Self-assembly of VPS41 promotes sorting required for biogenesis of the regulated secretory pathway.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Developmental Cell

• Publication date

  2013-11-25

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.devcel.2013.10.007PMID 24210660PMCID PMC3974617
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• hVps41 and VAMP7 function in direct TGN to late endosome transport of lysosomal membrane proteins

  2013cited by this paper
• Structural Basis of the Intracellular Sorting of the SNARE VAMP7 by the AP3 Adaptor Complex

  2012cited by this paper
• Spatial restriction of bone morphogenetic protein signaling in mouse gastrula through the mVam2-dependent endocytic pathway.

  2012cited by this paper
• Lysosomal Membrane Protein Composition, Acidic pH and Sterol Content are Regulated via a Light‐Dependent Pathway in Metazoan Cells

  2011cited by this paper
• Acute knockdown of AMPA receptors reveals a trans‐synaptic signal for presynaptic maturation

  2011cited by this paper
• A Genetically Encoded Tag for Correlated Light and Electron Microscopy of Intact Cells, Tissues, and Organisms

  2011cited by this paper
• Subunit organization and Rab interactions of Vps-C protein complexes that control endolysosomal membrane traffic

  2011influential reference
• Vesicular Monoamine and Glutamate Transporters Select Distinct Synaptic Vesicle Recycling Pathways

  2010cited by this paper
• University of Groningen Phosphorylation of a membrane curvature-sensing motif switches function of the HOPS subunit Vps41 in membrane tethering

  2010cited by this paper
• RNAi screen identifies a role for adaptor protein AP-3 in sorting to the regulated secretory pathway

  2010cited by this paper
• Phosphorylation of a membrane curvature–sensing motif switches function of the HOPS subunit Vps41 in membrane tethering

  2010cited by this paper
• HOPS interacts with Apl5 at the vacuole membrane and is required for consumption of AP-3 transport vesicles.

  2009influential reference
• The SM protein Car/Vps33A regulates SNARE-mediated trafficking to lysosomes and lysosome-related organelles.

  2009cited by this paper
• Vps41 phosphorylation and the Rab Ypt7 control the targeting of the HOPS complex to endosome-vacuole fusion sites.

  2009influential reference
• Vps-C complexes: gatekeepers of endolysosomal traffic.

  2009influential reference
• Roles of BLOC-1 and adaptor protein-3 complexes in cargo sorting to synaptic vesicles.

  2009cited by this paper
• AP-3-dependent trafficking and disease: the first decade.

  2009influential reference
• Discovery and progress in our understanding of the regulated secretory pathway in neuroendocrine cells

  2008cited by this paper
• Synaptotagmin I and IX function redundantly in controlling fusion pore of large dense core vesicles.

  2007cited by this paper
• Melanosomes — dark organelles enlighten endosomal membrane transport

  2007cited by this paper
• Regulation of large dense-core vesicle volume and neurotransmitter content mediated by adaptor protein 3.

  2006influential reference
• Role of the AP2 β-Appendage Hub in Recruiting Partners for Clathrin-Coated Vesicle Assembly

  2006cited by this paper
• Novel Binding Sites on Clathrin and Adaptors Regulate Distinct Aspects of Coat Assembly

  2006cited by this paper
• Sorting of vesicular monoamine transporter 2 to the regulated secretory pathway confers the somatodendritic exocytosis of monoamines.

  2005cited by this paper
• Chromogranin A Deficiency in Transgenic Mice Leads to Aberrant Chromaffin Granule Biogenesis

  2005cited by this paper
• Cytoplasmic Transport Signal is Involved in Phogrin Targeting and Localization to Secretory Granules

  2005cited by this paper
• Drosophila Vps16A is required for trafficking to lysosomes and biogenesis of pigment granules

  2005cited by this paper
• Out with a Bang! Tetrahymena as a Model System to Study Secretory Granule Biogenesis

  2004cited by this paper
• Selective and signal-dependent recruitment of membrane proteins to secretory granules formed by heterologously expressed von Willebrand factor.

  2002cited by this paper
• Vps41p function in the alkaline phosphatase pathway requires homo-oligomerization and interaction with AP-3 through two distinct domains.

  2001cited by this paper
• An Acidic Motif Retains Vesicular Monoamine Transporter 2 on Large Dense Core Vesicles

  2001cited by this paper
• Adaptor-related proteins.

  2001cited by this paper
• Chromogranin A, an "on/off" switch controlling dense-core secretory granule biogenesis.

  2001cited by this paper
• Targeting of Membrane Proteins to the Regulated Secretory Pathway in Anterior Pituitary Endocrine Cells*

  2001cited by this paper
• Role of clathrin in the regulated secretory pathway of pancreatic beta-cells.

  2001cited by this paper
• Biogenesis of Regulated Exocytotic Carriers in Neuroendocrine Cells

  2000cited by this paper
• A Phosphorylation Site Regulates Sorting of the Vesicular Acetylcholine Transporter to Dense Core Vesicles

  2000cited by this paper
• The structure and function of the β2‐adaptin appendage domain

  2000cited by this paper
• Clathrin self-assembly is mediated by a tandemly repeated superhelix

  1999cited by this paper
• Formation of AP-3 transport intermediates requires Vps41 function

  1999cited by this paper
• A role for the deep orange and carnation eye color genes in lysosomal delivery in Drosophila.

  1999cited by this paper
• A Complex Web of Signal-dependent Trafficking Underlies the Triorganellar Distribution of P-Selectin in Neuroendocrine PC12 Cells

  1999cited by this paper
• A Leucine-based Motif Mediates the Endocytosis of Vesicular Monoamine and Acetylcholine Transporters*

  1998cited by this paper
• Sorting and storage during secretory granule biogenesis: looking backward and looking forward.

  1998cited by this paper
• The AP-3 complex: a coat of many colours.

  1998influential reference
• Acidic Di-leucine Motif Essential for AP-3–dependent Sorting and Restriction of the Functional Specificity of the Vam3p Vacuolar t-SNARE

  1998cited by this paper
• Association of the AP-3 adaptor complex with clathrin.

  1998cited by this paper
• A function for the AP3 coat complex in synaptic vesicle formation from endosomes.

  1998cited by this paper
• The AP-3 adaptor complex is essential for cargo-selective transport to the yeast vacuole.

  1997influential reference
• Neurosecretory vesicles can be hybrids of synaptic vesicles and secretory granules.

  1995cited by this paper
• Regulation of clathrin assembly and trimerization defined using recombinant triskelion hubs.

  1995cited by this paper
• Characterization of the immature secretory granule, an intermediate in granule biogenesis

  1991cited by this paper
• Cell-free protein sorting to the regulated and constitutive secretory pathways

  1990influential reference
• The trans-most cisternae of the Golgi complex: a compartment for sorting of secretory and plasma membrane proteins.

  1987cited by this paper

• VPS41 recruits biosynthetic LAMP-positive vesicles through interaction with Arl8b

  2025cites this paper
• Vesicle adaptors in malaria parasites show conservation and flexibility of protein sorting machinery.

  2025cites this paper
• An optimized fluorescent reporter enables rapid and cost-effective quantification of regulated secretion from neuroendocrine cells

  2025cites this paper
• EccDNA‐Driven VPS41 Amplification Alleviates Genotoxic Stress via Lysosomal KAI1 Degradation

  2025cites this paper
• Structuring of the endolysosomal system by HOPS and CORVET tethering complexes.

  2025cites this paper
• Disordered hinge regions of the AP-3 adaptor complex promote vesicle budding from the late Golgi in yeast

  2024cites this paper
• Biogenesis and reformation of synaptic vesicles

  2024cites this paper
• VPS41 deletion triggers progressive loss of insulin stores and downregulation of beta-cell identity

  2024cites this paper
• HOPS, CORVET and newly-identified Hybrid tethering complexes contribute differentially towards multiple modes of endocytosis

  2023cites this paper
• Adaptor protein-3 produces synaptic vesicles that release phasic dopamine

  2023cites this paper
• Identification of the functional domain of the dense core vesicle biogenesis factor HID-1

  2023cites this paper
• The role of crinophagy in quality control of the regulated secretory pathway.

  2023cites this paper
• Adaptor Protein-3 Produces Synaptic Vesicles that Release Phasic Dopamine

  2023cites this paper
• A voyage from the ER: spatiotemporal insights into polarized protein secretion in neurons

  2023cites this paper
• VPS8D, a CORVET subunit, is required to maintain the contractile vacuole complex in Tetrahymena thermophila

  2023influential citation
• Teaching an old dog new tricks: The plant-specific role of VPS41 in vacuolar transport and development

  2022influential citation
• Molecular insights into endolysosomal microcompartment formation and maintenance

  2022cites this paper
• Mutations in CmVPS41 controlling resistance to Cucumber Mosaic Virus display specific subcellular localizations

  2022cites this paper
• From bugs to bedside: functional annotation of human genetic variation for neurological disorders using invertebrate models.

  2022cites this paper
• SNX5 targets a monoamine transporter to the TGN for assembly into dense core vesicles by AP-3

  2022cites this paper
• Arabidopsis HOPS subunit VPS41 carries out plant-specific roles in vacuolar transport and vegetative growth.

  2022cites this paper
• New insights into the pathogenesis of Hermansky–Pudlak syndrome

  2022cites this paper
• Endocrine secretory granule production is caused by a lack of REST and intragranular secretory content and accelerated by PROX1

  2022cites this paper
• Maturing secretory granules: Where secretory and endocytic pathways converge.

  2021cites this paper
• Neurodegenerative VPS41 variants inhibit HOPS function and mTORC1‐dependent TFEB/TFE3 regulation

  2021cites this paper
• RAB19 Directs Cortical Remodeling and Membrane Growth for Primary Ciliogenesis.

  2021cites this paper
• Flexible open conformation of the AP-3 complex explains its role in cargo recruitment at the Golgi

  2021cites this paper
• Vam6/Vps39/TRAP1‐domain proteins influence vacuolar morphology, iron acquisition and virulence in Cryptococcus neoformans

  2021cites this paper
• AP-3 adaptor complex-mediated vesicle trafficking

  2021cites this paper
• Cargo Release from Myosin V Requires the Convergence of Parallel Pathways that Phosphorylate and Ubiquitylate the Cargo Adaptor.

  2020cites this paper
• Rab2 drives axonal transport of dense core vesicles and lysosomal organelles

  2020cites this paper
• A Presynaptic Perspective on Transport and Assembly Mechanisms for Synapse Formation.

  2020cites this paper
• Pancreatic β-Cell–Specific Deletion of VPS41 Causes Diabetes Due to Defects in Insulin Secretion

  2020influential citation
• AP‐3 vesicle uncoating occurs after HOPS‐dependent vacuole tethering

  2020influential citation
• An early endosome–derived retrograde trafficking pathway promotes secretory granule maturation

  2020cites this paper
• Diversification of CORVET tethers facilitates transport complexity in Tetrahymena thermophila

  2019cites this paper
• Vti Proteins: Beyond Endolysosomal Trafficking.

  2019cites this paper
• CORVET, CHEVI and HOPS – multisubunit tethers of the endo-lysosomal system in health and disease

  2019influential citation
• Coatopathies: Genetic Disorders of Protein Coats.

  2019cites this paper
• CmVPS41 Is a General Gatekeeper for Resistance to Cucumber Mosaic Virus Phloem Entry in Melon

  2019cites this paper
• Characterization of VPS41 and Its Role in the Regulated Secretory Pathway

  2019cites this paper
• Differential sorting behavior for soluble and transmembrane cargoes at the trans-Golgi network in endocrine cells

  2019cites this paper
• VPS41 recessive mutation causes ataxia and dystonia with retinal dystrophy and mental retardation by inhibiting HOPS function and mTORC1 signaling

  2019influential citation
• Vti1a/b regulate synaptic vesicle and dense core vesicle secretion via protein sorting at the Golgi

  2018cites this paper
• A subunit of the HOPS endocytic tethering complex, FgVps41, is important for fungal development and plant infection in Fusarium graminearum

  2018cites this paper
• Neuronal functions of adaptor complexes involved in protein sorting.

  2018cites this paper
• New approaches for solving old problems in neuronal protein trafficking

  2018cites this paper
• EIPR1 controls dense-core vesicle cargo retention and EARP complex localization in insulin-secreting cells

  2018cites this paper
• Presynaptic Biogenesis Requires Axonal Transport of Lysosome-Related Vesicles.

  2018cites this paper
• HID-1 controls formation of large dense core vesicles by influencing cargo sorting and trans-Golgi network acidification

  2017influential citation
• The Dense-Core Vesicle Maturation Protein CCCP-1 Binds both RAB-2 and Membranes through a Conserved C-terminal Coiled-coil Domain

  2017cites this paper
• Structure function analysis of CCCP-1 The Dense-Core Vesicle Maturation Protein CCCP-1 Binds RAB-2 and Membranes through its C-terminal Domain

  2017cites this paper
• HID-1 controls cargo sorting and dense core formation by influencing trans-Golgi network acidification in neuroendocrine cells

  2017influential citation
• Oncogenic Extracellular Vesicle Biogenesis and Protein Trafficking

  2017cites this paper
• Adaptor protein-3: A key player in RBL-2H3 mast cell mediator release

  2017cites this paper
• A mutation in the melon Vacuolar Protein Sorting 41prevents systemic infection of Cucumber mosaic virus

  2017cites this paper
• α-Synuclein Promotes Dilation of the Exocytotic Fusion Pore

  2017cites this paper
• HID-1 is required for homotypic fusion of immature secretory granules during maturation

  2016cites this paper
• Clathrin and Clathrin-Dependent Endocytosis

  2016cites this paper
• The HOPS/Class C Vps Complex Tethers High‐Curvature Membranes via a Direct Protein–Membrane Interaction

  2016cites this paper
• The EARP Complex and its Interactor EIPR-1 are Required for 2 Cargo Sorting to Dense-Core Vesicles 3 4 Short title : The EARP Complex Controls Dense-Core-Vesicle Biogenesis

  2016cites this paper
• AtVPS41-mediated endocytic pathway is essential for pollen tube–stigma interaction in Arabidopsis

  2016cites this paper
• Membrane Tethering Complexes in the Endosomal System

  2016cites this paper
• Nanoparticle analysis sheds budding insights into genetic drivers of extracellular vesicle biogenesis

  2016cites this paper
• Chapter 3 – Control of Hormone Secretion

  2016cites this paper
• The EARP Complex and Its Interactor EIPR-1 Are Required for Cargo Sorting to Dense-Core Vesicles

  2016cites this paper
• Carboxypeptidase E, Identified As a Direct Interactor of Growth Hormone, Is Important for Efficient Secretion of the Hormone

  2016cites this paper
• Functional homologies in vesicle tethering

  2015cites this paper
• Impaired maturation of large dense-core vesicles in muted-deficient adrenal chromaffin cells

  2015cites this paper
• Recruitment of VPS33A to HOPS by VPS16 Is Required for Lysosome Fusion with Endosomes and Autophagosomes

  2015cites this paper
• Souffle/Spastizin Controls Secretory Vesicle Maturation during Zebrafish Oogenesis

  2014cites this paper
• Protein sorting at the trans-Golgi network.

  2014cites this paper
• Adaptor protein complexes and intracellular transport

  2014cites this paper
• Characterization of TSET, an ancient and widespread membrane trafficking complex

  2014cites this paper
• From all to (nearly) none

  2014cites this paper