Melanocortin-1 receptor activation is neuroprotective in mouse models of neuroinflammatory disease

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Science Translational Medicine

• Publication date

  2016-10-26

• Fields of study

  Medicine

• Identifiers
  DOI 10.1126/scitranslmed.aaf8732PMID 27797962
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Advances in the immunopathogenesis of multiple sclerosis.

  2015cited by this paper
• Role of the innate and adaptive immune responses in the course of multiple sclerosis.

  2015cited by this paper
• Deficiency in Melanocortin 1 Receptor Signaling Predisposes to Vascular Endothelial Dysfunction and Increased Arterial Stiffness in Mice and Humans

  2015cited by this paper
• Changes in Th17 and regulatory T cells after fingolimod initiation to treat multiple sclerosis.

  2014cited by this paper
• Effects of glatiramer acetate in a spontaneous model of autoimmune neuroinflammation.

  2014cited by this paper
• Induction of Nur77-dependent apoptotic pathway by a coumarin derivative through activation of JNK and p38 MAPK.

  2014cited by this paper
• Treg cells mediate recovery from EAE by controlling effector T cell proliferation and motility in the CNS

  2014cited by this paper
• Regulatory T cells in autoimmune neuroinflammation

  2014cited by this paper
• Melanocortins protect against brain damage and counteract cognitive decline in a transgenic mouse model of moderate Alzheimer׳s disease.

  2014cited by this paper
• Effects of Isoxazolo-Pyridinone 7e, a Potent Activator of the Nurr1 Signaling Pathway, on Experimental Autoimmune Encephalomyelitis in Mice

  2014cited by this paper
• Alpha-Melanocyte Stimulating Hormone: An Emerging Anti-Inflammatory Antimicrobial Peptide

  2014cited by this paper
• Induction of Nur 77-dependent apoptotic pathway by a coumarin derivative through activation of JNK and p 38 MAPK

  2014cited by this paper
• MC1R and NR4A receptors in cellular stress and DNA repair: implications for UVR protection

  2014cited by this paper
• SVα-MSH, a novel α-melanocyte stimulating hormone analog, ameliorates autoimmune encephalomyelitis through inhibiting autoreactive CD4(+) T cells activation.

  2014cited by this paper
• α-Melanocyte-stimulating hormone regulates vascular NO availability and protects against endothelial dysfunction.

  2013cited by this paper
• Single Administration of Tripeptide α-MSH(11–13) Attenuates Brain Damage by Reduced Inflammation and Apoptosis after Experimental Traumatic Brain Injury in Mice

  2013cited by this paper
• Endothelial TWIK-related potassium channel-1 (TREK1) regulates immune-cell trafficking into the CNS

  2013cited by this paper
• Systemic α-melanocyte-stimulating hormone administration decreases arthritis-induced anorexia and muscle wasting.

  2013cited by this paper
• Excitotoxic neuronal cell death during an oligodendrocyte-directed CD8+ T cell attack in the CNS gray matter

  2013cited by this paper
• Caspase-2 and caspase-8 trigger caspase-3 activation following 6-OHDA-induced stress in human dopaminergic neurons differentiated from ReNVM stem cells

  2013cited by this paper
• α-MSH-stimulated tolerogenic dendritic cells induce functional regulatory T cells and ameliorate ongoing skin inflammation.

  2012cited by this paper
• NR4All in the vessel wall.

  2012cited by this paper
• Immunoregulatory T cells in multiple sclerosis and the effect of interferon beta and glatiramer acetate treatment on T cell subpopulations.

  2012cited by this paper
• Pertussis toxin permeabilization enhances the traversal of Escherichia coli K1, macrophages, and monocytes in a cerebral endothelial barrier model in vitro.

  2011cited by this paper
• Glatiramer acetate attenuates pro-inflammatory T cell responses but does not directly protect neurons from inflammatory cell death.

  2010cited by this paper
• CREB‐dependent Nur77 induction following depolarization in PC12 cells and neurons is modulated by MEF2 transcription factors

  2010cited by this paper
• The Melanocortin System in Control of Inflammation

  2010cited by this paper
• Differentiation of human neural progenitor cells regulated by Wnt-3a.

  2010cited by this paper
• Glatiramer acetate reduces Th-17 inflammation and induces regulatory T-cells in the CNS of mice with relapsing-remitting or chronic EAE.

  2010cited by this paper
• The Neuropeptide Alpha-Melanocyte-Stimulating Hormone Is Critically Involved in the Development of Cytotoxic CD8+ T Cells in Mice and Humans

  2010cited by this paper
• NR4A orphan nuclear receptors as mediators of CREB-dependent neuroprotection

  2010cited by this paper
• Melanocortins in brain inflammation: the role of melanocortin receptor subtypes.

  2010cited by this paper
• Endothelial basement membrane laminin α5 selectively inhibits T lymphocyte extravasation into the brain

  2009cited by this paper
• The Orphan Nuclear Receptor Nur77 Suppresses Endothelial Cell Activation Through Induction of I&kgr;Bα Expression

  2009cited by this paper
• Cytotoxic CD8+ T Cell–Neuron Interactions: Perforin-Dependent Electrical Silencing Precedes But Is Not Causally Linked to Neuronal Cell Death

  2009cited by this paper
• PD-1 Regulates Neural Damage in Oligodendroglia-Induced Inflammation

  2009cited by this paper
• Regulatory T cells fail to suppress CD4+ T‐bet+ T cells in relapsing multiple sclerosis patients

  2009cited by this paper
• -Melanocyte-Stimulating Hormone and Related Tripeptides: Biochemistry, Antiinflammatory and Protective Effects in Vitro and in Vivo, and Future Perspectives for the Treatment of Immune-Mediated Inflammatory Diseases

  2008cited by this paper
• The diminishment of experimental autoimmune encephalomyelitis (EAE) by neuropeptide alpha-melanocyte stimulating hormone (α-MSH) therapy

  2008cited by this paper
• A novel CD11c.DTR transgenic mouse for depletion of dendritic cells reveals their requirement for homeostatic proliferation of natural killer cells

  2008influential reference
• Melanocortin-1 Receptor Signaling Markedly Induces the Expression of the NR4A Nuclear Receptor Subgroup in Melanocytic Cells*

  2008cited by this paper
• Alpha-melanocyte-stimulating hormone and related tripeptides: biochemistry, antiinflammatory and protective effects in vitro and in vivo, and future perspectives for the treatment of immune-mediated inflammatory diseases.

  2008cited by this paper
• Ingested (oral) alpha-MSH inhibits acute EAE.

  2008cited by this paper
• Natural Naive CD4+CD25+CD127low Regulatory T Cell (Treg) Development and Function Are Disturbed in Multiple Sclerosis Patients: Recovery of Memory Treg Homeostasis during Disease Progression1

  2008cited by this paper
• Interferon- and neuroprotection in multiple sclerosisFacts, hopes and phantasies

  2007cited by this paper
• Migration of leukocytes across an endothelium-epithelium bilayer as a model of renal interstitial inflammation.

  2007cited by this paper
• Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease

  2007cited by this paper
• Pertussis toxin as an adjuvant suppresses the number and function of CD4+CD25+ T regulatory cells

  2006cited by this paper
• Myelin oligodendrocyte glycoprotein-specific T and B cells cooperate to induce a Devic-like disease in mice.

  2006cited by this paper
• Crucial role of the melanocortin receptor MC1R in experimental colitis

  2006cited by this paper
• Orphan nuclear receptor TR3/Nur77 regulates VEGF-A–induced angiogenesis through its transcriptional activity

  2006cited by this paper
• Orphan nuclear receptor TR 3 / Nur 77 regulates VEGF-A – induced angiogenesis through its transcriptional activity

  2006cited by this paper
• Alpha-MSH inhibits inflammatory signalling in Schwann cells.

  2004cited by this paper
• A comparison of normalization methods for high density oligonucleotide array data based on variance and bias

  2003cited by this paper
• Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.

  2001cited by this paper
• Autocrine alpha-melanocyte-stimulating hormone inhibits NF-kappaB activation in human glioma.

  1999cited by this paper
• Advances in the Immunopathogenesis of Multiple Sclerosis

  1999cited by this paper
• α-Melanocyte-Stimulating Hormone Inhibits NF-κB Activation and IκBα Degradation in Human Glioma Cells and in Experimental Brain Inflammation

  1999cited by this paper
• alpha-melanocyte-stimulating hormone inhibits NF-kappaB activation and IkappaBalpha degradation in human glioma cells and in experimental brain inflammation.

  1999cited by this paper
• Autocrine α‐melanocyte‐stimulating hormone inhibits NF‐κB activation in human glioma

  1999cited by this paper
• Discovery and development of novel melanogenic drugs. Melanotan-I and -II.

  1998cited by this paper
• Molecular Basis for the Interaction of [Nle4,d-Phe7]Melanocyte Stimulating Hormone with the Human Melanocortin-1 Receptor (Melanocyte α-MSH Receptor)*

  1997cited by this paper
• Unimpaired thymic and peripheral T cell death in mice lacking the nuclear receptor NGFI-B (Nur77).

  1995cited by this paper
• Identification of a melanocortin receptor expressed by murine brain microvascular endothelial cells in culture.

  1995cited by this paper
• Three types of alpha-melanocyte-stimulating hormone: bioactivities and half-lives.

  1983cited by this paper
• Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2 2 DD C T Method

  year unknowncited by this paper

• Polymorphism of Melanocortin Receptor Genes—Association with Inflammatory Traits and Diseases

  2025cites this paper
• Anti-inflammatory treatment using alpha melanocyte stimulating hormone (α-MSH) does not alter osteoblasts differentiation and fracture healing

  2025cites this paper
• Electroacupuncture alleviates blood-brain barrier disruption and neuroinflammation via astrocytic MC4R in a mouse model of multiple sclerosis

  2025cites this paper
• AhR signaling in skin-resident CD207+ cells is involved in UV-B-induced amelioration of neuroinflammation

  2025cites this paper
• Dysregulated Angiogenin and Related Pathways in the Ventral Midbrain of "Redhead" Mice with MC1R Disruption.

  2025cites this paper
• The Skin–Brain Axis: From UV and Pigmentation to Behaviour Modulation

  2024cites this paper
• A Review of the Common Neurodegenerative Disorders: Current Therapeutic Approaches and the Potential Role of Bioactive Peptides.

  2024cites this paper
• Activation of the melanocortin-1 receptor attenuates neuronal apoptosis after traumatic brain injury by upregulating Merlin expression.

  2024cites this paper
• Astrocyte Activation and Drug Target in Pathophysiology of Multiple Sclerosis.

  2024cites this paper
• CBL/Cbl‐b mediates Fas degradation to reduce neuronal damage in experimental autoimmune encephalomyelitis

  2024cites this paper
• ISMRM Clinical Focus Meeting 2023: “Imaging the Fire in the Brain”

  2024cites this paper
• Endogenous retroviruses in multiple sclerosis: a network-based etiopathogenic model.

  2024cites this paper
• Hederagenol improves multiple sclerosis by modulating Th17 cell differentiation

  2024cites this paper
• Peripheral MC1R activation modulates immune responses and is neuroprotective in a mouse model of Parkinson’s disease

  2023cites this paper
• Tregs dysfunction aggravates postoperative cognitive impairment in aged mice

  2023cites this paper
• Peripheral MC1R Activation Modulates Immune Responses and is Neuroprotective in a Mouse Model of Parkinson’s Disease

  2023influential citation
• A gel-forming α-MSH analog promotes lasting melanogenesis.

  2023cites this paper
• A feasibility and safety study of afamelanotide in acute stroke patients – an open label, proof of concept, phase iia clinical trial

  2023cites this paper
• The Melanocortin System in Inflammatory Bowel Diseases: Insights into Its Mechanisms and Therapeutic Potentials

  2023cites this paper
• A Randomized Prospective Trial Comparing Repository Corticotropin Injection and Intravenous Methylprednisolone for Neuroprotection in Acute Optic Neuritis

  2023cites this paper
• Hematopoietic-specific melanocortin 1 receptor signaling protects against nephrotoxic serum nephritis and mediates the beneficial effect of melanocortin therapy.

  2022cites this paper
• Type 1 melanocortin receptors in pro‐opiomelanocortin‐, vasopressin‐, and oxytocin‐immunopositive neurons in different areas of mouse brain

  2022cites this paper
• Negative Modulation of B Cell Activation by Melanocortin 1 Receptor Signaling Protects against Membranous Nephropathy

  2022cites this paper
• Anti-inflammatory Properties of the Alpha-Melanocyte-Stimulating Hormone in Models of Granulomatous Inflammation

  2022cites this paper
• Brain Protein Expression Profile Confirms the Protective Effect of the ACTH(4–7)PGP Peptide (Semax) in a Rat Model of Cerebral Ischemia–Reperfusion

  2021cites this paper
• Sunlight exposure exerts immunomodulatory effects to reduce multiple sclerosis severity

  2021cites this paper
• Antifibrotic and Anti-Inflammatory Actions of α-Melanocytic Hormone: New Roles for an Old Player

  2021cites this paper
• Activation of MC1R with BMS-470539 attenuates neuroinflammation via cAMP/PKA/Nurr1 pathway after neonatal hypoxic-ischemic brain injury in rats

  2021cites this paper
• Multiple sclerosis is linked to MAPKERK overactivity in microglia

  2021cites this paper
• Melanocortin 1 receptor activation protects against alpha-synuclein pathologies in models of Parkinson’s disease

  2021influential citation
• Crosstalk of Microorganisms and Immune Responses in Autoimmune Neuroinflammation: A Focus on Regulatory T Cells

  2021cites this paper
• Aged Brains Express Less Melanocortin Receptors, Which Correlates with Age-Related Decline of Cognitive Functions

  2021cites this paper
• The neuropeptide alpha-melanocyte-stimulating hormone is critical for corneal endothelial cell protection and graft survival after transplantation.

  2021cites this paper
• Therapeutic senescence via GPCR activation in synovial fibroblasts facilitates resolution of arthritis

  2020cites this paper
• Protective role of anticancer drugs in neurodegenerative disorders: A drug repurposing approach.

  2020cites this paper
• Sunlight exposure exerts immunomodulatory effects to reduce multiple sclerosis severity

  2020cites this paper
• Distinct binding and signaling activity of Acthar Gel compared to other melanocortin receptor agonists

  2020cites this paper
• Pharmacotranscriptomics of peptide drugs with neuroprotective properties

  2020cites this paper
• Novel Insights into the Protective Properties of ACTH(4-7)PGP (Semax) Peptide at the Transcriptome Level Following Cerebral Ischaemia–Reperfusion in Rats

  2020cites this paper
• PACAP is a pathogen-inducible resident antimicrobial neuropeptide affording rapid and contextual molecular host defense of the brain

  2020cites this paper
• Neuroprotective Effects of Peptides in the Brain: Transcriptome Approach

  2020cites this paper
• Immunoregulatory Effects of Neuropeptides on Endothelial Cells: Relevance to Dermatological Disorders

  2019cites this paper
• Does the environment influence multiple sclerosis pathogenesis via UVB light and/or induction of vitamin D?

  2019cites this paper
• NDP-MSH binding melanocortin-1 receptor ameliorates neuroinflammation and BBB disruption through CREB/Nr4a1/NF-κB pathway after intracerebral hemorrhage in mice

  2019cites this paper
• Setmelanotide, a Novel, Selective Melanocortin Receptor-4 Agonist Exerts Anti-inflammatory Actions in Astrocytes and Promotes an Anti-inflammatory Macrophage Phenotype

  2019cites this paper
• Activation of Melanocortin 1 Receptor Attenuates Early Brain Injury in a Rat Model of Subarachnoid Hemorrhage viathe Suppression of Neuroinflammation through AMPK/TBK1/NF-κB Pathway in Rats

  2019cites this paper
• Imaging in mice and men: pathophysiological insights into multiple sclerosis from conventional and advanced MRI techniques.

  2019cites this paper
• The effects of BMS-470539 on lipopolysaccharide-induced acute lung injury

  2019cites this paper
• Are melanocortin peptides future therapeutics for cutaneous wound healing?

  2019cites this paper
• Melanocortin receptor subtypes are expressed on cells in the oligodendroglial lineage and signal ACTH protection

  2018cites this paper
• Machine learning antimicrobial peptide sequences: Some surprising variations on the theme of amphiphilic assembly.

  2018cites this paper
• Development of Novel Quinoxaline-Based κ-Opioid Receptor Agonists for the Treatment of Neuroinflammation.

  2018cites this paper
• CNS infection and immune privilege

  2018cites this paper
• The role of T cells in the pathogenesis of Parkinson’s disease

  2018cites this paper
• New Implications for the Melanocortin System in Alcohol Drinking Behavior in Adolescents: The Glial Dysfunction Hypothesis

  2017cites this paper
• Melanocortins, Melanocortin Receptors and Multiple Sclerosis

  2017cites this paper
• Novel insights into the pathogenesis of psoriasis.

  2017cites this paper