The UK Standardisation of Breast Radiotherapy (START) trials of radiotherapy hypofractionation for treatment of early breast cancer: 10-year follow-up results of two randomised controlled trials.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  The Lancet Oncology

• Publication date

  2013-10-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/S1470-2045(13)70386-3PMID 24055415
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Fraction size in radiation treatment for breast conservation in early breast cancer.

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