survie/apoptose des cellules infectées par le virus d’Epstein-Barr :

  2008cites this paper
• Gamma herpesviruses: Pathogenesis of infection and cell signaling

  2008cites this paper
• Epstein-Barr Virus Latent Membrane Protein 2A Preferentially Signals through the Src Family Kinase Lyn

  2008influential citation
• Epstein–Barr virus latent membrane protein 2A upregulates UDP‐glucose dehydrogenase gene expression via ERK and PI3K/Akt pathway

  2008cites this paper
• Functional Analysis and Characterization of Epstein Barr Virus Latent Membrane Protein 2b

  2008influential citation
• The K15 protein of Kaposi's sarcoma-associated herpesvirus recruits the endocytic regulator intersectin 2 through a selective SH3 domain interaction.

  2007cites this paper
• Epstein-Barr Virus Latent Membrane Protein 2A Mediates Transformation through Constitutive Activation of the Ras/PI3-K/Akt Pathway

  2007cites this paper
• Regulation of the STAT1 by the Epstein-Barr virus.

  2007cites this paper
• An Introduction to the Evolutionary Ecology of Viruses

  2007cites this paper
• Minimal protein domain requirements for the intracellular localization and self-aggregation of Epstein-Barr Virus Latent Membrane Protein 2

  2007cites this paper
• Epstein-Barr Virus Latent Membrane Protein 2B (LMP2B) Modulates LMP2A Activity

  2006cites this paper
• The Intersection Between Viral Transforming Proteins and Cellular Signal Transduction Pathways

  2006cites this paper
• Study of nuclear targets of phosphatidylinositol-3 kinase in lymphocytes

  2006cites this paper
• The role of Epstein–Barr virus in cancer

  2006cites this paper
• Regulation of intracellular signalling by the terminal membrane proteins of members of the Gammaherpesvirinae.

  2006cites this paper
• Complications infectieuses et néoplasiques après transplantation rénale

  2005cites this paper
• Epstein‐Barr virus latent membrane 2A (LMP2A) down‐regulates telomerase reverse transcriptase (hTERT) in epithelial cell lines

  2005cites this paper
• The Epstein-Barr Virus Protein, Latent Membrane Protein 2A, Co-opts Tyrosine Kinases Used by the T Cell Receptor*

  2005cites this paper
• The Epstein-Barr Virus-Encoded LMP2A and LMP2B Proteins Promote Epithelial Cell Spreading and Motility

  2005cites this paper
• Epstein-Barr virus (EBV) LMP2A alters normal transcriptional regulation following B-cell receptor activation.

  2004cites this paper
• 46 - Infection and Guillain-Barré syndrome

  2004cites this paper
• Sequence Variations of Epstein-Barr Virus LMP2A Gene in Gastric Carcinoma in Japan

  2004cites this paper
• Epstein–Barr virus (EBV) LMP2A mediates B-lymphocyte survival through constitutive activation of the Ras/PI3K/Akt pathway

  2004cites this paper
• Epstein-Barr virus signal transduction and B-lymphocyte growth transformation.

  2004cites this paper
• Down-regulation of membrane immunoglobulin-associated proteins, MB-1, B29 and Lyn, in AIDS-lymphomas and related conditions

  2004cites this paper
• vOX2- a potential immune regulatory protein involved in Kaposi's sarcoma-associated herpesvirus pathogenesis

  2004cites this paper
• The Nedd4 family of E3 ubiquitin ligases: functional diversity within a common modular architecture

  2004cites this paper
• Viruses and Apoptosis

  2004cites this paper
• Identification of latent membrane protein 2A (LMP2A) specific targets for treatment and eradication of Epstein-Barr virus (EBV)-associated diseases.

  2003cites this paper
• Epstein-Barr Virus (EBV) LMP2A induces alterations in gene transcription similar to those observed in Reed-Sternberg cells of Hodgkin lymphoma.

  2003cites this paper
• Epstein-Barr Virus LMP2A Interferes with Global Transcription Factor Regulation When Expressed during B-Lymphocyte Development

  2003cites this paper
• Expression of the anti-apoptotic bfl-1/A1 gene is regulated by the Epstein Barr virus nuclear antigen 2(EBNA2)

  2003cites this paper
• Complete Genomic Sequence of an Epstein-Barr Virus-Related Herpesvirus Naturally Infecting a New World Primate: a Defining Point in the Evolution of Oncogenic Lymphocryptoviruses

  2002cites this paper
• Das BPLF1-Gen des Epstein-Barr-Virus

  2002cites this paper
• Herpesviral protein targets a cellular WD repeat endosomal protein to downregulate T lymphocyte receptor expression.

  2002cites this paper
• Epstein-Barr Virus Latent Membrane Protein 2A Regulates c-Jun Protein through Extracellular Signal-Regulated Kinase

  2002cites this paper
• The LMP2A signalosome--a therapeutic target for Epstein-Barr virus latency and associated disease.

  2002cites this paper
• Bovine leukemia virus gp30 transmembrane (TM) protein is not tyrosine phosphorylated: examining potential interactions with host tyrosine-mediated signaling.

  2002cites this paper
• Inhibition of host kinase activity altered by the LMP2A signalosome-a therapeutic target for Epstein-Barr virus latency and associated disease.

  2002cites this paper
• Regulation der Latenz des Epstein-Barr-Virus in humanen B-Lymphozyten durch die viralen Latenten Membranproteine 1 und 2A

  2002cites this paper
• The Effects of the Epstein-Barr Virus Latent Membrane Protein 2a on B Cell Function

  2001cites this paper
• Molecular virology of Epstein-Barr virus.

  2001cites this paper
• Epstein-Barr Virus Latent Membrane Protein 2a (Lmp2a) Employs the Slp-65 Signaling Module

  2001cites this paper
• Role of Epstein-Barr virus-encoded latent membrane protein 2A on virus-induced immortalization and virus activation.

  2001cites this paper
• C-Terminal Domain of the Epstein-Barr Virus LMP2A Membrane Protein Contains a Clustering Signal

  2001cites this paper
• The Epstein-Barr virus encoded latent membrane protein 2A augments signaling from latent membrane protein 1.

  2001cites this paper
• Comparative analysis of the transforming mechanisms of Epstein-Barr virus, Kaposi's sarcoma-associated herpesvirus, and Herpesvirus saimiri.

  2001cites this paper
• Non-Hodgkin's lymphoma: pathogenesis, clinical presentation, and treatment.

  2001cites this paper
• Epstein–Barr virus latent-infection membrane proteins are palmitoylated and raft-associated: Protein 1 binds to the cytoskeleton through TNF receptor cytoplasmic factors

  2001cites this paper
• Analysis of the phosphorylation status of Epstein-Barr virus LMP2A in epithelial cells.

  2001cites this paper
• Regulation of apoptosis by the Epstein-Barr virus latent membrane protein LMP1

  2001cites this paper
• Cis- und trans-wirksame Elemente der latenten Replikation des Epstein-Barr-Virus

  2001cites this paper
• Large granular lymphocyte dysregulation in malignant catarrhal fever

  2001cites this paper
• Latent Membrane Protein 2A-Mediated Effects on the Phosphatidylinositol 3-Kinase/Akt Pathway

  2000cites this paper
• WW- and SH3-domain interactions with Epstein-Barr virus LMP2A.

  2000cites this paper
• Epstein-Barr virus latent membrane protein 2A has no growth-altering effects when expressed in differentiating epithelia.

  2000influential citation
• Epstein-Barr virus latency: LMP2, a regulator or means for Epstein-Barr virus persistence?

  2000cites this paper
• Signaling Activities of Gammaherpesvirus Membrane Proteins

  2000cites this paper
• Epstein-Barr virus LMP2A-induced B-cell survival in two unique classes of EmuLMP2A transgenic mice.

  2000cites this paper
• Epstein-Barr Virus LMP2A-Induced B-Cell Survival in Two Unique Classes of EμLMP2A Transgenic Mice

  2000cites this paper
• Membrane Proteins Signaling Activities of Gammaherpesvirus

  2000cites this paper
• Evolutionary aspects of oncogenic herpesviruses

  2000cites this paper
• Latent Membrane Protein 2A of Epstein-Barr Virus Binds WW Domain E3 Protein-Ubiquitin Ligases That Ubiquitinate B-Cell Tyrosine Kinases

  2000cites this paper
• MINIREVIEW Signaling Activities of Gammaherpesvirus Membrane Proteins

  2000cites this paper
• Epstein-Barr Virus LMP2A Transforms Epithelial Cells, Inhibits Cell Differentiation, and Activates Akt

  2000cites this paper
• Epstein-Barr Virus LMP2A-Induced B-Cell Survival in Two Unique Classes of EmLMP2A Transgenic Mice

  1999cites this paper
• Epstein-Barr virus lacking latent membrane protein 2 immortalizes B cells with efficiency indistinguishable from that of wild-type virus.

  1999cites this paper
• Identification of Kaposin (Open Reading Frame K12) as a Human Herpesvirus 8 (Kaposi’s Sarcoma-Associated Herpesvirus) Transforming Gene

  1999cites this paper