Structure/function studies of lin-12/Notch proteins.

No abstract is available for this paper.

• Publication year

  1994

• Venue

  Current Opinion in Genetics and Development

• Publication date

  1994-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/0959-437X(94)90072-BPMID 7950324
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Notch1 is essential for postimplantation development in mice.

  1994cited by this paper
• Sequence of C. elegans lag-2 reveals a cell-signalling domain shared with Delta and Serrate of Drosophila

  1994cited by this paper
• Modifications of the notch function by Abruptex mutations in Drosophila melanogaster.

  1994cited by this paper
• Further evidence for function of the Drosophila Notch protein as a transmembrane receptor.

  1993cited by this paper
• Intragenic dominant suppressors of glp-1, a gene essential for cell-signaling in Caenorhabditis elegans, support a role for cdc10/SWI6/ankyrin motifs in GLP-1 function.

  1993cited by this paper
• Intrinsic activity of the Lin-12 and Notch intracellular domains in vivo.

  1993cited by this paper
• Control of cell fate in C. elegans by a GLP-1 peptide consisting primarily of ankyrin repeats

  1993cited by this paper
• Altered epidermal growth factor-like sequences provide evidence for a role of Notch as a receptor in cell fate decisions.

  1993cited by this paper
• glp-1 can substitute for lin-12 in specifying cell fate decisions in Caenorhabditis elegans.

  1993cited by this paper
• Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei.

  1993cited by this paper
• Specific truncations of Drosophila Notch define dominant activated and dominant negative forms of the receptor.

  1993cited by this paper
• An activated Notch receptor blocks cell-fate commitment in the developing Drosophila eye

  1993cited by this paper
• Expression of an extracellular deletion of Xotch diverts cell fate in Xenopus embryos.

  1993cited by this paper
• Genetic and molecular characterization of a Notch mutation in its Delta- and Serrate-binding domain in Drosophila.

  1993cited by this paper
• Making a difference: The role of cell-cell interactions in establishing separate identities for equivalent cells

  1992cited by this paper
• Mouse mammary tumor gene int-3: a member of the notch gene family transforms mammary epithelial cells

  1992cited by this paper
• The involvement of the Notch locus in Drosophila oogenesis.

  1992cited by this paper
• Notch2: a second mammalian Notch gene.

  1992cited by this paper
• Molecular basis of loss-of-function mutations in the glp-1 gene of Caenorhabditis elegans.

  1992cited by this paper
• Expression of an activated Notch-related int-3 transgene interferes with cell differentiation and induces neoplastic transformation in mammary and salivary glands.

  1992cited by this paper
• Human homologs of a Drosophila Enhancer of Split gene product define a novel family of nuclear proteins

  1992cited by this paper
• Characterization of the Drosophila cactus locus and analysis of interactions between cactus and dorsal proteins.

  1992cited by this paper
• Single amino acid substitutions in EGF-like elements of Notch and Delta modify Drosophila development and affect cell adhesion in vitro.

  1992cited by this paper
• Two homologous regulatory genes, lin-12 and glp-1, have overlapping functions.

  1991cited by this paper
• The Drosophila gene Serrate encodes an EGF-like transmembrane protein with a complex expression pattern in embryos and wing discs.

  1991cited by this paper
• The choice of cell fate in the epidermis of Drosophila.

  1991cited by this paper
• Carboxy-terminal truncation activates glp-1 protein to specify vulval fates in Caenorhabditis elegans

  1991cited by this paper
• TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms.

  1991cited by this paper
• Specific EGF repeats of Notch mediate interactions with Delta and Serrate: implications for Notch as a multifunctional receptor.

  1991cited by this paper
• Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila.

  1990cited by this paper
• The let-60 locus controls the switch between vulval and nonvulval cell fates in Caenorhabditis elegans.

  1990cited by this paper
• The Notch locus and the genetic circuitry involved in early Drosophila neurogenesis.

  1990cited by this paper
• Notch and the choice of cell fate in Drosophila neuroepithelium.

  1990cited by this paper
• The Notch gene, adhesion, and developmental fate in the Drosophila embryo.

  1990cited by this paper
• The gene Serrate encodes a putative EGF-like transmembrane protein essential for proper ectodermal development in Drosophila melanogaster.

  1990cited by this paper
• Analysis of gain-of-function mutations of the lin-12 gene of Caenorhabditis elegans

  1990cited by this paper
• Xotch, the Xenopus homolog of Drosophila notch.

  1990cited by this paper
• Cell autonomy of lin-12 function in a cell fate decision in C. elegans.

  1989cited by this paper
• glp-1 and lin-12, genes implicated in distinct cell-cell interactions in C. elegans, encode similar transmembrane proteins.

  1989cited by this paper
• The notch gene product is a glycoprotein expressed on the cell surface of both epidermal and neuronal precursor cells during Drosophila development

  1989cited by this paper
• Structure and distribution of the Notch protein in developing Drosophila.

  1989cited by this paper
• The embryonic expression of the Notch locus of Drosophila melanogaster and the implications of point mutations in the extracellular EGF‐like domain of the predicted protein.

  1987cited by this paper
• The glp-1 locus and cellular interactions in early C. elegans embryos.

  1987cited by this paper
• Similarity between cell-cycle genes of budding yeast and fission yeast and the Notch gene of Drosophila

  1987cited by this paper
• glp-1 is required in the germ line for regulation of the decision between mitosis and meiosis in C. elegans.

  1987cited by this paper
• Mammary tumorigenesis in feral mice: identification of a new int locus in mouse mammary tumor virus (Czech II)-induced mammary tumors

  1987cited by this paper
• Mutations altering the structure of epidermal growth factor-like coding sequences at the Drosophila Notch locus.

  1987cited by this paper
• Amino acid sequences common to rapidly degraded proteins: the PEST hypothesis.

  1986cited by this paper
• The lin-12 locus specifies cell fates in Caenorhabditis elegans.

  1983cited by this paper
• On the phenotype and development of mutants of early neurogenesis inDrosophila melanogaster

  1983cited by this paper
• Radiocarbon dates and deglaciation of Rannoch Moor, Scotland

  1976cited by this paper
• Allelic negative complementation at the Abruptex locus of Drosophila melanogaster.

  1975cited by this paper
• Negative complementation at the notch locus of Drosophila melanogaster.

  1975cited by this paper
• The effects of certain X-chromosome deficiencies on the embryonic development of Drosophila melanogaster

  1940cited by this paper
• Further studies on the nature and causes of gene mutations.

  1932cited by this paper

• The Intricate Notch Signaling Dynamics in Therapeutic Realms of Cancer.

  2023cites this paper
• Notch Signaling: Linking Embryonic Lung Development and Asthmatic Airway Remodeling

  2017cites this paper
• Methyllysine binding domains: Structural insight and small molecule probe development.

  2017cites this paper
• Perturbations of interactome networks in acute lymphoblastic leukaemia: identification of EXT1 tumor suppressor as a Notch pathway regulator

  2016cites this paper
• Notch in cancer and cancer metabolism : six degrees of intracellular turbulence

  2016cites this paper
• Targeted therapy in cancer

  2015cites this paper
• Jagged2 Stimulates the Generation of Cytotoxic T Lymphocytes: Relevance to Acute Graft-Versus-Host Disease

  2014cites this paper
• The Role Of Jagged1 In The Subventricular Zone During Late Embryonic Development

  2014cites this paper
• Assessment of Notch1 ligands production - key protein targets in breast cancer

  2014cites this paper
• PRESENILIN, "A NEW GENE TARGET IN NEURODEGENERATIVE DISORDERS" A REVIEW

  2013cites this paper
• Notch inhibitors for cancer treatment.

  2013cites this paper
• Notch2 Transduction by Feline Leukemia Virus in a Naturally Infected Cat

  2013cites this paper
• κ repeats and involves signaling through RBP-J Notch4-induced inhibition of endothelial sprouting requires the ankyrin

  2013cites this paper
• Development of Notch Pathway Inhibitors for Cancer Therapy

  2013cites this paper
• Untersuchungen zur Rolle von Notch-3 Rezeptoren in experimentellen Schädigungsmodellen der Niere

  2013cites this paper
• Notch and the Awesome Power of Genetics

  2012cites this paper
• The role of Adams in Notch signaling.

  2012cites this paper
• The role of Notch-1 in ex vivo expansion of CD34(+) cells

  2012influential citation
• Notch Signaling Pathway and Human Placenta

  2012cites this paper
• New pathogenic mechanisms in diabetic wound healing

  2012cites this paper
• Notch Signaling during Oogenesis in Drosophila melanogaster

  2012influential citation
• Notch signalling in cancer progression and bone metastasis

  2011cites this paper
• Proteolytic cleavage of Notch: "HIT and RUN".

  2011influential citation
• Notch signalling pathway in tooth development and adult dental cells

  2011cites this paper
• A role for Notch signaling in corneal wound healing

  2011cites this paper
• Notch as a molecular switch in neural stem cells

  2010cites this paper
• Selective Use of ADAM10 and ADAM17 in Activation of Notch1 Signaling

  2009cites this paper
• The role of multiple DSL ligands - DII1, DII4 and Jag1 - in vertebrate neurogenesis

  2009cites this paper
• Computational Models of the Notch Network Elucidate Mechanisms of Context-dependent Signaling

  2009cites this paper
• The canonical Notch signaling pathway: unfolding the activation mechanism.

  2009cites this paper
• The role of NOTCH2 gene in human malignant glial brain tumours

  2008cites this paper
• XSu(H)2 is an essential factor for gene expression and morphogenesis of the Xenopus gastrula embryo.

  2007cites this paper
• γ-Secretase Mediated Proteolysis: At the Cutting Edge of Notch Signaling

  2007cites this paper
• The Notch signaling pathway in the cnidarian Hydra.

  2007cites this paper
• Cell and molecular biology of Notch.

  2007cites this paper
• ON THE ROLE OF NOTCH, NUMB AND NUMBLIKE IN DEVELOPMENT AND CANCER

  2007cites this paper
• Signal Integration During Development: Mechanisms of EGFR and Notch Pathway Function and Cross-Talk

  2006cites this paper
• CHAPTER 10 – Developmental Signaling Networks: The Notch Pathway

  2006cites this paper
• Expression of constitutively active Notch1 in male genital tracts results in ectopic growth and blockage of efferent ducts, epididymal hyperplasia and sterility.

  2006cites this paper
• XMam1, Xenopus Mastermind1, induces neural gene expression in a Notch-independent manner.

  2006cites this paper
• Vía de señalización Notch y nuevas estrategias para el tratamiento de cáncer

  2006cites this paper
• Notch signaling : From receptor cleavage to chromatin remodeling

  2005cites this paper
• Epstein-Barr virus latent proteins regulate expression of the anti-apoptotic cellular bfl-1 gene

  2005cites this paper
• Effect of experimental varicocele on the expressions of Notch 1, 2, and 3 in rat testes: an immunohistochemical study.

  2005cites this paper
• Notch4-induced inhibition of endothelial sprouting requires the ankyrin repeats and involves signaling through RBP-Jkappa.

  2004cites this paper
• Ectodomain Shedding and Intramembrane Cleavage of Mammalian Notch Proteins Are Not Regulated through Oligomerization*

  2004cites this paper
• Notch in mammary gland development and breast cancer.

  2004cites this paper
• Anchoring notch genetics and biochemistry; structural analysis of the ankyrin domain sheds light on existing data.

  2004cites this paper
• Viruses and Apoptosis

  2004cites this paper
• SV40 and Notch-I: multi-functionality meets pleiotropy.

  2004cites this paper
• Notch Signaling Induces Multilineage Myeloid Differentiation and Up-Regulates PU.1 Expression1

  2003cites this paper
• XMam1, the Xenopus homologue of mastermind, is essential to primary neurogenesis in Xenopus laevis embryos.

  2003influential citation
• The Tat Protein of the Caprine Arthritis Encephalitis Virus Interacts with the Notch2 EGF-Like Repeats and the Epithelin/Granulin Precursor

  2003cites this paper
• PU . 1 Expression Myeloid Differentiation and UpRegulates Notch Signaling Induces Multilineage

  2003cites this paper
• γ‐Secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations in Drosophila

  2003cites this paper
• Genetic analysis of Caenorhabditis elegans glp-1 mutants suggests receptor interaction or competition.

  2003cites this paper
• Notch1 on CD4 and CD8 T Cell Development A Reassessment of the Effect of Activated

  2002cites this paper
• Activated Notch4 inhibits angiogenesis: role of beta 1-integrin activation.

  2002cites this paper
• Cysteine-rich region of X-Serrate-1 is required for activation of Notch signaling in Xenopus primary neurogenesis.

  2002influential citation
• The Notch Pathway: Modulation of Cell Fate Decisions in Hematopoiesis

  2002cites this paper
• A Reassessment of the Effect of Activated Notch1 on CD4 and CD8 T Cell Development1

  2002cites this paper
• A secreted Delta1‐Fc fusion protein functions both as an activator and inhibitor of Notch1 signaling

  2002cites this paper
• Signalling: γ-Secretase-mediated proteolysis in cell-surface-receptor signalling

  2002cites this paper
• Activated Notch4 Inhibits Angiogenesis: Role of β1-Integrin Activation

  2002cites this paper
• Requirement of Notch 1 and its ligand jagged 2 expressions for spermatogenesis in rat and human testes.

  2001cites this paper
• Notch and presenilin: a proteolytic mechanism emerges.

  2001cites this paper
• Notch1 and Notch3 instructively restrict bFGF-responsive multipotent neural progenitor cells to an astroglial fate.

  2001cites this paper
• The germline in C. elegans: origins, proliferation, and silencing.

  2001cites this paper
• Expression patterns of Notch1, Notch2, and Notch3 suggest multiple functional roles for the Notch‐DSL signaling system during brain development

  2001cites this paper
• The NEXT Step in Notch Processing and its Relevance to Amyloid Precursor Protein

  2001cites this paper
• Spatiotemporal Patterning in Models of Juxtacrine Intercellular Signalling with Feedback

  2001cites this paper
• A carboxy-terminal deletion mutant of Notch1 accelerates lymphoid oncogenesis in E2A-PBX1 transgenic mice.

  2000cites this paper
• A carboxy-terminal deletion mutant of Notch1 accelerates lymphoid oncogenesis in E2A-PBX1 transgenic mice

  2000cites this paper
• A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1.

  2000cites this paper
• Characterization, chromosomal localization, and the complete 30-kb DNA sequence of the human Jagged2 (JAG2) gene.

  2000cites this paper
• Notch Signaling Enhances Survival and Alters Differentiation of 32D Myeloblasts1

  2000cites this paper
• Mini-Review Radial Glia Phenotype: Origin, Regulation, and Transdifferentiation

  2000cites this paper
• Activation of the Notch pathway in the hair cortex leads to aberrant differentiation of the adjacent hair-shaft layers.

  2000cites this paper
• Deletion of an insulator element by the mutation facet-strawberry in Drosophila melanogaster.

  2000cites this paper
• Expression of notch receptors, notch ligands, and fringe genes in hematopoiesis.

  2000cites this paper
• Two Distinct Notch1 Mutant Alleles Are Involved in the Induction of T-Cell Leukemia in c-myc Transgenic Mice

  2000cites this paper
• Radial glia phenotype: Origin, regulation, and transdifferentiation

  2000influential citation
• A common enzyme connects notch signaling and Alzheimer's disease.

  2000cites this paper
• Mutations in the human Delta homologue, DLL3, cause axial skeletal defects in spondylocostal dysostosis

  2000cites this paper
• Notch signaling: from the outside in.

  2000cites this paper
• Regulation of T cell fate by Notch.

  1999cites this paper
• Competence and commitment of Caenorhabditis elegans vulval precursor cells.

  1999cites this paper
• Notch and the CD4 versus CD8 lineage decision.

  1999cites this paper
• MyoD stimulates Delta‐1 transcription and triggers Notch signaling in the Xenopus gastrula

  1999cites this paper
• Human ligands of the Notch receptor.

  1999cites this paper
• The Notch pathway helps to pattern the tips of the Drosophila tracheal branches by selecting cell fates.

  1999cites this paper
• Specification of Neural Crest Cell Fate in the Embryonic Zebrafish

  1999cites this paper
• The alpha beta versus gamma delta T-cell lineage choice.

  1998cites this paper
• Notch signaling: direct or what?

  1998cites this paper
• The Notch Pathway Intermediate HES-1 Silences CD4 Gene Expression

  1998cites this paper
• Notch4 and Wnt-1 proteins function to regulate branching morphogenesis of mammary epithelial cells in an opposing fashion.

  1998cites this paper
• Notch receptors, partners and regulators: from conserved domains to powerful functions.

  1998cites this paper
• The αβ versus γδ T-cell lineage choice

  1998cites this paper
• Conservation of the Notch signalling pathway in mammalian neurogenesis.

  1997cites this paper
• Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane.

  1997cites this paper