New therapeutic opportunities for 5‐HT2 receptor ligands

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Pharmacology and Therapeutics

• Publication date

  2016-10-19

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.pharmthera.2016.10.008PMID 27771435
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Serotonin Improves High Fat Diet Induced Obesity in Mice

  2016cited by this paper
• Serotonin competence of mouse beta cells during pregnancy

  2016cited by this paper
• Serotonin Is Involved in Autoimmune Arthritis through Th17 Immunity and Bone Resorption.

  2016cited by this paper
• Presynaptic serotonin 2A receptors modulate thalamocortical plasticity and associative learning

  2016cited by this paper
• Serotonin 2B receptor slows disease progression and prevents degeneration of spinal cord mononuclear phagocytes in amyotrophic lateral sclerosis

  2016cited by this paper
• Alpha-smooth muscle actin and serotonin receptors 2A and 2B in dogs with myxomatous mitral valve disease.

  2015cited by this paper
• Recent advances in the neuropsychopharmacology of serotonergic hallucinogens.

  2015cited by this paper
• Serotonin markers show altered transcription levels in an experimental pig model of mitral regurgitation.

  2015cited by this paper
• Structure and function of serotonin G protein-coupled receptors.

  2015cited by this paper
• Modulation of osteoblast differentiation and bone mass by 5-HT2A receptor signaling in mice.

  2015cited by this paper
• Cognitive Impairment Induced by Delta9-tetrahydrocannabinol Occurs through Heteromers between Cannabinoid CB1 and Serotonin 5-HT2A Receptors

  2015cited by this paper
• Mice Lacking the Serotonin Htr2B Receptor Gene Present an Antipsychotic-Sensitive Schizophrenic-Like Phenotype

  2015cited by this paper
• Serotonin (5-HT) 5-HT2A Receptor (5-HT2AR):5-HT2CR Imbalance in Medial Prefrontal Cortex Associates with Motor Impulsivity.

  2015cited by this paper
• Serotonin Modulates Developmental Microglia via 5-HT2B Receptors: Potential Implication during Synaptic Refinement of Retinogeniculate Projections.

  2015cited by this paper
• Contribution of serotonin to cardiac remodeling associated with hypertensive diastolic ventricular dysfunction in rats

  2015cited by this paper
• Serotonin and cancer: what is the link?

  2015cited by this paper
• Ghrelin's Orexigenic Effect Is Modulated via a Serotonin 2C Receptor Interaction.

  2015cited by this paper
• Altered serotonin (5-HT) 1D and 2A receptor expression may contribute to defective insulin and glucagon secretion in human type 2 diabetes.

  2015cited by this paper
• Convergence of Melatonin and Serotonin (5-HT) Signaling at MT2/5-HT2C Receptor Heteromers*

  2015cited by this paper
• Prospective Randomized Study of Sarpogrelate Versus Clopidogrel-based Dual Antiplatelet Therapies in Patients Undergoing Femoropopliteal Arterial Endovascular Interventions: Preliminary Results

  2015cited by this paper
• Central serotonin(2B) receptor blockade inhibits cocaine-induced hyperlocomotion independently of changes of subcortical dopamine outflow.

  2015cited by this paper
• Central serotonergic neurons activate and recruit thermogenic brown and beige fat and regulate glucose and lipid homeostasis.

  2015cited by this paper
• Repeated exposure to MDMA triggers long-term plasticity of noradrenergic and serotonergic neurons

  2014cited by this paper
• Old spontaneously hypertensive rats gather together typical features of human chronic left-ventricular dysfunction with preserved ejection fraction

  2014cited by this paper
• The role of endothelium-derived hyperpolarizing factor and cyclooxygenase pathways in the inhibitory serotonergic response to the pressor effect elicited by sympathetic stimulation in chronic sarpogrelate treated rats.

  2014cited by this paper
• Expression analysis of genes and pathways associated with liver metastases of the uveal melanoma

  2014cited by this paper
• Controversies on the role of 5-HT(2C) receptors in the mechanisms of action of antidepressant drugs.

  2014cited by this paper
• Deletion of Serotonin 2B Receptor Provokes Structural Alterations of Mouse Dental Tissues

  2014cited by this paper
• Role of melatonin, serotonin 2B, and serotonin 2C receptors in modulating the firing activity of rat dopamine neurons

  2014cited by this paper
• Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis

  2014cited by this paper
• Serotonin Enhances Megakaryopoiesis and Proplatelet Formation via p‐Erk1/2 and F‐Actin Reorganization

  2014cited by this paper
• A Novel Aminotetralin-Type Serotonin (5-HT) 2C Receptor-Specific Agonist and 5-HT2A Competitive Antagonist/5-HT2B Inverse Agonist with Preclinical Efficacy for Psychoses

  2014cited by this paper
• A Dynamic View of Molecular Switch Behavior at Serotonin Receptors: Implications for Functional Selectivity

  2014cited by this paper
• Structural Basis for Molecular Recognition at Serotonin Receptors

  2013cited by this paper
• Serial Femtosecond Crystallography of G Protein–Coupled Receptors

  2013cited by this paper
• Serotonin 2C receptors in pro-opiomelanocortin neurons regulate energy and glucose homeostasis.

  2013cited by this paper
• Effect of sarpogrelate treatment on the prognosis after endovascular therapy for critical limb ischemia

  2013cited by this paper
• Selective Serotonin Reuptake Inhibitors Inhibit Human Osteoclast and Osteoblast Formation and Function

  2013cited by this paper
• Degeneration of serotonergic neurons in amyotrophic lateral sclerosis: a link to spasticity.

  2013cited by this paper
• Sarpogrelate dilates cerebral arteries in the absence of exogenous serotonin.

  2013cited by this paper
• Role of serotonin 5-HT2A receptors in the development of cardiac hypertrophy in response to aortic constriction in mice

  2013cited by this paper
• The expression and role of serotonin receptor 5HTR2A in canine osteoblasts and an osteosarcoma cell line

  2013cited by this paper
• 5-HT2A receptor inactivation potentiates the acute antidepressant-like activity of escitalopram: involvement of the noradrenergic system

  2013cited by this paper
• Update on typical and atypical antipsychotic drugs.

  2013cited by this paper
• Expression and localization of serotonin receptors in human breast cancer.

  2013cited by this paper
• Influence of age on wound healing and fibrosis

  2013cited by this paper
• Impact of Serotonin (5-HT)2C Receptors On Executive Control Processes

  2013cited by this paper
• Synergism between a serotonin 5-HT2A receptor (5-HT2AR) antagonist and 5-HT2CR agonist suggests new pharmacotherapeutics for cocaine addiction.

  2013cited by this paper
• Prospective study of sarpogrelate hydrochloride on patients with arteriosclerosis obliterans.

  2013cited by this paper
• Serotonin 2B Receptor (5-HT2B R) Signals through Prostacyclin and PPAR-ß/δ in Osteoblasts

  2013cited by this paper
• Serotonin promotes the proliferation of serum-deprived hepatocellular carcinoma cells via upregulation of FOXO3a

  2013cited by this paper
• Role of the N-Terminal Region in G Protein–Coupled Receptor Functions: Negative Modulation Revealed by 5-HT2B Receptor Polymorphisms

  2013cited by this paper
• Serotonin Skews Human Macrophage Polarization through HTR2B and HTR7

  2013cited by this paper
• Serotonin 2A Receptors Differentially Contribute to Abuse-Related Effects of Cocaine and Cocaine-Induced Nigrostriatal and Mesolimbic Dopamine Overflow in Nonhuman Primates

  2013cited by this paper
• Structural Features for Functional Selectivity at Serotonin Receptors

  2013cited by this paper
• Serotonin paracrine signaling in tissue fibrosis☆☆☆

  2013cited by this paper
• 5-HT2 Receptors Facilitate JC Polyomavirus Entry

  2013cited by this paper
• Head-twitch response in rodents induced by the hallucinogen 2,5-dimethoxy-4-iodoamphetamine: a comprehensive history, a re-evaluation of mechanisms, and its utility as a model.

  2012cited by this paper
• 5‐HT2A receptor blockade and 5‐HT2C receptor activation interact to reduce cocaine hyperlocomotion and fos protein expression in the caudate‐putamen

  2012cited by this paper
• Role of serotonin in angiogenesis: induction of angiogenesis by sarpogrelate via endothelial 5-HT1B/Akt/eNOS pathway in diabetic mice.

  2012cited by this paper
• Expression of Serotonin Receptors in Human Hepatocellular Cancer

  2012cited by this paper
• Identification of New Genes Involved in Human Adipogenesis and Fat Storage

  2012cited by this paper
• Exploration of synthetic approaches and pharmacological evaluation of PNU-69176E and its stereoisomer as 5-HT2C receptor allosteric modulators.

  2012cited by this paper
• Mechanism of inverse agonist action of sarpogrelate at the constitutively active mutant of human 5-HT2A receptor revealed by molecular modeling.

  2012cited by this paper
• Reduced Forebrain Serotonin Transmission is Causally Involved in the Development of Compulsive Cocaine Seeking in Rats

  2012cited by this paper
• A simple method for quantifying functional selectivity and agonist bias.

  2012cited by this paper
• An integrative computational systems biology approach identifies differentially regulated dynamic transcriptome signatures which drive the initiation of human T helper cell differentiation

  2012cited by this paper
• Gut-derived serotonin is a multifunctional determinant to fasting adaptation.

  2012cited by this paper
• Mitral bioprosthesis hypertrophic scaring and native aortic valve fibrosis during benfluorex therapy

  2012cited by this paper
• Serotonin 5-HT2A receptor-mediated hypertrophy is negatively regulated by caveolin-3 in cardiomyoblasts and neonatal cardiomyocytes.

  2012cited by this paper
• Role of serotonergic system in the pathogenesis of fibrosis in canine idiopathic inflammatory myopathies.

  2012cited by this paper
• Serotonin 5-HT2B receptors are required for bone-marrow contribution to pulmonary arterial hypertension.

  2012cited by this paper
• Serotonin potentiates high-glucose-induced endothelial injury: the role of serotonin and 5-HT(2A) receptors in promoting thrombosis in diabetes.

  2012cited by this paper
• Signaling pathways in mitral valve degeneration.

  2012cited by this paper
• 5-HT2B receptors are required for serotonin-selective antidepressant actions

  2012cited by this paper
• Involvement of 5-HT2A receptors in MDMA reinforcement and cue-induced reinstatement of MDMA-seeking behaviour.

  2011cited by this paper
• Sensitization to MDMA locomotor effects and changes in the functionality of 5-HT2A and D2 receptors in mice

  2011cited by this paper
• mRNA and microRNA expression patterns in adrenocortical cancer.

  2011cited by this paper
• 5-Hydroxytryptamine induces cyclooxygenase-2 in rat vascular smooth muscle cells: Mechanisms involving Src, PKC and MAPK activation [corrected].

  2011cited by this paper
• Decoding the signaling of a GPCR heteromeric complex reveals a unifying mechanism of action of antipsychotic drugs.

  2011cited by this paper
• Ineffective erythropoiesis with reduced red blood cell survival in serotonin-deficient mice

  2011cited by this paper
• Sarpogrelate protects against high glucose-induced endothelial dysfunction and oxidative stress.

  2011cited by this paper
• Regulation of dorsal raphe nucleus function by serotonin autoreceptors: a behavioral perspective.

  2011cited by this paper
• Convergence of the Insulin and Serotonin Programs in the Pancreatic β-Cell

  2011cited by this paper
• Switching-on of serotonergic calcium signaling in activated hepatic stellate cells.

  2011cited by this paper
• Platelet-derived serotonin links vascular disease and tissue fibrosis

  2011cited by this paper
• Stimulating healthy tissue regeneration by targeting the 5-HT2B receptor in chronic liver disease

  2011cited by this paper
• Deconstructing Antiobesity Compound Action: Requirement of Serotonin 5-HT2B Receptors for Dexfenfluramine Anorectic Effects

  2011cited by this paper
• C-122, a novel antagonist of serotonin receptor 5-HT2B, prevents monocrotaline-induced pulmonary arterial hypertension in rats.

  2011cited by this paper
• Motoneuron excitability and muscle spasms are regulated by 5-HT2B and 5-HT2C receptor activity.

  2011cited by this paper
• Functional crosstalk and heteromerization of serotonin 5-HT2A and dopamine D2 receptors.

  2011cited by this paper
• Increased expression of 5-hydroxytryptamine2A/B receptors in idiopathic pulmonary fibrosis: a rationale for therapeutic intervention

  2010cited by this paper
• Multicenter, placebo-controlled trial of lorcaserin for weight management.

  2010cited by this paper
• Cariprazine (RGH-188), a Dopamine D3 Receptor-Preferring, D3/D2 Dopamine Receptor Antagonist–Partial Agonist Antipsychotic Candidate: In Vitro and Neurochemical Profile

  2010cited by this paper
• The central serotonin2B receptor: a new pharmacological target to modulate the mesoaccumbens dopaminergic pathway activity

  2010cited by this paper
• Placental lactogens induce serotonin biosynthesis in a subset of mouse beta cells during pregnancy

  2010cited by this paper
• Essential role of TRPC1 channels in cardiomyoblasts hypertrophy mediated by 5-HT2A serotonin receptors.

  2010cited by this paper
• Terguride ameliorates monocrotaline-induced pulmonary hypertension in rats

  2010cited by this paper
• The 5‐HT2B receptor plays a key regulatory role in both neuroendocrine tumor cell proliferation and the modulation of the fibroblast component of the neoplastic microenvironment

  2010cited by this paper
• Functional expression of 5-HT2A receptor in osteoblastic MC3T3-E1 cells.

  2010cited by this paper

• Psychedelic Experiences Elicited by Serotonergic Psychedelics; Molecular Mechanisms and Functional Connectivity Changes in /the Brain.

  2025cites this paper
• Serotonin Receptors as a Potential Therapeutic Target in Epilepsy

  2025cites this paper
• Hereditary Patterns and Genetic Associations in Obsessive-Compulsive Disorder (OCD): Neuropsychiatric Insights, Genetic Influences, and Treatment Perspectives

  2024cites this paper
• Deciphering the 4′,7‐Dihydroxy‐3′‐Methylflavone from Boerhavia, Agonist/Antagonist Interactions Against 5‐HT2 Receptors using Homology Modeling, Molecular Docking, and Dynamic Simulation Studies

  2024cites this paper
• Pharmacological Gq inhibition induces strong pulmonary vasorelaxation and reverses pulmonary hypertension

  2024cites this paper
• The roles of 5‐HT in orofacial pain

  2024cites this paper
• Evaluation of the Indazole Analogs of 5-MeO-DMT and Related Tryptamines as Serotonin Receptor 2 Agonists

  2024cites this paper
• Converged avenues: depression and Alzheimer’s disease– shared pathophysiology and novel therapeutics

  2024cites this paper
• Potent and Selective Human 5-HT2B Serotonin Receptor Antagonists: 4'-Cyano-(N)-methanocarba-adenosines by Synthetic Serendipity.

  2024cites this paper
• Recent Studies on Serotonin 5-HT2A Receptor Antagonists in Medicinal Chemistry: A Last Decades Survey.

  2023cites this paper
• Putative neural mechanisms underlying release‐mode‐specific abnormalities in dopamine neural activity in a schizophrenia‐like model: The distinct roles of glutamate and serotonin in the impaired regulation of dopamine neurons

  2023cites this paper
• Dissecting the novel abilities of aripiprazole: The generation of anti-colorectal cancer effects by targeting Gαq via HTR2B

  2023cites this paper
• Abnormalities in dopamine function might be related to psychiatric disorders

  2023cites this paper
• Development of Pharmacophore Models for the Important Off-Target 5-HT2B Receptor.

  2023cites this paper
• Serotonin receptors in epilepsy: Novel treatment targets?

  2022cites this paper
• Clozapine's multiple cellular mechanisms: What do we know after more than fifty years? A systematic review and critical assessment of translational mechanisms relevant for innovative strategies in treatment-resistant schizophrenia.

  2022cites this paper
• Differential expression of serotonin2B receptors in GABAergic and serotoninergic neurons of the rat and mouse dorsal raphe nucleus.

  2022cites this paper
• Forgetting generates a novel state that is reactivatable

  2022cites this paper
• In vitro assays for the functional characterization of (psychedelic) substances at the serotonin receptor 5‐HT2AR

  2022influential citation
• Agomelatine attenuates alcohol craving and withdrawal symptoms by modulating the Notch1 signaling pathway in rats.

  2021cites this paper
• Targeting 5-HT2B Receptor Signaling Prevents Border Zone Expansion and Improves Microstructural Remodeling after Myocardial Infarction.

  2021cites this paper
• Structure, Function, and Pharmaceutical Ligands of 5-Hydroxytryptamine 2B Receptor

  2021influential citation
• Serotonin 2B Receptor by Interacting with NMDA Receptor and CIPP Protein Complex May Control Structural Plasticity at Glutamatergic Synapses.

  2021cites this paper
• Bridging the gap between single receptor type activity and whole‐brain dynamics

  2021cites this paper
• 5-HT2B Receptor in Cardiopulmonary Disease

  2021cites this paper
• Stem Cells to Decipher the Physiological Roles of 5-HT2B Receptor Signaling

  2021cites this paper
• Gene Structure, Expression, and 5-HT2B Receptor Signaling

  2021cites this paper
• Serotonin 2B Receptor Interactions with Dopamine Network: Implications for Therapeutics in Schizophrenia

  2021cites this paper
• Radioligands for Serotonin Receptors and Transporter PET Imaging

  2021cites this paper
• Structural and Functional Definition of Pulmonary Vein System in Chronic Hypoxia-induced Pulmonary Hypertension Rat Model.

  2020cites this paper
• International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function

  2020cites this paper
• Central 5-HT receptors and their function; present and future.

  2020cites this paper
• Free energy calculations of the functional selectivity of 5-HT2B G protein-coupled receptor

  2020influential citation
• Genetic ablation of serotonin receptor 2B improves aortic valve hemodynamics of Notch1 heterozygous mice in a high-cholesterol diet model

  2020cites this paper
• PDGF mediates pulmonary arterial smooth muscle cell proliferation and migration by regulating NFATc2

  2020cites this paper
• Pharmacological evidence for transactivation within melatonin MT2 and serotonin 5‐HT2C receptor heteromers in mouse brain

  2020cites this paper
• New Insights into the Mechanism of Action of Viloxazine: Serotonin and Norepinephrine Modulating Properties

  2020cites this paper
• Prognostic and immune regulating roles of YIF1B in Pan-Cancer: a potential target for both survival and therapy response evaluation

  2020cites this paper
• Opportunities for multiscale computational modelling of serotonergic drug effects in Alzheimer's disease

  2020cites this paper
• Development and trend in the field of valvular heart disease in China: an analysis based on the National Natural Science Foundation of China

  2020cites this paper
• The selective 5-HT2A receptor agonist 25CN-NBOH: structure-activity relationship, in vivo pharmacology, and in vitro and ex vivo binding characteristics of [3H]25CN-NBOH.

  2020cites this paper
• Serotonin (5-HT) Shapes the Macrophage Gene Profile through the 5-HT2B–Dependent Activation of the Aryl Hydrocarbon Receptor

  2020cites this paper
• The serotonin2B receptor and neurochemical regulation in the brain

  2020cites this paper
• University of Birmingham Central 5-HT receptors and their function ; present and future

  2020cites this paper
• 5‐HT2A receptor activation enhances NMDA receptor‐mediated glutamate responses through Src kinase in the dendrites of rat jaw‐closing motoneurons

  2019influential citation
• CaMello-XR enables visualization and optogenetic control of Gq/11 signals and receptor trafficking in GPCR-specific domains

  2019cites this paper
• Serotonergic Mechanisms in Locomotor Effects of Electrical Spinal Cord Stimulation

  2019cites this paper
• Electrochemical DNA biosensors: a review

  2019cites this paper
• 5-HT2B serotonin receptor agonist BW723C86 shapes the macrophage gene profile via AhR and impairs monocyte-to-osteoclast differentiation

  2019cites this paper
• Serotonergic 5-HT 2B receptors in mitral valvulopathy: bone marrow mobilization of endothelial progenitors

  2018cites this paper
• Inhibition of 5‐Hydroxytryptamine Receptor 2B Reduced Vascular Restenosis and Mitigated the β‐Arrestin2–Mammalian Target of Rapamycin/p70S6K Pathway

  2018cites this paper
• The central serotonin2B receptor as a new pharmacological target for the treatment of dopamine‐related neuropsychiatric disorders: Rationale and current status of research

  2018cites this paper
• Crucial Roles of 5-HT and 5-HT2 Receptor in Diabetes-Related Lipid Accumulation and Pro-Inflammatory Cytokine Generation in Hepatocytes

  2018cites this paper
• Personalized Treatment of Antisocial Personality Disorder with Inherent Impulsivity and Severe Alcoholism: A Brief Review of Relevant Literature

  2018cites this paper
• Detailed Characterization of the In Vitro Pharmacological and Pharmacokinetic Properties of N-(2-Hydroxybenzyl)-2,5-Dimethoxy-4-Cyanophenylethylamine (25CN-NBOH), a Highly Selective and Brain-Penetrant 5-HT2A Receptor Agonist

  2017influential citation
• The role of 5‐HT2B receptors in mitral valvulopathy: bone marrow mobilization of endothelial progenitors

  2017cites this paper
• Effect fingerprinting of new psychoactive substances (NPS): What can we learn from in vitro data?

  2017cites this paper
• Cortical high gamma network oscillations and connectivity: a translational index for antipsychotics to normalize aberrant neurophysiological activity

  2017cites this paper