Ubiquitin Conjugation and Deconjugation in NF-κB Signaling.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Sub-cellular biochemistry

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1007/978-1-4419-6676-6_7PMID 21222275
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Structural basis for the lack of E2 interaction in the RING domain of TRAF2.

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• Ubiquitylation in innate and adaptive immunity

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• Molecular discrimination of structurally equivalent Lys 63‐linked and linear polyubiquitin chains

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• Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation.

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• Direct Activation of Protein Kinases by Unanchored Polyubiquitin Chains

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• Mutations of multiple genes cause deregulation of NF-κB in diffuse large B-cell lymphoma

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• Inhibition of MALT1 protease activity is selectively toxic for activated B cell–like diffuse large B cell lymphoma cells

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• Breaking the chains: structure and function of the deubiquitinases

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• Regulation and function of NF-kappaB transcription factors in the immune system.

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• Phosphorylation of the tumor suppressor CYLD by the breast cancer oncogene IKKepsilon promotes cell transformation.

  2009cited by this paper
• The ubiquitin‐editing enzyme A20 requires RNF11 to downregulate NF‐κB signalling

  2009cited by this paper
• Involvement of linear polyubiquitylation of NEMO in NF-κB activation

  2009cited by this paper
• NEMO specifically recognizes K63‐linked poly‐ubiquitin chains through a new bipartite ubiquitin‐binding domain

  2009cited by this paper
• The ubiquitin-editing enzyme A20 (TNFAIP3) is a central regulator of immunopathology.

  2009cited by this paper
• A ubiquitin replacement strategy in human cells reveals distinct mechanisms of IKK activation by TNFalpha and IL-1beta.

  2009cited by this paper
• Crystal structure of the NEMO ubiquitin‐binding domain in complex with Lys 63‐linked di‐ubiquitin

  2009cited by this paper
• TRAF6 negatively regulates TNFalpha-induced NF-kappaB activation.

  2009cited by this paper
• Frequent inactivation of A20 in B-cell lymphomas

  2009cited by this paper
• A20 Negatively Regulates T Cell Receptor Signaling to NF-κB by Cleaving Malt1 Ubiquitin Chains1

  2009cited by this paper
• Structural basis for recognition of diubiquitins by NEMO.

  2009cited by this paper
• New regulators of NF-κB in inflammation

  2008cited by this paper
• The structure of the CYLD USP domain explains its specificity for Lys63-linked polyubiquitin and reveals a B box module.

  2008cited by this paper
• c-IAP1 and c-IAP2 Are Critical Mediators of Tumor Necrosis Factor α (TNFα)-induced NF-κB Activation*

  2008cited by this paper
• NEMO recognition of ubiquitinated Bcl10 is required for T cell receptor-mediated NF-κB activation

  2008cited by this paper
• A20 is a negative regulator of BCL10- and CARMA3-mediated activation of NF-κB

  2008cited by this paper
• Atypical ubiquitin chains: new molecular signals

  2008cited by this paper
• Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in mice.

  2008cited by this paper
• The type I TGF-β receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner

  2008cited by this paper
• Encoding NF-kappaB temporal control in response to TNF: distinct roles for the negative regulators IkappaBalpha and A20.

  2008cited by this paper
• Molecular basis for the unique deubiquitinating activity of the NF-kappaB inhibitor A20.

  2008cited by this paper
• Both cIAP1 and cIAP2 regulate TNFα-mediated NF-κB activation

  2008cited by this paper
• Structure of the A20 OTU domain and mechanistic insights into deubiquitination.

  2008cited by this paper
• NF-kappaB suppression by the deubiquitinating enzyme Cezanne: a novel negative feedback loop in pro-inflammatory signaling.

  2008cited by this paper
• Interleukin-1 (IL-1) Induces the Lys63-Linked Polyubiquitination of IL-1 Receptor-Associated Kinase 1 To Facilitate NEMO Binding and the Activation of IκBα Kinase

  2008cited by this paper
• T cell antigen receptor stimulation induces MALT1 paracaspase–mediated cleavage of the NF-κB inhibitor A20

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• Shared principles in NF-kappaB signaling.

  2008cited by this paper
• Localization of A20 to a lysosome-associated compartment and its role in NFkappaB signaling.

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• Lys63-Linked Polyubiquitination of IRAK-1 Is Required for Interleukin-1 Receptor- and Toll-Like Receptor-Mediated NF-κB Activation

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• Homeostatic MyD88-dependent signals cause lethal inflamMation in the absence of A20

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• The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20

  2008cited by this paper
• Malt1 ubiquitination triggers NF-kappaB signaling upon T-cell activation.

  2007cited by this paper
• IkappaB kinase beta phosphorylates the K63 deubiquitinase A20 to cause feedback inhibition of the NF-kappaB pathway.

  2007cited by this paper
• CSN controls NF‐κB by deubiquitinylation of IκBα

  2007cited by this paper
• CSN controls NF-kappaB by deubiquitinylation of IkappaBalpha.

  2007cited by this paper
• Regulation of early wave of germ cell apoptosis and spermatogenesis by deubiquitinating enzyme CYLD.

  2007cited by this paper
• IκB Kinase β Phosphorylates the K63 Deubiquitinase A20 To Cause Feedback Inhibition of the NF-κB Pathway

  2007cited by this paper
• Deubiquitinating enzyme CYLD negatively regulates the ubiquitin-dependent kinase Tak1 and prevents abnormal T cell responses

  2007cited by this paper
• Malt1 ubiquitination triggers NF‐κB signaling upon T‐cell activation

  2007cited by this paper
• IkappaB kinase complexes: gateways to NF-kappaB activation and transcription.

  2006cited by this paper
• IκB kinase complexes: gateways to NF-κB activation and transcription

  2006cited by this paper
• Regulation of T cell development by the deubiquitinating enzyme CYLD

  2006cited by this paper
• Transcriptional regulation via the NF-κB signaling module

  2006cited by this paper
• Caspase-8 regulation by direct interaction with TRAF6 in T cell receptor-induced NF-kappaB activation.

  2006cited by this paper
• Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling.

  2006cited by this paper
• The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function

  2006cited by this paper
• Ubiquitination of RIP Is Required for Tumor Necrosis Factor α-induced NF-κB Activation*

  2006cited by this paper
• Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-κB activation

  2006cited by this paper
• Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation [corrected].

  2006cited by this paper
• Transcriptional regulation via the NF-kappaB signaling module.

  2006cited by this paper
• TAK1-dependent Signaling Requires Functional Interaction with TAB2/TAB3*

  2006cited by this paper
• Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling

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• Ubiquitination of RIP is required for tumor necrosis factor alpha-induced NF-kappaB activation.

  2006cited by this paper
• TRAF6 is a T cell–intrinsic negative regulator required for the maintenance of immune homeostasis

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• Thymocyte TCR Signaling Cutting Edge: Pivotal Function of Ubc13 in

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• Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO.

  2006cited by this paper
• cIAP2 is a ubiquitin protein ligase for BCL10 and is dysregulated in mucosa-associated lymphoid tissue lymphomas.

  2005cited by this paper
• The Tumor Suppressor Cylindromatosis (CYLD) Acts as a Negative Regulator for Toll-like Receptor 2 Signaling via Negative Cross-talk with TRAF6 and TRAF7*

  2005cited by this paper
• Regulation of the Deubiquitinating Enzyme CYLD by IκB Kinase Gamma-Dependent Phosphorylation

  2005cited by this paper
• Essential function for the kinase TAK1 in innate and adaptive immune responses

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• Modulation of Toll–interleukin 1 receptor mediated signaling

  2005cited by this paper
• TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo.

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• NF-κB Is Essential for Induction of CYLD, the Negative Regulator of NF-κB

  2004cited by this paper
• The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes.

  2004cited by this paper
• TLR signaling pathways.

  2004cited by this paper
• TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains.

  2004cited by this paper
• De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling

  2004cited by this paper
• The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses

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• NF-kappaB is essential for induction of CYLD, the negative regulator of NF-kappaB: evidence for a novel inducible autoregulatory feedback pathway.

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• CYLD is a deubiquitinating enzyme that negatively regulates NF-κB activation by TNFR family members

  2003cited by this paper
• Role of the TAB2‐related protein TAB3 in IL‐1 and TNF signaling

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• The tumour suppressor CYLD negatively regulates NF-κB signalling by deubiquitination

  2003cited by this paper
• Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-κB

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• The SCF ubiquitin ligase: an extended look.

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• Isolation and characterization of two novel A20-like proteins.

  2001cited by this paper
• TAK1 is a ubiquitin-dependent kinase of MKK and IKK

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• Critical Roles of TRAF2 and TRAF5 in Tumor Necrosis Factor-induced NF-κB Activation and Protection from Cell Death*

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• Identification of the familial cylindromatosis tumour-suppressor gene

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• Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice.

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• TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling.

  1999cited by this paper
• Structural basis for self-association and receptor recognition of human TRAF2

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• Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activity.

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• Noncoding RNAs Regulating NF-κB Signaling.

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• Uncoupling Malt1 threshold function from paracaspase activity results in destructive autoimmune inflammation.

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• Functional Studies of Deubiquitinating Enzymes

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