Abrupt withdrawal from intrathecal baclofen: recognition and management of a potentially life-threatening syndrome.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Archives of Physical Medicine and Rehabilitation

• Publication date

  2002-06-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1053/APMR.2002.32820PMID 12048649
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Principles of Neural Science, 4th ed.

  2001cited by this paper
• RHABDOMYOLYSIS AND HYPERTHERMIA ASSOCIATED WITH INTRATHECAL BACLOFEN WITHDRAWAL IN THE ABSENCE OF PUMP OR CATHETER DEFECT

  2000cited by this paper
• Withdrawal syndromes.

  2000cited by this paper
• Evidence of the effects of intrathecal baclofen for spastic and dystonic cerebral palsy. AACPDM Treatment Outcomes Committee Review Panel.

  2000cited by this paper
• Intrathecal Baclofen for Management of Spastic Cerebral Palsy: Multicenter Trial

  2000cited by this paper
• Cardiovascular consequences of loss of supraspinal control of the sympathetic nervous system after spinal cord injury.

  2000cited by this paper
• Intrathecal baclofen withdrawal simulating neuroleptic malignant syndrome in a child with cerebral palsy

  2000cited by this paper
• Evidence of the effects of intrathecal baclofen for spastic and dystonic cerebral palsy

  2000cited by this paper
• Death after acute withdrawal of intrathecal baclofen: case report and literature review.

  1999cited by this paper
• Symptoms of recurrent intrathecal baclofen withdrawal resulting from drug delivery failure: a case report.

  1999cited by this paper
• Baclofen withdrawal presenting as multiorgan system failure.

  1998cited by this paper
• An unusual exposure to methyl bromide leading to fatality.

  1998cited by this paper
• Prolonged severe withdrawal symptoms after acute-on-chronic baclofen overdose.

  1998cited by this paper
• Infusion of intrathecal baclofen for generalized dystonia in cerebral palsy.

  1998cited by this paper
• Hyperthermia, rhabdomyolysis, and disseminated intravascular coagulation associated with baclofen pump catheter failure.

  1998cited by this paper
• Prospective assessment of continuous intrathecal infusion of baclofen for spasticity caused by acquired brain injury: a preliminary report.

  1997cited by this paper
• [Severe hyperthermia caused by sudden withdrawal of continuous intrathecal administration of baclofen].

  1996cited by this paper
• Topical Review: Baclofen in the Treatment of Cerebral Palsy

  1996cited by this paper
• Hyperthermie grave liée à un sevrage brutal de baclofène administré de façon continue par voie intrathécale

  1996cited by this paper
• Baclofen in the treatment of cerebral palsy.

  1996cited by this paper
• Dantrolene treatment for abrupt intrathecal baclofen withdrawal.

  1995cited by this paper
• Intrathecal baclofen treatment for stiff‐man syndrome

  1994cited by this paper
• Intrathecal baclofen down-regulates GABAB receptors in the rat substantia gelatinosa.

  1993cited by this paper
• Intrathecal baclofen for intractable spasticity of spinal origin: results of a long-term multicenter study.

  1993cited by this paper
• Hyperthermia associated with baclofen withdrawal and increased spasticity.

  1993cited by this paper
• Prolonged seizure activity after baclofen withdrawal

  1992cited by this paper
• Prolonged seizure activity after baclofen withdrawal.

  1992cited by this paper
• Development of an acute withdrawal syndrome following the cessation of intrathecal baclofen in a patient with spasticity.

  1992cited by this paper
• Intrathecal baclofen for spasticity in cerebral palsy.

  1991cited by this paper
• Medical Neurosciences: An Approach to Anatomy, Pathology, and Physiology by Systems and Levels

  1986cited by this paper
• Adverse Effects Secondary to Baclofen Withdrawal

  1985cited by this paper
• Hallucinations after Preoperative Baclofen Discontinuation in Spinal Cord Injury Patients

  1985cited by this paper
• Status epilepticus after baclofen withdrawal.

  1984cited by this paper
• Dyskinesia and psychosis in a patient following baclofen withdrawal.

  1984cited by this paper
• Baclofen (LioresalR) Intoxication Report of 4 Cases and Review of the Literature

  1983cited by this paper
• Baclofen (Lioresal) intoxication report of 4 cases and review of the literature.

  1983cited by this paper
• Convulsions after abrupt withdrawal of baclofen.

  1982cited by this paper
• Drug therapy: spasticity (first of two parts).

  1981cited by this paper
• Principles of Neural Science

  1981cited by this paper
• Drug therapy: spasticity (second of two parts).

  1981cited by this paper
• Complications of baclofen withdrawal.

  1981cited by this paper
• Drug therapy: spasticity (first of two parts).

  1981cited by this paper
• Drug therapy: spasticity (second of two parts).

  1981cited by this paper
• Hallucinations after withdrawal of baclofen.

  1977cited by this paper
• Letter: Pyelonephritis and coliform infections of the urinary tract.

  1975cited by this paper
• Semi-security and psychiatric hospitals.

  1974cited by this paper

• Oral Baclofen Withdrawal: A Case Report of an Iranian Infant with Gastroesophageal Reflux Disease, Presenting with Seizure

  2025cites this paper
• Lost in conversion: navigating the challenges of converting intrathecal opioids to oral equivalents—a case report and literature review

  2025cites this paper
• Hyperselective neurectomy for spastic equinovarus in pediatric patients with hypertonia

  2025cites this paper
• Emergency Scenarios in Functional Neurosurgery

  2025cites this paper
• A Case with Baclofen Withdrawal: Clinical Insights and the Need for Regulated Access

  2025cites this paper
• Cardiac Arrest: A Rare Complication of Intrathecal Baclofen Withdrawal

  2025cites this paper
• Severe Case of Intrathecal Baclofen Withdrawal: A Case Report

  2025cites this paper
• Dantrolene and cyproheptadine as salvage therapy for severe intrathecal baclofen withdrawal: A case report.

  2025cites this paper
• Evaluating drug withdrawal syndrome risks through food and drug administration adverse event reporting system: a comprehensive disproportionality analysis

  2024cites this paper
• Intrathecal baclofen efficacy for managing motor function and spasticity severity in patients with cerebral palsy: a systematic review and meta-analysis

  2024cites this paper
• Adults with Cerebral Palsy: Navigating the Complexities of Aging

  2023cites this paper
• Assessment of Health Care Costs and Total Baclofen Use Associated With Targeted Drug Delivery for Spasticity.

  2023cites this paper
• Calcification of the pump pouch in patients receiving ITB therapy: A rare complication affecting refill procedure - Analysis of two cases.

  2023cites this paper
• Decompression for lumbar spinal stenosis at the intrathecal catheter insertion site during intrathecal baclofen therapy: a case report

  2023cites this paper
• An unusual intrathecal baclofen pump failure thirteen months after implantation

  2023cites this paper
• Intrathecal Baclofen Pump Perioperative Management: Case Report and Literature Review

  2022cites this paper
• Estimating the National Population of Hospitalized Chronic Baclofen Users: A Cross-Sectional Analysis of a Commercial Claims Database

  2022cites this paper
• Approach to the Treatment of Pediatric Dystonia

  2022cites this paper
• Severe Case of Oral Baclofen Withdrawal Resulting in Mechanical Ventilation

  2022cites this paper
• Intravenous dantrolene in hypermetabolic syndromes: a survey of the U.S. Veterans Health Administration database

  2022cites this paper
• Intrathecal and oral baclofen use in adults with spinal cord injury (SCI): a systematic review of efficacy in spasticity reduction and functional improvement, dosing and adverse events.

  2022cites this paper
• Multiple Electroencephalogram Recordings for Monitoring the Evolution of Neurological Complications during Baclofen Withdrawal Syndrome

  2022cites this paper
• Drug-induced Hyperthermic Syndromes in Psychiatry

  2021cites this paper
• Preoperative and Postoperative Care of Patients with Neurologic Disorders

  2021cites this paper
• Treatment of dystonia

  2021cites this paper
• Spasticity

  2021cites this paper
• Probable Encephalopathy and Spasticity in a Multiple Sclerosis Patient Following Carbapenem Administration: A Case Report and Brief Literature Review

  2021cites this paper
• Neuropharmacology

  2021cites this paper
• Spasticity and contractures

  2021cites this paper
• Baclofen therapeutics, toxicity, and withdrawal: A narrative review

  2021cites this paper
• Instituting an intrathecal baclofen pump program at an academic institution

  2021cites this paper
• Intrathecal baclofen, selective dorsal rhizotomy, and extracorporeal shockwave therapy for the treatment of spasticity in cerebral palsy: a systematic review

  2021cites this paper
• In Support of Initial Parenteral Medical Management of Intrathecal Baclofen Withdrawal in Spasticity Patients

  2021cites this paper
• Intrathecal Baclofen Overdose With Paradoxical Autonomic Features Mimicking Withdrawal.

  2020cites this paper
• Caring for patients with pain during the COVID‐19 pandemic: consensus recommendations from an international expert panel

  2020cites this paper
• Complications associated with intrathecal drug delivery systems.

  2020cites this paper
• Effect of Bolus Dose of Intrathecal Baclofen Followed by Pump Implantation in Severe Spasticity in Multiple Sclerosis Patients

  2020cites this paper
• Spasticity Management After Spinal Cord Injury

  2020cites this paper
• The neuroleptic malignant syndrome—a systematic case series analysis focusing on therapy regimes and outcome

  2020cites this paper
• Principles of Pharmacotherapy of Seizures and Status Epilepticus

  2020cites this paper
• Classics in Chemical Neuroscience: Baclofen.

  2020cites this paper
• Point of care procedures in physiatry: Practice considerations during the Covid-19 pandemic

  2020cites this paper
• Practical Chronic Pain Management: A Case-Based Approach

  2020cites this paper
• Early Rotation of Intrathecal Baclofen Pump – a Case Report

  2020cites this paper
• From quail to earthquakes and human conflict: a historical perspective of rhabdomyolysis.

  2020cites this paper
• Managing Intrathecal Drug Delivery Devices in a Global Pandemic

  2020cites this paper
• Spasticity Following Spinal Cord Injury

  2020cites this paper
• A 38-Year-Old Woman with Baclofen Withdrawal

  2020cites this paper
• Intrathecal baclofen for dystonia treatment during pregnancy: A case report

  2019cites this paper
• Staged pallidotomy: MRI and clinical follow-up in status dystonicus

  2019cites this paper
• Treatment of the Neuroleptic Malignant Syndrome in International Therapy Guidelines: A Comparative Analysis

  2019cites this paper
• Rehabilitation Following TBI

  2019cites this paper
• Dexmedetomidine for Acute Management of Intrathecal Baclofen Withdrawal.

  2019cites this paper
• IDDS for Spasticity, Dystonia, and Rigidity

  2019cites this paper
• Accuracy of Template Versus Ultrasound Identification of the Reservoir Access Port of Intrathecal Drug Delivery System

  2019cites this paper
• Generalized Itching and Lower-Extremity Spasticity in a Patient with Intrathecal Baclofen Pump.

  2018cites this paper
• Persons With Chronic Spinal Cord Injuries in the Emergency Department: a Review of a Unique Population.

  2018cites this paper
• Perioperative and Periprocedural Care of Patients With Intrathecal Pump Therapy

  2018cites this paper
• Expert to Expert: Paediatric Movement Disorders Pre-course Reading Bristol 18-19 October 2018

  2018cites this paper
• Intrathecal Baclofen Therapy—Practical Approach: Clinical Benefits and Complication Management

  2018cites this paper
• Autonomic dysfunction in the neurological intensive care unit

  2018cites this paper
• Baclofen Pump Implantation for Cerebral Palsy

  2018cites this paper
• Intrathecal Medication Withdrawal

  2018cites this paper
• A Case of Drug Dependence Syndrome to Baclofen Following High-Dose Therapy.

  2018cites this paper
• Medications in Intrathecal Pumps

  2018cites this paper
• Muscle Overactivity in the Upper Motor Neuron Syndrome: Conceptualizing a Treatment Plan and Establishing Meaningful Goals.

  2018cites this paper
• Meaningful Assessment in Patients with Acquired Brain Injuries.

  2018cites this paper
• Baclofen Pump Implantation for Cerebral Palsy Baclofen Pump Implantation for Cerebral Palsy

  2018cites this paper
• Is Intrathecal Baclofen Pump Safe as It Thought To Be?

  2018influential citation
• Pharmacokinetics and pharmacodynamics of intrathecal baclofen therapy

  2018cites this paper
• Intrathecal Baclofen Injection to Avoid Withdrawal in a Multiple Sclerosis Patient Undergoing Lumbar Spine Surgery: A Case Report.

  2017cites this paper
• Baclofen Pumps: Uses and Complications

  2017cites this paper
• Plain radiography in patients treated with intrathecal drug delivery using an implantable pump device

  2017cites this paper
• Physician-assisted death should be available to people with MS – YES

  2017cites this paper
• Neuroleptic malignant syndrome: an easily overlooked neurologic emergency

  2017cites this paper
• Programmable baclofen pump implantation as a treatment modality for spasticity: A clinical prospective study

  2017cites this paper
• Nurse Practitioner Lead Pediatric Baclofen Pump Program: Impact on Safety and Quality of Care

  2017cites this paper
• Perioperative Patient Management of Adult Lumbar Scoliosis

  2017cites this paper
• Oral Baclofen Withdrawal Resulting in Progressive Weakness and Sedation Requiring Intensive Care Admission

  2017cites this paper
• Can Cerebrospinal Fluid Pressure Detect Catheter Complications in Patients Who Experience Loss of Effectiveness With Intrathecal Baclofen Therapy?

  2017cites this paper
• Neuromodulation in multiple sclerosis

  2017cites this paper
• A Randomized Dose Escalation Study of Intravenous Baclofen in Healthy Volunteers: Clinical Tolerance and Pharmacokinetics

  2017cites this paper
• Perioperative complications associated with spine surgery in patients with established spinal cord injury.

  2016cites this paper
• Intrathecal baclofen for dystonia treatment during pregnancy: A case report ☆

  2016cites this paper
• Síndrome neuroléptico maligno

  2016cites this paper
• Successful treatment of severe baclofen toxicosis initially refractory to conventional treatment

  2016cites this paper
• Evaluation of intrathecal baclofen delivery system malfunction by computed tomography scan

  2016cites this paper
• Neonatal Baclofen Withdrawal: A Case Report of an Infant Presenting With Severe Feeding Difficulties.

  2016cites this paper
• Baclofeno intratecal para el tratamiento de la distonía durante el embarazo: un caso clínico

  2016cites this paper
• Intrathecal baclofen withdrawal: A rare cause of reversible cardiomyopathy*

  2016cites this paper
• Psychosis Following an Increase in Intrathecal Baclofen

  2016cites this paper
• Best Practices for Intrathecal Baclofen Therapy: Dosing and Long‐Term Management

  2016cites this paper
• Best Practices for Intrathecal Baclofen Therapy: Troubleshooting

  2016cites this paper
• Ultrasound Guidance for Technically Challenging Intrathecal Baclofen Pump Refill: Three Cases and Procedure Description

  2016cites this paper
• Novel psychoactive substances of interest for psychiatry

  2015cites this paper
• Intrathecal Pump: An Abrupt Intermittent Pump Failure

  2015cites this paper
• A Pilot Study Assessing Pharmacokinetics and Tolerability of Oral and Intravenous Baclofen in Healthy Adult Volunteers

  2015cites this paper
• Intrathecal Baclofen in Spinal Spasticity: Frequency and Severity of Withdrawal Syndrome.

  2015cites this paper
• Device‐Enabled Drug Infusion Therapies

  2015cites this paper
• Tratamiento de las complicaciones y de las secuelas neurológicas de los pacientes con traumatismos medulares

  2015cites this paper