Calcium regulates ERK signaling by modulating its protein-protein interactions

Intracellular transmission of extracellular signals is mediated by a complex network of second messengers, interacting proteins and signaling cascades that cumulatively govern essentially all stimulated cellular processes. Two important signaling components in the network are the extracellular signal-regulated kinase (ERK) signaling cascade and elevation of calcium concentrations, which transmit signals of hormones, nerve factors and other ligands. Each of these components is known to independently regulate a large number of targets in various cellular organelles. The cooperation between them, however, seems to modulate the fate of their individual signals, and accordingly, their regulated processes. We have recently shown that calcium modulates the protein interaction properties of ERKs, which further affect the subcellular localization of the latter and as a consequence also the distribution of their targets. These effects of calcium are important in determining the specificity of the ERK cascade, and thereby, play important roles in the regulation of ERK-dependent cellular processes. Our findings, as well as their possible implications, are further discussed in this addendum. Addendum to: Chuderland D, Marmor G. Shainskaya A, Seger R. Calcium-mediated interactions regulate the subcellular localization of extracellular signal-regulated kinases. J Biol Chem 2008; 283:11176-88.

• Publication year

  2008

• Venue

  Communicative & Integrative Biology

• Publication date

  2008-06-09

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.4161/cib.1.1.6107PMID 19704446PMCID PMC2633783
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• Calcium-dependent effects on ERK interactions contribute to signaling specificity in the ERK cascade and influence ERK-dependent cellular processes.

  Confidence 0.93

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewq (76h6bfydm6) reviewAnonymous (12632b8b5f) reviewKiller Whale (322360f1c1) reviewAK (4715169a40) review
• Changes in ERK protein-protein interactions alter ERK subcellular localization and the distribution of ERK targets.

  Confidence 0.94

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewq (76h6bfydm6) reviewAnonymous (12632b8b5f) reviewKiller Whale (322360f1c1) reviewAK (4715169a40) review
• Calcium modulates the protein interaction properties of ERKs.

  Confidence 0.98

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewq (76h6bfydm6) reviewAnonymous (12632b8b5f) reviewKiller Whale (322360f1c1) reviewAK (4715169a40) review

• calcium

  signal, ion

  A divalent signaling ion whose intracellular concentration changes are discussed as a regulator of ERK behavior in this context.

  Aliases: Ca2+, calcium concentrations

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewq (76h6bfydm6) reviewAnonymous (12632b8b5f) reviewKiller Whale (322360f1c1) reviewAK (4715169a40) review
• erk-dependent cellular processes

  cellular process, outcome

  Cellular processes whose regulation depends on ERK signaling activity and downstream target distribution.

  Aliases: ERK-dependent processes

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewq (76h6bfydm6) reviewAnonymous (12632b8b5f) reviewKiller Whale (322360f1c1) reviewAK (4715169a40) review
• erks

  protein, kinase

  Extracellular signal-regulated kinases whose interaction properties and localization are the focus of the discussed findings.

  Aliases: extracellular signal-regulated kinases, ERK

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewq (76h6bfydm6) reviewAnonymous (12632b8b5f) reviewKiller Whale (322360f1c1) reviewAK (4715169a40) review
• erk signaling cascade

  signaling pathway, cascade

  The extracellular signal-regulated kinase signaling pathway that transmits extracellular cues to downstream cellular responses.

  Aliases: ERK cascade

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewq (76h6bfydm6) reviewAnonymous (12632b8b5f) reviewKiller Whale (322360f1c1) reviewAK (4715169a40) review
• protein-protein interactions

  molecular interaction, biological process

  Physical interactions among proteins, here referring to interaction properties of ERKs with other proteins.

  Aliases: protein interaction properties

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewq (76h6bfydm6) reviewAnonymous (12632b8b5f) reviewKiller Whale (322360f1c1) reviewAK (4715169a40) review
• signal specificity

  property, signaling feature

  The selective routing of signaling information toward particular downstream outcomes in the ERK pathway.

  Aliases: specificity of the ERK cascade

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewq (76h6bfydm6) reviewAnonymous (12632b8b5f) reviewKiller Whale (322360f1c1) reviewAK (4715169a40) review
• subcellular localization

  cellular process, property

  The distribution of ERKs within specific compartments of the cell.

  Aliases: cellular localization

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewq (76h6bfydm6) reviewAnonymous (12632b8b5f) reviewKiller Whale (322360f1c1) reviewAK (4715169a40) review

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