Yersiniabactin synthetase: a four-protein assembly line producing the nonribosomal peptide/polyketide hybrid siderophore of Yersinia pestis.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Chemistry and Biology

• Publication date

  2002-03-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/S1074-5521(02)00115-1PMID 11927258
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• In vitro reconstitution of the Pseudomonas aeruginosa nonribosomal peptide synthesis of pyochelin: characterization of backbone tailoring thiazoline reductase and N-methyltransferase activities.

  2001cited by this paper
• C-methyltransferase and cyclization domain activity at the intraprotein PK/NRP switch point of yersiniabactin synthetase.

  2001cited by this paper
• Essential PchG-Dependent Reduction in Pyochelin Biosynthesis of Pseudomonas aeruginosa

  2001cited by this paper
• Purification, priming, and catalytic acylation of carrier protein domains in the polyketide synthase and nonribosomal peptidyl synthetase modules of the HMWP1 subunit of yersiniabactin synthetase.

  2001cited by this paper
• Yersiniabactin synthetase: probing the recognition of carrier protein domains by the catalytic heterocyclization domains, Cy1 and Cy2, in the chain-initiating HWMP2 subunit.

  2001cited by this paper
• Role of type II thioesterases: evidence for removal of short acyl chains produced by aberrant decarboxylation of chain extender units.

  2001cited by this paper
• Synthetic studies of thiazoline and thiazolidine-containing natural products. Part 3: Total synthesis and absolute configuration of the siderophore yersiniabactin

  2001cited by this paper
• Novel features in a combined polyketide synthase/non-ribosomal peptide synthetase: the myxalamid biosynthetic gene cluster of the myxobacterium Stigmatella aurantiaca Sga15.

  2001cited by this paper
• Substrate specificity of the loading didomain of the erythromycin polyketide synthase.

  2000cited by this paper
• Expression, purification, and characterization of HMWP2, a 229 kDa, six domain protein subunit of Yersiniabactin synthetase.

  2000cited by this paper
• Yersinia pestis YbtU and YbtT Are Involved in Synthesis of the Siderophore Yersiniabactin but Have Different Effects on Regulation

  2000cited by this paper
• Acyl-CoA hydrolysis by the high molecular weight protein 1 subunit of yersiniabactin synthetase: mutational evidence for a cascade of four acyl-enzyme intermediates during hydrolytic editing.

  2000cited by this paper
• Yersiniabactin from Yersinia pestis: biochemical characterization of the siderophore and its role in iron transport and regulation.

  1999cited by this paper
• Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis.

  1999cited by this paper
• Tandem heterocyclization activity of the multidomain 230 kDa HMWP2 subunit of Yersinia pestis yersiniabactin synthetase: interaction of the 1-1382 and 1383-2035 fragments.

  1999cited by this paper
• Bleomycin Biosynthesis inStreptomyces verticillusATCC15003: A Model of Hybrid Peptide and Polyketide Biosynthesis☆☆☆★

  1999cited by this paper
• Intermediates of rifamycin polyketide synthase produced by an Amycolatopsis mediterranei mutant with inactivated rifF gene.

  1999cited by this paper
• Direct evidence that the rifamycin polyketide synthase assembles polyketide chains processively.

  1999cited by this paper
• How do peptide synthetases generate structural diversity?

  1999cited by this paper
• The Yersiniabactin Biosynthetic Gene Cluster of Yersinia enterocolitica: Organization and Siderophore-Dependent Regulation

  1998cited by this paper
• Iron acquisition in plague: modular logic in enzymatic biogenesis of yersiniabactin by Yersinia pestis.

  1998cited by this paper
• Reconstitution and characterization of the Escherichia coli enterobactin synthetase from EntB, EntE, and EntF.

  1998cited by this paper
• The nonribosomal peptide synthetase HMWP2 forms a thiazoline ring during biogenesis of yersiniabactin, an iron-chelating virulence factor of Yersinia pestis.

  1998cited by this paper
• Peptide siderophores

  1998cited by this paper
• Micacocidin A, B and C, novel antimycoplasma agents from Pseudomonas sp. II. Structure elucidation.

  1998cited by this paper
• Characterization of Sfp, a Bacillus subtilis phosphopantetheinyl transferase for peptidyl carrier protein domains in peptide synthetases.

  1998cited by this paper
• Manipulation of Modular Polyketide Synthases.

  1997cited by this paper
• Transition Metals in Microbial Metabolism

  1997cited by this paper
• Genetic organization of the yersiniabactin biosynthetic region and construction of avirulent mutants in Yersinia pestis

  1997cited by this paper
• Comprehensive Supramolecular Chemistry

  1996cited by this paper
• Characterization of a large chromosomal "high-pathogenicity island" in biotype 1B Yersinia enterocolitica

  1996cited by this paper
• Divergent sequence motifs correlated with the substrate specificity of (methyl)malonyl‐CoA:acyl carrier protein transacylase domains in modular polyketide synthases

  1995cited by this paper
• Siderophores: Structure and Function of Microbial Iron Transport Compounds (*)

  1995cited by this paper
• Structure elucidation of yersiniabactin, a siderophore from highly virulent Yersinia strains

  1995cited by this paper
• Biosynthesis and Chemical Synthesis of Bleomycin

  1991cited by this paper

• OSMAC guided bioprospecting of Atlantic sponges reveals novel bacterial species and evidence for the antimicrobial thiazole alkaloid agrochelin II

  2026cites this paper
• A review on hypervirulent and multidrug-resistant Klebsiella pneumoniae: An emerging threat to human health.

  2026cites this paper
• Avian Pathogenic Escherichia coli: Advances in Pathogenesis, Diagnosis, and Control

  2025cites this paper
• Iron Uptake Systems: Chemical Tools for Advancing Infectious Disease Treatment and Diagnosis.

  2025cites this paper
• Decoding Lusichelins A–E: An In-Depth Look at the Metallophores of Lusitaniella coriacea LEGE 07167–Structure, Production, and Functionality

  2025cites this paper
• Reaction Engineering of In Vitro Natural Product Biosynthesis: Challenges and Strategies

  2025cites this paper
• Structures, biosynthetic pathways, and biological significance of bacterial aryl-heterocycle metallophores with emphasis on yersiniabactin-type derivatives.

  2025cites this paper
• Fatuamide A, a Hybrid PKS/NRPS Metallophore from a Leptolyngbya sp. Marine Cyanobacterium Collected in American Samoa

  2025cites this paper
• Genomic mechanisms underlying the adaptation of Anaerobutyricum species to the human host.

  2025cites this paper
• Biosynthetic Investigations of Ulbactins Unveil Two Novel Thiazolinyl Imine Reductases Crucial for the Generation of Siderophore Activity.

  2025cites this paper
• Discovery of Cladoescherins, Unusual Hybrid Metabolites Derived from a Fungal PKS and a Bacterial NRPS by Co-cultivation.

  2025cites this paper
• The structural basis of substrate selectivity of the acinetobactin biosynthetic adenylation domain, BasE

  2025cites this paper
• Recent advances in metallophore research uncover functions in quorum sensing, antimicrobial activity, and lanthanide acquisition.

  2025cites this paper
• Stuffed Epimerase Domains of Pyochelin Biosynthesis are Defunct Methyltransferases.

  2025cites this paper
• Mucosal sugars delineate pyrazine vs pyrazinone autoinducer signaling in Klebsiella oxytoca

  2024cites this paper
• Identification of the bacterial metabolite aerugine as potential trigger of human dopaminergic neurodegeneration

  2023cites this paper
• Structural advances toward understanding the catalytic activity and conformational dynamics of modular nonribosomal peptide synthetases

  2023cites this paper
• Discovery and Biosynthesis of Anthrochelin, a Growth‐Promoting Metallophore of the Human Pathogen Luteibacter anthropi

  2023cites this paper
• Engineering Siderophore Biosynthesis and Regulation Pathways to Increase Diversity and Availability

  2023influential citation
• Biofilm control on metallic materials in medical fields from the viewpoint of materials science – from the fundamental aspects to evaluation

  2023cites this paper
• High-quality genome-scale metabolic network reconstruction of probiotic bacterium Escherichia coli Nissle 1917

  2022cites this paper
• Programmable Synthesis of Biobased Materials Using Cell‐Free Systems

  2022cites this paper
• Emulating nonribosomal peptides with ribosomal biosynthetic strategies

  2022cites this paper
• Multiple Functions of the Type II Thioesterase Associated with the Phoslactomycin Polyketide Synthase

  2022cites this paper
• Cleavage Off-Loading and Post-assembly-Line Conversions Yield Products with Unusual Termini during Biosynthesis

  2022cites this paper
• Global analysis of biosynthetic gene clusters reveals conserved and unique natural products in entomopathogenic nematode-symbiotic bacteria

  2022cites this paper
• Siderophores and iron transport

  2021cites this paper
• Iron Transport and Metabolism in Escherichia, Shigella, and Salmonella

  2021cites this paper
• Diversity, Function, and Application of Fungal Iron Chelators (Siderophores) for Integrated Disease Management

  2021cites this paper
• Beyond peptide bond formation: the versatile role of condensation domains in natural product biosynthesis.

  2021cites this paper
• Biosynthesis of Fusapyrone Depends on the H3K9 Methyltransferase, FmKmt1, in Fusarium mangiferae

  2021cites this paper
• Hybrid Peptide–Polyketide Natural Product Biosynthesis

  2020cites this paper
• Type II non-ribosomal peptide synthetase proteins: structure, mechanism, and protein-protein interactions.

  2020cites this paper
• Consolidated plasmid Design for Stabilized Heterologous Production of the complex natural product Siderophore Yersiniabactin

  2020cites this paper
• Metabolomics Study on Pathogenic and Non-pathogenic E. coli with Closely Related Genomes with a Focus on Yersiniabactin and Its Known and Novel Derivatives

  2020cites this paper
• Epidemiology of E. coli in Cystic Fibrosis Airways Demonstrates the Capacity for Persistent Infection but Not Patient-Patient Transmission

  2020cites this paper
• Activity-Based Protein Profiling of Non-ribosomal Peptide Synthetases.

  2019cites this paper
• Genomics-inspired discovery of massiliachelin, an agrochelin epimer from Massilia sp. NR 4-1

  2019cites this paper
• Genome Features and Secondary Metabolites Biosynthetic Potential of the Class Ktedonobacteria

  2019cites this paper
• Complete genome sequence of Crohn ’ s disease-associated adherent-invasive E . coli strain LF 82 .

  2019cites this paper
• Characterisation of the bioremediation of chromate by Methylococcus capsulatus

  2019cites this paper
• Mechanistic Aspects of Methyltransferases with Small-Molecule Metabolites and Natural Products as Substrates

  2019cites this paper
• Biocatalysis: Nature's Chemical Toolbox

  2018cites this paper
• YbtT is a low-specificity type II thioesterase that maintains production of the metallophore yersiniabactin in pathogenic enterobacteria

  2018influential citation
• Protein-protein interactions in polyketide synthase-nonribosomal peptide synthetase hybrid assembly lines.

  2018cites this paper
• YbtT - Type II thioesterase from Yersiniabactin NRPS/PKS biosynthetic pathway

  2018cites this paper
• Biosynthesis of t-Butyl in Apratoxin A: Functional Analysis and Architecture of a PKS Loading Module.

  2018cites this paper
• 73-deoxychondropsin A : a novel inhibitor of bone resorption sourced from a Great Barrier Reef sponge

  2018cites this paper
• Cell-free synthetic biology for in vitro biosynthesis of pharmaceutical natural products

  2018cites this paper
• Nonribosomal peptides for iron acquisition: pyochelin biosynthesis as a case study.

  2018cites this paper
• Structural and functional delineation of aerobactin biosynthesis in hypervirulent Klebsiella pneumoniae

  2018cites this paper
• Nonribosomal peptide synthetase biosynthetic clusters of ESKAPE pathogens.

  2017cites this paper
• Enterobacteria secrete an inhibitor of Pseudomonas virulence during clinical bacteriuria

  2017cites this paper
• Reversible Product Release and Recapture by a Fungal Polyketide Synthase Using a Carnitine Acyltransferase Domain.

  2017cites this paper
• Enzymatic Carbon-Sulfur Bond Formation in Natural Product Biosynthesis.

  2017cites this paper
• DEVELOPMENT AND APPLICATION OF NUCLEAR MAGNETIC RESONANCE TECHNIQUES FOR THE STUDY OF PROTEIN DYNAMICS

  2017cites this paper
• X-Ray Crystallography and Electron Microscopy of Cross- and Multi-Module Nonribosomal Peptide Synthetase Proteins Reveal a Flexible Architecture.

  2017cites this paper
• Rigid Oxazole Acinetobactin Analog Blocks Siderophore Cycling in Acinetobacter baumannii.

  2017cites this paper
• A Mononuclear Iron-Dependent Methyltransferase Catalyzes Initial Steps in Assembly of the Apratoxin A Polyketide Starter Unit.

  2017cites this paper
• Structural and Biochemical Studies of the Initiation Steps in Three Natural Product Biosynthetic Pathways

  2017cites this paper
• Identification of Secondary Metabolite Gene Clusters in the Pseudovibrio Genus Reveals Encouraging Biosynthetic Potential toward the Production of Novel Bioactive Compounds

  2017cites this paper
• Total Biosynthesis of the Pyrrolo[4,2]benzodiazepine Scaffold Tomaymycin on an In Vitro Reconstituted NRPS System.

  2017cites this paper
• Structural and functional aspects of the nonribosomal peptide synthetase condensation domain superfamily: discovery, dissection and diversity.

  2017cites this paper
• The high-pathogenicity island (HPI) promotes flagellum-mediated motility in extraintestinal pathogenic Escherichia coli

  2017cites this paper
• Molecular variation of the nonribosomal peptide‐polyketide siderophore yersiniabactin through biosynthetic and metabolic engineering

  2016cites this paper
• Regulation of the P450 Oxygenation Cascade Involved in Glycopeptide Antibiotic Biosynthesis.

  2016cites this paper
• Human commensals producing a novel antibiotic impair pathogen colonization

  2016cites this paper
• ANALYZING THE ROLE OF COVALENT MODIFICATIONS TO AN ARYL CARRIER PROTEIN IN DIRECTING SEQUENTIAL INTERACTIONS IN YERSINIABACTIN SYNTHETASE

  2016cites this paper
• Holo Structure and Steady State Kinetics of the Thiazolinyl Imine Reductases for Siderophore Biosynthesis.

  2016cites this paper
• α-Methylation follows condensation in the gephyronic acid modular polyketide synthase.

  2016cites this paper
• Methyltransferases excised from trans-AT polyketide synthases operate on N-acetylcysteamine-bound substrates

  2016cites this paper
• Insights into the chemical logic and enzymatic machinery of NRPS assembly lines.

  2016cites this paper
• Domain Organization and Active Site Architecture of a Polyketide Synthase C-methyltransferase.

  2016cites this paper
• Nature loves nitrogen heterocycles

  2015cites this paper
• Divergent mechanistic routes for the formation of gem-dimethyl groups in the biosynthesis of complex polyketides.

  2015cites this paper
• Microbial Copper-binding Siderophores at the Host-Pathogen Interface*

  2015cites this paper
• Interrupted adenylation domains: unique bifunctional enzymes involved in nonribosomal peptide biosynthesis.

  2015cites this paper
• Biocatalytic Imine Reduction and Reductive Amination of Ketones

  2015cites this paper
• Total Synthesis and Configurational Assignment of Ascospiroketal A.

  2015cites this paper
• Analysis of iron acquisition and storage‐related genes in clinical and non‐clinical strains of Yersinia enterocolitica biovar 1A

  2015cites this paper
• Solution Structure of a Nonribosomal Peptide Synthetase Carrier Protein Loaded with Its Substrate Reveals Transient, Well-Defined Contacts.

  2015cites this paper
• Towards Biochemical Conversion of CO2 to Higher Value Chemicals Using Enzyme Design and Engineered Polyketide Synthases

  2015influential citation
• Characterization of Cereulide Synthetase, a Toxin-Producing Macromolecular Machine

  2015cites this paper
• Comparative Metabolomics and Structural Characterizations Illuminate Colibactin Pathway-Dependent Small Molecules

  2014cites this paper
• Understanding the Role of Histidine in the GHSxG Acyltransferase Active Site Motif: Evidence for Histidine Stabilization of the Malonyl-Enzyme Intermediate

  2014cites this paper
• Tailoring complex natural products by manipulating the biosynthetic machinery that builds them

  2014cites this paper
• Roles of type II thioesterases and their application for secondary metabolite yield improvement

  2014cites this paper
• Regulation of iron transport systems in Enterobacteriaceae in response to oxygen and iron availability.

  2014cites this paper
• Precursor-directed biosynthesis of micacocidin derivatives with activity against Mycoplasma pneumoniae.

  2014cites this paper
• Adenylation and S-methylation of cysteine by the bifunctional enzyme TioN in thiocoraline biosynthesis.

  2014cites this paper
• The Yersinia pestis siderophore, yersiniabactin, and the ZnuABC system both contribute to zinc acquisition and the development of lethal septicaemic plague in mice

  2014cites this paper
• Elucidation of gephyronic acid biosynthetic pathway revealed unexpected SAM-dependent methylations.

  2013cites this paper
• Genomics-driven discovery of the pneumocandin biosynthetic gene cluster in the fungus Glarea lozoyensis

  2013cites this paper
• Pathway and protein engineering approaches to produce novel and commodity small molecules.

  2013cites this paper
• Metabolic engineering of Escherichia coli: a sustainable industrial platform for bio-based chemical production.

  2013cites this paper
• An iterative type I polyketide synthase initiates the biosynthesis of the antimycoplasma agent micacocidin.

  2013cites this paper
• Characterization of AusA: a dimodular nonribosomal peptide synthetase responsible for the production of aureusimine pyrazinones.

  2013cites this paper
• A PKS/NRPS/FAS Hybrid Gene Cluster from Serratia plymuthica RVH1 Encoding the Biosynthesis of Three Broad Spectrum, Zeamine-Related Antibiotics

  2013cites this paper
• Two structures of a thiazolinyl imine reductase from Yersinia enterocolitica provide insight into catalysis and binding to the nonribosomal peptide synthetase module of HMWP1.

  2012cites this paper
• Aminobenzoates as building blocks for natural product assembly lines.

  2012cites this paper