Methylation of p15INK4B is common, is associated with deletion of genes on chromosome arm 7q and predicts a poor prognosis in therapy-related myelodysplasia and acute myeloid leukemia

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Leukemia

• Publication date

  2003-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/sj.leu.2403054PMID 12970781
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Demethylation of a hypermethylated P15/INK4B gene in patients with myelodysplastic syndrome by 5-Aza-2'-deoxycytidine (decitabine) treatment.

  2002cited by this paper
• Causality of myelodysplasia and acute myeloid leukemia and their genetic abnormalities

  2002cited by this paper
• Expression profiling of CD34+ hematopoietic stem/ progenitor cells reveals distinct subtypes of therapy-related acute myeloid leukemia

  2002cited by this paper
• The RB and p53 pathways in cancer.

  2002cited by this paper
• Methylation of p15 and p16 genes in acute promyelocytic leukemia: potential diagnostic and prognostic significance.

  2001cited by this paper
• Mutations with loss of heterozygosity of p53 are common in therapy-related myelodysplasia and acute myeloid leukemia after exposure to alkylating agents and significantly associated with deletion or loss of 5q, a complex karyotype, and a poor prognosis.

  2001cited by this paper
• Expression of p15(ink4b) gene during megakaryocytic differentiation of normal and myelodysplastic hematopoietic progenitors.

  2001cited by this paper
• Methylation of p15 and p16 genes in adult acute leukemia

  2001cited by this paper
• P15INK4B gene methylation and expression in normal, myelodysplastic, and acute myelogenous leukemia cells and in the marrow cells of cured lymphoma patients

  2001cited by this paper
• Duplication or amplification of chromosome band 11q23, including the unrearranged MLL gene, is a recurrent abnormality in therapy‐related MDS and AML, and is closely related to mutation of the TP53 gene and to previous therapy with alkylating agents

  2001cited by this paper
• Methylation of the p15INK4B gene in myelodysplastic syndrome: it can be detected early at diagnosis or during disease progression and is highly associated with leukaemic transformation

  2001cited by this paper
• Internal tandem duplications of the FLT3 and MLL genes are mainly observed in atypical cases of therapy-related acute myeloid leukemia with a normal karyotype and are unrelated to type of previous therapy

  2001cited by this paper
• Anticorresponding p15 promoter methylation and microsatellite instability in acute myeloblastic leukemia.

  2000cited by this paper
• Methylation status of the p15INK4B gene in hematopoietic progenitors and peripheral blood cells in myelodysplastic syndromes

  2000cited by this paper
• Transforming growth factor-beta: pleiotropic role in the regulation of hematopoiesis.

  2000cited by this paper
• Aberrant p15 promoter methylation in adult and childhood acute leukemias of nearly all morphologic subtypes: potential prognostic implications.

  2000cited by this paper
• Methylation status of the p15[INK 48] gene in hematopoietic progenitors and peripheral blood cells in myelodysplastic syndromes

  2000cited by this paper
• Lineage‐specific regulation of cell cycle control gene expression during haematopoietic cell differentiation

  2000cited by this paper
• Expression of cyclin-dependent kinase inhibitor p15(INK4B) during normal and leukemic myeloid differentiation.

  2000cited by this paper
• Anticorresponding p15 promoter methylation and microsatellite instability in acute myeloblastic leukemia

  2000cited by this paper
• Extensive intra- and interindividual heterogeneity of p15INK4B methylation in acute myeloid leukemia.

  1999cited by this paper
• ABL1 methylation is a distinct molecular event associated with clonal evolution of chronic myeloid leukemia.

  1999cited by this paper
• p15(INK4B) CpG island methylation in primary acute leukemia is heterogeneous and suggests density as a critical factor for transcriptional silencing.

  1999cited by this paper
• Signaling to p53: breaking the MDM2-p53 circuit.

  1998cited by this paper
• Review of alterations of the cyclin-dependent kinase inhibitor INK4 family genes p15, p16, p18 and p19 in human leukemia–lymphoma cells

  1998cited by this paper
• Methylation of the p15(INK4b) gene in myelodysplastic syndromes is frequent and acquired during disease progression.

  1998cited by this paper
• Expression of p15INK4B in normal hematopoiesis.

  1998cited by this paper
• Expression and regulation of G1 cell-cycle inhibitors (p16INK4A , p15INK4B, p18 INK4C, p19INK4D ) in human acute myeloid leukemia and normal myeloid cells

  1997cited by this paper
• Hypermethylation of the p15INK4B gene in myelodysplastic syndromes.

  1997cited by this paper
• Cancer Cell Cycles

  1996cited by this paper
• Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B.

  1996cited by this paper
• Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands.

  1996cited by this paper
• Different genetic pathways in leukemogenesis for patients presenting with therapy-related myelodysplasia and therapy-related acute myeloid leukemia.

  1995cited by this paper
• A bisulfite method of 5-methylcytosine mapping that minimizes template degradation.

  1995cited by this paper
• p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest.

  1994cited by this paper
• High sensitivity mapping of methylated cytosines.

  1994cited by this paper
• pl5INK4B is a potentia| effector of TGF-β-induced cell cycle arrest

  1994cited by this paper
• The balanced and the unbalanced chromosome aberrations of acute myeloid leukemia may develop in different ways and may contribute differently to malignant transformation.

  1994cited by this paper
• A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands.

  1992cited by this paper

• From pathogenesis to management: therapy-related myeloid neoplasms in survivors of female-specific cancers

  2026cites this paper
• Molecular insights and treatment innovations: Advancing outcomes in acute myeloid leukemia with myelodysplasia‑related changes (Review).

  2025cites this paper
• Epigenetic signature of ionizing radiation in therapy-related AML patients.

  2023cites this paper
• The Effect of the Persian Gulf Jellyfish (Cassiopea andromeda) Venom on the Expression of P15, P21, P53, DNMT1, and Bcl-2 in Acute Lymphoblastic Leukemia Jurkat Cells

  2023cites this paper
• Cyclin-dependent kinase inhibitors in malignant hematopoiesis

  2022cites this paper
• Effects of hypoxia on DNA hydroxymethylase Tet methylcytosine dioxygenase 2 in a KG-1 human acute myeloid leukemia cell line and its mechanism

  2021cites this paper
• Characterization of the Immune Response Induced by Rhabdovirus-Infected Leukemia Cell Vaccines

  2020cites this paper
• Intracellular Pharmacokinetics of Pyrimidine Analogues used in Oncology and the Correlation with Drug Action

  2020cites this paper
• Characterization of secondary and therapy-related acute myeloid leukemia

  2020cites this paper
• Role of p15(INK4B) Methylation in Patients With Myelodysplastic Syndromes: A Systematic Meta-Analysis.

  2019cites this paper
• Oncogenic Roles and Inhibitors of DNMT1, DNMT3A, and DNMT3B in Acute Myeloid Leukaemia

  2019cites this paper
• Azacytidine in Newly Diagnosed FLT3-ITD-Positive Acute Myeloid Leukemia Presenting with Pneumonia: A Case Series

  2019cites this paper
• Azacitidine Use for Myeloid Neoplasms

  2018cites this paper
• Analysis of the Methylation Status of CpG Sites Within Cancer-Related Genes in Equine Sarcoids

  2018cites this paper
• Population Pharmacokinetic Analysis of Decitabine in Pediatric Patients With Acute Myeloid Leukemia

  2018cites this paper
• Aging- and Senescence-associated Changes of Mesenchymal Stromal Cells in Myelodysplastic Syndromes

  2018cites this paper
• Decitabine Versus Intensive Chemotherapy for Elderly Patients With Newly Diagnosed Acute Myeloid Leukemia.

  2018cites this paper
• Data integration by multi-tuning parameter elastic net regression

  2018cites this paper
• Exploring the role of epigenetic alterations in myeloid malignancies with focus on drug response

  2018cites this paper
• A vicious loop of fatty acid-binding protein 4 and DNA methyltransferase 1 promotes acute myeloid leukemia and acts as a therapeutic target

  2017cites this paper
• Significance of Inactivated Genes in Leukemia: Pathogenesis and Prognosis

  2017cites this paper
• Prognostic impact of p15 gene aberrations in acute leukemia

  2017influential citation
• Pyrosequencing quantified methylation level of miR-124 predicts shorter survival for patients with myelodysplastic syndrome

  2017cites this paper
• 15 p 15 INK 4 b , a Tumor Suppressor in Acute Myeloid Leukemia

  2017influential citation
• CDKN2B Methylation Correlates with Survival in AML Patients

  2017cites this paper
• DNA Methylation Events as Markers for Diagnosis and Management of Acute Myeloid Leukemia and Myelodysplastic Syndrome

  2017cites this paper
• Novel therapeutic strategies in myelodysplastic syndromes: do molecular genetics help?

  2016cites this paper
• [Aberrant methylation of the promoter regions of the SOX7 and p15INK4b genes and Wnt signaling pathway antagonists in patients with acute myeloid leukemias].

  2016cites this paper
• New treatment strategies in myelodysplastic syndromes and acute myeloid leukemia: Hypomethylating agents and proteasome inhibitors

  2016cites this paper
• Mutations of myelodysplastic syndromes (MDS): An update.

  2016cites this paper
• Increased DNA methylation of Dnmt3b targets impairs leukemogenesis.

  2016cites this paper
• The role of microRNA in myelodysplastic syndromes: beyond DNA methylation and histone modification

  2016cites this paper
• Spotlight on decitabine for myelodysplastic syndromes in Chinese patients

  2015cites this paper
• Dysregulation of the MIRLET7/HMGA2 axis with methylation of the CDKN2A promoter in myeloproliferative neoplasms

  2015cites this paper
• Development of Epigenetic Targeted Therapies in Hematological Malignancies: From Serendipity to Synthetic Lethality

  2015cites this paper
• Digging deep into “dirty” drugs – modulation of the methylation machinery

  2015cites this paper
• MicroRNA expression profiles in BCR-ABL-negative primary myelofibrosis with chromosome 7q defects

  2015cites this paper
• RETRACTED ARTICLE: 5-Azacitidine for treating acute myelogenous leukemia

  2015cites this paper
• Epigenetic aberrations in acute myeloid leukemia: Early key events during leukemogenesis.

  2015cites this paper
• Machine Learning Based Analysis of DNA Methylation Patterns in Pediatric Acute Leukemia

  2015cites this paper
• Genetic mutations in epigenetic modifiers as therapeutic targets in acute myeloid leukemia

  2015cites this paper
• Myelodysplastic Syndromes

  2015cites this paper
• Methylenetetrahydrofolate reductase polymorphisms in myelodysplastic syndromes and therapy-related myeloid neoplasms

  2014cites this paper
• The Diagnostic Value of DNA Methylation in Leukemia: A Systematic Review and Meta-Analysis

  2014cites this paper
• Mechanisms of resistance to azacitidine in human leukemia cell lines.

  2014cites this paper
• DNA Methylation Abnormalities in Hematopoietic Disorders: Biological Significance and Methodological Approaches

  2014cites this paper
• DNA hypermethylation of cell cycle (p15 and p16) and apoptotic (p14, p53, DAPK and TMS1) genes in peripheral blood of leukemia patients.

  2014influential citation
• −7/7q− syndrome in myeloid-lineage hematopoietic malignancies: attempts to understand this complex disease entity

  2014cites this paper
• Pharmacodynamic Responses to DNA Methyltransferase Inhibition

  2014cites this paper
• 5-Azacytidine/5-Azacitidine.

  2014cites this paper
• Five important advances in hematopathology.

  2014cites this paper
• Therapy-Related Acute Myelogenous Leukemia

  2013cites this paper
• Chapter 9 Role of Cytogenetic Analysis in the Diagnosis and Classification of Hematopoietic Neoplasms

  2013cites this paper
• Treatment of Myelodysplastic Syndrome and Acute Myeloid Leukemia by Immunomodulatory and Epigenetic Drugs

  2013cites this paper
• Curcumin Down-Regulates DNA Methyltransferase 1 and Plays an Anti-Leukemic Role in Acute Myeloid Leukemia

  2013cites this paper
• Prognostic role of immunohistochemical analysis of 5 mc in myelodysplastic syndromes

  2013cites this paper
• Treatment of Acute Myeloid Leukemia with 20–30% Bone Marrow Blasts

  2013cites this paper
• ХРОМОСОМНЫЕ АНОМАЛИИ В КРОВЕТВОРНЫХ И СТРОМАЛЬНЫХ КЛЕТКАХ- ПРЕДШЕСТВЕННИКАХ ПРИ МИЕЛОДИСПЛАСТИЧЕСКОМ СИНДРОМЕ

  2013cites this paper
• p15Ink4b Functions in determining hematopoietic cell fates: implications for its role as a tumor suppressor.

  2013cites this paper
• Epigenetic alterations and microRNAs

  2013cites this paper
• Epigenetic aspects of MDS and its molecular targeted therapy

  2013cites this paper
• Comparison of Methylation Profiling in Cancerous and Their Corresponding Normal Tissues from Korean Patients with Breast Cancer

  2013cites this paper
• Detection of aberrant methylation of tumor suppressor genes in plasma from cancer patients

  2013cites this paper
• Role of DNA methylation in the pathogenesis and treatment of myelodysplastic syndromes.

  2013cites this paper
• Decitabine for the treatment of adult patients (age ≥65 years) with newly diagnosed de novo or secondary acute myeloid leukemia

  2013cites this paper
• Concise Review: Erythroid Versus Myeloid Lineage Commitment: Regulating the Master Regulators

  2013cites this paper
• Identification of genetic aberrations in myelodysplastic syndromes

  2012cites this paper
• Interface of Epigenetics and Carcinogenic Risk Assessment

  2012cites this paper
• Evaluation of targeted methylation at the CDKN2B promoter

  2012cites this paper
• A critical appraisal of tools available for monitoring epigenetic changes in clinical samples from patients with myeloid malignancies

  2012cites this paper
• Molecular-Based Classification of Acute Myeloid Leukemia and Its Role in Directing Rational Therapy

  2012cites this paper
• Epigenetics and Myelodysplastic Syndrome

  2012cites this paper
• Interpreting new molecular genetics in myelodysplastic syndromes.

  2012cites this paper
• 5 Epigenetics and Targeted Therapy in Acute Leukemia

  2012cites this paper
• p15Ink4b Loss Impairs the Maturation and Activation of Conventional Dendritic Cells

  2012cites this paper
• Aberration of p73 promoter methylation in de novo myelodysplastic syndrome

  2012cites this paper
• Chapter 16 – Biochemical Mechanisms of Drug Toxicity

  2012cites this paper
• Outcome of therapy-related myeloid neoplasms treated with azacitidine

  2012cites this paper
• Clinical applications of epigenetic markers and epigenetic profiling in myeloid malignancies.

  2012cites this paper
• Decreased DNA methylation in acute myeloid leukemia patients with DNMT3A mutations and prognostic implications of DNA methylation.

  2012cites this paper
• Behandlung des drohenden hämatologischen Rezidivs von Patienten mit MDS und AML nach allogener Stammzelltransplantation mit 5-Azacytidin (Vidaza®)

  2012cites this paper
• Cytogenetic abnormalities in myelodysplastic syndrome: an overview

  2011cites this paper
• Unfavorable-risk cytogenetics in acute myeloid leukemia

  2011cites this paper
• Aberrant Epigenetic and Genetic Marks Are Seen in Myelodysplastic Leukocytes and Reveal Dock4 as a Candidate Pathogenic Gene on Chromosome 7q*

  2011cites this paper
• Mediterranean Journal of Hematology and Infectious Diseases Perspectives Genetic Pathways Leading to Therapy

  2011cites this paper
• Epigenetics and Targeted Therapy in Acute Leukemia

  2011cites this paper
• Myelodysplastic syndromes.

  2011cites this paper
• Genetic abnormalities in leukemia secondary to treatment in patients with Hodgkin's disease.

  2011cites this paper
• p15INK4b, a Tumor Suppressor in Acute Myeloid Leukemia

  2011influential citation
• Myelodysplastic Syndromes: Pathophysiology

  2011cites this paper
• The Role of Epigenetic Modifications in Cancer

  2011cites this paper
• Nuevas estrategias terapéuticas en leucemias agudas mieloblásticas: evaluación preclínica de la eficacia y el mecanismo de ación

  2011cites this paper
• Acute Myeloid Leukemias with Normal Cytogenetics

  2010cites this paper
• Epigenetic mechanisms in AML - a target for therapy.

  2010cites this paper
• Epigenetic approaches in the treatment of myelodysplastic syndromes: clinical utility of azacitidine

  2010cites this paper
• 5-Azacytidine/Azacitidine.

  2010cites this paper
• DNA methylation predicts survival and response to therapy in patients with myelodysplastic syndromes.

  2010cites this paper
• Cytogenetic and genetic pathways in therapy-related acute myeloid leukemia.

  2010cites this paper
• Epigenetic changes in the myelodysplastic syndrome.

  2010cites this paper
• Epigenetic differences in cytogenetically normal versus abnormal acute myeloid leukemia

  2010cites this paper