Effects of TSLP on obstetrical and gynecological diseases

Thymic stromal lymphopoietin (TSLP) is produced mainly by epithelial cells and was originally found to stimulate the growth and activation of B cells, but it is now shown to function on both hematopoietic and non‐hematopoietic cell lineages. Despite a number of studies focusing on the role of TSLP in Th2 response for allergic disorders, it is becoming increasingly evident that TSLP may also be involved in multiple other disease states. This review will focus on recent advances on the effects of TSLP on obstetrical and gynecological diseases, including pregnancy failure, endometriosis, and cervical cancer.

• Publication year

  2016

• Venue

  American Journal of Reproductive Immunology

• Publication date

  2016-12-15

• Fields of study

  Medicine

• Identifiers
  DOI 10.1111/aji.12612PMID 27976427
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The infiltration and functional regulation of eosinophils induced by TSLP promote the proliferation of cervical cancer cell.

  2015cited by this paper
• Eosinophils and Cancer

  2014cited by this paper
• Embryonic Trophoblasts Induce Decidual Regulatory T Cell Differentiation and Maternal–Fetal Tolerance through Thymic Stromal Lymphopoietin Instructing Dendritic Cells

  2014cited by this paper
• TSLP induced by estrogen stimulates secretion of MCP-1 and IL-8 and growth of human endometrial stromal cells through JNK and NF-κB signal pathways.

  2014cited by this paper
• Chemokines in the pathogenesis of endometriosis and infertility.

  2013cited by this paper
• STAT5 is critical in Dendritic Cells for development of TH2- but not TH1-dependent Immunity

  2013cited by this paper
• Thymic stromal lymphopoietin–elicited basophil responses promote eosinophilic esophagitis

  2013cited by this paper
• IL-22 in the endometriotic milieu promotes the proliferation of endometrial stromal cells via stimulating the secretion of CCL2 and IL-8.

  2013cited by this paper
• Cervical Carcinoma Cells Stimulate the Angiogenesis through TSLP Promoting Growth and Activation of Vascular Endothelial Cells

  2013cited by this paper
• Thymic Stromal Lymphopoietin Suppresses the Apoptosis of Decidual Gamma‐delta T Cells via Regulation of the Signal Transduction and Activation of Transcription 3/Caspase‐3 Signaling Pathway

  2013cited by this paper
• Regulation of interleukin‐33 and thymic stromal lymphopoietin in human nasal fibroblasts by proinflammatory cytokines

  2012cited by this paper
• Interleukin-1β stimulates the secretion of thymic stromal lymphopoietin (TSLP) from endometrioma stromal cells: possible involvement of TSLP in endometriosis.

  2012cited by this paper
• Thymic stromal lymphopoietin downregulates NME1 expression and promotes invasion in human trophoblasts via the activation of STAT3 signaling pathway.

  2012cited by this paper
• Thymic stromal lymphopoietin promotes the proliferation of human trophoblasts via phosphorylated STAT3-mediated c-Myc upregulation.

  2012cited by this paper
• Lysophosphatidic acid receptor 2/3‐mediated IL‐8‐dependent angiogenesis in cervical cancer cells

  2012cited by this paper
• Vascular density and endothelial cell expression of integrin alpha v beta 3 and E-selectin in murine tumours

  2012cited by this paper
• Mast cell-airway smooth muscle crosstalk: the role of thymic stromal lymphopoietin.

  2012cited by this paper
• Protective role of regulatory decidual γδ T cells in pregnancy.

  2011cited by this paper
• Lymphocytes in Endometriosis

  2011cited by this paper
• Risk of carcinoma in women with ovarian endometrioma.

  2011cited by this paper
• Interleukin-1β induces cyclooxygenase-2 expression and promotes the invasive ability of human mesenchymal stem cells derived from ovarian endometrioma.

  2011cited by this paper
• Gimme shelter: the immune system during pregnancy

  2011cited by this paper
• Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells

  2011cited by this paper
• Activin-A is induced by interleukin-1β and tumor necrosis factor-α and enhances the mRNA expression of interleukin-6 and protease-activated receptor-2 and proliferation of stromal cells from endometrioma.

  2011cited by this paper
• TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation

  2011cited by this paper
• The decidual gamma-delta T cells up-regulate the biological functions of trophoblasts via IL-10 secretion in early human pregnancy.

  2011cited by this paper
• Thymic Stromal Lymphopoietin Interferes with Airway Tolerance by Suppressing the Generation of Antigen-Specific Regulatory T Cells

  2011cited by this paper
• Thymic stromal lymphopoetin-induced expression of the endogenous inhibitory enzyme SLPI mediates recovery from colonic inflammation.

  2011cited by this paper
• Thymic Stromal Lymphopoietin Is Produced by Dendritic Cells

  2011cited by this paper
• Interleukin-4 induces expression of eotaxin in endometriotic stromal cells.

  2010cited by this paper
• Metabolic , Endocrine and Genitourinary Pathobiology Interleukin-4 Stimulates Proliferation of Endometriotic Stromal Cells

  2010cited by this paper
• REVIEW ARTICLE: Governing the Invasive Trophoblast: Current Aspects on Intra‐ and Extracellular Regulation

  2010cited by this paper
• The DSCs-Expressed CD82 Controls the Invasiveness of Trophoblast Cells via Integrinbeta1/MAPK/MAPK3/1 Signaling Pathway in Human First-Trimester Pregnancy1

  2010cited by this paper
• Distinct Signal Codes Generate Dendritic Cell Functional Plasticity

  2010cited by this paper
• The role of thymic stromal lymphopoietin (TSLP) in allergic disorders.

  2010cited by this paper
• Functional regulation of thymic stromal lymphopoietin on proliferation and invasion of trophoblasts in human first-trimester pregnancy.

  2010cited by this paper
• Clinical practice. Endometriosis.

  2010cited by this paper
• Immunology of Endometriosis

  2010cited by this paper
• Thymic stromal lymphopoietin induces chemotactic and prosurvival effects in eosinophils: implications in allergic inflammation.

  2010cited by this paper
• Thymic stromal lymphopoietin from trophoblasts induces dendritic cell-mediated regulatory TH2 bias in the decidua during early gestation in humans.

  2010cited by this paper
• Thymic stromal lymphopoietin-mediated STAT5 phosphorylation via kinases JAK1 and JAK2 reveals a key difference from IL-7–induced signaling

  2010cited by this paper
• Thymic Stromal Lymphopoietin-Activated Plasmacytoid Dendritic Cells Induce the Generation of FOXP3+ Regulatory T Cells in Human Thymus

  2010cited by this paper
• Endometriosis and infertility: pathophysiology and management.

  2010cited by this paper
• Glucocorticoids Inhibit Double-Stranded RNA-Induced Thymic Stromal Lymphopoietin Release from Keratinocytes in an Atopic Cytokine Milieu More Effectively than Tacrolimus

  2010cited by this paper
• Thymic Stromal Lymphopoietin Receptor-Mediated IL-6 and CC/CXC Chemokines Expression in Human Airway Smooth Muscle Cells: Role of MAPKs (ERK1/2, p38, and JNK) and STAT3 Pathways

  2010cited by this paper
• Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008

  2010cited by this paper
• REVIEW ARTICLE: Regulatory T Cells and Their Role in Pregnancy

  2010cited by this paper
• Human corneal epithelium-derived thymic stromal lymphopoietin links the innate and adaptive immune responses via TLRs and Th2 cytokines.

  2009cited by this paper
• p53 Mediates epidermal growth factor (EGF) induction of MMP-2 transcription and trophoblast invasion.

  2009cited by this paper
• Comparison of murine thymic stromal lymphopoietin- and polyinosinic polycytidylic acid-mediated placental dendritic cell activation.

  2009cited by this paper
• The regulatory role of thymic stromal lymphopoietin (TSLP) in maternal-fetal immune tolerance during early human pregnancy.

  2009cited by this paper
• Estrogen metabolism and action in endometriosis.

  2009cited by this paper
• Role of cytokines in the endometrial-peritoneal cross-talk and development of endometriosis.

  2009cited by this paper
• TSLP-induced placental DC activation and IL-10(+) NK cell expansion: comparative study based on BALB/c x C57BL/6 and NOD/SCID x C57BL/6 pregnant models.

  2008cited by this paper
• REVIEW ARTICLE: Immunopathogenesis of Pelvic Endometriosis: Role of Hepatocyte Growth Factor, Macrophages and Ovarian Steroids

  2008cited by this paper
• Trophoblast invasion: the role of intracellular cytokine signalling via signal transducer and activator of transcription 3 (STAT3).

  2008cited by this paper
• Fetal tolerance in human pregnancy--a crucial balance between acceptance and limitation of trophoblast invasion.

  2008cited by this paper
• Pathogenic mechanisms in endometriosis-associated infertility.

  2008cited by this paper
• Novel Therapeutic Strategies for Endometriosis: A Pathophysiological Perspective

  2008cited by this paper
• Up-regulation of VEGF, c-fms and COX-2 expression correlates with severity of cervical cancer precursor (CIN) lesions and invasive disease.

  2008cited by this paper
• Fetal tolerance in human pregnancy--a crucial balance between acceptance and limitation of trophoblast invasion.

  2008cited by this paper
• Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells

  2007cited by this paper
• Inducible expression of the proallergic cytokine thymic stromal lymphopoietin in airway epithelial cells is controlled by NFkappaB.

  2007cited by this paper
• Differential Role of Thymic Stromal Lymphopoietin in the Induction of Airway Hyperreactivity and Th2 Immune Response in Antigen-Induced Asthma with Respect to Natural Killer T Cell Function

  2007cited by this paper
• TSLP: an epithelial cell cytokine that regulates T cell differentiation by conditioning dendritic cell maturation.

  2007cited by this paper
• Endometriosis: an inflammatory disease with a Th2 immune response component.

  2007cited by this paper
• Cutting Edge: Proinflammatory and Th2 Cytokines Synergize to Induce Thymic Stromal Lymphopoietin Production by Human Skin Keratinocytes1

  2007cited by this paper
• Thymic stromal lymphopoietin secretion of synovial fibroblasts is positively and negatively regulated by Toll-like receptors/nuclear factor-κB pathway and interferon-γ/dexamethasone

  2007cited by this paper
• Interleukin‐1 Stimulates Macrophage Migration Inhibitory Factor Secretion in Ectopic Endometrial Cells of Women with Endometriosis

  2007cited by this paper
• Metformin suppresses interleukin (IL)-1beta-induced IL-8 production, aromatase activation, and proliferation of endometriotic stromal cells.

  2007cited by this paper
• Inducible expression of the proallergic cytokine thymic stromal lymphopoietin in airway epithelial cells is controlled by NFκB

  2007cited by this paper
• Thymic stromal lymphopoietin secretion of synovial fibroblasts is positively and negatively regulated by Toll-like receptors/nuclear factor-kappaB pathway and interferon-gamma/dexamethasone.

  2007cited by this paper
• TLR3- and Th2 Cytokine-Dependent Production of Thymic Stromal Lymphopoietin in Human Airway Epithelial Cells1

  2007cited by this paper
• Pivotal Advance: Eosinophil infiltration of solid tumors is an early and persistent inflammatory host response

  2006cited by this paper
• T cells in normal pregnancy and recurrent pregnancy loss.

  2006cited by this paper
• Maintenance and polarization of human TH2 central memory T cells by thymic stromal lymphopoietin-activated dendritic cells.

  2006cited by this paper
• Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis.

  2006cited by this paper
• Activin A Functions as a Th2 Cytokine in the Promotion of the Alternative Activation of Macrophages1

  2006cited by this paper
• Human First-Trimester Trophoblast Cells Recruit CD56brightCD16− NK Cells into Decidua by Way of Expressing and Secreting of CXCL12/Stromal Cell-Derived Factor 1

  2005cited by this paper
• TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand

  2005cited by this paper
• Interleukin-1 stimulates macrophage migration inhibitory factor secretion in ectopic endometrial cells of women with endometriosis.

  2005cited by this paper
• Blockade of CD86 Signaling Facilitates a Th2 Bias at the Maternal-Fetal Interface and Expands Peripheral CD4+CD25+ Regulatory T Cells to Rescue Abortion-Prone Fetuses1

  2005cited by this paper
• Thymic Stromal Lymphopoietin Expression Is Increased in Asthmatic Airways and Correlates with Expression of Th2-Attracting Chemokines and Disease Severity1

  2005cited by this paper
• Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice

  2005cited by this paper
• Changes in the T-helper cytokine profile and in lymphocyte activation at the systemic and local levels in women with endometriosis.

  2005cited by this paper
• Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus

  2005cited by this paper
• Expression of human papillomavirus type 16 E6 and E7 oncoproteins in primary foreskin keratinocytes is sufficient to alter the expression of angiogenic factors

  2004cited by this paper
• Regulatory T cells mediate maternal tolerance to the fetus

  2004cited by this paper
• Danger signals derived from stressed and necrotic epithelial cells activate human eosinophils

  2004cited by this paper
• A Role for Thymic Stromal Lymphopoietin in CD4+ T Cell Development

  2004cited by this paper
• Human decidual lymphocytes and the immunobiology of pregnancy.

  2004cited by this paper
• Human thymic stromal lymphopoietin promotes dendritic cell–mediated CD4+ T cell homeostatic expansion

  2004cited by this paper
• Normal human pregnancy is associated with an elevation in the immune suppressive CD25+ CD4+ regulatory T‐cell subset

  2004cited by this paper
• Predominance of Th2‐promoting dendritic cells in early human pregnancy decidua

  2003cited by this paper
• Endoglin (CD105): a powerful therapeutic target on tumor-associated angiogenetic blood vessels

  2003cited by this paper
• A review of immune cells and molecules in women with recurrent miscarriage.

  2003cited by this paper
• The Role of Cytokines in Endometriosis *

  2003cited by this paper
• Dendritic Cells in the Human Decidua1

  2003cited by this paper
• Role of Laparoscopy in the Treatment of Endometriosis-Associated Infertility

  2002cited by this paper
• Dominant IL‐10 and TGF‐β mRNA Expression in γδT Cells of Human Early Pregnancy Decidua Suggests Immunoregulatory Potential

  2002cited by this paper

• TSLP enhances progestin response in endometrial cancer via androgen receptor signal pathway

  2024cites this paper
• From drug repositioning to target repositioning: prediction of therapeutic targets using genetically perturbed transcriptomic signatures

  2022cites this paper
• Short-Form Thymic Stromal Lymphopoietin (sfTSLP) Is the Predominant Isoform Expressed by Gynaecologic Cancers and Promotes Tumour Growth

  2021cites this paper
• Nursing interventions for perioperative infections in obstetric and gynecological diseases

  2020cites this paper
• Molecular characteristics and possible functions of innate lymphoid cells in the uterus and gut.

  2019cites this paper
• Anti-inflammatory cytokines in endometriosis

  2019cites this paper
• TSLP: from allergy to cancer

  2019cites this paper
• Estrogen restricts the apoptosis of endometrial stromal cells by promoting TSLP secretion

  2018cites this paper
• Estimating global gross primary productivity using chlorophyll fluorescence and a data assimilation system with the BETHY-SCOPE model

  2018cites this paper
• The involvement of multifunctional TGF-β and related cytokines in pathogenesis of endometriosis.

  2018cites this paper