Troglitazone prevents insulin dependent diabetes in the non-obese diabetic mouse.

No abstract is available for this paper.

• Publication year

  1998

• Venue

  European Journal of Pharmacology

• Publication date

  1998-09-18

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/S0014-2999(98)00574-3PMID 9797040
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Leptin- or troglitazone-induced lipopenia protects islets from interleukin 1beta cytotoxicity.

  1997cited by this paper
• Thiazolidinediones in the Treatment of Insulin Resistance and Type II Diabetes

  1996cited by this paper
• A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation.

  1995cited by this paper
• The Prevention of IDDM: Injecting Insulin Into the Cytokine Network

  1995cited by this paper
• Differential Activation of Peroxisome Proliferator-activated Receptors by Eicosanoids (*)

  1995cited by this paper
• Isolation of the human peroxisome proliferator activated receptor gamma cDNA: expression in hematopoietic cells and chromosomal mapping.

  1995cited by this paper
• Type I Diabetes Masquerading as Type II Diabetes: Possible implications for prevention and treatment

  1994cited by this paper
• Tumor Necrosis Factor α: A Key Component of the Obesity-Diabetes Link

  1994cited by this paper
• Evidence for a common mechanism of action for fatty acids and thiazolidinedione antidiabetic agents on gene expression in preadipose cells.

  1994cited by this paper
• Prevention of diabetes in the NOD mouse: implications for therapeutic intervention in human disease.

  1994cited by this paper
• Altered gene expression for tumor necrosis factor-alpha and its receptors during drug and dietary modulation of insulin resistance.

  1994cited by this paper
• Troglitazone prevents the inhibitory effects of inflammatory cytokines on insulin-induced adipocyte differentiation in 3T3-L1 cells.

  1994cited by this paper
• Histological study of pancreatic beta-cell loss in relation to the insulitis process in the non-obese diabetic mouse

  1994cited by this paper
• Lymphocytic traffic and homing into target tissue and the generation of endocrine autoimmunity

  1994cited by this paper
• Immunoregulatory and Cytokine Imbalances in the Pathogenesis of IDDM: Therapeutic Intervention by Immunostimulation?

  1994cited by this paper
• Inflammatory roles of P-selectin.

  1993cited by this paper
• Insulin-dependent diabetes in the NOD mouse model. II. Beta cell destruction in autoimmune diabetes is a TH2 and not a TH1 mediated event.

  1993cited by this paper
• NOD mouse colonies around the world--recent facts and figures.

  1993cited by this paper
• Relief of metastatic biliary obstruction by stent placement: is it worthwhile?

  1993cited by this paper
• Selectins: interpreters of cell-specific carbohydrate information during inflammation.

  1992cited by this paper
• Structure and Function of Leukocyte Integrins

  1990cited by this paper
• The natural history of lymphocyte subsets infiltrating the pancreas of NOD mice

  1989cited by this paper
• The Animals (scientific procedures) Act 1986.

  1986cited by this paper
• Insulitis and Type I Diabetes: Lessons from the Nod Mouse

  1986cited by this paper
• Breeding of a non-obese, diabetic strain of mice.

  1980cited by this paper

• Phenolic Compounds Inhibit 3T3-L1 Adipogenesis Depending on the Stage of Differentiation and Their Binding Affinity to PPARγ

  2019influential citation
• Characterisation of an immune-modulating peptide secreted by a helminth worm

  2018cites this paper
• Insulin sensitizer prevents and ameliorates experimental type 1 diabetes.

  2017influential citation
• Metabolic Regulation of T Cell Immunity.

  2017cites this paper
• Peroxisome Proliferator-activated Receptor-γ Activation Augments the β-Cell Unfolded Protein Response and Rescues Early Glycemic Deterioration and β Cell Death in Non-obese Diabetic Mice*

  2016cites this paper
• Mechanisms of transcriptional regulation in the maintenance of β cell function

  2015cites this paper
• Attenuation of islet‐specific T cell responses is associated with C‐peptide improvement in autoimmune type 2 diabetes patients

  2013cites this paper
• Diabetic mouse models

  2013cites this paper
• Influence of Tyrphostin AG490 on the expression of diabetes-associated markers in human adipocytes

  2012cites this paper
• mTOR, metabolism, and the regulation of T‐cell differentiation and function

  2012cites this paper
• Tyrphostin AG490 Agent Modestly but Significantly Prevents Onset of Type 1 in NOD Mouse; Implication of Immunologic and Metabolic Effects of a Jak-Stat Pathway Inhibitor

  2012cites this paper
• Peroxisome Proliferator-Activated Receptor γ Is Required for CD4+ T Cell-Mediated Lymphopenia-Associated Autoimmunity

  2011cites this paper
• PPARγ regulates retinoic acid‐mediated DC induction of Tregs

  2009cites this paper
• Effects of 15-Deoxy-Δ12,14-Prostaglandin J2 (15d-PGJ2) and Rosiglitazone on Human Vδ2+ T Cells

  2009cites this paper
• Pioglitazone might prevent the progression of slowly progressive type 1 diabetes.

  2009cites this paper
• Peroxisome Proliferator-Activated Receptor γ (PPARγ) and Immunoregulation: Enhancement of Regulatory T Cells through PPARγ-Dependent and -Independent Mechanisms

  2007cites this paper
• PGJ2-stimulated β-cell apoptosis is associated with prolonged UPR activation

  2007cites this paper
• EFFECT OF CYCLOPENTANONE PROSTAGLANDIN 15-DEOXY-&Dgr;12,14PGJ2 ON EARLY FUNCTIONAL RECOVERY FROM EXPERIMENTAL SPINAL CORD INJURY

  2007cites this paper
• PGJ2-stimulated beta-cell apoptosis is associated with prolonged UPR activation.

  2007cites this paper
• PGJ 2 -stimulated (cid:1) -cell apoptosis is associated with prolonged UPR activation

  2007cites this paper
• Exploration of Conditions Affecting Cytokine Production in Experimental Type 1 Diabetes Mellitus

  2007cites this paper
• Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 277 Exploration of Conditions Affecting Cytokine Production in Experimental type 1 Diabetes Mellitus

  2007cites this paper
• Troglitazone Reduces Leptinemia during Experimental Dexamethasone-induced Stress

  2005cites this paper
• Insulinotropic and anti-inflammatory effects of rosiglitazone in experimental autoimmune diabetes.

  2005cites this paper
• Transcriptional regulation of lipid metabolism by fatty acids: a key determinant of pancreatic β-cell function

  2005cites this paper
• Role of endogenous ligands for the peroxisome proliferators activated receptors alpha in the secondary damage in experimental spinal cord trauma.

  2005cites this paper
• Investigational agents that protect pancreatic islet β-cells from failure

  2005cites this paper
• Protective effect of peroxisome proliferator activated receptor gamma agonists on diabetic and non‐diabetic renal diseases

  2005cites this paper
• Alleviation of insulitis and moderation of diabetes in NOD mice following treatment with a synthetic Pseudomonas aeruginosasignal molecule, N-(3-oxododecanoyl)-L-homoserine lactone

  2005cites this paper
• Investigational agents that protect pancreatic islet beta-cells from failure.

  2005cites this paper
• Troglitazone reduces leptinemia during experimental dexamethasone-induced stress.

  2005cites this paper
• Rosiglitazone combined with insulin preserves islet β cell function in adult‐onset latent autoimmune diabetes (LADA)

  2005cites this paper
• PPARgamma ligands induce ER stress in pancreatic beta-cells: ER stress activation results in attenuation of cytokine signaling.

  2004cites this paper
• PPARγ ligands induce ER stress in pancreatic β-cells: ER stress activation results in attenuation of cytokine signaling

  2004cites this paper
• Analysis of the type 2 diabetes-associated single nucleotide polymorphisms in the genes IRS1, KCNJ11, and PPARG2 in type 1 diabetes.

  2004cites this paper
• Ligands for the peroxisome proliferator-activated receptor-gamma and the retinoid X receptor exert additive anti-inflammatory effects on experimental autoimmune encephalomyelitis.

  2004cites this paper
• REVIEW Central role of defective apoptosis in autoimmunity

  2003cites this paper
• Central role of defective apoptosis in autoimmunity.

  2003cites this paper
• Glutamic acid decarboxylase 65 autoantibody levels discriminate two subtypes of latent autoimmune diabetes in adults.

  2003cites this paper
• Critical role of c-Jun N-terminal protein kinase activation in troglitazone-induced apoptosis of human HepG2 hepatoma cells.

  2003cites this paper
• Cytokine release by murine spleen cells following multiple low dose streptozotocin-induced diabetes and treatment with a TNFalpha transcriptional inhibitor.

  2003cites this paper
• Prevention of autoimmune diabetes in NOD mice by troglitazone is associated with modulation of ICAM-1 expression on pancreatic islet cells and IFN-gamma expression in splenic T cells.

  2003cites this paper
• Protective effect of pioglitazone against multiple low-dose streptozotocin-induced diabetes in rats.

  2003cites this paper
• Use of L-alpha-lysophosphatidylcholine to obtain the differentiation of monocytes into mature dendritic cells in vitro

  2003cites this paper
• Use of alpha-lysophosphatidylcholine for the differentiation of monocytes into mature dendritic cells in vitro

  2003cites this paper
• Siomerieux s.a. - inserm

  2003cites this paper
• Novel insulin sensitizers: pharmacogenomic aspects.

  2002cites this paper
• Malonyl-CoA signaling, lipid partitioning, and glucolipotoxicity: role in beta-cell adaptation and failure in the etiology of diabetes.

  2002cites this paper
• Thiazolidinediones increase the number of platelets in immune thrombocytopenic purpura mice via inhibition of phagocytic activity of the reticulo-endothelial system.

  2002cites this paper
• Thiazolidinediones for the prevention of diabetes in the non‐obese diabetic (NOD) mouse: implications for human type 1 diabetes

  2002influential citation
• Nicotine reduces the incidence of type I diabetes in mice.

  2002cites this paper
• Peroxisome proliferator-activated receptor-gamma in the renal mesangium.

  2002cites this paper
• Regulation of Cytokine Expression by Ligands of Peroxisome Proliferator Activated Receptors1

  2002cites this paper
• WY14,643, a PPARα Ligand, Has Profound Effects on Immune Responses In Vivo1

  2002cites this paper
• Peroxisome proliferator-activated receptor-γ in the renal mesangium

  2002cites this paper
• This information is current as Receptors Ligands of Peroxisome Proliferator Activated Regulation of Cytokine Expression by

  2002cites this paper
• Peroxisome proliferator-activated receptor-gamma agonist troglitazone protects against nondiabetic glomerulosclerosis in rats.

  2001cites this paper
• A transcriptional inhibitor of TNF-alpha prevents diabetes induced by multiple low-dose streptozotocin injections in mice.

  2001cites this paper
• Autoimmune diabetes not requiring insulin at diagnosis (latent autoimmune diabetes of the adult): definition, characterization, and potential prevention.

  2001cites this paper
• The nuclear receptor PPAR gamma is expressed by mouse T lymphocytes and PPAR gamma agonists induce apoptosis

  2001cites this paper
• PPAR gamma/RXR as a molecular target for diabetes.

  2001cites this paper
• Troglitazone and related compounds: therapeutic potential beyond diabetes.

  2000cites this paper
• Troglitazone exhibits immunomodulatory activity on the cytokine production of activated human lymphocytes.

  1999cites this paper
• Troglitazone Exhibits Immunomodulatory Activity on the Cytokine Production of Activated Human Lymphocytes

  1999cites this paper
• Pioglitazone prevents mice from multiple low-dose streptozotocin-induced insulitis and diabetes.

  1999cites this paper