Tityustoxin‐K(alpha) blockade of the voltage‐gated potassium channel Kv1.3

No abstract is available for this paper.

• Publication year

  2003

• Venue

  British Journal of Pharmacology

• Publication date

  2003-07-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1038/sj.bjp.0705343PMID 12871837PMCID PMC1573937
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A CHARACTERIZATION OF FIBRANT SEGAL CATEGORIES

  2006cited by this paper
• Two Heteromeric Kv1 Potassium Channels Differentially Regulate Action Potential Firing

  2002influential reference
• Interaction of a toxin from the scorpion Tityus serrulatus with a cloned K+ channel from squid (sqKv1A).

  2001cited by this paper
• Electrostatic interaction between charybdotoxin and a tetrameric mutant of Shaker K(+) channels.

  2000cited by this paper
• Subunit Composition of Kv1 Channels in Human CNS

  1999cited by this paper
• Toxin and subunit specificity of blocking affinity of three peptide toxins for heteromultimeric, voltage-gated potassium channels expressed in Xenopus oocytes.

  1998influential reference
• Electrophysiologic recordings from Xenopus oocytes.

  1998cited by this paper
• Subunit Composition of Brain Voltage-gated Potassium Channels Determined by Hongotoxin-1, a Novel Peptide Derived fromCentruroides limbatus Venom*

  1998cited by this paper
• Scorpion Toxin Block of the Early K+ Current (IKf) in Rat Dorsal root Ganglion Neurones

  1997cited by this paper
• Subunit combinations defined for K+ channel Kv1 subtypes in synaptic membranes from bovine brain.

  1997cited by this paper
• Tityustoxin Kα blocks voltage-gated noninactivating K + channels and unblocks inactivating K + channels blocked by α-dendrotoxin in synaptosomes

  1996cited by this paper
• Characterization of a new peptide from Tityus serrulatus scorpion venom which is a ligand of the apamin‐binding site

  1996cited by this paper
• Topology of the pore-region of a K+ channel revealed by the NMR-derived structures of scorpion toxins.

  1995cited by this paper
• Electrostatic distance geometry in a K+ channel vestibule.

  1994cited by this paper
• Tityustoxin-Kα, from scorpion venom, blocks voltage-gated, non-inactivating potassium current in cultured central neurons

  1994cited by this paper
• Tityustoxin K alpha blocks voltage-gated noninactivating K+ channels and unblocks inactivating K+ channels blocked by alpha-dendrotoxin in synaptosomes.

  1994cited by this paper
• Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines.

  1994cited by this paper
• Tityustoxin-K alpha, a structurally novel and highly potent K+ channel peptide toxin, interacts with the alpha-dendrotoxin binding site on the cloned Kv1.2 K+ channel.

  1993cited by this paper
• Heteromultimeric K+ channels in terminal and juxtaparanodal regions of neurons

  1993cited by this paper
• Electrophysiological recording from Xenopus oocytes.

  1992cited by this paper
• Polypeptide toxins from the venoms of Old World and New World scorpions preferentially block different potassium channels.

  1991cited by this paper
• Characterization and functional expression of a rat genomic DNA clone encoding a lymphocyte potassium channel.

  1990cited by this paper
• Expression and chromosomal localization of a lymphocyte K+ channel gene.

  1990cited by this paper
• TEA prevents inactivation while blocking open K+ channels in human T lymphocytes.

  1989influential reference
• Molecular basis of functional diversity of voltage‐gated potassium channels in mammalian brain.

  1989cited by this paper
• A simplified procedure for the fractionation of Tityus serrulatus venom: isolation and partial characterization of TsTX-IV, a new neurotoxin.

  1989cited by this paper
• Modification of Na channel gating by an alpha scorpion toxin from Tityus serrulatus

  1989cited by this paper
• A voltage‐gated potassium channel in human T lymphocytes.

  1985cited by this paper
• Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

  1981cited by this paper

• The First K+-Channel Blocker Described from Tityus fasciolatus Venom: The Purification, Molecular Cloning, and Functional Characterization of α-KTx4.9 (Tf5)

  2025cites this paper
• Characterization of Kv1.2-mediated outward current in TRIP8b-deficient mice

  2023cites this paper
• Characterization and Chemical Synthesis of Cm39 (α-KTx 4.8): A Scorpion Toxin That Inhibits Voltage-Gated K+ Channel KV1.2 and Small- and Intermediate-Conductance Ca2+-Activated K+ Channels KCa2.2 and KCa3.1

  2023cites this paper
• Ion Channels Orchestrate Pancreatic Ductal Adenocarcinoma Progression and Therapy

  2021cites this paper
• A- and D-type potassium currents regulate axonal action potential repolarization in midbrain dopamine neurons.

  2021cites this paper
• A Venomics approach coupled to high-throughput toxin production strategies identifies the first venom-derived melanocortin receptor agonists.

  2020cites this paper
• Novel components of Tityus serrulatus venom: A transcriptomic approach.

  2020cites this paper
• Effects of Brazilian scorpion venoms on the central nervous system

  2018cites this paper
• 4-Chloro-3-nitro-N-butylbenzenesulfonamide acts on KV3.1 channels by an open-channel blocker mechanism

  2017cites this paper
• Treating autoimmune disorders with venom-derived peptides

  2017cites this paper
• Protein Kinase Mzeta (PKM-zeta) Regulates Kv1.2 Dependent Cerebellar Eyeblink Classical Conditioning

  2017cites this paper
• Scorpion toxin peptide action at the ion channel subunit level

  2017cites this paper
• Potassium channel blockers from the venom of the Brazilian scorpion Tityus serrulatus ().

  2016cites this paper
• Mass spectrometry study of N-alkylbenzenesulfonamides with potential antagonist activity to potassium channels

  2015cites this paper
• Use-Dependent Activation of Neuronal Kv1.2 Channel Complexes

  2015influential citation
• Electrophysiological Characterization of Ts6 and Ts7, K+ Channel Toxins Isolated through an Improved Tityus serrulatus Venom Purification Procedure

  2014cites this paper
• Targeting the voltage-dependent K(+) channels Kv1.3 and Kv1.5 as tumor biomarkers for cancer detection and prevention.

  2012cites this paper
• Developing a Comparative Docking Protocol for the Prediction of Peptide Selectivity Profiles: Investigation of Potassium Channel Toxins

  2012cites this paper
• Cellular Mechanisms and Behavioral Consequences of Kv1.2 Regulation in the Rat Cerebellum

  2012cites this paper
• Involvement of C-type inactivation gating in the actions of voltage-gated K+ channel inhibitors.

  2012cites this paper
• Ion Channels in Cardiac Fibroblasts: Link to Mechanically Gated Channels and their Regulation

  2012cites this paper
• Effect of dextromethorphan on human K(v)1.3 channel activity: involvement of C-type inactivation.

  2011cites this paper
• Tityus serrulatus venom and toxins Ts1, Ts2 and Ts6 induce macrophage activation and production of immune mediators.

  2011cites this paper
• Tityus serrulatus scorpion venom and toxins: an overview.

  2009cites this paper
• Enantioselective total synthesis of (-)-candelalides A, B and C: potential Kv1.3 blocking immunosuppressive agents.

  2009cites this paper
• Variable Threshold of Trigeminal Cold-Thermosensitive Neurons Is Determined by a Balance between TRPM8 and Kv1 Potassium Channels

  2009cites this paper
• Tst26, a novel peptide blocker of Kv1.2 and Kv1.3 channels from the venom of Tityus stigmurus.

  2009cites this paper
• Voltage gated ion channels shape subthreshold synaptic integration in principal neurons of the medial superior olive

  2008cites this paper
• Convergent and Enantioselective Total Synthesis of (‐)‐Nalanthalide, a Potential Kv1.3 Blocking Immunosuppressant.

  2006cites this paper
• K+ channel blockers: novel tools to inhibit T cell activation leading to specific immunosuppression.

  2006cites this paper
• K+ currents activated by depolarization in cardiac fibroblasts.

  2005cites this paper
• MILITARY POTENTIAL OF BIOLOGICAL NEUROTOXINS

  2005cites this paper
• Kv1 channels selectively prevent dendritic hyperexcitability in rat Purkinje cells

  2005cites this paper
• Preferential Expression and Function of Voltage-Gated, O2-Sensitive K+ Channels in Resistance Pulmonary Arteries Explains Regional Heterogeneity in Hypoxic Pulmonary Vasoconstriction: Ionic Diversity in Smooth Muscle Cells

  2004cites this paper