Tityustoxin K alpha blocks voltage-gated noninactivating K+ channels and unblocks inactivating K+ channels blocked by alpha-dendrotoxin in synaptosomes.

No abstract is available for this paper.

• Publication year

  1994

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  1994-02-15

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1073/PNAS.91.4.1475PMID 7509073PMCID PMC43182
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Tityustoxin-K alpha, a structurally novel and highly potent K+ channel peptide toxin, interacts with the alpha-dendrotoxin binding site on the cloned Kv1.2 K+ channel.

  1993cited by this paper
• Scyllatoxin, a blocker of Ca(2+)-activated K+ channels: structure-function relationships and brain localization of the binding sites.

  1992cited by this paper
• Dendrotoxin-like effects of noxiustoxin.

  1992cited by this paper
• Mapping function to structure in a channel-blocking peptide: electrostatic mutants of charybdotoxin.

  1992cited by this paper
• Charybdotoxin, dendrotoxin and mast cell degranulating peptide block the voltage-activated K+ current of fibroblast cells stably transfected with NGK1 (Kv1.2) K+ channel complementary DNA.

  1992cited by this paper
• Kaliotoxin, a novel peptidyl inhibitor of neuronal BK-type Ca(2+)-activated K+ channels characterized from Androctonus mauretanicus mauretanicus venom.

  1992cited by this paper
• Structural elements involved in specific K+ channel functions.

  1992cited by this paper
• Interaction of charybdotoxin with permeant ions inside the pore of a K+ channel.

  1992cited by this paper
• Polypeptide toxins from the venoms of Old World and New World scorpions preferentially block different potassium channels.

  1991cited by this paper
• Swapping of functional domains in voltage-gated K+ channels

  1991cited by this paper
• Identification of amino acid residues involved in dendrotoxin block of rat voltage-dependent potassium channels.

  1991cited by this paper
• Synthesis and structural characterization of charybdotoxin, a potent peptidyl inhibitor of the high conductance Ca2(+)-activated K+ channel.

  1990cited by this paper
• Mapping the receptor site for charybdotoxin, a pore-blocking potassium channel inhibitor.

  1990cited by this paper
• Peptide toxins and potassium channels.

  1990cited by this paper
• Purification and characterization of a unique, potent, peptidyl probe for the high conductance calcium-activated potassium channel from venom of the scorpion Buthus tamulus.

  1990cited by this paper
• Rat brain dendrotoxin receptors associated with voltage-gated potassium channels: dendrotoxin binding and receptor solubilization.

  1989cited by this paper
• Charybdotoxin blocks dendrotoxin‐sensitive voltage‐activated K+ channels

  1989cited by this paper
• Charybdotoxin blocks both Ca‐activated K channels and Ca‐independent voltage‐gated K channels in rat brain synaptosomes

  1989cited by this paper
• Analysis of the blocking activity of charybdotoxin homologs and iodinated derivatives against Ca2+-Activated K+ channels

  1989cited by this paper
• Charybdotoxin and noxiustoxin, two homologous peptide inhibitors of the K+(Ca2+) channel

  1988cited by this paper
• An emerging pharmacology of peptide toxins targeted against potassium channels

  1988cited by this paper
• Purification and characterization of a unique, potent inhibitor of apamin binding from Leiurus quinquestriatus hebraeus venom.

  1988cited by this paper
• Purification, sequence, and model structure of charybdotoxin, a potent selective inhibitor of calcium-activated potassium channels.

  1988cited by this paper
• Four polypeptide components of green mamba venom selectively block certain potassium channels in rat brain synaptosomes.

  1988cited by this paper
• Dendrotoxins: snake toxins that block potassium channels and facilitate neurotransmitter release.

  1985cited by this paper
• Potassium channels in isolated presynaptic nerve terminals from rat brain.

  1985cited by this paper
• Charybdotoxin, a protein inhibitor of single Ca2+-activated K+ channels from mammalian skeletal muscle

  1985cited by this paper

• The First K+-Channel Blocker Described from Tityus fasciolatus Venom: The Purification, Molecular Cloning, and Functional Characterization of α-KTx4.9 (Tf5)

  2025cites this paper
• Beta-KTx14.3, a scorpion toxin, blocks the human potassium channel KCNQ1.

  2023cites this paper
• Heterologous expression of Ts8, a neurotoxin from Tityus serrulatus venom, evidences its antifungal activity.

  2022cites this paper
• Structural and functional studies of scorpine: A channel blocker and cytolytic peptide.

  2022cites this paper
• A Venomics approach coupled to high-throughput toxin production strategies identifies the first venom-derived melanocortin receptor agonists.

  2020cites this paper
• Novel components of Tityus serrulatus venom: A transcriptomic approach.

  2020cites this paper
• Weaponisation 'on the fly': convergent recruitment of knottin and defensin peptide scaffolds into the venom of predatory assassin flies.

  2019cites this paper
• Molecular basis of Tityus stigmurus alpha toxin and potassium channel kV1.2 interactions.

  2019cites this paper
• Profiling the short, linear, non-disulfide bond-containing peptidome from the venom of the scorpion Tityus obscurus.

  2018cites this paper
• Effects of Brazilian scorpion venoms on the central nervous system

  2018cites this paper
• Ts8 scorpion toxin inhibits the Kv4.2 channel and produces nociception in vivo.

  2016cites this paper
• A single-point mutation enhances dual functionality of a scorpion toxin.

  2016cites this paper
• Isolation and characterization of Ts19 Fragment II, a new long-chain potassium channel toxin from Tityus serrulatus venom.

  2016cites this paper
• Potassium channel blockers from the venom of the Brazilian scorpion Tityus serrulatus ().

  2016cites this paper
• Solution structure and antiparasitic activity of scorpine‐like peptides from Hoffmannihadrurus gertschi

  2016cites this paper
• Tityus serrulatus venom--A lethal cocktail.

  2015cites this paper
• Isolamento e caracterização estrutural e funcional de neurotoxinas presentes nas frações XIIA e XIIB da peçonha do escorpião Tityus serrulatus

  2015cites this paper
• inotropic effects on diaphragm channels: + Peptide toxin blockers of voltage-sensitive K

  2015cites this paper
• Partial purification and functional characterization of Ts19 Frag-I, a novel toxin from Tityus serrulatus scorpion venom

  2015cites this paper
• Potassium channel blocking peptide toxins from scorpion venom

  2015cites this paper
• Scorpion Venom Research Around the World: Tityus serrulatus

  2014cites this paper
• Electrophysiological Characterization of Ts6 and Ts7, K+ Channel Toxins Isolated through an Improved Tityus serrulatus Venom Purification Procedure

  2014cites this paper
• The Mediterranean scorpion Mesobuthus gibbosus (Scorpiones, Buthidae): transcriptome analysis and organization of the genome encoding chlorotoxin-like peptides

  2014cites this paper
• Orthogonal separation and identification of long-chain peptides from scorpion Buthus martensi Karsch venom by using two-dimensional mixed-mode reversed phase-reversed phase chromatography coupled to tandem mass spectrometry.

  2013cites this paper
• Subtype-Selective Activation of Kv7 Channels by AaTXKβ(2–64), a Novel Toxin Variant from the Androctonus australis Scorpion Venom

  2013influential citation
• Another record of significant regional variation in toxicity of Tityus serrulatus venom in Brazil: a step towards understanding the possible role of sodium channel modulators.

  2013cites this paper
• Tropical dermatology: Venomous arthropods and human skin: Part I. Insecta.

  2012cites this paper
• Tropical dermatology: Venomous arthropods and human skin: Part II. Diplopoda, Chilopoda, and Arachnida.

  2012cites this paper
• MeuTXKbeta1, a scorpion venom-derived two-domain potassium channel toxin-like peptide with cytolytic activity.

  2010cites this paper
• Arrangement of Kv1 α subunits dictates sensitivity to tetraethylammonium

  2010cites this paper
• Tityus serrulatus scorpion venom and toxins: an overview.

  2009cites this paper
• Purification and cDNA Cloning of LaIT2, a Novel Insecticidal Toxin from Venom of the Scorpion Liocheles australasiae

  2009cites this paper
• Expression of Kv1.2 in microglia and its putative roles in modulating production of proinflammatory cytokines and reactive oxygen species

  2008cites this paper
• Hemitoxin, the first potassium channel toxin from the venom of the Iranian scorpion Hemiscorpius lepturus

  2008cites this paper
• Proteomic analysis of the venom from the scorpion Tityus stigmurus: biochemical and physiological comparison with other Tityus species.

  2007cites this paper
• Wide phylogenetic distribution of Scorpine and long-chain β-KTx-like peptides in scorpion venoms: Identification of “orphan” components

  2007cites this paper
• Cytolytic and K+ channel blocking activities of β-KTx and scorpine-like peptides purified from scorpion venoms

  2007cites this paper
• Wide phylogenetic distribution of Scorpine and long-chain beta-KTx-like peptides in scorpion venoms: identification of "orphan" components.

  2007cites this paper
• Moderate hypoxia influences excitability and blocks dendrotoxin sensitive K+ currents in rat primary sensory neurones

  2006influential citation
• Proteomic analysis of Tityus discrepans scorpion venom and amino acid sequence of novel toxins

  2006cites this paper
• Genetic mechanisms of scorpion venom peptide diversification.

  2006cites this paper
• Adaptive Evolution after Gene Duplication in α‐KT × 14 Subfamily from Buthus martensii Karsch

  2005cites this paper
• A new type of scorpion Na+-channel-toxin-like polypeptide active on K+ channels.

  2005cites this paper
• New "Birtoxin analogs" from Androctonus australis venom.

  2005cites this paper
• Toxicity, Mechanisms, Prophylaxis, and Therapy of Inhaled Biological Toxins

  2005cites this paper
• Pharmacological investigation of the nociceptive response and edema induced by venom of the scorpion Tityus serrulatus.

  2005cites this paper
• The Brazilian scorpion Tityus costatus Karsch: genes, peptides and function.

  2005cites this paper
• BmP09, a “Long Chain” Scorpion Peptide Blocker of BK Channels*

  2005cites this paper
• Expression and characterization of delayed rectifying K+ channels in anterior rat taste buds.

  2005cites this paper
• ular biological data is the interpretation that the major DRK channel functionally expressed in rat

  2005cites this paper
• The scorpine family of defensins: gene structure, alternative polyadenylation and fold recognition

  2004cites this paper
• Cobatoxin 1 from Centruroides noxius scorpion venom: chemical synthesis, three-dimensional structure in solution, pharmacology and docking on K+ channels.

  2004cites this paper
• Opioids Inhibit Lateral Amygdala Pyramidal Neurons by Enhancing a Dendritic Potassium Current

  2004cites this paper
• Role of K+ channels in L-6 myoblast migration

  2004cites this paper
• Cobatoxin 1 from Centruroides noxius Scorpion venom: Chemical Synthesis, 3-D Structure in Solution, Pharmacology and Docking on K+ channels

  2004cites this paper
• Therapy and prophylaxis of inhaled biological toxins

  2003cites this paper
• Synthesis and characterization of Pi4, a scorpion toxin from Pandinus imperator that acts on K+ channels.

  2003cites this paper
• Expression, purification and functional characterization of a recombinant scorpion venom peptide BmTXKbeta.

  2003cites this paper
• Tityustoxin‐K(alpha) blockade of the voltage‐gated potassium channel Kv1.3

  2003cites this paper
• Evidence for the existence of a common ancestor of scorpion toxins affecting ion channels

  2003cites this paper
• Scorpion toxins from Tityus cambridgei that affect Na(+)-channels.

  2002cites this paper
• Glycine 30 in iberiotoxin is a critical determinant of its specificity for maxi‐K versus KV channels

  2002cites this paper
• Neurotoxins from Scorpion Venoms

  2002cites this paper
• Molecular cloning and characterization of four scorpion K(+)-toxin-like peptides: a new subfamily of venom peptides (alpha-KTx14) and genomic analysis of a member.

  2001cites this paper
• Screening of expression libraries using ELISA: identification of immunogenic proteins from Tityus bahiensis and Tityus serrulatus venom.

  2001cites this paper
• Moving pieces in a proteomic puzzle: mass fingerprinting of toxic fractions from the venom of Tityus serrulatus (Scorpiones, Buthidae).

  2001cites this paper
• Structural determinants of scorpion toxin affinity: the charybdotoxin (alpha-KTX) family of K(+)-channel blocking peptides.

  2000cites this paper
• Induction of seizures by the potent K+ channel-blocking scorpion venom peptide toxins tityustoxin-K(alpha) and pandinustoxin-K(alpha).

  1999cites this paper
• Molecular cloning and sequencing of two ‘short chain’ and two ‘long chain’ K+ channel‐blocking peptides from the Chinese scorpion Buthus martensii Karsch

  1999cites this paper
• Peptide toxin blockers of voltage-sensitive K+ channels: inotropic effects on diaphragm.

  1999influential citation
• Structural and functional consequences of the presence of a fourth disulfide bridge in the scorpion short toxins: Solution structure of the potassium channel inhibitor HsTX1

  1999cites this paper
• TsTX-IV, a short chain four-disulfide-bridged neurotoxin from Tityus serrulatus venom which acts on Ca2+-activated K+ channels.

  1999cites this paper
• A unified nomenclature for short-chain peptides isolated from scorpion venoms: alpha-KTx molecular subfamilies.

  1999cites this paper
• Pharmacology of Voltage-Gated Potassium Channels

  1999cites this paper
• A novel K+ channel blocking toxin from Tityus discrepans scorpion venom

  1999cites this paper
• Genomic organization of three neurotoxins active on small conductance Ca2+‐activated potassium channels from the scorpion Buthus martensi Karsch 1

  1999cites this paper
• Induction of seizures by the potent K+ channel-blocking scorpion venom peptide toxins tityustoxin-Kα and pandinustoxin-Kα

  1999cites this paper
• Antibodies against Tityus discrepans venom do not abolish the effect of Tityus serrulatus venom on the rat sodium and potassium channels.

  1999cites this paper
• Cobatoxins 1 and 2 from Centruroides noxius Hoffmann constitute a subfamily of potassium-channel-blocking scorpion toxins.

  1998cites this paper
• Evidence for a new class of scorpion toxins active against K+ channels

  1998cites this paper
• Effect of Tityus serrulatus scorpion venom on the rabbit isolated corpus cavernosum and the involvement of NANC nitrergic nerve fibres

  1998cites this paper
• Toxin and subunit specificity of blocking affinity of three peptide toxins for heteromultimeric, voltage-gated potassium channels expressed in Xenopus oocytes.

  1998cites this paper
• 1H NMR structural analysis of novel potassium blocking toxins using a nano-NMR probe.

  1998cites this paper
• Consequence of the removal of evolutionary conserved disulfide bridges on the structure and function of charybdotoxin and evidence that particular cysteine spacings govern specific disulfide bond formation.

  1998cites this paper
• Toxins and genes isolated from scorpions of the genus Tityus.

  1997cites this paper
• Pharmacology of Potassium Channels

  1997cites this paper
• A novel potassium channel blocking toxin from the scorpion Pandinus imperator: A 1H NMR analysis using a nano-NMR probe.

  1997cites this paper
• Solution structure for Pandinus toxin K-alpha (PiTX-K alpha), a selective blocker of A-type potassium channels.

  1997cites this paper
• Purification, characterization, and synthesis of three novel toxins from the Chinese scorpion Buthus martensi, which act on K+ channels.

  1997cites this paper
• Scorpion Toxin Block of the Early K+ Current (IKf) in Rat Dorsal root Ganglion Neurones

  1997cites this paper
• Characterization of a new peptide from Tityus serrulatus scorpion venom which is a ligand of the apamin‐binding site

  1996cites this paper
• Kalicludines and kaliseptine. Two different classes of sea anemone toxins for voltage sensitive K+ channels.

  1996cites this paper
• Lipolytic action of Buthus occitanus tunetanus venom: involvement of the beta adrenergic pathway.

  1996cites this paper
• Three new toxins from the scorpion Pandinus imperator selectively block certain voltage-gated K+ channels.

  1996cites this paper
• Action of New World scorpion venom and its neurotoxins in secretion.

  1996cites this paper
• Kalicludines and Kaliseptine

  1995cites this paper
• The Toxins Purified from Tityus Serrulatus (Lutz & Mello)Venom

  1995cites this paper
• The charybdotoxin family of K+ channel-blocking peptides

  1995cites this paper
• The charybdotoxin family of K+ channel-blocking peptides.

  1995cites this paper
• The kaliotoxin family enlarged. Purification, characterization, and precursor nucleotide sequence of KTX2 from Androctonus australis venom.

  1994cites this paper