Induction of endocycles represses apoptosis independently of differentiation and predisposes cells to genome instability

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Development

• Publication date

  2014-01-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1242/dev.098871PMID 24284207PMCID PMC3865753
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Drosophila Oogenesis

  2015cited by this paper
• Endoreplication and polyploidy: insights into development and disease

  2013influential reference
• Fundamental differences in endoreplication in mammals and Drosophila revealed by analysis of endocycling and endomitotic cells

  2013influential reference
• Making big cells: One size does not fit all

  2013influential reference
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  2013cited by this paper
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  2012cited by this paper
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  2012cited by this paper
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  2012cited by this paper
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  2012cited by this paper
• E2F8 is essential for polyploidization in mammalian cells

  2012cited by this paper
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  2012cited by this paper
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  2012cited by this paper
• "Two" much of a good thing: telomere damage-induced genome doubling drives tumorigenesis.

  2012influential reference
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  2012cited by this paper
• Developmental control of gene copy number by repression of replication initiation and fork progression.

  2012cited by this paper
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  2012cited by this paper
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  2011cited by this paper
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  2011cited by this paper
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  2011cited by this paper
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  2011cited by this paper
• Integrative analysis of gene amplification in Drosophila follicle cells: parameters of origin activation and repression.

  2011cited by this paper
• Programmed cell death in animal development and disease.

  2011influential reference
• Control of Drosophila endocycles by E2F and CRL4Cdt2

  2011cited by this paper
• Tumour evolution inferred by single-cell sequencing

  2011cited by this paper
• The causes and consequences of polyploidy in normal development and cancer.

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  2010cited by this paper
• Leading Edge Previews Cancer Genomes Evolve by Pulverizing Single Chromosomes

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• The DNA damage response: making it safe to play with knives.

  2010cited by this paper
• The emerging role of APC/CCdh1 in controlling differentiation, genomic stability and tumor suppression

  2010cited by this paper
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  2010cited by this paper
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  2010cited by this paper
• Error-prone polyploid mitosis during normal Drosophila development.

  2010cited by this paper
• Dampened activity of E2F1–DP and Myb–MuvB transcription factors in Drosophila endocycling cells

  2010cited by this paper
• A Mechanism Linking Extra Centrosomes to Chromosomal Instability

  2009cited by this paper
• Regulation of Cyclin A protein in meiosis and early embryogenesis

  2009influential reference
• p53-Independent Apoptosis Limits DNA Damage-Induced Aneuploidy

  2009cited by this paper
• Developmentally programmed endoreduplication in animals

  2009cited by this paper
• Cracking open cell death in the Drosophila ovary

  2009cited by this paper
• Endoreplication: polyploidy with purpose.

  2009influential reference
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  2009cited by this paper
• Centrosomin: A Complex Mix of Long and Short Isoforms Is Required for Centrosome Function During Early Development in Drosophila melanogaster

  2009cited by this paper
• Regulation of the endocycle/gene amplification switch by Notch and ecdysone signaling

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  2008cited by this paper
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  2008influential reference
• Growing evidence of the repopulation of regressed tumours by the division of giant cells

  2008influential reference
• Endoreduplication control during plant development.

  2008cited by this paper
• Concerning the Origin of Malignant Tumours by Theodor Boveri. Translated and annotated by Henry Harris

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  2008cited by this paper
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  2008cited by this paper
• The anaphase-promoting complex/cyclosome (APC/C) is required for rereplication control in endoreplication cycles.

  2008influential reference
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  2007influential reference
• Evolution of genes and genomes on the Drosophila phylogeny

  2007cited by this paper
• Down-regulation of inhibitor of apoptosis levels provides competence for steroid-triggered cell death

  2007cited by this paper
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  2007cited by this paper
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  2007cited by this paper
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  2007cited by this paper
• Ionizing radiation induces caspase-dependent but Chk2- and p53-independent cell death in Drosophila melanogaster.

  2006cited by this paper
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  2006cited by this paper
• Selective Resistance of Tetraploid Cancer Cells against DNA Damage‐Induced Apoptosis

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  2006cited by this paper
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  2006cited by this paper
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  2006cited by this paper
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  2005influential reference
• Drosophila melanogaster

  2005cited by this paper
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  2005cited by this paper
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  1999cited by this paper
• Reprogramming the cell cycle for endoreduplication in rodent trophoblast cells.

  1998cited by this paper
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  1998influential reference

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