Reduction of Unnecessary Antibiotic Therapy in Newborn Infants Using Interleukin-8 and C-Reactive Protein as Markers of Bacterial Infections

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Pediatrics

• Publication date

  1999-09-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1542/peds.104.3.447PMID 10469768
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Vancomycin-Resistant Enterococcus

  1998cited by this paper
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  1998cited by this paper
• Interleukin-6 concentrations in neonates evaluated for sepsis.

  1998cited by this paper
• Interleukin-1 receptor antagonist and interleukin-6 for early diagnosis of neonatal sepsis 2 days before clinical manifestation.

  1998cited by this paper
• C-reactive protein is a useful marker for guiding duration of antibiotic therapy in suspected neonatal bacterial infection.

  1997cited by this paper
• Perinatally transmitted neonatal bacterial infections.

  1997cited by this paper
• INTERLEUKIN‐6: A SENSITIVE PARAMETER FOR THE EARLY DIAGNOSIS OF NEONATAL BACTERIAL INFECTION: 480

  1997cited by this paper
• VANCOMYCIN-RESISTANT ENTEROCOCCUS: Detection, Epidemiology, and Control Measures

  1997cited by this paper
• Diagnosis of late onset neonatal sepsis with cytokines, adhesion molecule, and C-reactive protein in preterm very low birthweight infants

  1997cited by this paper
• Interleukin 8 (Il-8) Is A Sensitive and Specific Marker for Early Onset Neonatal Bacterial Infection (Eobi) and Nosocomial Bacterial Infection (Nbi) in Preterm Infants (Pi)

  1997cited by this paper
• Inflammatory and immunological markers in preterm infants: correlation with disease

  1996cited by this paper
• Evaluation of interleukin-6 and soluble receptors of tumor necrosis factor for early diagnosis of neonatal infection.

  1996cited by this paper
• Immunologic parameters in cord blood indicating early-onset sepsis.

  1996cited by this paper
• Granulocyte colony-stimulating factor as a marker for bacterial infection in neonates.

  1996cited by this paper
• Early-onset sepsis in very low birth weight neonates: a report from the National Institute of Child Health and Human Development Neonatal Research Network.

  1996cited by this paper
• Late-onset sepsis in very low birth weight neonates: a report from the National Institute of Child Health and Human Development Neonatal Research Network.

  1996cited by this paper
• Procalcitonin as a marker for the early diagnosis of neonatal infection.

  1996cited by this paper
• Increased Plasma Concentrations of Interleukin-1 Receptor Antagonist in Neonatal Sepsis

  1995cited by this paper
• Interleukin‐6 and soluble interleukin‐6 receptor in cord blood in the diagnosis of early onset sepsis in neonates

  1995cited by this paper
• Interleukin-6: a sensitive parameter for the early diagnosis of neonatal bacterial infection.

  1994cited by this paper
• Comparative study of four tests of bacterial infection in the neonate. Total neutrophil count, CRP, fibrinogen and C3d.

  1994cited by this paper
• Can antibiotic resistance be controlled?

  1994cited by this paper
• Predictive value of soluble immunological mediators in neonatal infection.

  1994cited by this paper
• Early discontinuation of antibiotic treatment in newborn admitted to rule out sepsis: a decision rule

  1994cited by this paper
• Sepsis + C-reactive protein.

  1994cited by this paper
• Diagnostic value of plasma levels of tumor necrosis factor α (TNFα) and interleukin‐6 (IL‐6) in newborns with sepsis

  1994cited by this paper
• Complement Activation in Newborn Infants with Early Onset Infection

  1993cited by this paper
• Significance of serial C-reactive protein responses in neonatal infection and other disorders.

  1993cited by this paper
• High serum procalcitonin concentrations in patients with sepsis and infection

  1993cited by this paper
• Circulating ICAM-1 in neonatal sepsis.

  1993cited by this paper
• Receiver operating characteristic curves for comparison of serial neutrophil band forms and C reactive protein in neonates at risk of infection.

  1992cited by this paper
• Complement activation in neonatal infection.

  1992cited by this paper
• Clinical application of urine antigen detection in early onset group B streptococcal disease.

  1992cited by this paper
• Detection of plasma tumor necrosis factor, interleukins 6, and 8 during the Jarisch-Herxheimer Reaction of relapsing fever

  1992cited by this paper
• Clinicopathologic approach to the diagnosis of neonatal sepsis.

  1991cited by this paper
• Detection of interleukin 8 and tumor necrosis factor in normal humans after intravenous endotoxin: the effect of antiinflammatory agents

  1991cited by this paper
• Infectious diseases in the neonate: diagnosis and monitoring by quantitative plasma polymorphonuclear leukocyte-elastase determination.

  1990cited by this paper
• Neutrophil-activating peptide-1/interleukin 8, a novel cytokine that activates neutrophils.

  1989cited by this paper
• Diagnostic audit of C-reactive protein in neonatal infection

  1987cited by this paper
• Elastase-α1-proteinase inhibitor in early diagnosis of neonatal septicemia

  1986cited by this paper
• Elastase-alpha 1-proteinase inhibitor in early diagnosis of neonatal septicemia.

  1986cited by this paper
• Early diagnosis of neonatal sepsis.

  1980cited by this paper
• [Blood picture in the early diagnosis of neonatal septicemia].

  1976cited by this paper
• Neutrophil and band counts in the diagnosis of neonatal infections.

  1974cited by this paper

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