When Clarity Is Crucial: Regulating Ocular Surface Immunity.

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Trends in immunology

• Publication date

  2017-12-13

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.it.2017.11.007PMID 29248310PMCID PMC5880704
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Subclinical Herpes Simplex Virus Type 1 Infections Provide Site-Specific Resistance to an Unrelated Pathogen

  2017cited by this paper
• IFN-γ–Expressing Th17 Cells Are Required for Development of Severe Ocular Surface Autoimmunity

  2017cited by this paper
• The Intriguing Role of Neuropeptides at the Ocular Surface.

  2017influential reference
• Goblet Cells Contribute to Ocular Surface Immune Tolerance—Implications for Dry Eye Disease

  2017cited by this paper
• Proangiogenic Function of T Cells in Corneal Transplantation

  2017cited by this paper
• Homeostatic Immunity and the Microbiota.

  2017cited by this paper
• Treg‐recruiting microspheres prevent inflammation in a murine model of dry eye disease

  2017influential reference
• Prevalence of Diagnosed Dry Eye Disease in the United States Among Adults Aged 18 Years and Older.

  2017cited by this paper
• Interleukin-7 and -15 maintain pathogenic memory Th17 cells in autoimmunity.

  2017cited by this paper
• Temporal Stability and Composition of the Ocular Surface Microbiome

  2017cited by this paper
• T Cell–Derived Granulocyte-Macrophage Colony-Stimulating Factor Contributes to Dry Eye Disease Pathogenesis by Promoting CD11b+ Myeloid Cell Maturation and Migration

  2017cited by this paper
• An Ocular Commensal Protects against Corneal Infection by Driving an Interleukin‐17 Response from Mucosal &ggr;&dgr; T Cells

  2017cited by this paper
• Role of Microbiota in Strengthening Ocular Mucosal Barrier Function Through Secretory IgA

  2017cited by this paper
• A Commencement for Eye Commensals.

  2017cited by this paper
• Mucosal immune tolerance at the ocular surface in health and disease

  2017cited by this paper
• Neuropeptide substance P and the immune response

  2016cited by this paper
• Impaired Function of Peripherally Induced Regulatory T Cells in Hosts at High Risk of Graft Rejection

  2016cited by this paper
• In Vivo Expansion of Regulatory T Cells by Low-Dose Interleukin-2 Treatment Increases Allograft Survival in Corneal Transplantation

  2016cited by this paper
• Global Survey of Corneal Transplantation and Eye Banking.

  2016cited by this paper
• Pseudomonas Keratitis, a Review of Where We’ve Been and What Lies Ahead

  2016cited by this paper
• Age-related spontaneous lacrimal keratoconjunctivitis is accompanied by dysfunctional T regulatory cells

  2016influential reference
• Corneal Neovascular Diseases

  2016cited by this paper
• Ocular Surface Membrane-Associated Mucins.

  2016cited by this paper
• Novel Insights Into the Immunoregulatory Function and Localization of Dendritic Cells

  2016cited by this paper
• Impact of Microbiome on Ocular Health.

  2016influential reference
• Alloimmunity and Tolerance in Corneal Transplantation

  2016cited by this paper
• Loss of Neurokinin-1 Receptor Alters Ocular Surface Homeostasis and Promotes an Early Development of Herpes Stromal Keratitis

  2016cited by this paper
• Pseudomonas Keratitis, a Review of Where Wehave Been and What LiesAhead

  2015cited by this paper
• Immunomodulatory Cross-Talk between Conjunctival Goblet Cells and Dendritic Cells

  2015cited by this paper
• Dendritic Cell Autophagy Contributes to Herpes Simplex Virus-Driven Stromal Keratitis and Immunopathology

  2015cited by this paper
• Severing Corneal Nerves in One Eye Induces Sympathetic Loss of Immune Privilege and Promotes Rejection of Future Corneal Allografts Placed in Either Eye

  2015cited by this paper
• Th17 and regulatory T cell balance in autoimmune and inflammatory diseases.

  2014cited by this paper
• Corneal plasmaytoid dendritic cells subpopulations demonstrate differential expression of the functional Siglec-H receptor that are altered after corneal inflammation

  2014cited by this paper
• Desiccating Stress–Induced Chemokine Expression in the Epithelium Is Dependent on Upregulation of NKG2D/RAE-1 and Release of IFN-γ in Experimental Dry Eye

  2014cited by this paper
• Dendritic cell–epithelial cell crosstalk in the gut

  2014cited by this paper
• CCR7 is critical for the induction and maintenance of Th17 immunity in dry eye disease.

  2014cited by this paper
• Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis

  2013cited by this paper
• Chronic Dry Eye Disease is Principally Mediated by Effector Memory Th17 Cells

  2013cited by this paper
• Nerves and neovessels inhibit each other in the cornea.

  2013cited by this paper
• Dendritic cell‐derived thrombospondin‐1 is critical for the generation of the ocular surface Th17 response to desiccating stress

  2013cited by this paper
• Peripherally Induced Tregs – Role in Immune Homeostasis and Autoimmunity

  2013cited by this paper
• Ocular Mucosal CD11b+ and CD103+ Mouse Dendritic Cells under Normal Conditions and in Allergic Immune Responses

  2013cited by this paper
• Dry Eye as a Mucosal Autoimmune Disease

  2013cited by this paper
• The neuropeptides α-MSH and NPY modulate phagocytosis and phagolysosome activation in RAW 264.7 cells.

  2013cited by this paper
• The intriguing mission of neuropeptide Y in the immune system

  2013cited by this paper
• CD8+ Cells Regulate the T helper-17 Response in an Experimental Murine Model of Sjögren Syndrome

  2013cited by this paper
• The CCR6/CCL20 axis mediates Th17 cell migration to the ocular surface in dry eye disease.

  2013cited by this paper
• Self-antigen-driven activation induces instability of regulatory T cells during an inflammatory autoimmune response.

  2013cited by this paper
• Antimicrobial compounds in tears.

  2013cited by this paper
• Donor‐derived, tolerogenic dendritic cells suppress immune rejection in the indirect allosensitization‐dominant setting of corneal transplantation

  2012cited by this paper
• Mice with Mutations in Fas and Fas Ligand Demonstrate Increased Herpetic Stromal Keratitis following Corneal Infection with HSV-1

  2012cited by this paper
• Mapping the protein domain structures of the respiratory mucins: a mucin proteome coverage study.

  2012cited by this paper
• Expression of toll-like receptor 4 contributes to corneal inflammation in experimental dry eye disease.

  2012cited by this paper
• Immunological Disruption of Antiangiogenic Signals by Recruited Allospecific T Cells Leads to Corneal Allograft Rejection

  2012cited by this paper
• Vasoactive intestinal peptide: a neuropeptide with pleiotropic immune functions

  2011cited by this paper
• Toll-like receptor activation modulates antimicrobial peptide expression by ocular surface cells.

  2011cited by this paper
• The Alpha-Melanocyte Stimulating Hormone Induces Conversion of Effector T Cells into Treg Cells

  2011cited by this paper
• Characterization of Langerin-expressing dendritic cell subsets in the normal cornea.

  2011cited by this paper
• Modulation of epithelial immunity by mucosal fluid

  2011cited by this paper
• A novel function for programmed death ligand-1 regulation of angiogenesis.

  2011cited by this paper
• Lung dendritic cells at the innate‐adaptive immune interface

  2011cited by this paper
• Ocular Surface APCs Are Necessary for Autoreactive T Cell-Mediated Experimental Autoimmune Lacrimal Keratoconjunctivitis

  2011cited by this paper
• IL-17A–Dependent CD4+CD25+ Regulatory T Cells Promote Immune Privilege of Corneal Allografts

  2011cited by this paper
• Membrane-tethered mucins have multiple functions on the ocular surface.

  2010cited by this paper
• Regulation of T-cell chemotaxis by programmed death-ligand 1 (PD-L1) in dry eye-associated corneal inflammation.

  2010cited by this paper
• HSV-1 infection of human corneal epithelial cells: Receptor-mediated entry and trends of re-infection

  2010cited by this paper
• Dendritic cell physiology and function in the eye

  2010cited by this paper
• GITR ligand-mediated local expansion of regulatory T cells and immune privilege of corneal allografts.

  2010cited by this paper
• The role of TLRs, NLRs, and RLRs in mucosal innate immunity and homeostasis

  2010cited by this paper
• CD4 T-cell differentiation and inflammatory bowel disease.

  2009cited by this paper
• Selective control of SIRP-alpha-positive airway dendritic cell trafficking through CD47 is critical for the development of T(H)2-mediated allergic inflammation.

  2009cited by this paper
• Human corneal epithelium-derived thymic stromal lymphopoietin links the innate and adaptive immune responses via TLRs and Th2 cytokines.

  2009cited by this paper
• Alternatively spliced VEGF receptor-2 is an essential endogenous inhibitor of lymphatic vessels

  2009cited by this paper
• Autoimmunity in Dry Eye Is Due to Resistance of Th17 to Treg Suppression1

  2009cited by this paper
• CD11b+ Myeloid Cells Are the Key Mediators of Th2 Cell Homing into the Airway in Allergic Inflammation1

  2009cited by this paper
• Intestinal lamina propria dendritic cell subsets have different origin and functions.

  2009cited by this paper
• Levels of Foxp3 in Regulatory T Cells Reflect Their Functional Status in Transplantation1

  2009cited by this paper
• Dendritic cell antigen presentation drives simultaneous cytokine production by effector and regulatory T cells in inflamed skin.

  2009cited by this paper
• NK-Dependent Increases in CCL22 Secretion Selectively Recruits Regulatory T Cells to the Tumor Microenvironment1

  2009cited by this paper
• Animal models of dry eye.

  2008cited by this paper
• Toll-like receptors at the ocular surface.

  2008cited by this paper
• Cytokines and chemokines in immune-based ocular surface inflammation

  2008cited by this paper
• Lack of MD2 expression in human corneal epithelial cells is an underlying mechanism of lipopolysaccharide (LPS) unresponsiveness

  2008cited by this paper
• Surgery for the Dry Eye

  2008cited by this paper
• Assay of mucins in human tear fluid.

  2007cited by this paper
• The Function of Donor versus Recipient Programmed Death-Ligand 1 in Corneal Allograft Survival1

  2007cited by this paper
• Characterization of antigen-presenting cells in fresh and cultured human corneas using novel dendritic cell markers.

  2007influential reference
• Molecular regulation of angiogenesis and lymphangiogenesis

  2007influential reference
• Desiccating Stress Induces T Cell-Mediated Sjögren’s Syndrome-Like Lacrimal Keratoconjunctivitis1

  2006cited by this paper
• Nonvascular VEGF receptor 3 expression by corneal epithelium maintains avascularity and vision.

  2006cited by this paper
• Corneal avascularity is due to soluble VEGF receptor-1

  2006influential reference
• Epithelial dendritic cell distribution in normal and inflamed human cornea: in vivo confocal microscopy study.

  2006cited by this paper
• The role of Fas ligand as an effector molecule in corneal graft rejection

  2005cited by this paper
• Substance P regulates natural killer cell interferon‐γ production and resistance to Pseudomonas aeruginosa infection

  2005cited by this paper
• Early events in HSV keratitis--setting the stage for a blinding disease.

  2005influential reference
• Distinct populations of dendritic cells in the normal human donor corneal epithelium.

  2005cited by this paper
• Experimental dry eye stimulates production of inflammatory cytokines and MMP-9 and activates MAPK signaling pathways on the ocular surface.

  2004cited by this paper
• The role of substance P in inflammatory disease

  2004cited by this paper
• Relevance of the Direct Pathway of Sensitization in Corneal Transplantation Is Dictated by the Graft Bed Microenvironment1

  2004cited by this paper
• Anti-angiogenic role of angiostatin during corneal wound healing.

  2004cited by this paper

• Oblique Light Sheet Fluorescence Microscopy With Surface Tracking for High-Speed Large-Area Imaging of Conjunctival Goblet Cells

  2025cites this paper
• Therapeutic potential of regulatory T cells for stem cell regulation: Insights from Treg-mediated enhancement of limbal stem cell functions

  2025cites this paper
• Understanding the immunology of the ocular surface and its relevance to clinical practice

  2025cites this paper
• Identification of glutamine as a potential therapeutic target in dry eye disease

  2025cites this paper
• A small-molecule enhancer of STAT1 affects herpes simplex keratitis prognosis by mediating plasmacytoid dendritic cells migration through CXCR3/CXCL10.

  2025cites this paper
• Tear fluid participates in systemic immunity.

  2025cites this paper
• Bioactive P(VDF‐TrFE) Bandage Contact Lenses Enhance Corneal Wound Healing Through Microelectric Field Stimulation

  2025cites this paper
• Medical and surgical approaches to prevent corneal graft rejection in high-risk recipients.

  2025cites this paper
• Periostin deletion reduces corneal opacity and the infiltration of immune cells.

  2025cites this paper
• The microenvironment of ocular surface in keratoconus: a systematic review

  2025cites this paper
• Profiles, Distribution, and Functions of Gamma Delta T Cells in Ocular Surface Homeostasis and Diseases.

  2024cites this paper
• Insulin eye drops improve corneal wound healing in STZ-induced diabetic mice by regulating corneal inflammation and neuropeptide release

  2024cites this paper
• Single cell analysis of short-term dry eye induced changes in cornea immune cell populations

  2024influential citation
• Suppression of Neovascularization by Topical and Subconjunctival Bevacizumab After High-Risk Corneal Transplantation

  2024cites this paper
• The Various Roles of PEDF in Cancer

  2024cites this paper
• Sialylated IVIg promotes clinical improvements in a rabbit dry eye model by regulating inflammatory cytokines.

  2024cites this paper
• Living with your biome: how the bacterial microbiome impacts ocular surface health and disease

  2024cites this paper
• Healing the Cornea: Exploring the Therapeutic Solutions Offered by MSCs and MSC-derived EVs.

  2024cites this paper
• Mouse Corneal Immune Cell Heterogeneity Revealed by Single-Cell RNA Sequencing

  2024cites this paper
• Eyelid dermatitis in patch-tested adult patients: a systematic review with a meta-analysis

  2024cites this paper
• Mast cells and Ocular Surface: An Update Review.

  2024cites this paper
• Impact of inflammasomes on the ocular surface

  2024cites this paper
• Contact lenses as a potential vehicle of Candida transmission.

  2024cites this paper
• Immunopathological mechanisms and clinical manifestations of ocular graft-versus-host disease following hematopoietic stem cell transplantation

  2024cites this paper
• Ocular RNA nanomedicine: engineered delivery nanoplatforms in treating eye diseases.

  2024cites this paper
• Retinal transplant immunology and advancements

  2024cites this paper
• Tear biomarkers in dry eye disease: Progress in the last decade

  2023cites this paper
• Comparative Proteomics Reveals Prolonged Corneal Preservation Impaired Ocular Surface Immunity Accompanied by Fibrosis in Human Stroma.

  2023cites this paper
• MHC II–EGFP Knock‐in Mouse Model

  2023cites this paper
• Thymoquinone attenuates inflammation in C. Albicans keratitis by activating Nrf2/HO-1 signaling pathway and reducing fungal load.

  2023cites this paper
• The miR-183/96/182 cluster is a checkpoint for resident immune cells and shapes the cellular landscape of the cornea.

  2023cites this paper
• Mapping Resident Immune Cells in the Murine Ocular Surface and Lacrimal Gland by Flow Cytometry

  2023cites this paper
• Hypothyroidism affects corneal homeostasis and wound healing in mice.

  2022cites this paper
• Activation of the STAT5 Signaling Pathway by Yiqi Jiedu Formula Induces Regulatory T Cell-Mediated Alleviation of Corneal Immunopathological Damage in Mice With Recurrent Herpes Simplex Keratitis

  2022cites this paper
• dsRNA Induced IFNβ-MMP13 Axis Drives Corneal Wound Healing

  2022cites this paper
• An Experimental Model of Neuro–Immune Interactions in the Eye: Corneal Sensory Nerves and Resident Dendritic Cells

  2022cites this paper
• Age-related ocular surface failure: A narrative review.

  2022cites this paper
• The effect of topical decorin on temporal changes to corneal immune cells after epithelial abrasion

  2022cites this paper
• Reflections on the Ocular Surface: Summary of the Presentations at the 4th Coronis Foundation Ophthalmic Symposium Debate: "A Multifactorial Approach to Ocular Surface Disorders" (August 31 2021).

  2022cites this paper
• Extracellular Vesicles in Corneal Fibrosis/Scarring

  2022cites this paper
• In vitro antimicrobial activity of ozonated oil in liposome eyedrop against multidrug-resistant bacteria

  2022cites this paper
• RETRACTED ARTICLE: Topical antibiotics reduce CD11c+ cell numbers in the healthy murine cornea and modulate their response to contact lens wear

  2022cites this paper
• Mucosal immunology of the ocular surface

  2022cites this paper
• Cytokine profile of human limbal myofibroblasts: Key players in corneal antiviral response.

  2022cites this paper
• MHC II - EGFP knock-in mouse model is a suitable tool for systems and quantitative immunology.

  2022cites this paper
• Infectious keratitis: an update on epidemiology, causative microorganisms, risk factors, and antimicrobial resistance

  2021cites this paper
• Gelatin scaffold with multifunctional curcumin-loaded lipid-PLGA hybrid microparticles for regenerating corneal endothelium.

  2021cites this paper
• Wound dressing gel with resisted bacterial penetration and enhanced re-epithelization for corneal epithelial-stromal regeneration

  2021cites this paper
• Pre‐incubation of corneal donor tissue with sCD83 improves graft survival via the induction of alternatively activated macrophages and tolerogenic dendritic cells

  2021cites this paper
• Pivotal Role of Corneal Fibroblasts in Progression to Corneal Ulcer in Bacterial Keratitis

  2021cites this paper
• Secreted Ly-6/uPAR-related protein-1 (SLURP1) is a pro-differentiation factor that stalls G1-S transition during corneal epithelial cell cycle progression.

  2021cites this paper
• Lipoxin A4 activates ALX/FPR2 to attenuate inflammation in Aspergillus fumigatus keratitis.

  2021cites this paper
• In vitro analysis of the interaction of tear film inflammatory markers with contemporary contact lens materials.

  2021cites this paper
• Spatial distribution of mast cells regulates asymmetrical angiogenesis at the ocular surface.

  2021cites this paper
• Resident Innate Immune Cells in the Cornea

  2021cites this paper
• Polluted Air Exposure Compromises Corneal Immunity and Exacerbates Inflammation in Acute Herpes Simplex Keratitis

  2021cites this paper
• The ocular surface immune system through the eyes of aging.

  2021cites this paper
• The cornea IV immunology, infection, neovascularization, and surgery chapter 1: Corneal immunology.

  2021cites this paper
• Pigment epithelium-derived factor (PEDF) plays anti-inflammatory roles in the pathogenesis of dry eye disease.

  2021cites this paper
• The potential of lipid mediator networks as ocular surface therapeutics and biomarkers.

  2020cites this paper
• Corneal Resident Macrophages The miR-183/96/182 Cluster Regulates the Functions of

  2020cites this paper
• Studies on the Optimization of Neuropeptides Detection in the Human Tear Film

  2020cites this paper
• The miR-183/96/182 Cluster Regulates the Functions of Corneal Resident Macrophages

  2020cites this paper
• There is a Role in Detection of SARS-CoV-2 in Conjunctiva and Tears: a comprehensive review.

  2020cites this paper
• COVID-19 and ophthalmology: Role of the immune system/ COVID-19 y oftalmología: Rol del sistema inmunitario

  2020influential citation
• Transient tear hyperosmolarity disrupts the neuroimmune homeostasis of the ocular surface and facilitates dry eye onset

  2020cites this paper
• The role of Th17 immunity in chronic ocular surface disorders.

  2020cites this paper
• Aged mice exhibit severe exacerbations of dry eye disease with an amplified memory Th17 cell response.

  2020cites this paper
• Ocular surface pathogenesis associated with precocious eyelid opening and necrotic autologous tissue in mouse with disruption of Prickle 1 gene

  2019cites this paper
• Pathophysiology of Corneal Graft Rejection

  2019cites this paper
• Insights from Clinical Trials in Corneal Surgery

  2019cites this paper
• A Pyrrhic Victory: The PMN Response to Ocular Bacterial Infections

  2019cites this paper
• Thrombospondin-1 in ocular surface health and disease.

  2019cites this paper
• Vaccine-induced Antibodies Target Sequestered Viral Antigens to Prevent Ocular HSV-1 Pathogenesis, Preserve Vision, and Preempt Productive Neuronal Infection

  2019cites this paper
• An Eye on Staphylococcus aureus Toxins: Roles in Ocular Damage and Inflammation

  2019cites this paper
• The purinergic receptor antagonist oxidized adenosine triphosphate suppresses immune-mediated corneal allograft rejection

  2019cites this paper
• Age-Related Changes to Human Tear Composition.

  2018cites this paper
• Reduced Corneal Innervation in the CD25 Null Model of Sjögren Syndrome †

  2018cites this paper