NMDA receptor complex antagonists have potential anxiolytic effects as measured with separation-induced ultrasonic vocalizations.

No abstract is available for this paper.

• Publication year

  1991

• Venue

  European Journal of Pharmacology

• Publication date

  1991-02-14

• Fields of study

  Biology, Medicine, Chemistry, Psychology

• Identifiers
  DOI 10.1016/0014-2999(91)90141-CPMID 1675993
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Buspirone

  2012cited by this paper
• An evaluation of the elevated plus-maze test using the novel anxiolytic buspirone

  2004cited by this paper
• Lack of effects of 5HT3 receptor antagonists in the social interaction and elevated plus-maze tests of anxiety in the rat

  2004cited by this paper
• Does the excitatory amino acid receptor antagonist 2-APH exhibit anxiolytic activity?

  2004cited by this paper
• Anxiolytic effects of buspirone and gepirone in the fear-potentiated startle paradigm

  2004cited by this paper
• Activity of 5,7-dichlorokynurenic acid, a potent antagonist at the N-methyl-D-aspartate receptor-associated glycine binding site.

  1990cited by this paper
• Glycine-insensitive NMDA-sensitive receptor expressed in Xenopus oocytes by guinea pig cerebellar mRNA

  1990cited by this paper
• Selective blockade of N-methyl-D-aspartate (NMDA)-induced convulsions by NMDA antagonists and putative glycine antagonists: relationship with phencyclidine-like behavioral effects.

  1990cited by this paper
• (R)-4-oxo-5-phosphononorvaline: a new competitive glutamate antagonist at the NMDA receptor complex.

  1990cited by this paper
• Serotonergic modulation of rat pup ultrasonic vocal development: studies with 3,4-methylenedioxymethamphetamine.

  1990cited by this paper
• Rat pup isolation calls are reduced by functional antagonists of the NMDA receptor complex.

  1990cited by this paper
• Characterization of MDL 73005EF as a 5‐HT1A selective ligand and its effects in animal models of anxiety: comparison with buspirone, 8‐OH‐DPAT and diazepam

  1990cited by this paper
• Comparative study in mice of tetrazepam and other centrally active skeletal muscle relaxants.

  1989cited by this paper
• Behavioral studies with anxiolytic drugs. VI. Effects on punished responding of drugs interacting with serotonin receptor subtypes.

  1989cited by this paper
• Effects of 5-HT1A receptor agonists and NMDA receptor antagonists in the social interaction test and the elevated plus maze.

  1989cited by this paper
• Rat pup isolation distress and the brain benzodiazepine receptor.

  1989cited by this paper
• Excitatory amino acid receptors in the vertebrate central nervous system.

  1989cited by this paper
• Behavioral pharmacological profile of CGS 19755, a competitive antagonist at N-methyl-D-aspartate receptors.

  1989cited by this paper
• The excitatory amino acid receptors: their classes, pharmacology, and distinct properties in the function of the central nervous system.

  1989cited by this paper
• Effect of acute and chronic MDL 73,147EF, a 5-HT3 receptor antagonist, on A9 and A10 dopamine neurons.

  1989cited by this paper
• Serotonergic mediation of the anxiolytic effect of intracerebrally injected propranolol measured in the elevated plus-maze.

  1989cited by this paper
• Anxiolytic properties of 1-aminocyclopropanecarboxylic acid, a ligand at strychnine-insensitive glycine receptors.

  1989cited by this paper
• Ontogeny of noradrenergic effects on ultrasonic vocalizations in rat pups.

  1989cited by this paper
• Effects of phencyclidine and other N-methyl-D-aspartate antagonists on the schedule-controlled behavior of rats.

  1989cited by this paper
• Two classes of N-methyl-D-aspartate recognition sites: differential distribution and differential regulation by glycine.

  1988cited by this paper
• Phencyclidine-like discriminative stimulus properties of MK-801 in rats.

  1988cited by this paper
• Potential use of drugs modulating 5HT activity in the treatment of anxiety.

  1988cited by this paper
• Requirement for glycine in activation of NMDA-receptors expressed in Xenopus oocytes.

  1988cited by this paper
• The potential anxiolytic activity of GR38032F, a 5‐HT3‐receptor antagonist

  1988cited by this paper
• Rat Pup Ultrasonic Isolation Calls and the Benzodiazepine Receptor

  1988cited by this paper
• Pharmacological effects of MDL 11,939: A selective, centrally acting antagonist of 5‐HT2 receptors

  1988cited by this paper
• Ontogeny of Adrenergic and Opioid Effects on Separation Vocalizations in Rats

  1988cited by this paper
• Isolation distress in two-week-old rats: influence of home cage, social companions, and prior experience with littermates.

  1987cited by this paper
• Electrophysiological responses of serotoninergic dorsal raphe neurons to 5‐HT1A and 5‐HT1B agonists

  1987cited by this paper
• Ketanserin Pretreatment Reverses Alfentanil‐induced Muscle Rigidity

  1987cited by this paper
• Buspirone. A preliminary review of its pharmacological properties and therapeutic efficacy as an anxiolytic.

  1986cited by this paper
• Rat pup ultrasonic isolation calls: possible mediation by the benzodiazepine receptor complex.

  1986cited by this paper
• A comparative study of the effects of ritanserin (R 55 667) and chlordiazepoxide on rat open field behavior

  1986cited by this paper
• (-)-Propranolol blocks the inhibition of serotonergic dorsal raphe cell firing by 5-HT1A selective agonists.

  1986cited by this paper
• 2-Amino-7-phosphonoheptanoic acid (AP7) produces discriminative stimuli and anticonflict effects similar to diazepam.

  1986cited by this paper
• Pharmacological and clinical effects of buspirone.

  1985cited by this paper
• Testing the statistical certainty of a response to increasing doses of a drug.

  1985cited by this paper
• Muscle relaxant action of excitatory amino acid antagonists.

  1985cited by this paper
• Selective interaction of novel anxiolytics with 5-hydroxytryptamine1A receptors.

  1985cited by this paper
• Analysis of Survival Data.

  1985cited by this paper
• Distress vocalization in rat pups. A simple screening method for anxiolytic drugs.

  1985cited by this paper
• The Influence of Ritanserin, a Serotonin Antagonist, in Anxiety Disorders: A Double-blind Placebo-controlled Study versus Lorazepam

  1985cited by this paper
• Restoration of shock‐suppressed behavior by treatment with (+)‐5‐methyl‐10,11‐dihydro‐5H‐dibenzo[a, d]cyclohepten‐5, 10‐imine (MK‐801), a substance with potent anticonvulsant, central sympathomimetic, and apparent anxiolytic properties

  1982cited by this paper
• Anticonvulsant activity of (+)‐5‐methyl‐10, 11‐dihydro‐5H‐dibenzo[a, d]cyclohepten‐5, 10‐imine (MK‐801), a substance with potent anticonvulsant, central sympathomimetic, and apparent anxiolytic properties

  1982cited by this paper
• Studies on the efficacy and depressant potential of muscle relaxants in mice

  1982cited by this paper
• Sensory processes in the control of isolation-induced ultrasonic vocalization by 2-week-old rats.

  1980cited by this paper
• Olfactory, thermal, and tactual influences on infantile ultrasonic vocalization in rats.

  1975cited by this paper
• Ultrasonic Communication by Animals

  1974cited by this paper
• Ultrasounds and maternal behavior in small rodents.

  1972cited by this paper
• Effects of temperature on ultrasound production by infant albino rats.

  1971cited by this paper
• Applied Regression Analysis.

  1967cited by this paper
• Statistical Method in Biological Assay

  1966cited by this paper

• Socio-affective communication in Tph2-deficient rat pups: communal nesting aggravates growth retardation despite ameliorating maternal affiliation deficits

  2024cites this paper
• Anxiolytic like effect of L-Carnitine in mice: Evidences for the involvement of NO-sGC-cGMP signaling pathway.

  2020cites this paper
• A Review of the Actions of D-cycloserine, a Putative Nootropic Agent, at the NMDA Receptor Complex-Associated Glycine Binding Site

  2020cites this paper
• Ultrasonic Vocalization Sex Differences in 5-HT1A-R Deficient Mouse Pups: Predictive Phenotypes Associated with Later-life Anxiety-like Behaviors.

  2019cites this paper
• The Role of the N-Methyl-D-Aspartate Receptors in Social Behavior in Rodents

  2019cites this paper
• The 5-HT1A-R Knockout Mouse as a Model of Later Life Anxiety Disorders: Implications for Sex Differences

  2019cites this paper
• Pharmacological Studies on the Role of Serotonin in Regulating Socioemotional Ultrasonic Vocalizations in Rats

  2018cites this paper
• Vocalization as a novel endpoint of atypical attachment behavior in 2,3,7,8-tetrachlorodibenzo-p-dioxin-exposed infant mice

  2018cites this paper
• Affective communication in rodents: serotonin and its modulating role in ultrasonic vocalizations

  2015influential citation
• Rat Ultrasonic Vocalizations and Behavioral Neuropharmacology: From the Screening of Drugs to the Study of Disease

  2015cites this paper
• Sexual differences in long‐term effects of prenatal chronic mild stress on anxiety‐like behavior and stress‐induced regional glutamate receptor expression in rat offspring

  2015cites this paper
• Inoculation stress hypothesis of environmental enrichment.

  2015cites this paper
• Involvement of the strychnine-sensitive glycine receptor in the anxiolytic effects of GlyT1 inhibitors on maternal separation-induced ultrasonic vocalization in rat pups.

  2015cites this paper
• Reduced isolation-induced pup ultrasonic communication in mouse pups lacking brain serotonin

  2015cites this paper
• Developmental rodent models of fear and anxiety: from neurobiology to pharmacology

  2014influential citation
• Perspectives on zebrafish models of hallucinogenic drugs and related psychotropic compounds.

  2013cites this paper
• Psychopharmacological effects of acute exposure to kynurenic acid (KYNA) in zebrafish.

  2013cites this paper
• Effect of Gtf2i Gene in Anxiety

  2013cites this paper
• Heterozygous deletion of NR1 subunit of the NMDA receptor alters ethanol-related behaviors and regional expression of NR2 subunits in the brain.

  2012cites this paper
• Metabotropic and ionotropic glutamate receptors as neurobiological targets in anxiety and stress-related disorders: focus on pharmacology and preclinical translational models.

  2012cites this paper
• Rebound increase in seizure susceptibility but not isolation-induced calls after single administration of clonazepam and Ro 19-8022 in infant rats.

  2011cites this paper
• Hippocampal NMDA receptors and anxiety: At the interface between cognition and emotion

  2010cites this paper
• Therapeutic utility of non-peptidic CRF1 receptor antagonists in anxiety, depression, and stress-related disorders: evidence from animal models.

  2010cites this paper
• Systemic administration of GMP induces anxiolytic-like behavior in rats.

  2010influential citation
• Studies of emotionality in genetic mouse models of altered glutamate or 5-HT function

  2010cites this paper
• The role of ionotropic glutamate receptors in the dorsomedial hypothalamus in the increase in core body temperature evoked by interoceptive and exteroceptive stresses in rats

  2010cites this paper
• Anxioselective profile of glycineB receptor partial agonist, D-cycloserine, in plus-maze-naïve but not plus-maze-experienced mice.

  2010cites this paper
• D-serine in health and disease

  2010cites this paper
• Measuring anxiety in zebrafish: a critical review.

  2010cites this paper
• Short- and long-term consequences of prenatal exposure to the cannabinoid agonist WIN55,212-2 on rat glutamate transmission and cognitive functions

  2009cites this paper
• PRX-00023, a selective serotonin 1A receptor agonist, reduces ultrasonic vocalizations in infant rats bred for high infantile anxiety.

  2009cites this paper
• Glutamatergic and GABAergic modulations of ultrasonic vocalizations during maternal separation distress in mouse pups

  2009cites this paper
• Importance of the kappa opoid system for ultrasonic vocalizations of young rats: Role of peripherally-versus centrally-located kappa opioid receptors

  2008cites this paper
• The role of 5-HT 2 A and 5-HT 2 C receptors in the signal attenuation rat model of obsessive – compulsive disorder

  2008cites this paper
• Duration of ultrasonic vocalizations in the isolated rat pup as a behavioral measure: sensitivity to anxiolytic and antidepressant drugs.

  2008cites this paper
• Chapter 4.4 The glutamatergic system as a potential therapeutic target for the treatment of anxiety disorders

  2008cites this paper
• The role of 5-HT2A and 5-HT2C receptors in the signal attenuation rat model of obsessive-compulsive disorder.

  2008cites this paper
• Modulação das funções do sistema glutamatérgico pelo receptor serotoninérgico 5-HT1A da substância cinzenta periaquedutal dorsal no comportamento defensivo de ratos

  2008cites this paper
• Chapter 4.1 Peptide receptor ligands to treat anxiety disorders

  2008cites this paper
• Metabotropic glutamate receptor ligands as possible anxiolytic and antidepressant drugs.

  2007cites this paper
• Analysis of Ultrasonic Vocalizations Emitted by Infant Rodents

  2006cites this paper
• Spontaneous alternation behaviour in rats: kynurenic acid attenuated deficits induced by MK-801.

  2006cites this paper
• D-amino acids in the central nervous system in health and disease.

  2005cites this paper
• Performance of male C57BL/6J mice and Wistar rats in the water maze following various schedules of phencyclidine treatment

  2005cites this paper
• Prenatal exposure to the CB1 receptor agonist WIN 55,212-2 causes learning disruption associated with impaired cortical NMDA receptor function and emotional reactivity changes in rat offspring.

  2005influential citation
• Anxiolytic effect of glycine antagonists microinjected into the dorsal periaqueductal grey

  2005cites this paper
• Lack of evidence for mu-opioid regulation of a socially mediated separation response.

  2005cites this paper
• CoMFA, synthesis, and pharmacological evaluation of (E)-3-(2-carboxy-2-arylvinyl)-4,6-dichloro-1H-indole-2-carboxylic acids: 3-[2-(3-aminophenyl)-2-carboxyvinyl]-4,6-dichloro-1H-indole-2-carboxylic acid, a potent selective glycine-site NMDA receptor antagonist.

  2005cites this paper
• MK-801 produces a reduction in anxiety-related antipredator defensiveness in male and female rats and a gender-dependent increase in locomotor behavior

  2005cites this paper
• Separation-induced ultrasonic vocalization in rat pups: further pharmacological characterization.

  2005cites this paper
• Pharmacological characterization of stress-induced hyperthermia in DBA/2 mice using metabotropic and ionotropic glutamate receptor ligands

  2005cites this paper
• Selective Breeding for an Infant Phenotype: Rat Pup Ultrasonic Vocalization (USV)

  2005cites this paper
• SSR181507, a putative atypical antipsychotic with dopamine D2 antagonist and 5-HT1A agonist activities: improvement of social interaction deficits induced by phencyclidine in rats.

  2004cites this paper
• Glutamate and anxiety.

  2004cites this paper
• SSR181507, a putative atypical antipsychotic with dopamine D2 antagonist and 5-HT1A agonist activities: improvement of social interaction deficits induced by phencyclidine in rats.

  2004cites this paper
• Reduced isolation-induced aggressiveness in mice following NAALADase inhibition

  2004cites this paper
• Effect of MS-153 on the acquisition and expression of conditioned fear in rats.

  2004cites this paper
• The neurobiology and control of anxious states.

  2003cites this paper
• Effects of selective NMDA and non-NMDA blockade in the nucleus accumbens on the plus-maze test.

  2002cites this paper
• 68 MECHANISM OF ACTION OF ANXIOLYTICS

  2002cites this paper
• Validation of a chromatographic method to determine E-6006 and its metabolite E-6332 in rat and dog plasma by solid-phase extraction and capillary gas chromatography. Application in pharmacokinetics.

  2001cites this paper
• Role of spinal NMDA receptors, protein kinase C and nitric oxide synthase in the hyperalgesia induced by magnesium deficiency in rats

  2001influential citation
• The effect of competitive and non-competitive NMDA receptor antagonists, ACPC and MK-801 on NPY and CRF-like immunoreactivity in the rat brain amygdala.

  2001cites this paper
• Modulation of defensive behavior by periaqueductal gray NMDA/glycine-B receptor.

  2001cites this paper
• Ultrasonic vocalisation emitted by infant rodents: a tool for assessment of neurobehavioural development.

  2001cites this paper
• Selective Breeding for an Infantile Phenotype (Isolation Calling)

  2001cites this paper
• Parental Deprivation Induces N-Methyl-D-Aspartate-Receptor Upregulation in Limbic Brain Areas of Octodon degus: Protective Role of the Maternal Call

  2000cites this paper
• Effects of the CRF(1) receptor antagonist, CP 154,526, in the separation-induced vocalization anxiolytic test in rat pups.

  2000cites this paper
• 5-HT(3) receptor antagonists and anxiety; a preclinical and clinical review.

  2000cites this paper
• Models of Anxiety: Ultrasonic Vocalizations of Isolated Rat Pups

  1999cites this paper
• Models of Anxiety: Ultrasonic Vocalizations of Isolated Rat Pups

  1999cites this paper
• Tolerance to anxiolytic- and antidepressant-like effects of a partial agonist of glycineB receptors.

  1999cites this paper
• The effects of 8-OH-DPAT and (+/-)-pindolol on isolation-induced ultrasonic vocalizations in 3-, 10-, and 14-day-old rats.

  1999cites this paper
• The "anxiety state" and its relation with rat models of memory and habituation.

  1999cites this paper
• Dopaminergic modulation of rat pup ultrasonic vocalizations.

  1999cites this paper
• Lorazepam attenuates the behavioral effects of dizocilpine.

  1999cites this paper
• Rat pup ultrasonic vocalization: effects of benzodiazepine receptor ligands.

  1998cites this paper
• Glutamate in CNS disorders as a target for drug development: an update.

  1998cites this paper
• The putative AMPA receptor antagonist, LY326325, produces anxiolytic-like effects without altering locomotor activity in rats.

  1998cites this paper
• A characterization of anxiolytic-like actions induced by the novel NMDA/glycine site antagonist, L-701,324

  1998cites this paper
• Glycine and N-methyl-D-aspartate receptors: physiological significance and possible therapeutic applications.

  1998cites this paper
• Potential anxiolytic-like activity of some amino acid derivatives.

  1998cites this paper
• Role of NMDA receptors in the emotional memory associated with neuroendocrine responses to conditioned fear stimuli in the rat.

  1998cites this paper
• The peripheral NK-1/NK-2 receptor antagonist MDL 105,172A inhibits tachykinin-mediated respiratory effects in guinea-pigs.

  1997cites this paper
• Antagonism of non-NMDA receptors in the dorsal periaqueductal grey induces anxiolytic effect in the elevated plus maze

  1997cites this paper
• Discriminative stimulus effects of site-selective N-methyl-d-aspartate antagonists in NPC 17742-trained rats and squirrel monkeys

  1997cites this paper
• The involvement of adenosine receptors in the effect of dizocilpine on mice in the elevated plus-maze.

  1997cites this paper
• Anxiolytic activity of glycine-B antagonists and partial agonists--no relation to intrinsic activity in the patch clamp.

  1997cites this paper
• Effects of NMDA-R1 antisense oligodeoxynucleotide administration: behavioral and radioligand binding studies.

  1997cites this paper
• Pharmacological characterization of MDL 105,519, an NMDA receptor glycine site antagonist.

  1997cites this paper
• Functional NMDA Antagonists

  1997cites this paper
• Free D-aspartate and D-serine in the mammalian brain and periphery.

  1997cites this paper
• L-701,324, a glycine/NMDA receptor antagonist, blocks the increase of cortical dopamine metabolism by stress and DMCM.

  1997cites this paper
• Differential effects of agents acting at various sites of the NMDA receptor complex in a place preference conditioning model.

  1996cites this paper
• The effects of a non-competitive NMDA receptor antagonist FR115427 on LTP, spontaneous behaviour and performance in the water maze

  1996cites this paper
• 1-Aminocyclopropane-carboxylic acid reduces NMDA-induced hippocampal neurodegeneration in vivo.

  1996cites this paper
• Preclinical characterization of the potential of the putative atypical antipsychotic MDL 100,907 as a potent 5-HT2A antagonist with a favorable CNS safety profile.

  1996cites this paper
• Anticonflict effects of a competitive NMDA receptor antagonist and a partial agonist at strychnine-insensitive glycine receptors.

  1996cites this paper
• Anxiety and Panic Disorders

  1996cites this paper
• Anxiogenic-like effect of glycine and D-serine microinjected into dorsal periaqueductal gray matter of rats.

  1995cites this paper