Pathogenic Importance of Intestinal Hypermotility in NSAID-Induced Small Intestinal Damage in Rats

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Digestion

• Publication date

  2002-10-04

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1159/000064419PMID 12379813
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Up-regulation of cyclooxygenase-2 by inhibition of cyclooxygenase-1: a key to nonsteroidal anti-inflammatory drug-induced intestinal damage.

  2002cited by this paper
• 16,16-Dimethyl Prostaglandin E2 Inhibits Indomethacin-Induced Small Intestinal Lesions Through EP3 and EP4 Receptors

  2002cited by this paper
• Protective effect of thiaton, an antispasmodic drug, against indomethacin-induced intestinal damage in rats.

  2002cited by this paper
• Up‐regulation of COX‐2 by inhibition of COX‐1 in the rat: a key to NSAID‐induced gastric injury

  2002cited by this paper
• Roles of inhibition of COX-1 and COX-2 in NSAID-induced small intestinal damage in rats

  2001cited by this paper
• Disturbance of peristalsis in the guinea‐pig isolated small intestine by indomethacin, but not cyclo‐oxygenase isoform‐selective inhibitors

  2001cited by this paper
• Gastrointestinal sparing anti-inflammatory drugs--effects on ulcerogenic and healing responses.

  2001cited by this paper
• Protection by aspirin of indomethacin-induced small intestinal damage in rats: mediation by salicylic acid.

  2001cited by this paper
• Roles of enterobacteria, nitric oxide and neutrophil in pathogenesis of indomethacin-induced small intestinal lesions in rats.

  1999cited by this paper
• Dual action of nitric oxide in pathogenesis of indomethacin-induced small intestinal ulceration in rats.

  1999cited by this paper
• Nonsteroidal anti-inflammatory drug enteropathy in rats: role of permeability, bacteria, and enterohepatic circulation.

  1997influential reference
• Vascular anatomy defines sites of indomethacin induced jejunal ulceration along the mesenteric margin

  1997cited by this paper
• Induction of nitric oxide synthase and microvascular injury in the rat jejunum provoked by indomethacin

  1995cited by this paper
• NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro.

  1994influential reference
• Mechanisms of acute and chronic intestinal inflammation induced by indomethacin

  1993cited by this paper
• Aminoguanidine selectively inhibits inducible nitric oxide synthase

  1993cited by this paper
• The induction of nitric oxide synthase and intestinal vascular permeability by endotoxin in the rat

  1993cited by this paper
• Early histological features of small intestinal injury induced by indomethacin

  1993cited by this paper
• Differential distribution of nitric oxide synthase between cell fractions isolated from the rat gastric mucosa.

  1992influential reference
• Oxygen free radicals and lipid peroxidation in the pathogenesis of gastric mucosal lesions induced by indomethacin in rats. Relation to gastric hypermotility.

  1991cited by this paper
• Oxygen Free Radicals and Lipid Peroxidation in the Pathogenesis of Gastric Mucosal Lesions Induced by Indomethacin in Rats

  1991cited by this paper
• Possible mechanisms involved in gastric hypermotility caused by indomethacin in the rat

  1990cited by this paper
• Nonsteroidal antiinflammatory drug-induced intestinal inflammation in humans.

  1987cited by this paper
• Importance of gastric motility in the pathogenesis of indomethacin-induced gastric lesions in rats

  1986cited by this paper
• Indometacin-induced gastrointestinal lesions in relation to tissue concentration, food intake and bacterial invasion in the rat.

  1985cited by this paper
• Central control of intestinal motility by prostaglandins: a mediator of the actions of several peptides in rats and dogs.

  1985cited by this paper
• Prostaglandin E2: a neuromodulator in the central control of gastrointestinal motility and feeding behavior by calcitonin.

  1984cited by this paper
• Prevention of phenylbutazone ulcer in the rat by glucose: role of a glycoprivic receptor system.

  1982cited by this paper
• Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker.

  1982cited by this paper
• Contractile responses of longitudinal and circular smooth muscle of the canine stomach to prostaglandins E and F2alpha.

  1982cited by this paper
• Temporal Relationship Between Cyclooxygenase Inhibition, as Measured by Prostacyclin Biosynthesis, and the Gastrointestinal Damage Induced by Indomethacin in the Rat

  1981cited by this paper
• Nitrate synthesis in the germfree and conventional rat.

  1981cited by this paper
• Temporal relationship between cyclooxygenase inhibition, as measured by prostacyclin biosynthesis, and the gastrointestinal damage induced by indomethacin in the rat.

  1981cited by this paper
• Indomethacin-induced intestinal inflammation

  1977cited by this paper
• Resistance of germfree rats to indomethacin-induced intestinal lesions.

  1977cited by this paper

• Network Pharmacology and Experimental Validation Reveal Sishen Pill’s Efficacy in Treating NSAID-Induced Small Intestinal Ulcers

  2025cites this paper
• Prostaglandins and Inflammatory Bowel Disease: From Mechanism to Clinic.

  2025cites this paper
• The origin of intraluminal pressure waves in gastrointestinal tract

  2024cites this paper
• Gastroparesis Worsens Indomethacin-Induced Gastric Antral Ulcers by Bile Reflux via Activation of 5-HT_3 and Dopamine D_2 Receptors in Mice

  2023cites this paper
• Statin Gastroprotective Mechanisms Independent of Gastric Acid Suppression

  2023cites this paper
• Interactions between NSAIDs, opioids and the gut microbiota - Future perspectives in the management of inflammation and pain.

  2022cites this paper
• The Nonsteroidal Anti-Inflammatory Drug Ketorolac Alters the Small Intestinal Microbiota and Bile Acids Without Inducing Intestinal Damage or Delaying Peristalsis in the Rat

  2021cites this paper
• Effect of roxithromycin on contractile activity of gastrointestinal smooth muscles in colitic rats

  2021cites this paper
• MR Measures of Small Bowel Wall T2 Are Associated With Increased Permeability

  2020cites this paper
• Efficacy of Esomeprazole in NSAIDs Induced Gastric Ulcer: A Meta-Analysis

  2019cites this paper
• Nonsteroidal Antiinflammatory Drug-Induced Gastrointestinal Toxicity

  2018cites this paper
• Isoliquiritigenin Ameliorates Indomethacin-Induced Small Intestinal Damage by Inhibiting NOD-Like Receptor Family, Pyrin Domain-Containing 3 Inflammasome Activation

  2018cites this paper
• Ventromedial hypothalamic nucleus in regulation of stress-induced gastric mucosal injury in rats

  2018cites this paper
• The influence of CYP2C19 polymorphisms on exacerbating effect of rabeprazole in celecoxib‐induced small bowel injury

  2017cites this paper
• A Rat Model of Ischemic Enteritis: Pathogenic Importance of Enterobacteria, iNOS/NO, and COX-2/PGE2.

  2017cites this paper
• FFA2 activation combined with ulcerogenic COX inhibition induces duodenal mucosal injury via the 5-HT pathway in rats.

  2017cites this paper
• FFA3 Activation Stimulates Duodenal Bicarbonate Secretion and Prevents NSAID-Induced Enteropathy via the GLP-2 Pathway in Rats

  2017cites this paper
• Roles of prostaglandin E and EP receptors in mucosal protection and ulcerhealing in the gastrointestinal tract

  2017cites this paper
• Polysaccharides derived from Ganoderma lucidum fungus mycelia ameliorate indomethacin-induced small intestinal injury via induction of GM-CSF from macrophages.

  2017cites this paper
• Epiisopiloturine hydrochloride, an imidazole alkaloid isolated from Pilocarpus microphyllus leaves, protects against naproxen-induced gastrointestinal damage in rats.

  2017cites this paper
• ANTIULCEROGENIC EFFICACY OF ETHANOLIC EXTRACT OF VITIS VINIFERA LEAVES IN RATS

  2016cites this paper
• Influence of Adrenalectomy on Protective Effects of Urocortin I, a Corticotropin-Releasing Factor, Against Indomethacin-Induced Entero-pathy in Rats

  2016cites this paper
• Involvement of corticotropin-releasing factor and corticotropin-releasing factor 2 receptors in pathogenesis of ischemia/reperfusion-induced enteritis in rats.

  2016cites this paper
• Clinical importance of nonsteroidal anti-inflammatory drug enteropathy: the relevance of tumor necrosis factor as a promising target.

  2016cites this paper
• Diets with no or low amounts of dietary fiber can reduce small intestinal ulcers induced by non-steroidal anti-inflammatory drugs in dogs.

  2016cites this paper
• Soluble Dietary Fiber Can Protect the Gastrointestinal Mucosa Against Nonsteroidal Anti-Inflammatory Drugs in Mice

  2016cites this paper
• Proton Pump Inhibitors Increase Incidence of Nonsteroidal Anti-Inflammatory Drug-Induced Small Bowel Injury: A Randomized, Placebo-Controlled Trial.

  2016cites this paper
• The microbiota-derived metabolite indole decreases mucosal inflammation and injury in a murine model of NSAID enteropathy

  2016cites this paper
• NSAID-Induced Small Intestinal Damage - Roles of Various Pathogenic Factors

  2015cites this paper
• Epithelium: Role of Prostaglandins Regulation of Smooth Muscle Contraction by the

  2015cites this paper
• Ameliorative effect of the sea cucumber Holothuria arenicola extract against gastric ulcer in rats

  2015cites this paper
• Prophylactic effects of prostaglandin E2 on NSAID-induced enteropathy-role of EP4 receptors in its protective and healing-promoting effects.

  2014cites this paper
• Lafutidine Protects the NSAID-Induced Small Intestinal Lesions Mediated by Capsaicin-Sensitive Afferent Neurons

  2014cites this paper
• Prostaglandin pathways in duodenal chemosensing

  2014cites this paper
• The role of mitochondria-derived reactive oxygen species in the pathogenesis of non-steroidal anti-inflammatory drug-induced small intestinal injury

  2014cites this paper
• Sodium alginate ameliorates indomethacin-induced gastrointestinal mucosal injury via inhibiting translocation in rats.

  2014cites this paper
• Lubiprostone Prevents Nonsteroidal Anti-Inflammatory Drug–Induced Small Intestinal Damage by Suppressing the Expression of Inflammatory Mediators via EP4 Receptors

  2014cites this paper
• Down-regulation of collagen I biosynthesis in intestinal epithelial cells exposed to indomethacin: a comparative proteome analysis.

  2014cites this paper
• Dipeptidyl Peptidase IV Inhibition Prevents the Formation and Promotes the Healing of Indomethacin-Induced Intestinal Ulcers in Rats

  2014cites this paper
• Prophylactic effect of monosodium glutamate on NSAID-induced enteropathy in rats.

  2014cites this paper
• In Vivo Measurement of Intragastric Pressure with a Rubber Balloon in the Anesthetized Rat

  2013cites this paper
• Mucosal Protective Agents Prevent Exacerbation of NSAID-Induced Small Intestinal Lesions Caused by Antisecretory Drugs in Rats

  2013cites this paper
• Hemin ameliorates indomethacin‐induced small intestinal injury in mice through the induction of heme oxygenase‐1

  2013cites this paper
• Prophylactic effect of egualen sodium, a stable azulene derivative, on gastrointestinal damage induced by ischemia/reperfusion, double antiplatelet therapy and loxoprofen in rats.

  2013cites this paper
• The Role of Food for the Formation and Prevention of Gastrointestinal Lesions Induced by Aspirin in Cats

  2013cites this paper
• Cinacalcet, a calcimimetic, prevents nonsteroidal antiinflammatory drug-induced small intestinal damage in rats.

  2013cites this paper
• Roles of EP4 Receptors in Protective and Healing-Promoting Effects of Prostaglandin E2 on NSAID-Induced Small Intestinal Damage

  2012cites this paper
• New therapeutic strategy for amino acid medicine: prophylactic and healing promoting effect of monosodium glutamate against NSAID-induced enteropathy.

  2012cites this paper
• A Sulfated-Polysaccharide Fraction from Seaweed Gracilaria birdiae Prevents Naproxen-Induced Gastrointestinal Damage in Rats

  2012cites this paper
• Title Page. Jpet #199182 Introduction

  2012cites this paper
• Chapter 43 – Gastroduodenal Mucosal Defense

  2012cites this paper
• In vitro and in vivo Protection against Indomethacin-Induced Small Intestinal Injury by Proton Pump Inhibitors, Acid Pump Antagonists, or Indomethacin-Phosphatidylcholine

  2012cites this paper
• Exacerbation of Nonsteroidal Anti-Inflammatory Drug-Induced Small Intestinal Lesions by Antisecretory Drugs in Rats: The Role of Intestinal Motility

  2012cites this paper
• epithelial cells by oxidation-related modifications of ZO-1 Acetyl salicylic acid induces damage to intestinal

  2012cites this paper
• Role of Food and Enterobacteria in the Formation and Prevention of Small Intestinal Damage Induced by NSAIDs

  2012cites this paper
• Biological activities of extracts and isolated compounds from Bauhinia galpinii (Fabaceae) and Combretum vendae (Combretaceae) as potential antidiarrhoeal agents

  2012cites this paper
• Discovery of lansoprazole and its unique pharmacological properties independent from anti-secretory activity.

  2012cites this paper
• [Development of NSAID-induced small intestinal lesions - pathogenic role of COX inhibition].

  2012cites this paper
• Management of NSAID/aspirin-induced small intestinal damage by GI-sparing NSAIDs, anti-ulcer drugs and food constituents.

  2012cites this paper
• Small intestinal injury caused by NSAIDs/aspirin: finding new from old.

  2012cites this paper
• Acetyl salicylic acid induces damage to intestinal epithelial cells by oxidation-related modifications of ZO-1.

  2012cites this paper
• Effects on neuroendocrinoimmune network of Lizhong Pill in the reserpine induced rats with spleen deficiency in traditional Chinese medicine.

  2011cites this paper
• Regulation of smooth muscle contraction by the epithelium: role of prostaglandins.

  2011cites this paper
• [Prophylactic effect of glutamate on gastrointestinal damage].

  2011cites this paper
• The pathophysiology of non-steroidal anti-inflammatory drug (NSAID)-induced mucosal injuries in stomach and small intestine

  2011cites this paper
• Dopamine D₂-receptor antagonists ameliorate indomethacin-induced small intestinal ulceration in mice by activating α7 nicotinic acetylcholine receptors.

  2011cites this paper
• Zinc protects against indomethacin-induced damage in the rat small intestine.

  2011cites this paper
• Activation of α7 nicotinic acetylcholine receptors ameliorates indomethacin-induced small intestinal ulceration in mice.

  2011cites this paper
• Diazoxide attenuates indomethacin-induced small intestinal damage in the rat.

  2011cites this paper
• Dopamine D2–Receptor Antagonists Ameliorate Indomethacin-Induced Small Intestinal Ulceration in Mice by Activating α7 Nicotinic Acetylcholine Receptors

  2011cites this paper
• Protective effect of geranylgeranylacetone against loxoprofen sodium-induced small intestinal lesions in rats.

  2011cites this paper
• Measurement of small intestinal damage.

  2010cites this paper
• Wireless Capsule Endoscopy in Enteropathy Induced by Nonsteroidal Anti-inflammatory Drugs in Pigs

  2010cites this paper
• Prostaglandin EP receptors and their roles in mucosal protection and ulcer healing in the gastrointestinal tract.

  2010cites this paper
• Soluble Dietary Fiber Protects Against Nonsteroidal Anti-inflammatory Drug-Induced Damage to the Small Intestine in Cats

  2010cites this paper
• Overexpression of a 60-kDa heat shock protein enhances cytoprotective function of small intestinal epithelial cells.

  2010cites this paper
• Protective effect of roxatidine against indomethacin‐induced small intestinal mucosal injury in rats

  2010cites this paper
• Roles of COX inhibition in pathogenesis of NSAID-induced small intestinal damage.

  2010cites this paper
• Vulnerable Sites and Changes in Mucin in the Rat Small Intestine After Non-steroidal Anti-inflammatory Drugs Administration

  2010cites this paper
• The 5-HT4 receptor agonist mosapride attenuates NSAID-induced gastric mucosal damage

  2010cites this paper
• Protective effect of lafutidine, a histamine H2 receptor antagonist, against loxoprofen‐induced small intestinal lesions in rats

  2010cites this paper
• Prostaglandin EP receptors involved in modulating gastrointestinal mucosal integrity.

  2010cites this paper
• Role of dietary fiber in formation and prevention of small intestinal ulcers induced by nonsteroidal anti-inflammatory drug.

  2010cites this paper
• Prevention by lansoprazole, a proton pump inhibitor, of indomethacin -induced small intestinal ulceration in rats through induction of heme oxygenase-1.

  2010cites this paper
• Urocortin Prevents Indomethacin-Induced Small Intestinal Lesions in Rats Through Activation of CRF2 Receptors

  2010cites this paper
• Inhibition of Bach1 ameliorates indomethacin-induced intestinal injury in mice.

  2009cites this paper
• Effects of indomethacin on the rat small intestinal mucosa: immunohistochemical and biochemical studies using anti-mucin monoclonal antibodies

  2009cites this paper
• Sildenafil, an Inhibitor of Phosphodiesterase Subtype 5, Prevents Indomethacin-Induced Small-Intestinal Ulceration in Rats via a NO/cGMP-Dependent Mechanism

  2009influential citation
• Present status and strategy of NSAIDs-induced small bowel injury

  2009cites this paper
• Prevention of NSAID-Induced Small Intestinal Mucosal Injury: Prophylactic Potential of Lansoprazole

  2009cites this paper
• S1625 Effect of Cj-42794, a Selective Antagonist of Prostaglandin E Receptor Subtype 4, On Ulcerogenic and Healing Responses in Rat Gastrointestinal Mucosa

  2008influential citation
• Prophylactic Effect of Irsogladine Maleate Against Indomethacin-Induced Small Intestinal Lesions in Rats

  2008cites this paper
• Gastroduodenal mucosal defense

  2008cites this paper
• Role of dietary fibres, intestinal hypermotility and leukotrienes in the pathogenesis of NSAID-induced small intestinal ulcers in cats

  2008cites this paper
• Der protektive Einfluss des TNF-alpha-Antikörpers auf die Pathogenese der nekrotisierenden Enterocolitis

  2007cites this paper
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  2007cites this paper
• Protective effect of pranlukast, a cysteinyl-leukotriene receptor 1 antagonist, on indomethacin-induced small intestinal damage in rats

  2007cites this paper
• Increased susceptibility of small intestine to NSAID-provoked ulceration in rats with adjuvant-induced arthritis: involvement of enhanced expression of TLR4.

  2007cites this paper
• Dexamethasone Damages the Rat Stomach but Not Small Intestine During Inhibition of COX-1

  2007cites this paper
• Nimesulide Alters Cell Recruitment into Mitosis in Murine Intestinal Crypts Without Influencing the Cell Production Rate

  2007cites this paper