Have we cut ourselves too short in mapping CTL epitopes?

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Trends in immunology

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.IT.2005.11.001PMID 16297661
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1998cited by this paper
• Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen.

  1998cited by this paper
• Mechanisms of MHC class I--restricted antigen processing.

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  1997cited by this paper
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