SCIENCE@home

Mechanical Properties and Degradation of Chain and Step-Polymerized Photodegradable Hydrogels

M. Tibbitt,April M. Kloxin,L. Sawicki,K. Anseth

Published 2013 in Macromolecules

ABSTRACT

The relationship between polymeric hydrogel microstructure and macroscopic properties is of specific interest to the materials science and polymer science communities for the rational design of materials for targeted applications. Specifically, research has focused on elucidating the role of network formation and connectivity on mechanical integrity and degradation behavior. Here, we compared the mechanical properties of chain- and step-polymerized, photodegradable hydrogels. Increased ductility, tensile toughness, and shear strain to yield were observed in step-polymerized hydrogels, as compared to the chain-polymerized gels, indicating that increased homogeneity and network cooperativity in the gel backbone improves mechanical integrity. Furthermore, the ability to degrade the hydrogels in a controlled fashion with light was exploited to explore how hydrogel microstructure influences photodegradation and erosion. Here, the decreased network connectivity at the junction points in the step-polymerized gels resulted in more rapid erosion. Finally, a relationship between the reverse gelation threshold and erosion rate was developed for the general class of photodegradable hydrogels. In all, these studies further elucidate the relationship between hydrogel formation and microarchitecture with macroscale behavior to facilitate the future design of polymer networks and degradable hydrogels, as well as photoresponsive materials such as cell culture templates, drug delivery vehicles, responsive coatings, and anisotropic materials.

PUBLICATION RECORD

CITATION MAP

EXTRACTION MAP

CLAIMS

  • No claims are published for this paper.

CONCEPTS

  • No concepts are published for this paper.

REFERENCES

Showing 1-52 of 52 references · Page 1 of 1

CITED BY

Showing 1-100 of 184 citing papers · Page 1 of 2

12
Next